Effect of cardiopulmonary bypass on thrombin generation and protein C pathway

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 27, Issue 1, 2013, Pages 35-40

  Taneja, Ravi ^a,b   Liaw, Patricia L ^c   Al Ghazaly, Samer ^b   Priestap, Fran ^b   Murkin, John M ^b   Martin, Claudio M ^a,b  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

activated protein C; cardiac surgery; cardiopulmonary bypass; endothelial protein C receptor; off cardiopulmonary bypass surgery; thrombin; thrombomodulin

Indexed keywords

ACTIVATED PROTEIN C; ENDOTHELIAL PROTEIN C RECEPTOR; PROTAMINE; PROTEIN C; PROTHROMBIN; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; THROMBOMODULIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; ELECTIVE SURGERY; FEMALE; HUMAN; INTENSIVE CARE; MALE; OBSERVATIONAL STUDY; OFF PUMP CORONARY SURGERY; PRIORITY JOURNAL; PROSPECTIVE STUDY; TERTIARY HEALTH CARE;

AGED; CARDIOPULMONARY BYPASS; COHORT STUDIES; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; PROTEIN C; SIGNAL TRANSDUCTION; THROMBIN; TREATMENT OUTCOME; UP-REGULATION;

EID: 84872170219     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2012.09.004     Document Type: Article

References (45)

