Effects of preoperative radiochemotherapy with capecitabine for resectable locally advanced rectal cancer in elderly patients

Tumori

Volumn 98, Issue 5, 2012, Pages 622-629

  Cèfaro, GiampieroAusili ^a   Genovesi, Domenico ^a   Vinciguerra, Annamaria ^a   Augurio, Antonietta ^a   Di Tommaso, Monica ^a   Marchese, Rita ^a   Borzillo, Valentina ^a   Tasciotti, Lucia ^a   Taraborrelli, Maria ^a   Innocenti, Paolo ^a   Colecchia, Giuseppe ^b   Nicola, Marta Di ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b SPIRITO SANTO HOSPITAL   (Italy)

Author keywords

Capecitabine; Elderly patients; Preoperative radiochemotherapy; Rectal cancer

Indexed keywords

CAPECITABINE; CISPLATIN; FLUOROURACIL;

ACUTE TOXICITY; ADJUVANT CHEMORADIOTHERAPY; ADVANCED CANCER; AGED; ANASTOMOSIS LEAKAGE; ANUS SPHINCTER; ARTICLE; BLOOD TOXICITY; CANCER STAGING; CANCER SURGERY; CLINICAL ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; ELDERLY CARE; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; MALE; PATIENT COMPLIANCE; POSTOPERATIVE COMPLICATION; PREOPERATIVE CARE; RECTUM CANCER; RETROSPECTIVE STUDY; SKIN TOXICITY; SURGICAL APPROACH; TREATMENT CONTRAINDICATION; TREATMENT REFUSAL; UROGENITAL TRACT TOXICITY;

AGED; AGED, 80 AND OVER; ANAL CANAL; ANTIMETABOLITES, ANTINEOPLASTIC; CHEMORADIOTHERAPY; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; HUMANS; MALE; NEOADJUVANT THERAPY; NEOPLASM STAGING; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84872089451     PISSN: 03008916     EISSN: 20382529     Source Type: Journal    
DOI: 10.1700/1190.13204     Document Type: Article

References (57)

