How Does (E)-2-(Acetamidomethylene)succinate Bind to Its Hydrolase? From the Binding Process to the Final Result

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Zhang, Ji Long ^a   Zheng, Qing Chuan ^a   Li, Zheng Qiang ^a   Zhang, Hong Xing ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ACETAMIDOMETHYLENE)SUCCINATE; 2 (ACETAMIDOMETHYLENE)SUCCINATE HYDROLASE; ARGININE; ASPARTIC ACID; HISTIDINE; ISOLEUCINE; LEUCINE; SERINE; SUCCINIC ACID; THREONINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CALCULATION; CATALYSIS; CONTROLLED STUDY; CONVENTIONAL MOLECULAR DYNAMICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FREE ENERGY CALCULATION METHOD; HYDROGEN BOND; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; STEERED MOLECULAR DYNAMICS;

ACETAMIDES; ARGININE; CATALYTIC DOMAIN; HYDROGEN BONDING; HYDROLASES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MESORHIZOBIUM; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; SUCCINATES; THERMODYNAMICS;

EID: 84872144180     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053811     Document Type: Article

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