Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes

Diabetes

Volumn 53, Issue 10, 2004, Pages 2709-2712

  Nejentsev, Sergey ^a,j   Cooper, Jason D ^a   Godfrey, Lisa ^a   Howson, Joanna M M ^a   Rance, Helen ^a   Nutland, Sarah ^a   Walker, Neil M ^a   Guja, Cristian ^b   Ionescu Tirgovişte, Constantin ^b   Savage, David A ^c   Undlien, Dag E ^d   Rønningen, Kjersti S ^e   Tuomilehto Wolf, Eva ^f   Tuomilehto, Jaakko ^f,g   Gillespie, Kathleen M ^h   Ring, Susan M ^h   Strachan, David P ⁱ   Widmer, Barry ^j   Dunger, David ^j   Todd, John A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Inst Diabet   (Romania)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^e NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^g UNIVERSITY OF HELSINKI   (Finland)

^h UNIVERSITY OF BRISTOL   (United Kingdom)

ⁱ ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D RECEPTOR;

ARTICLE; GENETIC VARIABILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 4644246531     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.10.2709     Document Type: Article

References (25)

1. Todd JA, Wicker LS: Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity 15:387-395, 2001
2. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Ronningen KS, Guja C, Ionescu Tirgoviste C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-511, 2003
3. Mathieu C, Laureys J, Sobis H, Vandeputte M, Waer M, Bouillon R: 1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice. Diabetes 41: 1491-1495, 1992
4. Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R: Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 37:552-558, 1994
5. Zella JB, McCary LC, DeLuca HF: Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus. Arch Biochem Biophys 417:77-80, 2003
6. Mathieu C, Adorini L: The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med 8:174-179, 2002
7. the EURODIAB Substudy 2 Study Group: Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. Diabetologia 42:51-54, 1999
8. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM: Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358: 1500-1503, 2001
9. Jones G, Strugnell SA, DeLuca HF: Current understanding of the molecular actions of vitamin D. Physiol Rev 78:1193-1231, 1998
10. Penna G, Adorini L: 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164:2405-2411, 2000
11. Crofts LA, Hancock MS, Morrison NA, Eisman JA: Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts. Proc Natl Acad Sci U S A 95:10529-10534, 1998
12. Zmuda JM, Cauley JA, Ferrell RE: Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev 22:203-217, 2000
13. Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, Tonai T, Nishisho T, Mori S, Takeda E: A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12:915-921, 1997
14. McDermott MF, Ramachandran A, Ogunkolade BW, Aganna E, Curtis D, Boucher BJ, Snehalatha C, Hitman GA: Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia 40:971-975, 1997
15. Pani MA, Knapp M, Donner H, Braun J, Baur MP, Usadel KH, Badenhoop K: Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans. Diabetes 49:504-507, 2000
16. Koeleman BP, Valdigem G, Eerligh P, Giphart MJ, Roep BO: Seasonality of birth in patients with type 1 diabetes (Letter). Lancet 359:1246-1247, 2002
17. Guja C, Marshall S, Welsh K, Merriman M, Smith A, Todd JA, Ionescu Tirgoviste C: The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population. J Cell Mol Med 6:75-81, 2002
18. Fassbender WJ, Goertz B, Weismuller K, Steinhauer B, Stracke H, Auch D, Linn T, Bretzel RG: VDR gene polymorphisms are overrepresented in German patients with type 1 diabetes compared to healthy controls without effect on biochemical parameters of bone metabolism. Horm Metab Res 34:330-337, 2002
19. Turpeinen H, Hermann R, Vaara S, Laine AP, Simell O, Knip M, Veijola R, Ilonen J: Vitamin D receptor polymorphisms: no association with type 1 diabetes in the Finnish population. Eur J Endocrinol 149:591-596, 2003
20. Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton DG, Todd JA: Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 13:1633-1639, 2004
21. Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehto Wolf E, Cucca F, Guja C, Ionescu-Tirgoviste C, Stevens H, Carr P, Nutland S, McKinney P, Shield JP, Wang W, Cordell HJ, Walker N, Todd JA, Concannon P: Parameters for reliable results in genetic association studies in common disease. Nat Genet 30:149-150, 2002
22. Risch NJ: Searching for genetic determinants in the new millennium. Nature 405:847-856, 2000
23. Marchini J, Cardon LR, Phillips MS, Donnelly P: The effects of human population structure on large genetic association studies. Nat Genet 36: 512-517, 2004
24. Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D: Assessing the impact of population stratification on genetic association studies. Nat Genet 36:388-393, 2004
25. Zittermann A: Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 89:552-572, 2003