Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 3, 2005, Pages 1117-1124

  Katsumi, Hidemasa ^a   Nishikawa, Makiya ^a   Yamashita, Fumiyoshi ^a   Hashida, Mitsuru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; GLYCERYL TRINITRATE; MACROGOL DERIVATIVE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRITE; POLY(ETHYLENE GLYCOL N SUCCINIMIDYL S ACETYLTHIOACETATE BOVINE SERUM ALBUMIN) CONJUGATE; POLY(ETHYLENE GLYCOL S NITROSATED SERUM ALBUMIN) OCNJUGATE; S NITROSOGLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE REGULATION; CIRCULATION; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG CROSS TOLERANCE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; MACROMOLECULE; MALE; MOUSE; NITROSATION; NONHUMAN; PRIORITY JOURNAL; RAT; SLOW DRUG RELEASE;

ANIMALS; BLOOD PRESSURE; DRUG DELIVERY SYSTEMS; FREE RADICALS; MALE; MICE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRITES; NITROGLYCERIN; NITROSATION; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE; VASODILATION;

EID: 23944449393     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.087429     Document Type: Article

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