1. Parkin MD, Whelan SL, Ferlay J, Teppo L, Thomas DB: Cancer incidence in five continents, vol VIII. IARC Scientific Publications, 155, IARC, Lyon, 2002.
2. Wobbes T: Carcinoma of the colon and rectum in geriatric patients. Age Ageing, 14: 321-326, 1985.
3. Trimble EL, Carter CL, Cain D, Freidlin B, Ungerleider RS, Friedman MA: Representation of older patients in cancer treatment trials. Cancer, 74: 2208-2014, 1994.
4. nd ed, Evans JG, Williams TF, Beattie BL, Michel JP, Wilcock GK (Eds), pp 1-4, Oxford University Press, Oxford, 2000.
5. Brody JA, Schneider EL: Diseases and disorders of ageing: an hypothesis. J Chron Dis, 39: 871-876, 1986.
6. De Marco MF, Janssen-Heijnen MLG, van der Heijden LH, Coebergh JW: Comorbidity and colorectal cancer according to subsite and stage: a population-based study. Eur J Cancer, 36: 95-99, 2000.
7. Lemmens VEPP, Janssen-Heijnen MLG, Verheij CD, Houterman S, Repelaer van Driel OJ, Coebergh JW: Comorbidity leads to altered treatment and worse survival of elderly patients with colorectal cancer. Br J Surg, 92: 615-623, 2005.
8. Abir F, Alva S, Longo WE: The management of rectal cancer in the elderly. Surg Oncol, 13: 223-234, 2004.
9. Swedish Rectal Cancer Trial: Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med, 336: 980-987, 1997.
10. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R; German Rectal Cancer Study Group: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med, 351: 1731-1740, 2004.
11. Colorectal Cancer Collaborative Group: Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomized trials. Lancet, 358: 1291-1304, 2001.
12. Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, Rutten HJ, Pahlman L, Glimelius B, van Krieken JH, Leer JW, van de Velde CJ; Dutch Colorectal Cancer Group: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med, 345: 638-646, 2001.
13. Camma C, Giunta M, Fiorica F, Pagliaro L, Craxì A, Cottone M: Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA, 284: 1008-1015, 2000.
14. Kim J, Kim J, Jang J: The treatment results of preoperative concurrent chemoradiation in locally advanced rectal cancer. J Korean Cancer Assoc, 32: 933-942, 2000.
15. Janjan NA, Khoo VS, Abbruzzese J, Pazdur R, Dubrow R, Cleary KR, Allen PK, Lynch PM, Glober G, Wolff R, Rich TA, Skibber J: Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: The MD Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys, 44: 1027-1038, 1999.
16. Rutten H, den Dulk M, Lemmens V, Nieuwenhuijzen G, Krijnen P, Jansen-Landheer M, van de Poll Franse L, Coebergh JW, Martijn H, Marijnen C, van de Velde C: Survival of elderly rectal cancer patients not improved: analysis of population based data on the impact of TME surgery. Eur J Cancer, 43: 2295-2300, 2007.
17. Gastrointestinal Tumor Study Group GITSG: Radiation therapy and fluorouracil with and without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. J Clin Oncol, 10: 549-557, 1992.
18. O'Connell MJ, Martenson JA, Wieand HS, Krook JE, Macdonald JS, Haller DG, Mayer RJ, Gunderson LL, Rich TA: Improving adjuvant therapy for rectal cancer by combining protracted infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med, 331: 502-507, 1994.
19. Smalley RS, Benedetti JK, Williamson SK, Robertson JM, Estes NC, Maher T, Fisher B, Rich TA, Martenson JA, Kugler JW, Benson AB 3rd, Haller DG, Mayer RJ, Atkins JN, Cripps C, Pedersen J, Periman PO, Tanaka MS Jr, Leichman CG, Macdonald JS: Phase III trial of fluorouracil-based chemotherapy regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144. J Clin Oncol, 24: 3542-3547, 2006.
20. Sargent D, Goldberg R, Jacobson SD, Macdonald JS, Labianca R, Haller DG, Shepherd LE, Seitz JF, Francini G: A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med, 345: 1091-1097, 2001.
21. Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D: Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol, 17: 2412-2418, 1999.
