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Volumn 2012, Issue , 2012, Pages

Traditional chinese medicine-based network pharmacology could lead to new multicompound drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

ASARICIN; ASARININ; CHINESE DRUG; CINNAMALDEHYDE; CINNAMIC ACID; FUZILINE; HIGENAMINE; INDIRUBIN; IRINOTECAN; METHOTREXATE; METHYLEUGENOL; PANAX NOTOGINSENG EXTRACT; PHY 906; REALGAR INDIGO NATURALIS; SAFROLE; SALAZOSULFAPYRIDINE; SALVIA MILTIORRHIZA EXTRACT; SHEXIANGBAOXIN PILL; TANSHINONE; UNCLASSIFIED DRUG;

EID: 84872149806     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/149762     Document Type: Review
Times cited : (99)

References (58)
  • 1
    • 7444253428 scopus 로고    scopus 로고
    • Systems biology and new technologies enable predictive and preventative medicine
    • DOI 10.1126/science.1104635
    • Hood L., Heath J. R., Phelps M. E., Lin B., Systems biology and new technologies enable predictive and preventative medicine. Science 2004 306 640 643 (Pubitemid 39440903)
    • (2004) Science , vol.306 , Issue.5696 , pp. 640-643
    • Hood, L.1    Heath, J.R.2    Phelps, M.E.3    Lin, B.4
  • 3
    • 41149167511 scopus 로고    scopus 로고
    • Network medicine
    • Pawson T., Linding R., Network medicine. FEBS Letters 2008 582 1266 1270
    • (2008) FEBS Letters , vol.582 , pp. 1266-1270
    • Pawson, T.1    Linding, R.2
  • 5
    • 4644289587 scopus 로고    scopus 로고
    • Multitargeted drugs: The end of the 'one-target-one-disease' philosophy?
    • DOI 10.1016/S1359-6446(04)03213-1, PII S1359644604032131
    • Wermuth C. G., Multitargeted drugs: the end of the "one-target-one- disease" philosophy? Drug Discovery Today 2004 9 19 826 827 2-s2.0-4644289587 10.1016/S1359-6446(04)03213-1 (Pubitemid 39286093)
    • (2004) Drug Discovery Today , vol.9 , Issue.19 , pp. 826-827
    • Wermuth, C.G.1
  • 6
    • 35148824614 scopus 로고    scopus 로고
    • Network pharmacology
    • DOI 10.1038/nbt1007-1110, PII NBT10071110
    • Hopkins A. L., Network pharmacology. Nature Biotechnology 2007 25 1110 1111 (Pubitemid 47538107)
    • (2007) Nature Biotechnology , vol.25 , Issue.10 , pp. 1110-1111
    • Hopkins, A.L.1
  • 7
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins A. L., Network pharmacology: the next paradigm in drug discovery. Nature Chemical Biology 2008 4 682 690
    • (2008) Nature Chemical Biology , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 8
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: Is something wrong?
