Inhibitory activity of aralia continentalis roots on protein tyrosine phosphatase 1B and rat lens aldose reductase

Archives of Pharmacal Research

Volumn 35, Issue 10, 2012, Pages 1771-1777

  Jung, Hee Jin ^a   Jung, Hyun Ah ^b   Kang, Sam Sik ^c   Lee, Je Hyun ^d   Cho, Yoon Sook ^e   Moon, Kyong Ho ^e   Choi, Jae Sue ^a,f  

^a Pukyong National University   (South Korea)

^b Chonbuk National University   (South Korea)

^c Seoul National University   (South Korea)

^d Dongguk University   (South Korea)

^e Kyungsung University   (South Korea)

^f Blue Bio Industry RIC   (South Korea)

Author keywords

4 formy 5 (methoxymethyl) 1H pyrrol 1 yl butanoic acid; Aralia cerebroside; Aralia continentalis; Diterpenoids; Protein tyrosine phosphates 1B; Rat lens aldose reductase

Indexed keywords

15ALPHA,16ALPAH EPOXY 17 HYDROXY ENT KAURAN 19 OIC ACID; 16ALPHA,17 DIHYDROXY ENT KAURAN 19 OIC ACID; 17 HYDROXY ENT KAUR 15 EN 19 OIC ACID; 4 [FORMY 5 (METHOXYMETHYL) 1H PYRROL 1 YL]BUTANOIC ACID; 4 EPIRULOPEZOL; 4 HYDROXYBENZOIC ACID; 4BETA HYDROXY 19 NORPIMARA 8(14),15 DIENE; 5 O FERULOLYQUINIC ACID; 6ALPHA HYDROXY 17 ISOVALEROYLOXY ENT KAURAN 19 OIC ACID; 7 OXO ENT PIMARA 8(14),15 DIENE 19 OIC ACID; 8ALPHA HYDROXY ENT PIMARA 15 EN 19 OL; ACETIC ACID ETHYL ESTER; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ANTIDIABETIC AGENT; ARALIA CEREBROSIDE; ARALIA CONTINENTALIS EXTRACT; CONTINENTALIC ACID; DITERPENOID; ENT PIMARA 8(14),15 DIENE 19 OL; HEXANE; KAURENOIC ACID; METHANOL; NICOTINIC ACID; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PROTOCATECHUIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLIC ACID;

ANIMAL TISSUE; ARALIA; ARALIA CONTINENTALIS; ARTICLE; BIOASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME INHIBITION; MASS SPECTROMETRY; NONHUMAN; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SOLVENT EXTRACTION; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMALS; ARALIA; DIABETES MELLITUS; DITERPENES; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; LENS, CRYSTALLINE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PLANT ROOTS; PLANTS, MEDICINAL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

EID: 84872119104     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-1009-7     Document Type: Article

References (26)

