Replication of Epstein-Barr viral DNA

Cold Spring Harbor Perspectives in Biology

Volumn 5, Issue 1, 2013, Pages

  Hammerschmidt, Wolfgang ^a   Sugden, Bill ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN HERPESVIRUS 4;

VIRUS DNA; VIRUS PROTEIN;

BIOSYNTHESIS; CELL CYCLE S PHASE; DNA REPLICATION; DNA REPLICATION ORIGIN; EPSTEIN BARR VIRUS; GENETICS; PHYSIOLOGY; REVIEW; VIRUS REPLICATION;

DNA REPLICATION; DNA, VIRAL; HERPESVIRUS 4, HUMAN; REPLICATION ORIGIN; S PHASE; VIRAL PROTEINS; VIRUS REPLICATION;

MLCS; MLOWN;

EID: 84872046551     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a013029     Document Type: Article

References (88)

1. Altmann M, Pich D, Ruiss R, Wang J, Sugden B, Hammerschmidt W. 2006. Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes. Proc Natl Acad Sci 103: 14188-14193.
2. Antson AA, Burns JE, Moroz OV, Scott DJ, Sanders CM, Bronstein IB, Dodson GG, Wilson KS, Maitland NJ. 2000. Structure of the intact transactivation domain of the human papillomavirus E2 protein. Nature 403: 805-809.
3. Aras S, Singh G, Johnston K, Foster T, Aiyar A. 2009. Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog 5: e1000469.
4. Atanasiu C, Deng Z, Wiedmer A, Norseen J, Lieberman PM. 2006. ORC binding to TRF2 stimulates OriP replication. EMBO Rep 7: 716-721.
5. Avolio-Hunter TM, Frappier L. 2003. EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus latent origin of replication. Virology 315: 398-408.
6. Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, et al. 1984. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310: 207-211.
7. Bashaw JM, Yates JL. 2001. Replication from oriP of Epstein-Barr virus requires exact spacing of two bound dimers of EBNA1 which bend DNA. J Virol 75: 10603-10611.
8. Baumann M, Feederle R, Kremmer E, Hammerschmidt W. 1999. Cellular transcription factors recruit viral replication proteins to activate the Epstein-Barr virus origin of lytic DNA replication, oriLyt. EMBO J 18: 6095-6105.
9. Bloss TA, Sugden B. 1994. Optimal lengths for DNAs encapsidated by Epstein-Barr virus. J Virol 68: 8217-8222.
10. Bochkarev A, Barwell JA, Pfuetzner RA, Bochkareva E, Frappier L, Edwards AM. 1996. Crystal structure of the DNA-binding domain of the Epstein-Barr virus originbinding protein, EBNA1, bound to DNA. Cell 84: 791-800.
11. Challberg MD. 1986. A method for identifying the viral genes required for herpesvirus DNA replication. Proc Natl Acad Sci 83: 9094-9098.
12. Challberg MD, Kelly TJ. 1989. Animal virus DNA replication. Annu Rev Biochem 58: 671-717.
13. Chaudhuri B, Xu H, Todorov I, Dutta A, Yates JL. 2001. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus. Proc Natl Acad Sci 98: 10085-10089.
14. Daikoku T, Kudoh A, Fujita M, Sugaya Y, Isomura H, Shirata N, Tsurumi T. 2005. Architecture of replication compartments formed during Epstein-Barr virus lytic replication. J Virol 79: 3409-3418.
15. Daikoku T, Kudoh A, Sugaya Y, Iwahori S, Shirata N, Isomura H, Tsurumi T. 2006. Postreplicative mismatch repair factors are recruited to Epstein-Barr virus replication compartments. J Biol Chem 281: 11422-11430.
16. Deng Z, Lezina L, Chen CJ, Shtivelband S, So W, Lieberman PM. 2002. Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication. Mol Cell 9: 493-503.
17. Deng Z, Atanasiu C, Burg JS, Broccoli D, Lieberman PM. 2003. Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP. J Virol 77: 11992-12001.
18. Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A. 2001. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. Cell 106: 287-296.