    • DOI 10.1016/S1359-6446(04)03316-1, PII S1359644604033161
    • Sams-Dodd F., Target-based drug discovery: is something wrong? Drug Discovery Today 2005 10 2 139 147 2-s2.0-13844276627 10.1016/S1359-6446(04) 03316-1 (Pubitemid 40247812)
    • (2005) Drug Discovery Today , vol.10 , Issue.2 , pp. 139-147
    • Sams-Dodd, F.1
  • 9
    • 84872139132 scopus 로고    scopus 로고
    • Strategies and techniques for multi-component drug design from medicinal herbs and traditional Chinese medicine
    • Wang Y., Fan X., Qu H., Gao X., Cheng Y., Strategies and techniques for multi-component drug design from medicinal herbs and traditional Chinese medicine. Current Topics in Medicinal Chemistry 2012 12 12 1356 1362
    • (2012) Current Topics in Medicinal Chemistry , vol.12 , Issue.12 , pp. 1356-1362
    • Wang, Y.1    Fan, X.2    Qu, H.3    Gao, X.4    Cheng, Y.5
  • 10
    • 77950803183 scopus 로고    scopus 로고
    • An integrated metabolomics and pharmacokinetics strategy for multi-component drugs evaluation
    • Lan K., Jia W., An integrated metabolomics and pharmacokinetics strategy for multi-component drugs evaluation. Current Drug Metabolism 2010 11 105 114
    • (2010) Current Drug Metabolism , vol.11 , pp. 105-114
    • Lan, K.1    Jia, W.2
  • 11
    • 85028111921 scopus 로고    scopus 로고
    • Drug discovery enters a new era with multi-target intervention strategy
    • In press 10.1007s11655-011-0900-2
    • Tian X. Y., Liu L., Drug discovery enters a new era with multi-target intervention strategy. Chinese Journal of Integrative Medicine. In press 10.1007s11655-011-0900-2
    • Chinese Journal of Integrative Medicine
    • Tian, X.Y.1    Liu, L.2
  • 12
    • 84856325297 scopus 로고    scopus 로고
    • The polypill concept: The future
    • Jaques H., The polypill concept: the future. European Heart Journal 2011 32 2732 2733
    • (2011) European Heart Journal , vol.32 , pp. 2732-2733
    • Jaques, H.1
  • 13
    • 84860994479 scopus 로고    scopus 로고
    • A polypill for all? Critical review of the polypill literature for primary prevention of cardiovascular disease and stroke
    • Carey K. M., Comee M. R., Donovan J. L., Kanaan A., A polypill for all? Critical review of the polypill literature for primary prevention of cardiovascular disease and stroke. The Annals of Pharmacotherapy 2012 46 688 695
    • (2012) The Annals of Pharmacotherapy , vol.46 , pp. 688-695
    • Carey, K.M.1    Comee, M.R.2    Donovan, J.L.3    Kanaan, A.4
  • 14
    • 84859002335 scopus 로고    scopus 로고
    • An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis
    • Lu A., Jiang M., Zhang C., Chan K., An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis. Journal of Ethnopharmacology 2011 141 2 549 556
    • (2011) Journal of Ethnopharmacology , vol.141 , Issue.2 , pp. 549-556
    • Lu, A.1    Jiang, M.2    Zhang, C.3    Chan, K.4
  • 15
    • 65349119431 scopus 로고    scopus 로고
    • Integrative medicine in clinical practice: From pattern differentiation in traditional Chinese medicine to disease treatment
    • Lu A. P., Chen K. J., Integrative medicine in clinical practice: from pattern differentiation in traditional Chinese medicine to disease treatment. Chinese Journal of Integrative Medicine 2009 15 2, article 152
    • (2009) Chinese Journal of Integrative Medicine , vol.15 , Issue.2 ARTICLE 152
    • Lu, A.P.1    Chen, K.J.2
  • 16