22. Desai SP, El-Rayes BF, Ben-Josef E, Greenson JK, Knol JA, Huang EH, Griffith KA, Philip PA, McGinn CJ, Zalupski MM: A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancer. Am J Clin Oncol, 30: 340-345, 2007.
23. Schuller J, Cassidy J, Dumont E, Roos B, Durston S, Banken L, Utoh M, Mori K, Weidekamm E, Reigner B: Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol, 45: 291-297, 2000.
24. Judson IR, Beale PJ, Trigo JM, Aherne W, Crompton T, Jones D, Bush E, Reigner B: A human capecitabine excretion balance and pharmacokinetic study after administration of a single dose of 14C-labelled drug. Invest New Drugs, 17: 49-56, 1999.
25. Kim DY, Jung KH, Kim TH, Kim DW, Chang HJ, Jeong JY, Kim YH, Son SH, Yun T, Hong CW, Sohn DK, Lim SB, Choi HS, Jeong SY, Park JG: Comparison of 5-fluoruracil/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys, 67: 378-384, 2007.
26. Twelves C, Boyer M, Findlay M, Cassidy J, Weitzel C, Barker C, Osterwalder B, Jamieson C, Hieke K; Xeloda Colorectal Cancer Study Group: Capecitabine (Xeloda) improves medical resource use compared with 5-fluorouracil plus leucovorin in a phase III trial conducted in patients with advanced colorectal carcinoma. Eur J Cancer, 37: 597-604, 2001.
27. Hoff PM, Ansari R, Batist G, Cox J, Kocha W, Kuperminc M, Maroun J, Walde D, Weaver C, Harrison E, Burger HU, Osterwalder B, Wong AO, Wong R: Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol, 19: 2282-2292, 2001.
28. Scheithauer W, McKendrick J, Begbie S, Borner M, Burns WI, Burris HA, Cassidy J, Jodrell D, Koralewski P, Levine EL, Marschner N, Maroun J, Garcia-Alfonso P, Tujakowski J, Van Hazel G, Wong A, Zaluski J, Twelves C; X-ACT Study Group: Oral capecitabine as an alternative to i.v. 5-fluo-rouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol, 14: 1735-1743, 2003.
29. Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, Bugat R, Burger U, Garin A, Graeven U, McKendric J, Maroun J, Marshall J, Osterwalder B, Pérez-Manga G, Rosso R, Rougier P, Schilsky RL; Capecitabine Colorectal Cancer Study Group: First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol, 13: 566-575, 2002.
30. American Joint Committee on Cancer: Colon and rectum. In: AJCC Cancer Staging Manual, 6th ed, pp 113-124, Springer, New York, 2002.
31. Conwell Y, Forbes N, Cox C, Caine E: Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc, 41: 38-41, 1993.
32. International Commission on Radiation Units and Measurements: Prescribing, recording and reporting photon beam therapy (supplement to ICRU Report 50). ICRU Report 62, ICRU, Bethesda, MD, 1999.
33. Capirci C, Polico C, Mandoliti G: Dislocation of small bowel volume within box pelvic treatment fields, using new "up down table" device. Int J Radiat Oncol Biol Phys, 51: 465-473, 2001.
34. Mandard AM, Dalibard F, Mandard JC, Marnay J, Henry- Amar M, Petiot JF, Roussel A, Jacob JH, Segol P, Samama G, Olivier JM, Bonvalot S, Gignoux M: Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Cancer, 73: 2680-2686, 1994.
35. Glimelius B, Holm T, Blomqvist L: Chemotherapy in addition to preoperative radiotherapy in locally advanced rectal cancer-a systematic overview. Rev Recent Clin Trials, 3: 204-211, 2008.
36. Sauer R, Fietkau R, Wittekind C, Martus P, Rödel C, Hohenberger W, Jatzko G, Sabitzer H, Karstens JH, Becker H, Hess C, Raab R: Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer. Strahlenther Onkol, 177: 173-181, 2001.
37. Fietkau R, Rodel C, Hohenberger W, Raab R, Hess C, Liersch T, Becker H, Wittekind C, Hutter M, Hager E, Karstens J, Ewald H, Christen N, Jagoditsch M, Martus P, Sauer R; German Rectal Cancer Study Group: Rectal cancer delivery of radiotherapy in adequate time and with adequate dose is influenced by treatment center, treatment schedule, and gender and is prognostic parameter for local control: results of study CAO/ARO/AIO-94. Int J Radiat Oncol Bol Phys, 67: 1008-1019, 2007.
