Characterising the tumour morphological response to therapeutic intervention: An ex vivo model

DMM Disease Models and Mechanisms

Volumn 6, Issue 1, 2013, Pages 252-260

  Savage, Anne ^a   Katz, Elad ^b   Eberst, Alistair ^a   Falconer, Ruth E ^a   Houston, Alasdair ^a   Harrison, David J ^b,c   Bown, James ^a  

^a UNIVERSITY OF ABERTAY DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN; TAMOXIFEN;

APOPTOSIS; ARTICLE; BREAST TUMOR; CANCER CELL CULTURE; CANCER GRADING; CELL PROLIFERATION; EX VIVO STUDY; GEOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MORPHOMETRICS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR VOLUME;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; DISCRIMINANT ANALYSIS; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MODELS, BIOLOGICAL; NEOPLASM GRADING; NEOPLASMS; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; REGRESSION ANALYSIS; TAMOXIFEN; TUMOR CELLS, CULTURED;

EID: 84872069403     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.009886     Document Type: Article

References (38)

1. Amjad, S. B., Carachi, R. and Edward, M. (2007). Keratinocyte regulation of TGF-beta and connective tissue growth factor expression: a role in suppression of scar tissue formation. Wound Repair Regen. 15, 748-755.
2. Arns, C. H., Knackstedt, M. A. and Mecke, K. (2010). 3D structural analysis: sensitivity of Minkowski functionals. J. Microsc. 240, 181-196.
3. Beck, A. H., Sangoi, A. R., Leung, S., Marinelli, R. J., Nielsen, T. O., van de Vijver, M. J., West, R. B., van de Rijn, M. and Koller, D. (2011). Systematic analysis of breast cancer morphology uncovers stromal features associated with survival. Sci. Transl. Med. 3, 108.
4. Bedin, V., Adam, R. L., de Sá, B. C., Landman, G. and Metze, K. (2010). Fractal dimension of chromatin is an independent prognostic factor for survival in melanoma. BMC Cancer 10, 260.
5. Bertos, N. R. and Park, M. (2011). Breast cancer-one term, many entities? J. Clin. Invest. 121, 3789-3796.
6. Boehm, H. F., Schneider, T., Buhmann-Kirchhoff, S. M., Schlossbauer, T., Rjosk-Dendorfer, D., Britsch, S. and Reiser, M. (2008). Automated classification of breast parenchymal density: topologic analysis of x-ray attenuation patterns depicted with digital mammography. AJR Am. J. Roentgenol. 191, W275-W282.
7. Debnath, J. and Brugge, J. S. (2005). Modelling glandular epithelial cancers in threedimensional cultures. Nat. Rev. Cancer 5, 675-688.
8. Dowsett, M., Smith, I. E., Ebbs, S. R., Dixon, J. M., Skene, A., Griffith, C., Boeddinghaus, I., Salter, J., Detre, S., Hills, M. et al. (2005). Short-term changes in Ki-67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival. Clin. Cancer Res. 11, 951s-958s.
9. Drewitz, M., Helbling, M., Fried, N., Bieri, M., Moritz, W., Lichtenberg, J. and Kelm, J. M. (2011). Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues. Biotechnol. J. 6, 1488-1496.
10. Egeblad, M., Nakasone, E. S. and Werb, Z. (2010). Tumors as organs: complex tissues that interface with the entire organism. Dev. Cell 18, 884-901.
11. Elston, C. W. and Ellis, I. O. (1991). Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19, 403-410.
12. Eynard, H. G., Soria, E. A., Cuestas, E., Rovasio, R. A. and Eynard, A. R. (2009). Assessment of colorectal cancer prognosis through nuclear morphometry. J. Surg. Res. 154, 345-348.
13. Falconer, R., Houston, A., Otten, W. and Baveye, P. (2012). Emergent behaviour of fungal dynamics: influence of soil architecture and moisture distribution. Soil Sci. 177, 111-119.
14. Fanshawe, T. R., Lynch, A. G., Ellis, I. O., Green, A. R. and Hanka, R. (2008). Assessing agreement between multiple raters with missing rating information, applied to breast cancer tumour grading. PLoS ONE 3, e2925.
15. Franzén, L. E., Hahn-Strömberg, V., Edvardsson, H. and Bodin, L. (2008). Characterization of colon carcinoma growth pattern by computerized morphometry: definition of a complexity index. Int. J. Mol. Med. 22, 465-472.
16. Goutzanis, L. P., Papadogeorgakis, N., Pavlopoulos, P. M., Petsinis, V., Plochoras, I., Eleftheriadis, E., Pantelidaki, A., Patsouris, E. and Alexandridis, C. (2009). Vascular fractal dimension and total vascular area in the study of oral cancer. Head Neck 31, 298-307.