    • 38649093681 scopus 로고    scopus 로고
    • Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine
    • DOI 10.3736/jcim20080107
    • He Y. T., Zha Q. L., Yu J. P., Tan Y., Lu C., Lu A. P., Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine 2008 6 32 36 (Pubitemid 351166462)
    • (2008) Journal of Chinese Integrative Medicine , vol.6 , Issue.1 , pp. 32-36
    • He, Y.-T.1    Zha, Q.-L.2    Yu, J.-P.3    Tan, Y.4    Lu, C.5    Lu, A.-P.6
  • 17
    • 71249115347 scopus 로고    scopus 로고
    • Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes
    • Huang C. H., Cong L., Xie J., Qiao B., Lo S. H., Zheng T., Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes. BMC Proceedings 2009 3 supplement 7 S75
    • (2009) BMC Proceedings , vol.3 , Issue.SUPPL. 7
    • Huang, C.H.1    Cong, L.2    Xie, J.3    Qiao, B.4    Lo, S.H.5    Zheng, T.6
  • 18
    • 77956300684 scopus 로고    scopus 로고
    • A comprehensive molecular interaction map for rheumatoid arthritis
    • e10137
    • Wu G., Zhu L., Dent J. E., Nardini C., A comprehensive molecular interaction map for rheumatoid arthritis. PLoS ONE 2010 5 e10137
    • (2010) PLoS ONE , vol.5
    • Wu, G.1    Zhu, L.2    Dent, J.E.3    Nardini, C.4
  • 19
    • 77955039434 scopus 로고    scopus 로고
    • Molecular networks for the study of TCM pharmacology
    • Zhao J., Jiang P., Zhang W., Molecular networks for the study of TCM pharmacology. Briefings in Bioinformatics 2010 11 417 430
    • (2010) Briefings in Bioinformatics , vol.11 , pp. 417-430
    • Zhao, J.1    Jiang, P.2    Zhang, W.3
  • 20
    • 84859707503 scopus 로고    scopus 로고
    • Network-based gene expression biomarkers for cold and heat patterns of rheumatoid arthritis in traditional Chinese medicine
    • 203043 10.1155/2012/203043
    • Lu C., Niu X., Xiao C., Network-based gene expression biomarkers for cold and heat patterns of rheumatoid arthritis in traditional Chinese medicine. Evidence-Based Complementary and Alternative Medicine 2012 2012 17 203043 10.1155/2012/203043
    • (2012) Evidence-Based Complementary and Alternative Medicine , vol.2012 , pp. 17
    • Lu, C.1    Niu, X.2    Xiao, C.3
  • 21
    • 84856532342 scopus 로고    scopus 로고
    • A network-based analysis of traditional Chinese medicine cold and hot patterns in rheumatoid arthritis
    • Chen G., Lu C., Zha Q., A network-based analysis of traditional Chinese medicine cold and hot patterns in rheumatoid arthritis. Complementary Therapies in Medicine 2012 20 23 30
    • (2012) Complementary Therapies in Medicine , vol.20 , pp. 23-30
    • Chen, G.1    Lu, C.2    Zha, Q.3
  • 22
    • 82355163396 scopus 로고    scopus 로고
    • Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis
    • Jiang M., Xiao C., Chen G., Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis. Frontiers of Medicine 2011 5 219 228
    • (2011) Frontiers of Medicine , vol.5 , pp. 219-228
    • Jiang, M.1    Xiao, C.2    Chen, G.3
  • 23
    • 84857122210 scopus 로고    scopus 로고
    • Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: Distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell
    • 2-s2.0-77954812917 10.1007/s00296-010-1546-7
    • Lu C., Xiao C., Chen G., Jiang M., Zha Q., Yan X., Kong W., Lu A., Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell. Rheumatology International 2012 32 1 61 68 2-s2.0-77954812917 10.1007/s00296-010-1546-7
