D-dimer assays in diagnosis and management of thrombotic and bleeding disorders

Seminars in Thrombosis and Hemostasis

Volumn 38, Issue 7, 2012, Pages 673-682

  Bates, Shannonm ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

anticoagulant duration; D dimer; recurrence; venous thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; D DIMER; HEPARIN; WARFARIN;

AGGLUTINATION TEST; ANTICOAGULANT THERAPY; ARTICLE; DEEP VEIN THROMBOSIS; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FIBRINOLYSIS; HUMAN; LATEX AGGLUTINATION TEST; LUNG ANGIOGRAPHY; LUNG EMBOLISM; LUNG VENTILATION PERFUSION RATIO; NEOPLASM; PREGNANCY; PRIORITY JOURNAL; QUALITY OF LIFE; SENSITIVITY AND SPECIFICITY; TREATMENT DURATION; TURBIDIMETRY; VENOUS THROMBOEMBOLISM;

ANTICOAGULANTS; DISSEMINATED INTRAVASCULAR COAGULATION; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HEMORRHAGE; HUMANS; THROMBOSIS; VENOUS THROMBOEMBOLISM;

EID: 84872114448     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0032-1326782     Document Type: Article

References (93)

1. Adam S. S., Key N. S., Greenberg C. S.; SS. D-dimer antigen: current concepts and future prospects. Blood: 2009; 113 13 2878 2887
2. Tripodi A. D-dimer testing in laboratory practice. Clin Chem: 2011; 57 9 1256 1262
3. Righini M., Perrier A., De Moerloose P., Bounameaux H. D-Dimer for venous thromboembolism diagnosis: 20 years later. J Thromb Haemost: 2008; 6 7 1059 1071
4. Hager K., Platt D. Fibrin degeneration product concentrations (D-dimers) in the course of ageing. Gerontology: 1995; 41 3 159 165
5. Dempfle C. E. Validation, calibration, and specificity of quantitative D-dimer assays. Semin Vasc Med: 2005; 5 4 315 320
6. Meijer P., Haverkate F., Kluft C., de Moerloose P., Verbruggen B., Spannagl M. A model for the harmonisation of test results of different quantitative D-dimer methods. Thromb Haemost: 2006; 95 3 567 572
7. Di Nisio M., Squizzato A., Rutjes A. WS, Büller H. R., Zwinderman A. H., Bossuyt P. M. Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review. J Thromb Haemost: 2007; 5 2 296 304
8. Rowbotham B. J., Carroll P., Whitaker A. N., et al. Measurement of crosslinked fibrin derivatives-use in the diagnosis of venous thrombosis. Thromb Haemost: 1987; 57 1 59 61
9. Bounameaux H., Schneider P. A., Reber G., de Moerloose P., Krahenbuhl B. Measurement of plasma D-dimer for diagnosis of deep venous thrombosis. Am J Clin Pathol: 1989; 91 1 82 85
10. Bounameaux H., Cirafici P., de Moerloose P., et al. Measurement of D-dimer in plasma as diagnostic aid in suspected pulmonary embolism. Lancet: 1991; 337 8735 196 200
11. Brotman D. J., Segal J. B., Jani J. T., Petty B. G., Kickler T. S. Limitations of D-dimer testing in unselected inpatients with suspected venous thromboembolism. Am J Med: 2003; 114 4 276 282
12. Arnason T., Wells P. S., Forster A. J. Appropriateness of diagnostic strategies for evaluating suspected venous thromboembolism. Thromb Haemost: 2007; 97 2 195 201
13. Bates S. M., Jaeschke R., Stevens S. M., et al. American College of Chest Physicians Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest: 2012; 141 2, Suppl e351S e418S
14. Couturaud F., Kearon C., Bates S. M., Ginsberg J. S. Decrease in sensitivity of D-dimer for acute venous thromboembolism after starting anticoagulant therapy. Blood Coagul Fibrinolysis: 2002; 13 3 241 246
15. Hull R., Hirsh J., Sackett D. L., et al. Clinical validity of a negative venogram in patients with clinically suspected venous thrombosis. Circulation: 1981; 64 3 622 625
16. Novelline R. A., Baltarowich O. H., Athanasoulis C. A., Waltman A. C., Greenfield A. J., McKusick K. A. The clinical course of patients with suspected pulmonary embolism and a negative pulmonary arteriogram. Radiology: 1978; 126 3 561 567
17. Hull R. D., Raskob G. E., Coates G., Panju A. A. Clinical validity of a normal perfusion lung scan in patients with suspected pulmonary embolism. Chest: 1990; 97 1 23 26
18. Fancher T. L., White R. H., Kravitz R. L. Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review. BMJ: 2004; 329 7470 821 829
19. Wells P. S., Anderson D. R., Rodger M., et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med: 2003; 349 13 1227 1235
20. Kearon C., Ginsberg J. S., Douketis J., et al. A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography. Ann Intern Med: 2005; 142 7 490 496
