Investigation of the skin repair and healing mechanism of N-carboxymethyl chitosan in second-degree burn wounds

Wound Repair and Regeneration

Volumn 21, Issue 1, 2013, Pages 113-121

  Chang, Jing ^a,b   Liu, Wanshun ^b   Han, Baoqin ^b   Peng, Sikai ^b   He, Bin ^a   Gu, Zhongwei ^a  

^a SICHUAN UNIVERSITY   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; CHITOSAN; INTERLEUKIN 8; LYSOZYME; N CARBOXYMETHYL CHITOSAN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BURN; CELL PROLIFERATION; CONTACT INHIBITION; CONTROLLED STUDY; CYTOTOXICITY TEST; EPITHELIZATION; FIBROBLAST; GRANULATION TISSUE; HISTOCOMPATIBILITY; HISTOLOGY; IN VIVO STUDY; INFLAMMATORY CELL; LYMPHOCYTE; MALE; NONHUMAN; POTENTIOMETRIC TITRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SKIN BIOPSY; SKIN REPAIR; SUBCUTANEOUS TISSUE; TISSUE REPAIR; WOUND CONTRACTION; WOUND HEALING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BURNS; CELL MOVEMENT; CELL PROLIFERATION; CHITOSAN; HYDROGEL; INTERLEUKIN-8; MALE; RATS; RATS, WISTAR; SKIN; SMAD PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 84872117483     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2012.00859.x     Document Type: Article

References (39)