    • (2012) Rheumatology International , vol.32 , Issue.1 , pp. 61-68
    • Lu, C.1    Xiao, C.2    Chen, G.3    Jiang, M.4    Zha, Q.5    Yan, X.6    Kong, W.7    Lu, A.8
  • 24
    • 84859842078 scopus 로고    scopus 로고
    • Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry
    • Gu Y., Lu C., Zha Q., Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry. Molecular BioSystems 2012 8 1535 1543
    • (2012) Molecular BioSystems , vol.8 , pp. 1535-1543
    • Gu, Y.1    Lu, C.2    Zha, Q.3
  • 26
    • 77949682260 scopus 로고    scopus 로고
    • Bridging the gap between traditional Chinese medicine and systems biology: The connection of Cold Syndrome and NEI network
    • Ma T., Tan C., Zhang H., Wang M., Ding W., Li S., Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network. Molecular BioSystems 2010 6 613 619
    • (2010) Molecular BioSystems , vol.6 , pp. 613-619
    • Ma, T.1    Tan, C.2    Zhang, H.3    Wang, M.4    Ding, W.5    Li, S.6
  • 27
    • 34249037449 scopus 로고    scopus 로고
    • Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network
    • DOI 10.1049/iet-syb:20060032
    • Li S., Zhang Z. Q., Wu L. J., Zhang X. G., Li Y. D., Wang Y. Y., Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. IET Systems Biology 2007 1 51 60 (Pubitemid 46779218)
    • (2007) IET Systems Biology , vol.1 , Issue.1 , pp. 51-60
    • Li, S.1    Zhang, Z.Q.2    Wu, L.J.3    Zhang, X.G.4    Li, Y.D.5    Wang, Y.Y.6
  • 28
    • 29144486833 scopus 로고    scopus 로고
    • Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model
    • DOI 10.1021/pr050158o
    • Chen M., Zhao L., Jia W., Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model. Journal of Proteome Research 2005 4 2391 2396 (Pubitemid 41814313)
    • (2005) Journal of Proteome Research , vol.4 , Issue.6 , pp. 2391-2396
    • Chen, M.1    Zhao, L.2    Jia, W.3
  • 29
    • 77955898834 scopus 로고    scopus 로고
    • Chemotherapy: The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity
    • 45ra59 2-s2.0-77955898834 10.1126/scitranslmed.3001270
    • Lam W., Bussom S., Guan F., Jiang Z., Zhang W., Gullen E. A., Liu S. H., Cheng Y. C., Chemotherapy: the four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Science Translational Medicine 2010 2 45 45ra59 2-s2.0-77955898834 10.1126/scitranslmed.3001270
    • (2010) Science Translational Medicine , vol.2 , Issue.45
    • Lam, W.1    Bussom, S.2    Guan, F.3    Jiang, Z.4    Zhang, W.5    Gullen, E.A.6    Liu, S.H.7    Cheng, Y.C.8
  • 31
    • 79951651095 scopus 로고    scopus 로고
    • Potential biomarkers in the urine of myocardial infarction rats: A metabolomic method and its application
    • 2-s2.0-79951651095 10.1039/c0mb00110d
    • Jiang P., Dai W., Yan S., Chen Z., Xu R., Ding J., Xiang L., Wang S., Liu R., Zhang W., Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application. Molecular BioSystems 2011 7 3 824 831 2-s2.0-79951651095 10.1039/c0mb00110d
    • (2011) Molecular BioSystems , vol.7 , Issue.3 , pp. 824-831
    • Jiang, P.1    Dai, W.2    Yan, S.3    Chen, Z.4    Xu, R.5    Ding, J.6    Xiang, L.7    Wang, S.8    Liu, R.9    Zhang, W.10
  • 32
    • 78650832745 scopus 로고    scopus 로고
    • Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae
    • 2-s2.0-78650832745 10.1186/1471-2105-11-S11-S6
    • Li S., Zhang B., Jiang D., Wei Y., Zhang N., Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics 2010 11 11, article S6 2-s2.0-78650832745 10.1186/1471-2105-11-S11-S6
