Studies on activation mechanism of a mitomycin dimer, 7-N,7'-N'- (1'',2''-dithiepanyl-3'',7''-dimethylenyl)bismitomycin C

Archives of Pharmacal Research

Volumn 35, Issue 9, 2012, Pages 1629-1637

  Kim, Jae Jin ^a   Kim, Hyoung Rae ^a   Lee, Sang Hyup ^a  

^a Duksung Women's University   (South Korea)

Author keywords

1,2 Dithiepane; Antitumor agent; Disulfide mitomycin; DNA interstrand cross link; Nucleophilic activation

Indexed keywords

2,6 DIHYDROXYHEPTANE; 7 N, 7' N' (1'',2'' DITHIEPANYL 3'',7'' DIMETHYLENYL)BISMITOMYCIN C; 7 N, 7' N' (2'',6'' DIHYDROXY 1'',7'' HEPTANEDIYL)BISMITOMYCIN C; DIMER; DISULFIDE; MITOMYCIN; UNCLASSIFIED DRUG;

ARTICLE; DNA ALKYLATION; DNA CROSS LINKING; DRUG STRUCTURE; KINETICS; METHANOLYSIS; SOLVOLYSIS; SYNTHESIS;

ALKYLATION; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; CATALYSIS; DITHIOTHREITOL; DNA; DNA ADDUCTS; ELECTROPHORESIS, AGAR GEL; GLUTATHIONE; HYDROLYSIS; INDICATORS AND REAGENTS; KINETICS; MITOMYCINS; PHOSPHINES; PLASMIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872100728     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0914-0     Document Type: Article

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