17. Han, J., Chang, H., Giricz, O., Lee, G. Y., Baehner, F. L., Gray, J. W., Bissell, M. J., Kenny, P. A. and Parvin, B. (2010). Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput. Biol. 6, e1000684.
18. Hikage, C., Schmalzing, J., Buchert, T., Suto, Y., Kayo, I., Taruya, A., Vogeley, M. S., Hoyle, F., Gott, J. R., III and Brinkmann, J. (2003). Minkowski Functionals of SDSS galaxies I: analysis of excursion sets. Publ. Astron. Soc. Jap. 55, 911-931.
19. Katz, E., Lareef, M. H., Rassa, J. C., Grande, S. M., King, L. B., Russo, J., Ross, S. R. and Monroe, J. G. (2005). MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture. J. Exp. Med. 201, 431-439.
20. Katz, E., Dubois-Marshall, S., Sims, A. H., Faratian, D., Li, J., Smith, E. S., Quinn, J. A., Edward, M., Meehan, R. R., Evans, E. E. et al. (2010). A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. Br. J. Cancer 103, 401-410.
21. Katz, E., Verleyen, W., Blackmore, C. G., Edward, M., Smith, V. A. and Harrison, D. J. (2011). An analytical approach differentiates between individual and collective cancer invasion. Anal. Cell. Pathol. (Amst.) 34, 35-48.
22. Katz, E., Sims, A. H., Sproul, D., Caldwell, H., Dixon, M. J., Meehan, R. R. and Harrison, D. J. (2012). Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget, 3, 608-619.
23. Kenny, P. A., Lee, G. Y., Myers, C. A., Neve, R. M., Semeiks, J. R., Spellman, P. T., Lorenz, K., Lee, E. H., Barcellos-Hoff, M. H., Petersen, O. W. et al. (2007). The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol. Oncol. 1, 84-96.
24. Lanigan, F., McKiernan, E., Brennan, D. J., Hegarty, S., Millikan, R. C., McBryan, J., Jirstrom, K., Landberg, G., Martin, F., Duffy, M. J. et al. (2009). Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int. J. Cancer 124, 2088-2097.
25. Lautensack, C. and Sych, T. (2006). 3D image analysis of open foams using random tessellations. Image Anal. Stereol. 25, 87-93.
26. Leeper, A. D., Farrell, J., Dixon, J. M., Wedden, S. E., Harrison, D. J. and Katz, E. (2011). Long-term culture of human breast cancer specimens and their analysis using optical projection tomography. J. Vis. Exp. 53, 3085.
27. Leeper, A. D., Farrell, J., Williams, L. J., Thomas, J. S., Dixon, J. M., Wedden, S. E., Harrison, D. J. and Katz, E. (2012). Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture. Biomaterials 33, 907-915.
28. Legland, D., Kiêu, K. and Devaux, M. (2007). Computation of Minkowski measures of 2D and 3D binary images. Image Anal. Stereol. 26, 83-92.
29. Mattfeldt, T., Meschenmoser, D., Pantle, U. and Schmidt, V. (2007). Characterization of mammary gland tissue using joint estimators of Minkowski functionals. Image Anal. Stereol. 26, 13-22.
30. Mullen, P., Cameron, D. A., Hasmann, M., Smyth, J. F. and Langdon, S. P. (2007). Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling. Mol. Cancer Ther. 6, 93-100.
31. Muranen, T., Selfors, L. M., Worster, D. T., Iwanicki, M. P., Song, L., Morales, F. C., Gao, S., Mills, G. B. and Brugge, J. S. (2012). Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell 21, 227-239.
32. Ohser, J. and Mücklich, F. (2000). Statistical Analysis of Microstructures in Material Science. New York, NY: Wiley.
33. Schmalzing, J. and Buchert, T. (1997). Beyond genus statistics: a unifying approach to the morphology of cosmic structure. Astrophysical J. 482, L1-L4.
34. Sundstrom, L., Biggs, T., Laskowski, A. and Stoppini, L. (2012). OrganDots-an organotypic 3D tissue culture platform for drug development. Expert Opin. Drug Discov. 7, 525-534.
35. Valastyan, S. and Weinberg, R. A. (2011). Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275-292.
36. Wang, L. M., Kevans, D., Mulcahy, H., O'Sullivan, J., Fennelly, D., Hyland, J., O'Donoghue, D. and Sheahan, K. (2009). Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. Am. J. Surg. Pathol. 33, 134-141.
37. Wöhlke, M., Schiffmann, L. and Prall, F. (2011). Aggressive colorectal carcinoma phenotypes of invasion can be assessed reproducibly and effectively predict poor survival: interobserver study and multivariate survival analysis of a prospectively collected series of 299 patients after potentially curative resections with long-term follow-up. Histopathology 59, 857-866.
38. Yaffe, M. J. (2008). Mammographic density. Measurement of mammographic density. Breast Cancer Res. 10, 209.