    • (2010) BMC Bioinformatics , vol.11 , Issue.11 ARTICLE S6
    • Li, S.1    Zhang, B.2    Jiang, D.3    Wei, Y.4    Zhang, N.5
  • 33
    • 31144438390 scopus 로고    scopus 로고
    • Rescuing drug discovery: In vivo systems pathology and systems pharmacology
    • 2-s2.0-31144438390 10.1038/nrd1904
    • van der Greef J., McBurney R. N., Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nature Reviews Drug Discovery 2005 4 12 961 967 2-s2.0-31144438390 10.1038/nrd1904
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.12 , pp. 961-967
    • Van Der Greef, J.1    McBurney, R.N.2
  • 34
    • 84863631240 scopus 로고    scopus 로고
    • Targeting the human genome-microbiome axis for drug discovery: Inspirations from global systems biology and traditional Chinese medicine
    • 10.1021/pr3001628
    • Zhao L., Nicholson J. K., Lu A., Targeting the human genome-microbiome axis for drug discovery: inspirations from global systems biology and traditional Chinese medicine. Journal of proteome research 2012 11 7 3509 3519 10.1021/pr3001628
    • (2012) Journal of Proteome Research , vol.11 , Issue.7 , pp. 3509-3519
    • Zhao, L.1    Nicholson, J.K.2    Lu, A.3
  • 35
    • 84855906454 scopus 로고    scopus 로고
    • Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action
    • Zhao S., Iyengar R., Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. Annual Review of Pharmacology and Toxicology 2012 52 505 521
    • (2012) Annual Review of Pharmacology and Toxicology , vol.52 , pp. 505-521
    • Zhao, S.1    Iyengar, R.2
  • 36
    • 84869027949 scopus 로고    scopus 로고
    • Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall on osteoarthritis disease: A computational pharmacology approach
    • Ye H. Z., Zheng C. S., Xu X. J., Wu M. X., Liu X. X., Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall on osteoarthritis disease: a computational pharmacology approach. Chinese Journal of Integrative Medicine 2011 17 698 703
    • (2011) Chinese Journal of Integrative Medicine , vol.17 , pp. 698-703
    • Ye, H.Z.1    Zheng, C.S.2    Xu, X.J.3    Wu, M.X.4    Liu, X.X.5
  • 37
    • 84872160056 scopus 로고    scopus 로고
    • Functional networks for Salvia miltiorrhiza and Panax notoginseng in combination explored with text mining and bioinformatical approach
    • Gao L. B. C., Miao J., Yong T., Aiping L., Functional networks for Salvia miltiorrhiza and Panax notoginseng in combination explored with text mining and bioinformatical approach. Journal of Medicinal Plants Research 2011 5, article 10
    • (2011) Journal of Medicinal Plants Research , vol.510
    • Gao, L.B.C.1    Miao, J.2    Yong, T.3    Aiping, L.4
  • 38
    • 79952844330 scopus 로고    scopus 로고
    • Prediction of the mechanisms of salvia miltiorrhiza against atherosclerosis using text mining and network-based analysis
    • 2-s2.0-79952844330 10.1260/1748-3018.5.1.139
    • Chen G., Lu A. P., Prediction of the mechanisms of salvia miltiorrhiza against atherosclerosis using text mining and network-based analysis. Journal of Algorithms and Computational Technology 2011 5 1 139 144 2-s2.0-79952844330 10.1260/1748-3018.5.1.139
    • (2011) Journal of Algorithms and Computational Technology , vol.5 , Issue.1 , pp. 139-144
    • Chen, G.1    Lu, A.P.2
  • 39
    • 84872152159 scopus 로고    scopus 로고
