Ruling out clinically suspected pulmonary embolism by assessment of clinical probability and D-dimer levels: A management study

Thrombosis and Haemostasis

Volumn 89, Issue 1, 2003, Pages 97-103

  Leclercq, Monique G L ^a   Lutisan, Johan G ^a   Van Marwijk Kooy, Marinus ^a   Kuipers, Bart F ^a   Oostdijk, Ad H J ^a   Van Der Leur, Jef J C M ^a   Büller, Harry R ^b  

^a ISALA HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Clinical probability; D dimer; Diagnosis; Management; Pulmonary embolism

Indexed keywords

ANTICOAGULANT AGENT; D DIMER; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; ARTERY PERFUSION; ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; COHORT ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; ECHOGRAPHY; FEMALE; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; PROBABILITY; PROSPECTIVE STUDY; RISK ASSESSMENT; SAFETY; SCINTIGRAPHY; THROMBOEMBOLISM; X RAY ANALYSIS;

EID: 0037247583     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613548     Document Type: Article

References (25)

1. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ, 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study. Arch Intern Med 1998; 158: 585-93.
2. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). The PIOPED Investigators. JAMA 1990; 263: 2753-9.
3. Perrier A, Bounameaux H, Morabia A, De Moerloose P, Slosman D, Didier D, et al. Diagnosis of pulmonary embolism by a decision analysis-based strategy including clinical probability, D-dimer levels, and ultrasonography: A management study. Arch Intern Med 1996; 156: 531-6.
4. Stein PD, Athanasoulis C, Alavi A, Greenspan RH, Hales CA, Saltzman HA, et al. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation 1992; 85: 462-8.
5. Kuijer PM, Turkstra F, Van Beek EJ, Ten Cate JW, Buller HR. A survey of the diagnostic and therapeutic management of patients with suspected pulmonary embolism in The Netherlands. Neth J Med 1997; 50: 261-6.
6. Carson JL, Kelley MA, Duff A, Weg JG, Fulkerson WJ, Palevsky HI, et al. The clinical course of pulmonary embolism. N Engl J Med 1992; 326: 1240-5.
7. Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med 1998; 129: 997-1005.
8. Perrier A, Miron MJ, Desmarais S, De Moerloose P, Slosman D, Didier D, et al. Using clinical evaluation and lung scan to rule out suspected pulmonary embolism: Is it a valid option in patients with normal results of lower-limb venous compression ultrasonography? Arch Intern Med 2000; 160: 512-6.
9. Perrier A, Desmarais S, Miron MJ, De Moerloose P, Lepage R, Slosman D, et al. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet 1999; 353: 190-5.
10. Sanson BJ, Lijmer JG, Mac Gillavry MR, Turkstra F, Prins MH, Buller HR. Comparison of a clinical probability estimate and two clinical models in patients with suspected pulmonary embolism. ANTELOPE-Study Group. Thromb Haemost 2000; 83: 199-203.
11. Ginsberg JS, Wells PS, Kearon C, Anderson D, Crowther M, Weitz JI, et al. Sensitivity and specificity of a rapid whole-blood assay for D-dimer in the diagnosis of pulmonary embolism. Ann Intern Med 1998; 129: 1006-11.
12. Kutinsky I, Blakley S, Roche V. Normal D-dimer levels in patients with pulmonary embolism. Arch Intern Med 1999; 159: 1569-72.
13. Perez-Rodriguez E, Jimenez D, Diaz G, Flores J. D-dimer and pulmonary embolism: Is there a good interpretation? Arch Intern Med 2000; 160: 2217-8.
14. De Groot MR, Van Marwijk Kooy M, Pouwels JG, Engelage AH, Kuipers BF, Buller HR. The use of a rapid D-dimer blood test in the diagnostic work-up for pulmonary embolism: A management study. Thromb Haemost 1999; 82: 1588-92.
15. Janssen MC, Heebels AE, De Metz M, Verbruggen H, Wollersheim H, Janssen S, et al. Reliability of five rapid D-dimer assays compared to ELISA in the exclusion of deep venous thrombosis. Thromb Haemost 1997; 77: 262-6.
16. Van Der Graaf F, Van Den Borne H, Van Der Kolk M, De Wild PJ, Janssen GW, Van Uum SH. Exclusion of deep venous thrombosis with D-dimer testing - Comparison of 13 D-dimer methods in 99 outpatients suspected of deep venous thrombosis using venography as reference standard. Thromb Haemost 2000; 83: 191-8.
17. Sijens PE, Van Ingen HE, Van Beek EJ, Berghout A, Oudkerk M. Rapid ELISA assay for plasma D-dimer in the diagnosis of segmental and subsegmental pulmonary embolism. A comparison with pulmonary angiography. Thromb Haemost 2000; 84: 156-9.
18. Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: Increasing the models utility with the SimpliRED D-dimer. Thromb Haemost 2000; 83: 416-20.
19. Wells PS, Anderson DR, Rodger M, Stiell I, Dreyer JF, Barnes D, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: Management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. Ann Intern Med 2001; 135: 98-107.
20. De Groot MR, Turkstra F, Van Marwijk Kooy M, Oostdijk AH, Van Beek EJ, Buller HR. Value of chest X-ray combined with perfusion scan versus ventilation/perfusion scan in acute pulmonary embolism. Thromb Haemost 2000; 83: 412-5.
21. Juni JE, Alavi A. Lung scanning in the diagnosis of pulmonary embolism: The emperor redressed. Semin Nucl Med 1991; 21: 281-96.
22. Turkstra F, Kuijer PM, Van Beek EJ, Brandjes DP, Ten Cate JW, Buller HR. Diagnostic utility of ultrasonography of leg veins in patients suspected of having pulmonary embolism. Ann Intern Med 1997; 126: 775-81.
23. Van Beek EJ, Reekers JA, Batchelor DA, Brandjes DP, Buller HR. Feasibility, safety and clinical utility of angiography in patients with suspected pulmonary embolism. Eur Radiol 1996; 6: 415-9.
24. Speiser W, Mallek R, Koppensteiner R, Stumpflen A, Kapiotis S, Minar E, et al. D-dimer and TAT measurement in patients with deep venous thrombosis: Utility in diagnosis and judgement of anticoagulant treatment effectiveness. Thromb Haemost 1990; 64: 196-201.
25. Raimondi P, Bongard O, De Moerloose P, Reber G, Waldvogel F, Bounameaux H. D-dimer plasma concentration in various clinical conditions: Implications for the use of this test in the diagnostic approach of venous thromboembolism. Thromb Res 1993; 69: 125-30.