An in vitro methodology for forecasting luminal concentrations and precipitation of highly permeable lipophilic weak bases in the fasted upper small intestine

Pharmaceutical Research

Volumn 29, Issue 12, 2012, Pages 3486-3498

  Psachoulias, Dimitrios ^a   Vertzoni, Maria ^a   Butler, James ^b   Busby, David ^b   Symillides, Moira ^a   Dressman, Jennifer ^c   Reppas, Christos ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

High permeability; In vitro assessment; Luminal concentrations; Precipitation; Weak bases

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; DIPYRIDAMOLE; KETOCONAZOLE; LINAPRAZAN;

ALKALINITY; ANALYTIC METHOD; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL; DIET RESTRICTION; DRUG ABSORPTION; DRUG TISSUE LEVEL; DUODENUM; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; PRECIPITATION; PREDICTION; PRIORITY JOURNAL; SMALL INTESTINE; STOMACH; SUSPENSION;

ANTIFUNGAL AGENTS; DIPYRIDAMOLE; FASTING; HUMANS; IMIDAZOLES; INTESTINAL ABSORPTION; INTESTINE, SMALL; KETOCONAZOLE; MODELS, BIOLOGICAL; PERMEABILITY; PLATELET AGGREGATION INHIBITORS; PYRIDINES; PYRROLIDINES; SOLUBILITY; TRPV CATION CHANNELS; UREA;

EID: 84872082242     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0844-z     Document Type: Article

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