Beneficial effects of stress-dose corticosteroid therapy in canines depend on the severity of staphylococcal pneumonia

Intensive Care Medicine

Volumn 38, Issue 12, 2012, Pages 2063-2071

  Hicks, Caitlin W ^a,b,c   Sweeney, Daniel A ^d   Danner, Robert L ^c   Eichacker, Peter Q ^c   Suffredini, Anthony F ^c   Feng, Jing ^c   Sun, Junfeng ^c   Moriyama, Brad ^c   Wesley, Robert ^c   Behrend, Ellen N ^e   Solomon, Steven B ^c   Natanson, Charles ^c  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Washington Hospital   (United States)

^e AUBURN UNIVERSITY   (United States)

Author keywords

Antimicrobial agents; Cardiopulmonary resuscitation; Host defenses against pathogens; Pulmonary nosocomial infections; Shock: experimental studies; SIRS sepsis: experimental studies

Indexed keywords

DEOXYCORTICOSTERONE; DEXAMETHASONE; INTERLEUKIN 6; OXACILLIN; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG MEGADOSE; LOW DRUG DOSE; LUNG INJURY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SEPTIC SHOCK; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCAL PNEUMONIA; SURVIVAL; TEMPERATURE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL LOAD; CARDIOPULMONARY RESUSCITATION; CROSS INFECTION; DESOXYCORTICOSTERONE; DEXAMETHASONE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; GLUCOCORTICOIDS; MICROBIAL SENSITIVITY TESTS; MINERALOCORTICOIDS; OXACILLIN; PNEUMONIA, STAPHYLOCOCCAL; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SURVIVAL ANALYSIS;

EID: 84872074252     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-012-2735-5     Document Type: Article

References (40)

1. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y (2004) Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. Br Med J 329:480
2. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J, CORTICUS Study Group (2008) Hydrocortisone therapy for patients with septic shock. N Engl J Med 358:111-124
3. Minneci PC, Deans KJ, Eichacker PQ, Natanson C (2009) The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis. Clin Microbiol Infect 15:308-318
4. Kalil AC, Sun J (2008) Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis. PLoS ONE 3:e2291
5. Eichacker PQ, Parent C, Kalil A, Esposito C, Cui X, Banks SM, Gerstenberger EP, Fitz Y, Danner RL, Natanson C (2002) Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med 166:1197-1205 (Pubitemid 35222596)
6. Skornik WA, Dressler DP (1974) The effects of short-term steroid therapy on lung bacterial clearance and survival in rats. Ann Surg 179:415-421
7. Heller AR, Heller SC, Borkenstein A, Stehr SN, Koch T (2003) Modulation of host defense by hydrocortisone in stress doses during endotoxemia. Intensive Care Med 29:1456-1463 (Pubitemid 37153589)
8. Cronin L, Cook DJ, Carlet J, Heyland DK, King D, Lansang MA, Fisher CJ Jr (1995) Corticosteroid treatment for sepsis: a critical appraisal and metaanalysis of the literature. Crit Care Med 23:1430-1439
9. Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C (2004) Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 141:47-56
10. Hicks CW, Sweeney DA, Danner RL, Eichacker PQ, Suffredini AF, Feng J, Sun J, Behrend EN, Solomon SB, Natanson C (2012) Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock. Crit Care Med 40(1):199-207
11. Minneci PC, Deans KJ, Hansen B, Parent C, Romines C, Gonzales DA, Ying SX, Munson P, Suffredini AF, Feng J, Solomon MA, Banks SM, Kern SJ, Danner RL, Eichacker PQ, Natanson C, Solomon SB (2007) A canine model of septic shock: balancing animal welfare and scientific relevance. Am J Physiol Heart Circ Physiol 293:H2487-H2500 (Pubitemid 47610417)
12. Becker KL (2001) Principles and practice of endocrinology and metabolism. Lippincott Williams & Wilkins, Philadelphia, pp 2108-2121
13. Plumb DC (2005) Plumb's veterinary drug handbook, 5th edn. PhrmaVet, Stockholm, Iowa, pp 578-80
14. Knaus WA, Harrell FE Jr, La Brecque JF, Wagner DP, Pribble JP, Draper EA, Fisher CJ Jr, Soll L (1996) Use of predicted risk of mortality to evaluate the efficacy of anticytokine therapy in sepsis. The rhIL-1ra Phase III Sepsis Syndrome Study Group. Crit Care Med 24:46-56
15. Keh D, Boehnke T, Weber-Cartens S, Schulz C, Ahlers O, Bercker S, Volk HD, Doecke WD, Falke KJ, Gerlach H (2003) Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 167:512-520
16. Oppert M, Schindler R, Husung C, Offermann K, Graf KJ, Boenisch O, Barckow D, Frei U, Eckardt KU (2005) Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 33:2457-2464 (Pubitemid 41682095)
17. Briegel J, Jochum M, Gippner-Steppert C, Thiel M (2001) Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses. J Am Soc Nephrol 12 [Suppl 17]: S70-S74 (Pubitemid 32119058)
18. Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E (1993) Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 103:565-575 (Pubitemid 23070764)
19. Novotny AR, Reim D, Assfalg V, Altmayr F, Friess HM, Emmanuel K, Holzmann B (2011) Mixed antagonist response and sepsis severity-dependent dysbalance of pro-and antiinflammatory responses at the onset of postoperative sepsis. Immunobiology 31(1):201-213
20. Osuchowski MF, Connett J, Welch K, Granger J, Remick DG (2009) Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit Care Med 37:1567-1573
21. van der Goes A, Hoekstra K, van den Berg TK, Dijkstra CD (2000) Dexamethasone promotes phagocytosis and bacterial killing by human monocytes/macrophages in vitro. J Leukoc Biol 67:801-807
22. Meduri GU, Kanangat S, Bronze M, Patterson DR, Meduri CU, Pak C, Tolley EA, Schaberg DR (2001) Effects of methylprednisolone on intracellular bacterial growth. Clin Diagn Lab Immunol 8:1156-1163 (Pubitemid 33035749)
23. Kaufmann I, Briegel J, Schliephake F, Hoelzl A, Chouker A, Hummel T, Schelling G, Thiel M (2008) Stress doses of hydrocortisone in septic shock: beneficial effects on opsonizationdependent neutrophil functions. Intensive Care Med 34:344-349 (Pubitemid 351207639)
24. Shurin MR, Kusnecov A, Hamill E, Kaplan S, Rabin BS (1994) Stressinduced alteration of polymorphonuclear leukocyte function in rats. Brain Behav Immun 8:163-169 (Pubitemid 24197049)
25. Rojas IG, Padgett DA, Sheridan JF, Marucha PT (2002) Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain Behav Immun 16:74-84 (Pubitemid 35435455)
26. Cetinkaya RA, Gorenek L, Coskun O, Eyigun CP, Senses Z, Ide T, Kilic S (2009) The effect of methylprednisolone on treatment in rats with induced sepsis. Clin Exp Med 9:45-50
27. Sibila O, Luna CM, Agusti C, Baquero S, Gando S, Patron JR, Morato JG, Absi R, Bassi N, Torres A (2008) Effects of glucocorticoids in ventilated piglets with severe pneumonia. Eur Respir J 32:1037-1046
28. Tagliabue C, Salvatore CM, Techasaensiri C, Mejias A, Torres JP, Katz K, Gomez AM, Esposito S, Principi N, Hardy RD (2008) The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection. J Infect Dis 198:1180-1188
29. Flynn PM, Shenep JL, Stokes DC, Hildner WK, Mackert PW, Snellgrove RL, Rehg JE (1986) Effect of methylprednisolone on bacterial clearance and endotoxin liberation during experimental sepsis induced by gram-negative bacteria. Infect Immun 52:26-30 (Pubitemid 16137674)
30. Fadel MV, Repka JC, Cunha CL, Leao MT (2008) Inadequate timing between corticosteroid and antibiotics applications increases mortality due to sepsis. Braz J Infect Dis 12:416-422
31. Assfalg V, Huser N, Reim D, Kaiser-Moore S, Rossmann-Bloeck T, Weighardt H, Novotny AR, Stangl MJ, Holzmann B, Emmanuel KL (2010) Combined immunosuppressive and antibiotic therapy improves bacterial clearance and survival of polymicrobial septic peritonitis. Shock 33:155-161
32. Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A (1998) Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 26:645-650 (Pubitemid 28201409)
33. Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, Peter K (1999) Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 27:723-732 (Pubitemid 29218204)
34. Chawla K, Kupfer Y, Goldman I (1999) Hydrocortisone reverses refractory septic shock. Crit Care Med 27:A33
35. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaud P, Bellissant E (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-871
36. Mussack T, Briegel J, Schelling G, Biberthaler P, Jochum M (2005) Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock. Clin Chem Lab Med 43:259-268
37. Tandan SM, Guleria R, Gupta N (2005) Low dose steroids and adrenocortical insufficiency in septic shock: a doubleblind randomized controlled trial from India. Am J Respir Crit Care Med 171:A43
38. Li Y, Cui X, Li X, Solomon SB, Danner RL, Banks SM, Fitz Y, Annane D, Natanson C, Eichacker PQ (2008) Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis. Intensive Care Med 34:568-577 (Pubitemid 351623024)
39. COIITSS Study Investigators, Annane D, Cariou A, Maxime V, Azoulay E, D'honneur G, Timsit JF, Cohen Y, Wolf M, Fartoukh M, Adrie C, Santre C, Bollaert PE, Mathonet A, Amathieu R, Tabah A, Clec'h C, Mayaud J, Lejeune J, Chevret S (2010) Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA 303:341-348
40. Scott WA, Pongiglione G, Bromberg BI, Schaffer MS, Deal BJ, Fish FA, Dick M (1995) Randomized comparison of atenolol and fludrocortisone acetate in the treatment of pediatric neurally mediated syncope. Am J Cardiol 76:400-402