Disrupted Functional Connectivity of the Anterior Cingulate Cortex in Cirrhotic Patients without Overt Hepatic Encephalopathy: A Resting State fMRI Study

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Zhang, Long Jiang ^a   Qi, Rongfeng ^a   Zhong, Jianhui ^b   Ni, Ling ^a   Zheng, Gang ^a   Xu, Jian ^a   Lu, Guang Ming ^a  

^a NANJING UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA;

ADULT; AMMONIA BLOOD LEVEL; ANTERIOR CINGULATE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEPATIC ENCEPHALOPATHY; HUMAN; INSULA; LINGUAL GYRUS; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE FRONTAL CORTEX; NERVE CELL NETWORK; NEUROPSYCHOLOGICAL TEST; PRECUNEUS; PUTAMEN; RETROSPECTIVE STUDY; THALAMUS;

ADULT; FEMALE; FIBROSIS; GYRUS CINGULI; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 84872051863     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053206     Document Type: Article

References (41)

1. Zhang LJ, Zhong J, Lu GM, (2012) Multimodality MR imaging findings of low grade brain edema in hepatic encephalopathy. AJNR Am J Neuroradiol.
2. Bajaj JS, Wade JB, Sanyal AJ, (2009) Spectrum of Neurocognitive Impairment in Cirrhosis: Implications for the Assessment of Hepatic Encephalopathy. Hepatology 50: 2014-2021.
3. Bajaj JS, Saeian K, Hafeezullah M, Hoffmann RG, Hammeke TA, (2008) Patients with minimal hepatic encephalopathy have poor insight into their driving skills. Clin Gastroenterol Hepatol 6: 1135-1139.
4. Bajaj JS, Hafeezullah M, Hoffmann RG, Varma RR, Franco J, et al. (2008) Navigation skill impairment: Another dimension of the driving difficulties in minimal hepatic encephalopathy. Hepatology 47: 596-604.
5. Wein C, Koch H, Popp B, Oehler G, Schauder P, (2004) Minimal hepatic encephalopathy impairs fitness to drive. Hepatology 39: 739-745.
6. Bajaj JS, (2008) Minimal hepatic encephalopathy matters in daily life. World J Gastroenterol 14: 3609-3615.
7. Román E, Córdoba J, Torrens M, Torras X, Villanueva C, et al. (2011) Minimal hepatic encephalopathy is associated with falls. Am J Gastroenterol 106: 476-482.
8. Weissenborn K, Heidenreich S, Ennen J, Rückert N, Hecker H, (2001) Attention deficits in minimal hepatic encephalopathy. Metab Brain Dis 16: 13-19.
9. Weissenborn K, Ennen JC, Schomerus H, Rückert N, Hecker H, (2001) Neuropsychological characterization of hepatic encephalopathy. J Hepatol 34: 768-773.
10. Amodio P, Schiff S, Del Piccolo F, Mapelli D, Gatta A, et al. (2005) Attention dysfunction in cirrhotic patients: an inquiry on the role of executive control, attention orienting and focusing. Metab Brain Dis 20: 115-127.
11. Zhang LJ, Yang G, Yin J, Liu Y, Qi J, (2007) Neural mechanism of cognitive control impairment in patients with hepatic cirrhosis: a functional magnetic resonance imaging study. Acta Radiol 48: 577-587.
12. Qi R, Zhang LJ, Xu Q, Zhong J, Wu S, et al. (2012) Selective impairments of resting-state networks in minimal hepatic encephalopathy. PLoS One 7: e37400.
13. Zafiris O, Kircheis G, Rood HA, Boers F, Haussinger D, et al. (2004) Neural mechanism underlying impaired visual judgement in the dysmetabolic brain: an fMRI study. Neuroimage 22: 541-552.
14. Posner MI, Petersen SE, (1990) The attention system of the human brain. Annu Rev Neurosci 13: 25-42.
15. Bush G, Luu P, Posner MI, (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4: 215-222.
16. Greicius MD, Krasnow B, Reiss AL, Menon V, (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100: 253-258.
17. Iwasa M, Matsumura K, Nakagawa Y, Yamamoto M, Tanaka H, et al. (2005) Evaluation of cingulate gyrus blood flow in patients with liver cirrhosis. Metab Brain Dis 20: 7-17.
18. Kato A, Suzuki K, Kaneta H, Obara H, Fujishima Y, et al. (2000) Regional differences in cerebral glucose metabolism in cirrhotic patients with subclinical hepatic encephalopathy using positron emission tomography. Hepatol Res 17: 237-245.
