When the Smad signaling pathway is impaired, fibroblasts advance open wound contraction

Experimental and Molecular Pathology

Volumn 89, Issue 3, 2010, Pages 236-240

  Au, Katherine ^a   Ehrlich, H Paul ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Myofibroblasts; Smad signaling; Wound contraction

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN FIBER; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIREFRINGENCE; CELL DENSITY; CELL MOTION; CONNECTIVE TISSUE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FIBROBLAST; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; MALE; MICROSCOPY; MYOFIBROBLAST; NONHUMAN; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WOUND CLOSURE; WOUND CONTRACTION; WOUND DRESSING; WOUND HEALING;

ANIMALS; BLOTTING, WESTERN; FIBROBLASTS; GRANULATION TISSUE; MALE; MYOFIBROBLASTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD PROTEINS; WOUND HEALING;

RATTUS;

EID: 78249286809     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.08.002     Document Type: Article

References (18)

1. Bell E., Ivarsson B., Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc. Natl Acad. Sci. USA 1979, 76:1274-1278.
2. Berry D.P., Harding K.G., Stanton M.R., Jasani B., Ehrlich H.P. Human wound contraction: collagen organization, fibroblasts, and myofibroblasts. Plast. Reconstr. Surg. 1998, 102:124-131. discussion 132-4.
3. DaCosta Byfield S., Major C., Laping N.J., Roberts A.B. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 2004, 65:744-752.
4. Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 1993, 122:103-111.
5. Ehrlich H.P. Wound closure: evidence of cooperation between fibroblasts and collagen matrix. Eye (Lond.) 1988, 2(Pt 2):149-157.
6. Ehrlich H.P., Rajaratnam J.B. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: an in vitro model of wound contraction. Tissue Cell 1990, 22:407-417.
7. Ehrlich H.P., Keefer K.A., Myers R.L., Passaniti A. Vanadate and the absence of myofibroblasts in wound contraction. Arch. Surg. 1999, 134:494-501.
8. Fukuchi M., Imamura T., Chiba T., Ebisawa T., Kawabata M., Tanaka K., Miyazono K. Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell 2001, 12:1431-1443.
9. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 2003, 200:500-503.
10. Harrison C.A., Gray P.C., Vale W.W., Robertson D.M. Antagonists of activin signaling: mechanisms and potential biological applications. Trends Endocrinol. Metab. 2005, 16:73-78.
11. Hubner G., Hu Q., Smola H., Werner S. Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev. Biol. 1996, 173:490-498.
12. Itoh S., Itoh F., Goumans M.J., Ten Dijke P. Signaling of transforming growth factor-beta family members through Smad proteins. Eur. J. Biochem. 2000, 267:6954-6967.
13. Li Z., Dranoff J.A., Chan E.P., Uemura M., Sevigny J., Wells R.G. Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology 2007, 46:1246-1256.
14. Malmsten M. Surfactants and Polymers in Drug Delivery 2002, Marcel Dekker, New York, NY.
15. Massague J. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 2000, 1:169-178.
16. Montesano R., Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc. Natl Acad. Sci. USA 1988, 85:4894-4897.
17. Munz B., Smola H., Engelhardt F., Bleuel K., Brauchle M., Lein I., Evans L.W., Huylebroeck D., Balling R., Werner S. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J. 1999, 18:5205-5215.
18. Tomasek J.J., Haaksma C.J., Eddy R.J., Vaughan M.B. Fibroblast contraction occurs on release of tension in attached collagen lattices: dependency on an organized actin cytoskeleton and serum. Anat. Rec. 1992, 232:359-368.