21. Wells P. S., Owen C., Doucette S., Fergusson D., Tran H. Does this patient have deep vein thrombosis? JAMA: 2006; 295 2 199 207
22. Bates S. M., Kearon C., Crowther M., et al. A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis. Ann Intern Med: 2003; 138 10 787 794
23. Perrier A., Desmarais S., Miron M. J., et al. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet: 1999; 353 9148 190 195
24. Anderson D. R., Kovacs M. J., Kovacs G., et al. Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study). J Thromb Haemost: 2003; 1 4 645 651
25. Schutgens R. EG, Ackermark P., Haas F. JLM., et al. Combination of a normal D-dimer concentration and a non-high pretest clinical probability score is a safe strategy to exclude deep venous thrombosis. Circulation: 2003; 107 4 593 597
26. Tick L. W., Ton E., van Voorthuizen T., et al. Practical diagnostic management of patients with clinically suspected deep vein thrombosis by clinical probability test, compression ultrasonography, and D-dimer test. Am J Med: 2002; 113 8 630 635
27. Janes S., Ashford N. Use of a simplified clinical scoring system and D-dimer testing can reduce the requirement for radiology in the exclusion of deep vein thrombosis by over 20%. Br J Haematol: 2001; 112 4 1079 1082
28. Aguilar C., Martinez A., Martinez A., Del Rio C., Vazquez M., Rodriguez F. J. Diagnostic value of d-dimer in patients with a moderate pretest probability of deep venous thrombosis. Br J Haematol: 2002; 118 1 275 277
29. Ruiz-Giménez N., Friera A., Artieda P., et al. Rapid D-dimer test combined a clinical model for deep vein thrombosis. Validation with ultrasonography and clinical follow-up in 383 patients. Thromb Haemost: 2004; 91 6 1237 1246
30. Elf J. L., Strandberg K., Nilsson C., Svensson P. J. Clinical probability assessment and D-dimer determination in patients with suspected deep vein thrombosis, a prospective multicenter management study. Thromb Res: 2009; 123 4 612 616
31. Bernardi E., Camporese G., Büller H. R., et al. Erasmus Study Group Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial. JAMA: 2008; 300 14 1653 1659
32. Bernardi E., Prandoni P., Lensing A. W., et al. The Multicentre Italian D-dimer Ultrasound Study Investigators Group D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ: 1998; 317 7165 1037 1040
33. Kearon C., Ginsberg J. S., Douketis J., et al. Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial. Ann Intern Med: 2006; 144 11 812 821
34. Wells P. S., Anderson D. R., Rodger M., et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med: 2001; 135 2 98 107
35. Anderson D. R., Kovacs M. J., Dennie C., et al. Use of spiral computed tomography contrast angiography and ultrasonography to exclude the diagnosis of pulmonary embolism in the emergency department. J Emerg Med: 2005; 29 4 399 404
36. Goekoop R. J., Steeghs N., Niessen R. W., et al. Simple and safe exclusion of pulmonary embolism in outpatients using quantitative D-dimer and Wells' simplified decision rule. Thromb Haemost: 2007; 97 1 146 150
37. Leclercq M. G., Lutisan J. G., van Marwijk Kooy M., et al. Ruling out clinically suspected pulmonary embolism by assessment of clinical probability and D-dimer levels: a management study. Thromb Haemost: 2003; 89 1 97 103
38. Ghanima W., Abelnoor M., Mowinckel M. C., Sandset P. M. The performance of STA-Liatest D-dimer assay in outpatients with suspected pulmonary embolism. Br J Haematol: 2006; 132 210 214
39. Pasha S. M., Klok F. A., Snoep J. D., et al. Safety of excluding acute pulmonary embolism based on an unlikely clinical probability by the Wells rule and normal D-dimer concentration: a meta-analysis. Thromb Res: 2010; 125 4 e123 e127
40. van Belle A., Büller H. R., Huisman M. V., et al. Christopher Study Investigators Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA: 2006; 295 2 172 179
41. Perrier A., Roy P. M., Sanchez O., et al. Multidetector-row computed tomography in suspected pulmonary embolism. N Engl J Med: 2005; 352 17 1760 1768
42. Carrier M., Righini M., Djurabi R. K., et al. VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism. A systematic review of management outcome studies. Thromb Haemost: 2009; 101 5 886 892
43. Merminod T., Pellicciotta S., Bounameaux H. Limited usefulness of D-dimer in suspected deep vein thrombosis of the upper extremities. Blood Coagul Fibrinolysis: 2006; 17 3 225 226