19. Zhang LJ, Lu GM, Yin JZ, Qi J, (2010) Metabolic changes of anterior cingulate cortex in patients with hepatic cirrhosis: A magnetic resonance spectroscopy study. Hepatol Res 40: 777-785.
20. Zhang L, Qi R, Wu S, Zhong J, Zhong Y, et al. (2012) Brain default-mode network abnormalities in hepatic encephalopathy: A resting-state functional MRI study. Hum Brain Mapp 33: 1384-1392.
21. Hsu TW, Wu CW, Cheng YF, Chen HL, Lu CH, et al. (2012) Impaired small-world network efficiency and dynamic functional distribution in patients with cirrhosis. PLoS One 7: e35266.
22. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, et al. (2002) Hepatic encephalopathy- definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35: 716-721.
23. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R, (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60: 646-649.
24. Yu C, Zhou Y, Liu Y, Jiang T, Dong H, et al. (2011) Functional segregation of the human cingulate cortex is confirmed by functional connectivity based neuroanatomical parcellation. Neuroimage 54: 2571-2581.
25. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH, (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19: 1233-1239.
26. Tang L, Ge Y, Sodickson DK, Miles L, Zhou Y, et al. (2011) Thalamic resting-state functional networks: disruption in patients with mild traumatic brain injury. Radiology 260: 831-840.
27. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, et al. (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A 102: 9673-9678.
28. Genovese CR, Lazar NA, Nichols T, (2002) Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15: 870-878.
29. Sohn MH, Albert MV, Jung K, Carter CS, Anderson JR, (2007) Anticipation of conflict monitoring in the anterior cingulate cortex and the prefrontal cortex. Proc Natl Acad Sci USA 104: 10330-10334.
30. Pourtois G, Vocat R, N'diaye K, Spinelli L, Seeck M, et al. (2010) Errors recruit both cognitive and emotional monitoring systems: simultaneous intracranial recordings in the dorsal anterior cingulate gyrus and amygdala combined with fMRI. Neuropsychologia 48: 1144-1159.
31. Paus T, (2001) Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci 2: 417-424.
32. Luo Q, Mitchell D, Jones M, Mondillo K, Vythilingam M, et al. (2007) Common regions of dorsal anterior cingulate and prefrontal-parietal cortices provide attentional control of distracters varying in emotionality and visibility. Neuroimage 38: 631-639.
33. Bates JF, Goldman-Rakic PS, (1993) Prefrontal connections of medial motor areas in the rhesus monkey. J Comp Neurol 336: 211-228.
34. Montoliu C, Gonzalez-Escamilla G, Atienza M, Urios A, Gonzalez O, et al. (2012) Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy. Neuroimage 61: 1165-1175.
35. Ciećko-Michalska I, Senderecka M, Szewczyk J, Panasiuk A, Słowik A, et al. (2006) Event-related cerebral potentials for the diagnosis of subclinical hepatic encephalopathy in patients with liver cirrhosis. Adv Med Sci 51: 273-277.
36. Dziobek I, Preissler S, Grozdanovic Z, Heuser I, Heekeren HR, et al. (2011) Neuronal correlates of altered empathy and social cognition in borderline personality disorder. Neuroimage 57: 539-548.
37. Durieux PF, Schiffmann SN, de Kerchove d'Exaerde A, (2011) Targeting neuronal populations of the striatum. Front Neuroanat 5: 40.
38. Grahn JA, Parkinson JA, Owen AM, (2009) The role of the basal ganglia in learning and memory: neuropsychological studies. Behav Brain Res 199: 53-60.
39. Luo J, Niki K, (2003) Function of hippocampus in "insight" of problem solving. Hippocampus 13: 316-323.
40. Petersen SE, Posner MI, (2012) The attention system of the human brain: 20 years after. Annu Rev Neurosci 35: 73-89.
41. Lin WC, Hsu TW, Chen CL, Wu CW, Lu CH, et al. (2012) Connectivity of default-mode network is associated with cerebral edema in hepatic encephalopathy. PLoS One 7 (5):: e36986.