1. Bae, K. W., Medicinal Plants of Korea, Kyohak Publishing Co. Ltd., Seoul, p. 363, (2000)
2. Berger, B., Stenstrom, G., and Sundkvist, G., Incidence, prevalence and mortality of diabetes in a large population: a report from the Skaraborg diabetes registry. Diabetes Care, 22, 773-777 (1999).
3. Brownlee, M., Biology and molecular cell biology if diabetic complications. Nature, 414, 813-820 (2001).
4. Chin, Y. W., Lim, S. W., Kim, S. H., Shin, D. Y., Suh, Y. G., Kim, Y. B., Kim, Y. C., and Kim, J. W., Hepatoprotective pyrrole derivatives of Lycium chinense fruits. Bioorg. Med. Chem. Lett., 13, 79-81 (2003).
5. Chung, Y. S., Choi, Y. H., Lee, S. J., Choi, S. A., Lee, J. H., Kim, H., and Hong, E. K.. Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo. J. Ethnopharmacol., 101, 49-54 (2005)
6. Cui, L., Na, M., Oh, H., Bae, E. Y., Jeong, D. G., Ryu, S. E., Kim, S., Kim, B. Y., Oh, W. K., and Ahn, J. S., Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorg. Med. Chem. Lett., 16, 1426-1429 (2006).
7. Fowler, M. J., Microvascular and macrovascular complications of diabetes. Clin. Diabetes, 26, 77-82 (2008).
8. Fujisawa, T., Ikegami, H., Inoue, K., Kawabata, Y., and Ogihara, T., Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms. Metabolism, 54, 387-390 (2005).
9. Hanefeld, M., The role of acarbose in the treatment of noninsulin- dependent diabetes mellitus. J. Diabetes Complications, 12, 228-237 (1998).
10. Hayman, S. and Kinoshita, J. H., Isolation and properties of lens aldose reductase. J. Biol. Chem., 240, 877-882 (1965).
11. Hu, W., Huang, C., and Wang, M. H., Chemical composition, nutritional value, and antioxidant constituents of Kalopanax pictus leaves. Food Chem., 131, 449-455 (2012).
12. Hur, J. M., Park, J. C., and Hwang, Y. H., Aromatic acid and flavonoids from the leaves of Zanthoxylum piperium. Nat. Prod. Sci., 7, 23-26 (2001).
13. Jung, H. A., Lee, E. J., Kim, J. S., Kang, S. S., Lee, J. H., Min, B. S., and Choi, J. S., Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata. Arch. Pharm. Res., 32, 1399-1408 (2009).
14. Kang, S. S., Chemistry and biological activity of the constitiuents from Aralia species. Ann. Rept. Nat. Prod. Sci., 5, 1-26 (1997).
15. Kang, S. S., Kim, J. S., Xu, Y. N., and Kim, Y. H., Isolation of a new cerebroside from the root bark of Aralia elate. J. Nat. Prod., 62, 1059-1062 (1999).
16. Kennedy, B. P., Role of protein tyrosine phosphatase-1B in diabetes and obesity. Biomed Pharmacother., 53, 466-470 (1999).
17. Kim, S., Na, M., Oh, H., Jang, J., Sohn, C. B., Kim, B. Y., Oh, W. K., and Ahn, J. S., PTP1B inhibitory activity of kaurane diterpenes isolated from Siegesbeckia glabrescens. J. Enzyme Inhib. Med. Chem., 21, 379-383 (2006).
18. Lee, H. S., Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. J. Agric. Food Chem., 50, 7013-7016 (2002).
19. Lee, I. S., Jin, W. Y., Zhang, X. F., Hung, T, M., Song, K. S., Seong, Y. H., and Bae, K. H., Cytotoxic and COX-2 inhibitory constituents from the aerial parts of Aralia cordata. Arch. Pharm. Res., 29, 548-555 (2006).
20. Lee, W. T., Lineamenta Flora Koreae, Academy, Seoul, pp. 771-772, (1996).
21. Na, M., Oh, W. K., Kim, Y. H., Cai, X. F., Kim, S., Kim, B. Y., and Ahn, J. S., Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum. Bioorg. Med. Chem. Lett., 16, 3061-3064 (2006).
22. Park, B. J. and Tomahiko, M., feruloly, caffeoyl, and flavonol glucosides from Equisetum hyemale. Chemistry of Natural Compounds, 47, 363-365 (2011).
23. Perry, L. M., Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses, The MIT press, Cambridge, p. 41, (1980).
24. Singh, S. K., Rai, P. K., Jaiswal, D., and Watal, G., Evidencebased critical evaluation of glycemic potential of Cynodon dactylon. Evid. Based Complement. Alternat. Med., 5, 415- 420 (2008).
25. Tahara, M., Okabe, T., Furihata, K., Tanaka, N., Yamaguchi, H., Nishimura, T., and Suzuki, H., Revised structure of resorthiomycin. J. Antibiot. (Tokyo), 44, 255 (1991).
26. Yu, Y., Gao, H., Tang, Z., Song, X., and Wu, L., Several phenolic acids from fruit of Capparis sainosa. Asian Journal of Traditional Medicines, 1, 1-4 (2006).