Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 295-304

  Narita, Koichi ^a   Fukui, Yurie ^a   Sano, Yui ^a   Yamori, Takao ^b   Ito, Akihiro ^c   Yoshida, Minoru ^c   Katoh, Tadashi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

^c RIKEN   (Japan)

Author keywords

Bicyclic depsipeptide; Histone deacetylase inhibitors; Natural products; Spiruchostatins; Total synthesis

Indexed keywords

AMINO ACID DERIVATIVE; CYCLODEPSIPEPTIDE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; SPIRUCHOSTATIN C; SPIRUCHOSTATIN D; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; JONES OXIDATION; MACROLACTONIZATION; POLYMERIZATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872104431     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.023     Document Type: Article

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