D-dimer and prothrombin fragment 1 + 2 predict venous thromboembolism in patients with cancer: Results from the Vienna Cancer and Thrombosis Study

Journal of Clinical Oncology

Volumn 27, Issue 25, 2009, Pages 4124-4129

  Ay, Cihan ^a   Vormittag, Rainer ^a   Dunkler, Daniela ^a   Simanek, Ralph ^a   Chiriac, Alexandru Laurentiu ^a   Drach, Johannes ^a   Quehenberger, Peter ^a   Wagner, Oswald ^a   Zielinski, Christoph ^a   Pabinger, Ingrid ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

D DIMER; PROTHROMBIN; BIOLOGICAL MARKER; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D; PEPTIDE FRAGMENT; PROTHROMBIN FRAGMENT 1.2;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER SURGERY; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DISEASE ASSOCIATION; FEMALE; FIBRINOLYSIS; GLIOMA; HAZARD RATIO; HUMAN; KIDNEY CANCER; LUNG CANCER; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; NEOPLASM; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SEX DIFFERENCE; STOMACH CANCER; VENOUS THROMBOEMBOLISM; AUSTRIA; BLOOD; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; TIME; UPREGULATION;

AGED; AUSTRIA; BIOLOGICAL MARKERS; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NEOPLASMS; PEPTIDE FRAGMENTS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PROTHROMBIN; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; UP-REGULATION; VENOUS THROMBOEMBOLISM;

EID: 70249119693     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2008.21.7752     Document Type: Article

References (39)

