메뉴 건너뛰기




Volumn 35, Issue 9, 2012, Pages 1505-1509

A novel therapeutic target, GPR43; Where it stands in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; FATTY ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 41; G PROTEIN COUPLED RECEPTOR 42; G PROTEIN COUPLED RECEPTOR 43; G PROTEIN COUPLED RECEPTOR 43 AGONIST; GLPG 0974; PEPTIDE YY; PROGLUCAGON; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG;

EID: 84872102587     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0900-6     Document Type: Article
Times cited : (12)

References (42)
  • 1
    • 77950167517 scopus 로고    scopus 로고
    • Identification of a small-molecule GPR43 agonist that Increases glucose uptake and inhibits lipolysis in adipocytes
    • New Orleans, LA, USA
    • Bernard, J., Hartiel, A. F., Brantis, C., Hoveyda, H., and Fraser, G., Identification of a small-molecule GPR43 agonist that Increases glucose uptake and inhibits lipolysis in adipocytes. American Diabetes Association Annual Meeting, New Orleans, LA, USA, 69, Abs1362p (2009).
    • (2009) American Diabetes Association Annual Meeting , vol.69
    • Bernard, J.1    Hartiel, A.F.2    Brantis, C.3    Hoveyda, H.4    Fraser, G.5
  • 3
    • 0033118334 scopus 로고    scopus 로고
    • Molecular tinkering of G proteincoupled receptors: An evolutionary success
    • Bockaert, J. and Pin, J. P., Molecular tinkering of G proteincoupled receptors: an evolutionary success. EMBO J., 18, 1723-1729 (1999).
    • (1999) EMBO J , vol.18 , pp. 1723-1729
    • Bockaert, J.1    Pin, J.P.2
  • 10
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson, R., Lagerstrom, M. C., Lundin, L. G., and Schioth, H. B., The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol. Pharmacol., 63, 1256-1272 (2003).
    • (2003) Mol. Pharmacol. , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 11
    • 50449087891 scopus 로고    scopus 로고
    • Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    • Ge, H., Li, X., Weiszmann, J., Wang, P., Baribault, H., Chen, J. L., Tian, H., and Li, Y., Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology, 149, 4519-4526 (2008).
    • (2008) Endocrinology , vol.149 , pp. 4519-4526
    • Ge, H.1    Li, X.2    Weiszmann, J.3    Wang, P.4    Baribault, H.5    Chen, J.L.6    Tian, H.7    Li, Y.8
  • 16
    • 33947379232 scopus 로고    scopus 로고
    • Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets
    • Insel, P. A., Tang, C. M., Hahntow, I., and Michel, M. C., Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets. Biochim. Biophys. Acta, 1768, 994-1005 (2007).
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 994-1005
    • Insel, P.A.1    Tang, C.M.2    Hahntow, I.3    Michel, M.C.4
  • 17
    • 33646376658 scopus 로고    scopus 로고
    • Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
    • Karaki, S., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J. B., and Kuwahara, A., Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res., 324, 353-360 (2006).
    • (2006) Cell Tissue Res. , vol.324 , pp. 353-360
    • Karaki, S.1    Mitsui, R.2    Hayashi, H.3    Kato, I.4    Sugiya, H.5    Iwanaga, T.6    Furness, J.B.7    Kuwahara, A.8
  • 19
    • 0028338534 scopus 로고
    • GCRDb: A G-protein-coupled receptor database
    • Kolakowski, L. F., Jr., GCRDb: a G-protein-coupled receptor database. Recept. Channels, 2, 1-7 (1994).
    • (1994) Recept. Channels , vol.2 , pp. 1-7
    • Kolakowski Jr., L.F.1
  • 20
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • Lagerstrom, M. C. and Schioth, H. B., Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov., 7, 339-357 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 339-357
    • Lagerstrom, M.C.1    Schioth, H.B.2
  • 25
    • 0021349077 scopus 로고