    • http://www.ncbi.nlm.nih.gov/pubchem
  • 40
    • 70349914727 scopus 로고    scopus 로고
    • PubChem as a source of polypharmacology
    • 2-s2.0-70349914727 10.1021/ci9001876
    • Chen B., Wild D., Guha R., PubChem as a source of polypharmacology. Journal of Chemical Information and Modeling 2009 49 9 2044 2055 2-s2.0-70349914727 10.1021/ci9001876
    • (2009) Journal of Chemical Information and Modeling , vol.49 , Issue.9 , pp. 2044-2055
    • Chen, B.1    Wild, D.2    Guha, R.3
  • 41
    • 78649633211 scopus 로고    scopus 로고
    • PubChem as a public resource for drug discovery
    • 2-s2.0-78649633211 10.1016/j.drudis.2010.10.003
    • Li Q., Cheng T., Wang Y., Bryant S. H., PubChem as a public resource for drug discovery. Drug Discovery Today 2010 15 23-24 1052 1057 2-s2.0-78649633211 10.1016/j.drudis.2010.10.003
    • (2010) Drug Discovery Today , vol.15 , Issue.23-24 , pp. 1052-1057
    • Li, Q.1    Cheng, T.2    Wang, Y.3    Bryant, S.H.4
  • 42
    • 79959380528 scopus 로고    scopus 로고
    • Predicting adverse drug reactions using publicly available PubChem bioassay data
    • 2-s2.0-79959380528 10.1038/clpt.2011.81
    • Pouliot Y., Chiang A. P., Butte A. J., Predicting adverse drug reactions using publicly available PubChem bioassay data. Clinical Pharmacology and Therapeutics 2011 90 1 90 99 2-s2.0-79959380528 10.1038/clpt.2011.81
    • (2011) Clinical Pharmacology and Therapeutics , vol.90 , Issue.1 , pp. 90-99
    • Pouliot, Y.1    Chiang, A.P.2    Butte, A.J.3
  • 43
    • 33748669610 scopus 로고    scopus 로고
    • Constructing biological networks through combined literature mining and microarray analysis: A LMMA approach
    • DOI 10.1093/bioinformatics/btl363
    • Li S., Wu L., Zhang Z., Constructing biological networks through combined literature mining and microarray analysis: a LMMA approach. Bioinformatics 2006 22 17 2143 2150 2-s2.0-33748669610 10.1093/bioinformatics/btl363 (Pubitemid 44390906)
    • (2006) Bioinformatics , vol.22 , Issue.17 , pp. 2143-2150
    • Li, S.1    Wu, L.2    Zhang, Z.3
  • 44
    • 10044240790 scopus 로고    scopus 로고
    • Using prior knowledge to improve genetic network reconstruction from microarray data
    • Le Phillip P., Bahl A., Ungar L. H., Using prior knowledge to improve genetic network reconstruction from microarray data. In Silico Biology 2004 4 3 335 353 2-s2.0-10044240790 (Pubitemid 39600480)
    • (2004) In Silico Biology , vol.4 , Issue.3 , pp. 335-353
    • Le, P.P.1    Bahl, A.2    Ungar, L.H.3
  • 45
    • 31144438390 scopus 로고    scopus 로고
    • Rescuing drug discovery: In vivo systems pathology and systems pharmacology
    • 2-s2.0-31144438390 10.1038/nrd1904
    • van der Greef J., McBurney R. N., Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nature Reviews Drug Discovery 2005 4 12 961 967 2-s2.0-31144438390 10.1038/nrd1904
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.12 , pp. 961-967
    • Van Der Greef, J.1    McBurney, R.N.2
  • 47
    • 0037079054 scopus 로고    scopus 로고
    • Computational systems biology
    • DOI 10.1038/nature01254
    • Kitano H., Computational systems biology. Nature 2002 420 206 210 (Pubitemid 35340131)
    • (2002) Nature , vol.420 , Issue.6912 , pp. 206-210
    • Kitano, H.1
  • 48
    • 33645675960 scopus 로고    scopus 로고
    • Market watch : Estimating the cost of new drug development: Is it really $802 million?