1. Khorana AA, Liebman HA, White RH, et al: The Risk of Venous Thromboembolism in Patients with Cancer. Am Soc Clin Oncol Ed Book 240-248, 2008
2. Chew HK, Wun T, Harvey DJ, et al: Incidence of venous thromboembolism and the impact on survival in breast patients with cancer. J Clin Oncol 25:70-76, 2007
3. Alcalay A, Wun T, Khatri V, et al: Venous thromboembolism in patients with colorectal cancer: Incidence and effect on survival. J Clin Oncol 24:1112-1118, 2006
4. Chew HK, Wun T, Harvey D, et al: Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med 166:458-464, 2006
5. Sørensen HT, Mellemkjaer L, Olsen JH, et al: Prognosis of cancers associated with venous thromboembolism. N Engl J Med 343:1846-1850, 2000
6. Prandoni P, Falanga A, Piccioli A: Cancer and venous thromboembolism. Lancet Oncol 6:401-410, 2005
7. Buller HR, van Doormaal FF, van Sluis GL, et al: Cancer and thrombosis: From molecular mechanisms to clinical presentations. J Thromb Haemost 5:246-254, 2007 (suppl 1)
8. Blom JW, Vanderschoot JP, Oostindier MJ, et al: Incidence of venous thrombosis in a large cohort of 66,329 patients with cancer: Results of a record linkage study. J Thromb Haemost 4:529-535, 2006
9. Rickles FR, Edwards RL: Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 62:14-31, 1983
10. Falanga A: Thrombophilia in cancer. Semin Thromb Hemost 31:104-110, 2005
11. Südhoff T, Schneider W: Fibrinolytic mechanisms in tumor growth and spreading. Clin Investig 70:631-636, 1992
12. Costantini V, Zacharski LR: The role of fibrin in tumor metastasis. Cancer Metastasis Rev 11:283-290, 1992
13. Palumbo JS, Kombrinck KW, Drew AF, et al: Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 96:3302-3309, 2000
14. Kohli M, Fink LM, Spencer HJ, et al: Advanced prostate cancer activates coagulation: A controlled study of activation markers of coagulation in ambulatory patients with localized and advanced prostate cancer. Blood Coagul Fibrinolysis 13:1-5, 2002
15. Hanzal E, Tatra G: Prothrombin fragment F 1 + 2 plasma concentrations in patients with gynecologic malignancies. Gynecol Oncol 49:373-376, 1993
16. Lippi G, Franchini M, Targher G, et al: Help me, Doctor! My D-dimer is raised. Ann Med 40:594-605, 2008
17. Seitz R, Rappe N, Kraus M, et al: Activation of coagulation and fibrinolysis in patients with lung cancer: Relation to tumour stage and prognosis. Blood Coagul Fibrinolysis 4:249-254, 1993
18. Cushman M, Folsom AR, Wang L, et al: Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood 101:1243-1248, 2003
19. Palareti G, Legnani C, Cosmi B, et al: Risk of venous thromboembolism recurrence: High negative predictive value of D-dimer performed after oral anticoagulation is stopped. Thromb Haemost 87:7-12, 2002
20. Eichinger S, Minar E, Bialonczyk C, et al: D-dimer levels and risk of recurrent venous thromboembolism. JAMA 290:1071-1074, 2003
21. Palareti G, Legnani C, Cosmi B, et al: Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia. Circulation 108: 313-318, 2003
22. Ota S, Wada H, Abe Y, et al: Elevated levels of prothrombin fragment 1 + 2 indicate high risk of thrombosis. Clin Appl Thromb Hemost 14:279-285, 2008
23. Kyrle PA, Eichinger S, Pabinger I, et al: Prothrombin fragment F 1 + 2 is not predictive for recurrent venous thromboembolism. Thromb Haemost 77:829-833, 1997
24. Poli D, Antonucci E, Cecchi E, et al: Clotting activation after oral anticoagulant therapy discontinuation: A risk factor for recurrent venous thromboembolism. Blood Coagul Fibrinolysis 15:221-225, 2004
25. Prandoni P, Lensing AW, Piccioli A, et al: Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 100:3484-3488, 2002
26. Kuderer NM, Khorana AA, Lyman GH, et al: A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: Impact on survival and bleeding complications. Cancer 110:1149-1161, 2007
27. Ay C, Simanek R, Vormittag R, et al: High plasma levels of soluble P-selectin are predictive of venous thromboembolism in patients with cancer: Results from the Vienna Cancer and Thrombosis Study (CATS). Blood 112:2703-2708, 2008
28. Schemper M, Smith TL: A note on quantifying follow-up in studies of failure time. Control Clin Trials 17:343-346, 1996
29. Khorana AA, Francis CW, Culakova E, et al: Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study. Cancer 104:2822-2829, 2005
30. Khorana AA, Francis CW, Menzies KE, et al: Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. J Thromb Haemost 6:1983-1985, 2008
31. Kröger K, Weiland D, Ose C, et al: Risk factors for venous thromboembolic events in patients with cancer. Ann Oncol 17:297-303, 2006
32. Khorana AA, Kuderer NM, Culakova E, et al: Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111:4902-4907, 2008
33. Falanga A, Levine MN, Consonni R, et al: The effect of very-low-dose warfarin on markers of hypercoagulation in metastatic breast cancer: Results from a randomized trial. Thromb Haemost 79:23-27, 1998
34. Tripodi A, Cattaneo M, Molteni A, et al: Changes of prothrombin fragment 1 + 2 (F 1 + 2) as a function of increasing intensity of oral anticoagulation-considerations on the suitability of F 1 + 2 to monitor oral anticoagulant treatment. Thromb Haemost 79:571-573, 1998
35. Estivals M, Pelzer H, Sie P, et al: Prothrombin fragment 1 + 2, thrombin-antithrombin III complexes and D-dimers in acute deep vein thrombosis: Effects of heparin treatment. Br J Haematol 78:421-424, 1991
36. Weitz IC, Israel VK, Waisman JR, et al: Chemotherapy-induced activation of hemostasis: Effect of a low molecular weight heparin (dalteparin sodium) on plasma markers of hemostatic activation. Thromb Haemost 88:213-220, 2002
37. Geerts WH, Bergqvist D, Pineo GF, et al: Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 133:381S-453S, 2008
38. Cosmi B, Legnani C, Cini M, et al: The role of D-dimer and residual venous obstruction in recurrence of venous thromboembolism after anticoagulation withdrawal in patients with cancer. Haematologica 90:713-715, 2005
39. Palareti G, Cosmi B, Legnani C, et al: D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med 355:1780-1789, 2006