    • The contribution of the large intestine to energy supplies in man
    • Mcneil, N. I., The contribution of the large intestine to energy supplies in man. Am. J. Clin. Nutr., 39, 338-342 (1984).
    • (1984) Am. J. Clin. Nutr. , vol.39 , pp. 338-342
    • McNeil, N.I.1
  • 26
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • Nilsson, N. E., Kotarsky, K., Owman, C., and Olde, B., Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem. Biophys. Res. Commun., 303, 1047-1052 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsky, K.2    Owman, C.3    Olde, B.4
  • 27
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
    • Reaven, G. M., Hollenbeck, C., Jeng, C. Y., Wu, M. S., and Chen, Y. D., Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes, 37, 1020-1024 (1988).
    • (1988) Diabetes , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.Y.3    Wu, M.S.4    Chen, Y.D.5
  • 28
    • 0031581088 scopus 로고    scopus 로고
    • A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1
    • Sawzdargo, M., George, S. R., Nguyen, T., Xu, S., Kolakowski, L. F., and O'dowd, B. F., A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem. Biophys. Res. Commun., 239, 543-547 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.239 , pp. 543-547
    • Sawzdargo, M.1    George, S.R.2    Nguyen, T.3    Xu, S.4    Kolakowski, L.F.5    O'Dowd, B.F.6
  • 31
    • 0037024360 scopus 로고    scopus 로고
    • Identification of G protein-coupled receptor genes from the human genome sequence
    • Takeda, S., Kadowaki, S., Haga, T., Takaesu, H., and Mitaku, S., Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett., 520, 97-101 (2002).
    • (2002) FEBS Lett. , vol.520 , pp. 97-101
    • Takeda, S.1    Kadowaki, S.2    Haga, T.3    Takaesu, H.4    Mitaku, S.5
  • 32
    • 78650618692 scopus 로고    scopus 로고
    • G-protein- coupled receptor for short-chain fatty acids suppresses colon cancer
    • Tang, Y., Chen, Y., Jiang, H., Robbins, G. T., and Nie, D., G-protein- coupled receptor for short-chain fatty acids suppresses colon cancer. Int. J. Cancer, 128, 847-856 (2011).
    • (2011) Int. J. Cancer , vol.128 , pp. 847-856
    • Tang, Y.1    Chen, Y.2    Jiang, H.3    Robbins, G.T.4    Nie, D.5
  • 33
    • 51449119654 scopus 로고    scopus 로고
    • Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions
    • Tazoe, H., Otomo, Y., Kaji, I., Tanaka, R., Karaki, S. I., and Kuwahara, A., Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J. Physiol. Pharmacol., 59 Suppl 2, 251-262 (2008).
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 2 , pp. 251-262
    • Tazoe, H.1    Otomo, Y.2    Kaji, I.3    Tanaka, R.4    Karaki, S.I.5    Kuwahara, A.6
  • 34
    • 77950120729 scopus 로고    scopus 로고
    • GPR43: An emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance
    • Tiwari, A., GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. Curr. Opin. Investig. Drugs, 11, 385-393 (2010).
    • (2010) Curr. Opin. Investig. Drugs , vol.11 , pp. 385-393
    • Tiwari, A.1
  • 36
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • Uronis, J. M., Muhlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S., and Jobin, C., Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One, 4, e6026 (2009).
    • (2009) PLoS One , vol.4
    • Uronis, J.M.1    Muhlbauer, M.2    Herfarth, H.H.3    Rubinas, T.C.4    Jones, G.S.5    Jobin, C.6
  • 42
    • 33845345276 scopus 로고    scopus 로고
    • Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line
    • Yonezawa, T., Kobayashi, Y., and Obara, Y., Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line. Cell Signal., 19, 185-193 (2007).
    • (2007) Cell Signal. , vol.19 , pp. 185-193
    • Yonezawa, T.1    Kobayashi, Y.2    Obara, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.