44. Kucher N. Clinical practice. Deep-vein thrombosis of the upper extremities. N Engl J Med: 2011; 364 9 861 869
45. Elias A., Bonfils S., Daoud-Elias M., et al. Influence of long term oral anticoagulants upon prothrombin fragment 1. +2, thrombin-antithrombin III complex and D-Dimer levels in patients affected by proximal deep vein thrombosis. Thromb Haemost: 1993; 69 4 302 305
46. Sié P., Cadroy Y., Elias A., Boccalon H., Boneu B. D-dimer levels in patients with long-term antecedents of deep venous thrombosis. Thromb Haemost: 1994; 72 1 161 162
47. Bates S. M., Kearon C., Kahn S. R., et al. A negative D-dimer excludes recurrent deep vein thrombosis: results of a multicentre management trial. Blood: 2007; 110 214a
48. Aguilar C., del Villar V. Combined D-dimer and clinical probability are useful for exclusion of recurrent deep venous thrombosis. Am J Hematol: 2007; 82 1 41 44
49. Prandoni P., Tormene D., Dalla Valle F., Concolato A., Pesavento R. D-dimer as an adjunct to compression ultrasonography in patients with suspected recurrent deep vein thrombosis. J Thromb Haemost: 2007; 5 5 1076 1077
50. Rathbun S. W., Whitsett T. L., Raskob G. E. Negative D-dimer result to exclude recurrent deep venous thrombosis: a management trial. Ann Intern Med: 2004; 141 11 839 845
51. Nolan T. E., Smith R. P., Devoe L. D. Maternal plasma D-dimer levels in normal and complicated pregnancies. Obstet Gynecol: 1993; 81 2 235 238
52. Francalanci I., Comeglio P., Liotta A. A., et al. D-dimer concentrations during normal pregnancy, as measured by ELISA. Thromb Res: 1995; 78 5 399 405
53. Ballegeer V., Mombaerts P., Declerck P. J., Spitz B., Van Assche F. A., Collen D. Fibrinolytic response to venous occlusion and fibrin fragment D-dimer levels in normal and complicated pregnancy. Thromb Haemost: 1987; 58 4 1030 1032
54. Morse M. Establishing a normal range for D-dimer levels through pregnancy to aid in the diagnosis of pulmonary embolism and deep vein thrombosis. J Thromb Haemost: 2004; 2 7 1202 1204
55. Chan W. SCS, Bates S., Naguit I., Sood R., Johnston M. The prevalence of positive soluble fibrin and D-dimer results in health asymptomatic pregnant women. Blood: 1999; 94 20a
56. Kline J. A., Williams G. W., Hernandez-Nino J. D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed. Clin Chem: 2005; 51 5 825 829
57. Kovac M., Mikovic Z., Rakicevic L., et al. The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. Eur J Obstet Gynecol Reprod Biol: 2010; 148 1 27 30
58. Chan W. S., Chunilal S., Lee A., Crowther M., Rodger M., Ginsberg J. S. A red blood cell agglutination D-dimer test to exclude deep venous thrombosis in pregnancy. Ann Intern Med: 2007; 147 3 165 170
59. Chan W. S., Lee A., Spencer F. A., et al. D-dimer testing in pregnant patients: towards determining the next 'level' in the diagnosis of deep vein thrombosis. J Thromb Haemost: 2010; 8 5 1004 1011
60. Harper P. L., Theakston E., Ahmed J., Ockelford P. D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly. Intern Med J: 2007; 37 9 607 613
61. Righini M., Goehring C., Bounameaux H., Perrier A. Effects of age on the performance of common diagnostic tests for pulmonary embolism. Am J Med: 2000; 109 5 357 361
62. Carrier M., Le Gal G., Bates S. M., Anderson D. R., Wells P. S. D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatients. J Thromb Haemost: 2008; 6 7 1072 1076
63. Douma R. A., le Gal G., Söhne M., et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ: 2010; 340 c1475
64. Douma R. A., Gibson N. S., Schutgens R. EG., et al. Age-adjusted D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Hematologica: 2012; 97 10.3324/haematol.2011. 060657. (e-pub ahead of print)
65. Lee A. Y., Julian J. A., Levine M. N., et al. Clinical utility of a rapid whole-blood D-dimer assay in patients with cancer who present with suspected acute deep venous thrombosis. Ann Intern Med: 1999; 131 6 417 423
66. ten Wolde M., Kraaijenhagen R. A., Prins M. H., Büller H. R. The clinical usefulness of D-dimer testing in cancer patients with suspected deep venous thrombosis. Arch Intern Med: 2002; 162 16 1880 1884
67. King V., Vaze A. A., Moskowitz C. S., Smith L. J., Ginsberg M. S. D-dimer assay to exclude pulmonary embolism in high-risk oncologic population: correlation with CT pulmonary angiography in an urgent care setting. Radiology: 2008; 247 3 854 861