    • DOI 10.1377/hlthaff.25.2.420
    • Adams C. P., Brantner V. V., Estimating the cost of new drug development: is it really 802 million dollars? Health Affairs 2006 25 420 428 (Pubitemid 43529550)
    • (2006) Health Affairs , vol.25 , Issue.2 , pp. 420-428
    • Adams, C.P.1    Van Brantner, V.2
  • 49
    • 33746222185 scopus 로고    scopus 로고
    • The cost of new drug discovery and development
    • Dickson M., Gagnon J. P., The cost of new drug discovery and development. Discovery Medicine 2004 4 172 179
    • (2004) Discovery Medicine , vol.4 , pp. 172-179
    • Dickson, M.1    Gagnon, J.P.2
  • 50
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I., Landis J., Can the pharmaceutical industry reduce attrition rates? Nature Reviews Drug Discovery 2004 3 8 711 715 2-s2.0-4344645978 (Pubitemid 39173511)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 51
    • 38349144393 scopus 로고    scopus 로고
    • Obstacles and opportunities in new drug development
    • Kaitin K. I., Obstacles and opportunities in new drug development. Clinical Pharmacology and Therapeutics 2008 83 210 212
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , pp. 210-212
    • Kaitin, K.I.1
  • 52
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn T. T., Thor K. B., Drug repositioning: identifying and developing new uses for existing drugs. Nature Reviews Drug Discovery 2004 3 8 673 683 2-s2.0-4344668661 (Pubitemid 39173508)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 53
    • 0035342428 scopus 로고    scopus 로고
    • Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule
    • Chen Y. Z., Zhi D. G., Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule. Proteins 2001 43 217 226
    • (2001) Proteins , vol.43 , pp. 217-226
    • Chen, Y.Z.1    Zhi, D.G.2
  • 54
    • 34250219235 scopus 로고    scopus 로고
    • A large-scale computational approach to drug repositioning
    • Li Y. Y., An J., Jones S. J., A large-scale computational approach to drug repositioning. Genome Informatics 2006 17 2 239 247
    • (2006) Genome Informatics , vol.17 , Issue.2 , pp. 239-247
    • Li, Y.Y.1    An, J.2    Jones, S.J.3
  • 55
    • 77953387346 scopus 로고    scopus 로고
    • Drug repositioning using in silico compound profiling
    • 2-s2.0-77953387346 10.4155/fmc.09.123
    • Dubus E., Ijjaali I., Barberan O., Petitet F., Drug repositioning using in silico compound profiling. Future Medicinal Chemistry 2009 1 9 1723 1736 2-s2.0-77953387346 10.4155/fmc.09.123
    • (2009) Future Medicinal Chemistry , vol.1 , Issue.9 , pp. 1723-1736
    • Dubus, E.1    Ijjaali, I.2    Barberan, O.3    Petitet, F.4
  • 56
    • 70349312650 scopus 로고    scopus 로고
    • Pattern differentiation in Traditional Chinese Medicine can help define specific indications for biomedical therapy in the treatment of rheumatoid arthritis
    • Lu C., Zha Q., Chang A., He Y., Lu A., Pattern differentiation in Traditional Chinese Medicine can help define specific indications for biomedical therapy in the treatment of rheumatoid arthritis. Journal of Alternative and Complementary Medicine 2009 15 1021 1025
    • (2009) Journal of Alternative and Complementary Medicine , vol.15 , pp. 1021-1025
    • Lu, C.1    Zha, Q.2    Chang, A.3    He, Y.4    Lu, A.5
  • 57
    • 84857122210 scopus 로고    scopus 로고
    • Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: Distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell
    • 2-s2.0-77954812917 10.1007/s00296-010-1546-7
    • Lu C., Xiao C., Chen G., Jiang M., Zha Q., Yan X., Kong W., Lu A., Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell. Rheumatology International 2010 1 8 2-s2.0-77954812917 10.1007/s00296-010-1546-7
    • (2010) Rheumatology International , pp. 1-8
    • Lu, C.1    Xiao, C.2    Chen, G.3    Jiang, M.4    Zha, Q.5    Yan, X.6    Kong, W.7    Lu, A.8
  • 58
    • 84869029380 scopus 로고    scopus 로고
    • Understanding the molecular mechanism of interventions in treating rheumatoid arthritis patients with corresponding traditional Chinese medicine patterns based on bioinformatics approach
    • 129452 10.1155/2012/129452
    • Miao Jiang C. L., Chen G., Xiao C., Understanding the molecular mechanism of interventions in treating rheumatoid arthritis patients with corresponding traditional Chinese medicine patterns based on bioinformatics approach. Evidence-Based Complementary and Alternative Medicine 2012 2012 11 129452 10.1155/2012/129452
    • (2012) Evidence-Based Complementary and Alternative Medicine , vol.2012 , pp. 11
    • Miao Jiang, C.L.1    Chen, G.2    Xiao, C.3


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