1. P. Raivio, J.A. Fernández, A. Kuitunen Activation of protein C and hemodynamic recovery after coronary artery bypass surgery J Thorac Cardiovasc Surg 133 2007 44 51
2. L.H. Edmunds, R.W. Colman Thrombin during cardiopulmonary bypass Ann Thorac Surg 82 2006 2315 2322
3. B. Dixon, J. Santamaria, D. Campbell Coagulation activation and organ dysfunction following cardiac surgery Chest 128 2005 229 236
4. J.M. Siller-Matula, M. Schwameis, A. Blann Thrombin as a multi-functional enzyme Focus on in vitro and in vivo effects Thromb Haemost 106 2011 1020 1033
5. J. Petäjä, E. Pesonen, J.A. Fernández Cardiopulmonary bypass and activation of antithrombotic plasma protein C J Thorac Cardiovasc Surg 118 1999 422 429
6. P. Raivio, A. Kuitunen, R. Suojaranta-Ylinen Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damage J Thromb Haemost 4 2006 1523 1529
7. G.J. Despotis, J.H. Joist, C.W. Hogue More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT Thromb Haemost 76 1996 902 908
8. G.J. Despotis, J.H. Joist, C.W. Hogue The impact of heparin concentration and activated clotting time monitoring on blood conservation A prospective, randomized evaluation in patients undergoing cardiac operation J Thorac Cardiovasc Surg 110 1995 46 54
9. D.R. Jobes, G.L. Aitken, G.W. Shaffer Increased accuracy and precision of heparin and protamine dosing reduces blood loss and transfusion in patients undergoing primary cardiac operations J Thorac Cardiovasc Surg 110 1995 36 45
10. C.T. Esmon The protein C pathway Chest 124 2003 26S 32S
11. J.E. Sadler Thrombomodulin structure and function Thromb Haemost 78 1997 392 395
12. H. Weiler Regulation of inflammation by the protein C system Crit Care Med 38 2010 S18 S25
13. Faust SN, Heyderman RS, Levin M: Coagulation in severe sepsis: A central role for thrombomodulin and activated protein C. Crit Care Med 29:S62-S67
14. R. Linder, S. Frebelius, K. Jansson Inhibition of endothelial cell-mediated generation of activated protein C by direct and antithrombin-dependent thrombin inhibitors Blood Coagul Fibrinolysis 14 2003 139 146
15. J. Aznar, F. España, A. Estellés Heparin stimulation of the inhibition of activated protein C and other enzymes by human protein C inhibitor - Influence of the molecular weightof heparin and ionic strength Thromb Haemost 76 1996 983 988
16. U. Friedrich, A.M. Blom, B. Dahlbäck Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C J Biol Chem 276 2001 24122 24128
17. J. Petäjä, E. Pesonen, J.A. Fernández Activated protein C and inflammation in human myocardium after heart surgery Am J Hematol 67 2001 210 212
18. P.C. Liaw, G. Ferrell, C.T. Esmon A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation J Thromb Haemost 1 2003 662 670
19. Z. Laszik, C.W. Carson, T. Nadasdy Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy Lab Invest 70 1994 862 867
20. S. Kurosawa, D.J. Stearns-Kurosawa, N. Hidari Identification of functional endothelial protein C receptor in human plasma J Clin Invest 100 1997 411 418
21. M.D. Boisclair, D.A. Lane, H. Philippou Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment; F1 + 2 Thromb Haemost 70 1993 253 258
22. B. Lo, R. Fijnheer, D. Castigliego Activation of hemostasis after coronary artery bypass grafting with or without cardiopulmonary bypass Anesth Analg 99 2004 634 640
23. B.J. Hunt, R.N. Parratt, H.C. Segal Activation of coagulation and fibrinolysis during cardiothoracic operations Ann Thorac Surg 65 1998 712 718
24. T.F. Slaughter, T.H. LeBleu, J.M. Douglas Characterization of prothrombin activation during cardiac surgery by hemostatic molecular markers Anesthesiology 80 1994 520 526
25. M.D. Boisclair, D.A. Lane, H. Philippou Mechanisms of thrombin generation during surgery and cardiopulmonary bypass Blood 82 1993 3350 3357
26. D. Paparella, A. Galeone, M.T. Venneri Activation of the coagulation system during coronary artery bypass grafting: Comparison between on-pump and off-pump techniques J Thorac Cardiovasc Surg 131 2006 290 297
27. M.A. Mariani, Y.J. Gu, P.W. Boonstra Procoagulant activity after off-pump coronary operation: Is the current anticoagulation adequate? Ann Thorac Surg 67 1999 1370 1375
28. D. Chen, A. Dorling Critical roles for thrombin in acute and chronic inflammation J Thromb Haemost 7 suppl 1 2009 122 126
29. M. Yavari, R.C. Becker Coagulation and fibrinolytic protein kinetics in cardiopulmonary bypass J Thromb Thrombolysis 27 2009 95 104
30. T.R. Snow, M.T. Deal, D.T. Dickey Protein C activation following coronary artery occlusion in the in situ porcine heart Circulation 84 1991 293 299
31. M. Jormalainen, A.E. Vento, H. Lukkarinen Inhibition of thrombin during reperfusion improves immediate postischemic myocardial function and modulates apoptosis in a porcine model of cardiopulmonary bypass J Cardiothorac Vasc Anesth 21 2007 224 231
32. J. Petäjä, E. Pesonen, J.A. Fernández Cardiopulmonary bypass and activation of antithrombotic plasma protein C J Thorac Cardiovasc Surg 118 1999 422 429
33. J. Petäjä, E. Pesonen, J.A. Fernández Activated protein C and inflammation in human myocardium after heart surgery Am J Hematol 67 2001 210 212
34. J. Babin-Ebell, M. Misoph, W. Müllges Intraoperative embolus formation during cardiopulmonary bypass affects the release of S100B J Thorac Cardiovasc Surg 47 1999 166 169
35. P.D. Raymond, N.A. Marsh Alterations to haemostasis following cardiopulmonary bypass and the relationship of these changes to neurocognitive morbidity Blood Coagul Fibrinolysis 12 2001 601 618
36. P.C. Liaw, C.T. Esmon, K. Kahnamoui Patients with severe sepsis vary markedly in their ability to generate activated protein C Blood 104 2004 3958 3964
37. D.J. Stearns-Kurosawa, S. Kurosawa, J.S. Mollica The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex Proc Natl Acad Sci U S A 93 1996 10212 10216
38. S. Kurosawa, D.J. Stearns-Kurosawa, C.W. Carson Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes Blood 91 1998 725 727
39. J. Xu, D. Qu, N.L. Esmon Metalloproteolytic release of endothelial cell protein C receptor J Biol Chem 275 2000 6038 6044
40. F.S. Orhon, H. Ergun, Y. Egin Soluble endothelial protein C receptor levels in healthy population J Thromb Thrombolysis 29 2010 46 51
41. X. Zheng, W. Li, J.M. Gu Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice Blood 109 2007 1003 1009
42. E.M. Conway, R.D. Rosenberg Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells Mol Cell Biol 8 1988 5588 5592
43. K. Fukudome, C.T. Esmon Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor J Biol Chem 269 1994 26486 26491
44. A. Parolari, S. Colli, L. Mussoni Coagulation and fibrinolytic markers in a two-month follow-up of coronary bypass surgery J Thorac Cardiovasc Surg 125 2003 336 343
45. R. Taneja, P. Fernandes, G. Marwaha Perioperative coagulation management and blood conservation in cardiac surgery: A Canadian Survey J Cardiothorac Vasc Anesth 22 2008 662 669