1. Kweon HY, Yeo JH, Lee KG, Lee HC, Na HS, Won YH, Cho CS,. Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing. Biomed Mater 2008; 3: 256-259.
2. Monstrey S, Hoeksema H, Verbelen J, Pirayesh A, Blondeel P,. Assessment of burn depth and burn wound healing potential. Burns 2008; 34: 761-769.
3. Merz KM, Pfau M, Blumenstock G, Tenenhaus M, Schaller HE, Rennekampff HO,. Cutaneous microcirculatory assessment of the burn wound is associated with depth of injury and predicts healing time. Burns 2010; 36: 477-482.
4. Cuttle L, Kempf M, Phillips GE, Mill J, Hayes MT, Fraser JF, Wang XQ, Kimble RM,. A porcine deep dermal partial thickness burn model with hypertrophic scarring. Burns 2006; 32: 806-820.
5. Ribeiro MP, Espiga A, Silva D, Baptista P, Henriques J, Ferreira C, Silva JC, Borges JP, Pires E, Chaves P, Correia IJ,. Development of a new chitosan hydrogel for wound dressing. Wound Repair Regen 2009; 17: 817-824.
6. Jackson CJ, Xue ML, Thompson P, Davey RA, Whitmont K, Smith S, Buisson-Legendre N, Sztynda T, Furphy LJ, Cooper A, Sambrook P, March L,. Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair Regen 2005; 13: 284-294.
7. Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA, Mitchell JB, Russo A, Roberts AB,. Interference with transforming growth factor-beta/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol 2003; 163: 2247-2257.
8. Lee WR, Park JH, Kim KH, Kim SJ, Park DH, Chae MH, Suh SH, Jeong SW, Park KK,. The biological effects of topical alginate treatment in an animal model of skin wound healing. Wound Repair Regen 2009; 17: 505-510.
9. Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN, Johnson KJ, Varani J,. A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin. Wound Repair Regen 2009; 17: 360-366.
10. Murakami K, Aoki H, Nakamura S, Nakamura S, Takikawa M, Hanzawa M, Kishimoto S, Hattori H, Tanaka Y, Kiyosawa T, Sato Y, Ishihara M,. Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. Biomaterials 2010; 31: 83-90.
11. Rayment EA, Dargaville TR, Shooter GK, George GA, Upton Z,. Attenuation of protease activity in chronic wound fluid with bisphosphonate-functionalised hydrogels. Biomaterials 2008; 29: 1785-1795.
12. Balakrishnan B, Mohanty M, Fernandez AC, Mohanan PV, Jayakrishnan A,. Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials 2006; 27: 1355-1361.
13. Balakrishnan B, Mohanty M, Umashankar PR, Jayakrishnan A,. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials 2005; 26: 6335-6342.
14. Yates CC, Whaley D, Babu R, Zhang J, Krishna P, Beckman E, Pasculle AW, Wells A,. The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. Biomaterials 2007; 28: 3977-3986.
15. Wang W, Itoh S, Aizawa T, Okawa A, Sakai K, Ohkuma T, Demura M,. Development of an injectable chitosan/marine collagen composite gel. Biomed Mater 2010; 5: 281-288.
16. Lu GZ, Ling KL, Zhao P, Xu ZH, Deng C, Zheng H, Huang J, Chen JH,. A novel in situ-formed hydrogel wound dressing by the photocross-linking of a chitosan derivative. Wound Repair Regen 2010; 18: 70-79.
17. Murakami K, Ishihara M, Aoki H, Nakamura S, Nakamura SI, Yanagibayashi S, Takikawa M, Kishimoto S, Yokoe H, Kiyosawa T, Sato Y,. Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed of chitin/chitosan, fucoidan, and alginate as wound dressings. Wound Repair Regen 2010; 18: 478-485.
18. Zheng L, Ao Q, Han H, Zhang X, Gong Y,. Evaluation of the chitosan/glycerol-beta-phosphate disodium salt hydrogel application in peripheral nerve regeneration. Biomed Mater 2010; 5: 281-287.
19. Yang C, Xu L, Zhou Y, Zhang XM, Huang X, Wang M, Han Y, Zhai ML, Wei SC, Li JQ,. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohyd Polym 2010; 82: 1297-1305.
20. Kweon DK, Song SB, Park YY,. Preparation of water-soluble chitosan/heparin complex and its application as wound healing accelerator. Biomaterials 2003; 24: 1595-1601.
21. Kim JH, Choi SJ, Park JS, Lim KT, Choung PH, Kim SW, Lee JB, Chung JH, Choung YH,. Tympanic membrane regeneration using a water-soluble chitosan patch. Tissue Eng Part A 2010; 16: 225-232.
22. Kim JH, Bae JH, Lim KT, Choung PH, Park JS, Choi SJ, Im AL, Lee ET, Choung YH, Chung JH,. Development of water-insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations. J Biomed Mater Res Part A 2009; 90A: 446-455.
23. Zhu AP, Fang N, Chan-Park MB, Chan V,. Interaction between O-carboxymethylchitosan and dipalmitoyl-sn-glycero-3-phosphocholine bilayer. Biomaterials 2005; 26: 6873-6879.
24. An NT, Thien DT, Dong NT, Dung PL,. Water-soluble N-carboxymethylchitosan derivatives: preparation, characteristicsand its application. Carbohyd Polym 2009; 75: 489-497.
25. Sun T, Yao Q, Zhou DX, Mao F,. Antioxidant activity of N-carboxymethyl chitosan oligosaccharides. Bioorg Med Chem Lett 2008; 18: 5774-5776.
26. Amorim CM, Netz DJ, Couto AG, Freitas RA, Bresolin TMB,. Stability-indicating LC-PDA method for determination of idebenonein nanoparticles based on chitosanand N-carboxymethylchitosan. Chromatographia 2009; 70: 1411-1415.
27. Muzzarelli RAA, Tanfani F, Emanuelli M, Pace DP, Chiurazzi E, Piani M,. Sulfated N-(carboxymethyl)chitosans: novel blood anticoagulants. Carbohydr Res 1984; 126: 225-231.
28. Ge HC, Luo DK,. Preparation of carboxymethyl chitosan in aqueous solution under microwave irradiation. Carbohydr Res 2005; 340: 1351-1356.
29. Mossan T,. Rapid colorimetric assay for cellular growth and survival, application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
30. Hansen MB, Niesen SE, Berg K,. Re-examination and further development of a precise and rapid dye method for measuring cell growth and cell kill. Immunol Methods 1989; 11: 9203-9210.
31. Itoh S, Itoh F, Goumans MJ, Ten Dijke P,. Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 2000; 267: 6954-6967.
32. Massague J,. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000; 1: 169-178.
33. Katherine A, Paul EH,. When the Smad signaling pathway is impaired, fibroblasts advance open wound contraction. Exp Mol Pathol 2010; 89: 236-240.
34. Hantamalala RR, Fatima P, Mark SW,. Albumin activates the canonical TGF receptor-smad signaling pathway but this is not required for activation of astrocytes. Exp Neurol 2010; 226: 310-319.
35. Bryan D, Walker KB, Ferguson M, Thorpe R,. Cytokine gene expression in a murine wound healing model. Cytokine 2005; 31: 429-438.
36. Chen C-C, Lau LF,. Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 2009; 41: 771-783.
37. Brush J, Lipnick SL, Phillips T, Sitko J, McDonald JT, McBride WH,. Molecular mechanisms of late normal tissue injury. Semin Radiat Oncol 2007; 17: 121-130.
38. Walter MNM, Wright KT, Fuller HR, MacNeil S, Johnson WEB,. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Expl Cell Res 2010; 316: 1271-1281.
39. Pinto D, Marzani B, Minervini F, Calasso M, Giuliani G, Gobbetti M, De Angelis M,. Plantaricin A synthesized by Lactobacillus plantarum induces in vitro proliferation and migration of human keratinocytes and increases the expression of TGF-β1, FGF7, VEGF-A and IL-8 genes. Peptides 2011; 32: 1815-1824.