Inhibition of Thrombin During Reperfusion Improves Immediate Postischemic Myocardial Function and Modulates Apoptosis in a Porcine Model of Cardiopulmonary Bypass

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 21, Issue 2, 2007, Pages 224-231

  Jormalainen, Mikko ^a   Vento, Antti E ^a   Lukkarinen, Heikki ^d   Kääpä, Pekka ^d   Kytö, Ville ^d   Lauronen, Jouni ^b,c   Paavonen, Timo ^b,f   Suojaranta Ylinen, Raili ^a   Petäjä, Jari ^c,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

^e JORVI HOSPITAL   (Finland)

^f UNIVERSITY OF OULU   (Finland)

Author keywords

apoptosis; cardiac; coagulation; ischemia reperfusion; thrombin

Indexed keywords

CASPASE 3; HIRUDIN; MYELOPEROXIDASE; THROMBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICOAGULATION; AORTA CLAMPING; APOPTOSIS; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CELL NUCLEUS; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG INFUSION; ENZYME ACTIVITY; HEART ARREST; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE BIOPSY; HEART MUSCLE ISCHEMIA; HEART OUTPUT; HEART STROKE VOLUME; HEART SURGERY; HEMODYNAMICS; HISTOLOGY; INFLAMMATION; LEUKOCYTE; MICROTHROMBUS; MUSCLE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; SWINE; WEANING;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOPULMONARY BYPASS; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOLYTIC AGENTS; HEART RATE; HIRUDINS; IN SITU NICK-END LABELING; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; RANDOM ALLOCATION; SWINE; THROMBIN; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE; WHOLE BLOOD COAGULATION TIME;

EID: 34047143837     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2006.02.028     Document Type: Article

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