Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex

FEBS Letters

Volumn 587, Issue 2, 2013, Pages 136-141

  Wang, Jingwen ^b   Zhao, Yuqi ^a   Wang, Yanjie ^a   Huang, Jingfei ^a,c  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b YANTAI YUHUANGDING HOSPITAL   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

CDK6 CDKN2A complex; Inter protein coevolution; Melanoma; Molecular dynamics simulation; Oncogenic mutations

Indexed keywords

CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ACCURACY; ARTICLE; COEVOLUTION; COMPLEX FORMATION; CONTROLLED STUDY; GENE MUTATION; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROBABILITY; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RESIDUE ANALYSIS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STATISTICAL ANALYSIS; STATISTICAL COUPLING ANALYSIS;

CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DRUG DESIGN; EVOLUTION, MOLECULAR; GENES, P16; HUMANS; MELANOMA; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MULTIPROTEIN COMPLEXES; MUTANT PROTEINS; MUTATION; ONCOGENES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASE INHIBITORS;

EID: 84872112060     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.11.001     Document Type: Article

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