38. Valentini V, Aristei C, Glimelius B, Minsky BD, Beets-Tan R, Borras JM, Haustermans K, Maingon P, Overgaard J, Pahlman L, Quirke P, Schmoll HJ, Sebag-Montefiore D, Taylor I, Van Cutsem E, Van de Velde C, Cellini N, Latini P, on behalf of the Scientific Committee: Multidisciplinary rectal cancer management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2). Radiother Oncol, 92: 148-163, 2009.
39. Kim JS, Kim JS, Cho MJ, Song KS, Yoon WH: Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys, 54: 403-408, 2002.
40. Korkolis DP, Boskos CS, Plataniotis GD, Gontikakis E, Karaitianos IJ, Avgerinos K, Katopodi A, Xinopoulos D, Dimitroulopoulos D, Beroukas K, Vassilopoulos PP: Preoperative chemoradiotherapy with oral capecitabine in locally advanced, resectable rectal cancer. Anticancer Res, 27: 541-545, 2007.
41. De Paoli A, Chiara S, Luppi G, Friso ML, Beretta GD, Del Prete S, Pasetto L, Santantonio M, Sarti E, Mantello G, Innocente R, Frustaci S, Corvò R, Rosso R: Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase II study. Ann Oncol, 17: 246-251, 2006.
42. De Bruin AFJ, Nuyttens JJ, Ferenschild FT, Planting AS, Verhoef C, de Wilt JH: Preoperative chemoradiation with capecitabine in locally advanced rectal cancer. Neth J Med, 66: 71-76, 2008.
43. Valenik V, Anderluh F, Oblak I, Strojan P, Zakotnik B: Capecitabine as a radiosensitizing agent in neoadjuvant treatment of locally advanced resectable rectal cancer: prospective phase II trial. Croat Med J, 47: 693-700, 2006.
44. Kim JC, Kim TW, Kim JH, Yu CS, Kim HC, Chang HM, Ryu MH, Park JH, Ahn SD, Lee SW, Shin SS, Kim JS, Choi EK: Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys, 63: 346-353, 2005.
45. Dunst J, Debus J, Rudat V, Wulf J, Budach W, Hoelscher T, Reese T, Mose S, Roedel C, Zuehlke H, Hinke A: Neoadjuvant capecitabine combined with standard radiotherapy in patients with locally advanced rectal cancer: mature results of a phase II trial. Strahlenther Onkol, 184: 450-456, 2008.
46. Hyams DM, Mamounas EP, Petrelli N, Rockette H, Jones J, Wieand HS, Deutsch M, Wickerham L, Fisher B, Wolmark N: A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: a progress report of National Surgical Adjuvant Breast and Bowel Project protocol R-03. Dis Colon Rectum, 40: 131-139, 1997.
47. Veerasarn V, Boonnuch W, Chinswangwatanakul V, Lohsiriwat D, Mahamadsolaeh P: Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m2/day. J Med Assoc Thai, 91: 1583-1588, 2008.
48. Pignon T, Horiot JC, Bolla M, van Poppel H, Bartelink H, Roelofsen F, Pene F, Gerard A, Einhorn N, Nguyen TD, Vanglabbeke M, Scalliet P: Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol, 42: 107-120, 1997.
49. Colorectal Cancer Collaborative Group: Surgery for colorectal cancer in elderly patients: a systematic review. Lancet, 356: 968-974, 2000.
50. Chiappa A, Zbar AP, Bertani E, Biella F, Audisio RA, Staudacher C: Surgical outcomes for colorectal cancer patients including the elderly. Hepatogastroenterology, 48: 440-444, 2001.
51. Au HJ, Mulder KE, Fields AL: Systematic review of management of colorectal cancer in elderly patients. Clin Colorectal Cancer, 3: 165-171, 2003.
52. Kohne CH, Grothey A, Bokemeyer C, Bontke N, Aapro M: Chemotherapy in elderly patients with colorectal cancer. Ann Oncol, 12: 435-442, 2001.
53. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M: Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg, 93: 1215-1223, 2006.
54. Goldberg PA, Nicholls RJ, Porter NH, Love S, Grimsey JE: Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: reduction in local treatment failure. Eur J Cancer, 30: 1602-1606, 1994.
55. Liu G, Franssen E, Fitch MI, Warner E: Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol, 15: 110-115, 1997.
56. Krishnan S, Janjan NA, Skibber JM, Rodriguez-Bigas MA, Wolff RA, Das P, Delclos ME, Chang GJ, Hoff PM, Eng C, Brown TD, Crane CH, Feig BW, Morris J, Vadhan-Raj S, Hamilton SR, Lin EH: Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys, 66: 762-771, 2006.
57. Lorchel F, Peignaux K, Créhange G, Bosset M, Puyraveau M, Mercier M, Bosset JF, Maingon P: Preoperative radiotherapy in elderly patients with rectal cancer. Gastroenterol Clin Biol, 31: 436-441, 2007.