Regional differences in cerebral glucose metabolism in cirrhotic patients with subclinical hepatic encephalopathy using positron emission tomography

Hepatology Research

Volumn 17, Issue 3, 2000, Pages 237-245

  Kato, Akinobu ^a   Suzuki, Kazuyuki ^a   Kaneta, Hirokazu ^a   Obara, Hirohiko ^a   Fujishima, Yuukou ^a   Sato, Shunichi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Auditory brain stem reaction; Electroencephalogram; Positron emission tomography; Regional cerebral glucose metabolism; Subclinical hepatic encephalopathy; Wechsler Adult Intelligence Scale

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ARTICLE; BASAL GANGLION; BRAIN ELECTROPHYSIOLOGY; BRAIN METABOLISM; BRAIN REGION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; FRONTAL CORTEX; GLUCOSE METABOLISM; GRAY MATTER; HEPATIC ENCEPHALOPATHY; HUMAN; INTELLIGENCE TEST; LIVER CIRRHOSIS; MALE; OCCIPITAL LOBE; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOMETRY; WHITE MATTER;

EID: 0034104902     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(99)00080-7     Document Type: Article

References (17)

1. Gitlin N. Subclinical portal-systemic encephalopathy. Am. J. Gastroentrol. 83:1988;8-11.
2. Rikkers L., Jenko P., Rudman D., Friedes D. Subclinical hepatic encephalopathy: detection, prevalence, and relationship to nitrogen metabolism. Gastroenterology. 75:1978;462-469.
3. Gitlin N., Lewis D.C., Hinkley L. The diagnosis and prevalence of subclinical hepatic encephalopathy in apparently healthy, non-shunted patients with cirrhosis. J. Hepatol. 3:1986;75-82.
4. Joelsson B., Aslund U., Hultberg B., Alwmark A., Gullstrand P., Bengmark S. Portal-systemic encephalopathy. Influence of shunt surgery and relations to serum amino acids. Scand. J. Gastroenterol. 21:1986;900-906.
5. Sood G.K., Sarin S.K., Mahaptra J., Broor S.L. Comparative efficacy of psychometric tests in detection of subclinical hepatic encephalopathy in nonalcoholic cirrhotics: search for a rational approach. Am. J. Gastroenterol. 2:1989;156-159.
6. Schomerus H., Schreiegg J. Prevalence of latent portasystemic encephalopathy in an unselected population of patients with liver cirrhosis in general practice. J. Gastroenterol. 31:1993;231-234.
7. McCandless D.W., Schenker S. Effect of acute ammonia intoxication on energy stores in the cerebral reticular activating system. Exp. Brain Res. 44:1981;325-330.
8. Hindfelt B., Plum F., Duffy T.E. Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts. J. Clin. Invest. 59:1997;386-396.
9. Butterworth R.F., Lavoie J., Giguere J.F., Layrargues G.P., Bergeren M. Cerebral GABA-ergic and glutamatergic function in hepatic encephalopathy. Neurochem. Pathol. 6:1987;131-144.
10. Lockwood A.H., Ginsberg M.D., Rhoades H.M., Gutierrez M.T. Cerebral glucose metabolism after portacaval shunting in the rat. J. Clin. Invest. 78:1986;86-95.
11. Mans A.M., Davis D.W., Biebuyuck J.F., Hawkins R.A. Failure of glucose and branched-chain amino acids to normalize brain glucose use in portacaval shunted rats. J. Neurochem. 47:1986;1434-1443.
12. Lockwood A.H., Yap E.W.H., Rhoades H.M., Wong W.H. Altered cerebral blood flow and glucose metabolism in patients with liver disease and minimal encephalopathy. J. Cereb. Blood Flow Metab. 11:1991;331-336.
13. Lockwood A.H., Murphy B.W., Donnelly K.Z., Mahl T.C., Perini S. Positron-emmision tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy. Hepatology. 18:1993;1061-1068.
14. Wechsler D. Wechsler Adult Intelligence Scale - Revised. 1981;Psychological Corporation, New York.
15. Hatazawa J., Ito M., Matuzawa T. et al. Measurement of the ratio of cerebral oxygen consumption to glucose utilization by positron emission tomography: its consistency with values determined by the Kety-Schmidt method in normal volunteers. J. Cereb. Blood Metab. 8:1988;426-432.
16. Burra P., Dam M., Chierichetti U. et al. 18F-fluorodeoxyglucose positron emission tomography study of brain metabolism in cirrhosis: effect of liver transplantation. Transplant Proc. 31:1999;418-420.
17. Watanabe A., Sakai T., Sato S. et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology. 26:1997;1414-1414.