68. Righini M., Le Gal G., De Lucia S., et al. Clinical usefulness of D-dimer testing in cancer patients with suspected pulmonary embolism. Thromb Haemost: 2006; 95 4 715 719
69. Carrier M., Lee A. YY, Bates S. M., Anderson D. R., Wells P. S. Accuracy and usefulness of a clinical prediction rule and D-dimer testing in excluding deep vein thrombosis in cancer patients. Thromb Res: 2008; 123 1 177 183
70. Kearon C., Akl E. A., Comerota A. J., et al. American College of Chest Physicians Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest: 2012; 141 2, Suppl e419S e494S
71. Verhovsek M., Douketis J. D., Yi Q., et al. Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism. Ann Intern Med: 2008; 149 7 481 490, W94
72. Bruinstroop E., Klok F. A., Van De Ree M. A., Oosterwijk F. L., Huisman M. V. Elevated D-dimer levels predict recurrence in patients with idiopathic venous thromboembolism: a meta-analysis. J Thromb Haemost: 2009; 7 4 611 618
73. Palareti G., Cosmi B., Legnani C., et al. PROLONG Investigators D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med: 2006; 355 17 1780 1789
74. Cosmi B., Legnani C., Tosetto A., et al. Use of D-dimer testing to determine duration of anticoagulation, risk of cardiovascular events and occult cancer after a first episode of idiopathic venous thromboembolism: the extended follow-up of the PROLONG study. J Thromb Thrombolysis: 2009; 28 4 381 388
75. Baglin T., Luddington R., Brown K., Baglin C. High risk of recurrent venous thromboemoblism in men. J Thromb Haemost: 2004; 2 2152 2155
76. Kyrle P. A., Minar E., Bialonczyk C., Hirschl M., Weltermann A., Eichinger S. The risk of recurent venous thromboemoblism in men and women. N Engl J Med: 2004; 350 2558 2563
77. McRae S., Tran H., Schulman S., Ginsberg J. S., Kearon C. Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis. Lancet: 2006; 368 9533 371 378
78. Cushman M., Glynn R. J., Goldhaber S. Z., et al. Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial. J Thromb Haemost: 2006; 4 10 2199 2203
79. Cosmi B., Legnani C., Tosetto A., et al. Prolong Investigators Sex, age and normal post-anticoagulation D-dimer as risk factors for recurrence after idiopathic venous thromboembolism in the Prolong study extension. J Thromb Haemost: 2010; 8 9 1933 1942
80. Rodger M. A., Kahn S. R., Wells P. S., et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ: 2008; 179 5 417 426
81. Tosetto A., Iorio A., Marcucci M., et al. Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH). J Thromb Haemost: 2012; 10 6 1019 1025
82. Stein P. D., Beemath A., Meyers F. A., Skaf E., Sanchez J., Olson R. E. Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med: 2006; 119 1 60 68
83. Heit J. A., O'Fallon W. M., Petterson T. M., et al. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med: 2002; 162 11 1245 1248
84. Blom J. W., Doggen C. J., Osanto S., Rosendaal F. R. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA: 2005; 293 6 715 722
85. Khorana A. A., Connolly G. C. Assessing risk of venous thromboembolism in the patient with cancer. J Clin Oncol: 2009; 27 29 4839 4847
86. Ay C., Vormittag R., Dunkler D., et al. D-dimer and prothrombin fragment 1. +2 predict venous thromboembolism in patients with cancer: results from the Vienna Cancer and Thrombosis Study. J Clin Oncol: 2009; 27 25 4124 4129
87. Khorana A. A., Kuderer N. M., Culakova E., Lyman G. H., Francis C. W. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood: 2008; 111 10 4902 4907
88. Ay C., Dunkler D., Marosi C., et al. Prediction of venous thromboembolism in cancer patients. Blood: 2010; 116 24 5377 5382
89. Favaloro E. J. Laboratory testing in disseminated intravascular coagulation. Semin Thromb Hemost: 2010; 36 4 458 467
90. Taylor F. B. Jr, Toh C. H., Hoots W. K., Wada H. Levi M for the Scientific Subcommitee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost: 2001; 86 1327 1330
91. Lee J. H., Song J. W., Song K. S. Diagnosis of overt disseminated intravascular coagulation: a comparative study using criteria from the International Society versus the Korean Society on Thrombosis and Hemostasis. Yonsei Med J: 2007; 48 4 595 600
92. Wada H., Gabazza E. C., Asakura H., et al. Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis and of the Japanese Ministry of Health and Welfare for overt DIC. Am J Hematol: 2003; 74 1 17 22
93. Gando S., Iba T., Eguchi Y., et al. Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med: 2006; 34 3 625 631