19. Dheekollu J, Lieberman PM. 2011. The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus. J Virol 85: 5853-5863.
20. El-Guindy A, Heston L, Miller G. 2010. A subset of replication proteins enhances origin recognition and lytic replication by the Epstein-Barr virus ZEBRA protein. PLoS Pathog 6: e1001054.
21. Feederle R, Delecluse HJ. 2004. Low level of lytic replication in a recombinant Epstein-Barr virus carrying an origin of replication devoid of BZLF1-binding sites. J Virol 78: 12082-12084.
22. Feederle R, Kost M, Baumann M, Janz A, Drouet E, Hammerschmidt W, Delecluse HJ. 2000. The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators. EMBOJ 19: 3080-3089.
23. Fernandez AF, Rosales C, Lopez-Nieva P, Grana O, Ballestar E, Ropero S, Espada J, Melo SA, Lujambio A, Fraga MF, et al. 2009. The dynamic DNA methylomes of double-stranded DNAviruses associated with human cancer. Genome Res 19: 438-451.
24. Fujii K, Yokoyama N, Kiyono T, Kuzushima K, Homma M, Nishiyama Y, Fujita M, Tsurumi T. 2000. The Epstein-Barr virus pol catalytic subunit physically interacts with the BBLF4-BSLF1-BBLF2/3 complex. J Virol 74: 2550-2557.
25. Gibson W, Roizman B. 1971. Compartmentalization of spermine and spermidine in the herpes simplex virion. Proc Natl Acad Sci 68: 2818-2821.
26. Gruffat H, Renner O, Pich D, Hammerschmidt W. 1995. Cellular proteins bind to the downstream component of the lytic origin of DNA replication of Epstein-Barr virus. J Virol 69: 1878-1886.
27. Hammerschmidt W, Sugden B. 1988. Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55: 427-433.
28. Hegde RS, Grossman SR, Laimins LA, Sigler PB. 1992. Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. Nature 359: 505-512.
29. Humme S, Reisbach G, Feederle R, Delecluse HJ, Bousset K, Hammerschmidt W, Schepers A. 2003. The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold. Proc Natl Acad Sci 100: 10989-10994.
30. Hung SC, Kang MS, Kieff E. 2001. Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1. Proc Natl Acad Sci 98: 1865-1870.
31. Jacob RJ, Roizman B. 1977. Anatomy of herpes simplex virus DNAVIII. Properties of the replicating DNA. J Virol 23: 394-411.
32. Julien MD, Polonskaya Z, Hearing J. 2004. Protein and sequence requirements for the recruitment of the human origin recognition complex to the latent cycle origin of DNA replication of Epstein-Barr virus oriP. Virology 326: 317-328.
33. Kalla M, Schmeinck A, Bergbauer M, Pich D, Hammerschmidt W. 2010. AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome. Proc Natl Acad Sci 107: 850-855.
34. Kennedy G, Sugden B. 2003. EBNA-1, a bifunctional transcriptional activator. Mol Cell Biol 23: 6901-6908.
35. Kim SS, Tam JK, Wang AF, Hegde RS. 2000. The structural basis of DNA target discrimination by papillomavirus E2 proteins. J Biol Chem 275: 31245-31254.
36. Kirchmaier AL, Sugden B. 1998. Rep_: Aviral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus. J Virol 72: 4657-4666.
37. Kobayashi T, Rein T, DePamphilis ML. 1998. Identification of primary initiation sites for DNA replication in the hamster dihydrofolate reductase gene initiation zone. Mol Cell Biol 18: 3266-3277.
38. Koons MD, Van Scoy S, Hearing J. 2001. The replicator of the Epstein-Barr virus latent cycle origin of DNA replication, oriP, is composed of multiple functional elements. J Virol 75: 10582-10592.
39. Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, Isomura H, Nishiyama Y, Tsurumi T. 2005. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phaselike cellular environment. J Biol Chem 280: 8156-8163.
40. Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura H, Murata T, Tsurumi T. 2009. Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments. J Virol 83: 6641-6651.
41. Leight ER, Sugden B. 2001. Establishment of an oriP replicon is dependent upon an infrequent, epigenetic event. Mol Cell Biol 21: 4149-4161.
42. Levitskaya J, Sharipo A, Leonchiks A, Ciechanover A, Masucci MG. 1997. Inhibition of ubiquitin/proteasomedependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci 94: 12616-12621.
43. Liao G, Wu FY, Hayward SD. 2001. Interaction with the Epstein-Barr virus helicase targets Zta to DNA replication compartments. J Virol 75: 8792-8802.
44. Liao G, Huang J, Fixman ED, Hayward SD. 2005. The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor. J Virol 79: 245-256.
45. Lindner SE, Zeller K, Schepers A, Sugden B. 2008. The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency. J Virol 82: 5693-6702.
46. Mackey D, Sugden B. 1999. The linking regions of EBNA1 are essential for its support of replication and transcription. Mol Cell Biol 19: 3349-3359.
47. Marechal V, Dehee A, Chikhi-Brachet R, Piolot T, Coppey-Moisan M, Nicolas JC. 1999. Mapping EBNA-1 domains involved in binding to metaphase chromosomes. J Virol 73: 4385-4392.
48. Moriyama K, Yoshizawa-Sugata N, Obuse C, Tsurimoto T, Masai H. 2012. Epstein-Barr nuclear antigen 1 (EBNA-1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: Stimulation by Cdc6 through its direct interaction with EBNA1. J Biol Chem 287: 23977-23994.
49. Murayama K, Nakayama S, Kato-Murayama M, Akasaka R, Ohbayashi N, Kamewari-Hayami Y, Terada T, Shirouzu M, Tsurumi T, Yokoyama S. 2009. Crystal structure of Epstein-Barr virus DNA polymerase processivity factor BMRF1. J Biol Chem 284: 35896-35905.
50. Nakayama S, Murata T, Murayama K, Yasui Y, Sato Y, Kudoh A, Iwahori S, Isomura H, Kanda T, Tsurumi T. 2009. Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein. J Biol Chem 284: 21557-21568.
51. Nakayama S, Murata T, Yasui Y, Murayama K, Isomura H, Kanda T, Tsurumi T. 2010. Tetrameric ring formation of Epstein-Barr virus polymerase processivity factor is crucial for viral replication. J Virol 84: 12589-12598.
52. Nanbo A, Sugden A, Sugden B. 2007. The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells. EMBO J 26: 4252-4262.
53. Niller HH, Glaser G, Knuchel R, Wolf H. 1995. Nucleoprotein complexes and DNA 50-ends at oriP of Epstein-Barr virus. J Biol Chem 270: 12864-12868.
54. Norio P, Schildkraut CL. 2004. Plasticity of DNA replication initiation in Epstein-Barr virus episomes. PLoS Biol 2: e152.
55. Norio P, Schildkraut CL, Yates JL. 2000. Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines. J Virol 74: 8563-8574.
56. Norseen J, Thomae A, Sridharan V, Aiyar A, Schepers A, Lieberman PM. 2008. RNA-dependent recruitment of the origin recognition complex. EMBO J 27: 3024-3035.
57. Paludan C, Schmid D, Landthaler M, Vockerodt M, Kube D, Tuschl T, Münz C. 2005. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 307: 593-596.
58. Pfuller R, Hammerschmidt W. 1996. Plasmid-like replicative intermediates of the Epstein-Barr virus lytic origin of DNA replication. J Virol 70: 3423-3431.
59. Rennekamp AJ, Lieberman PM. 2011. Initiation of Epstein-Barr virus lytic replication requires transcription and the formation of a stable RNA-DNA hybrid molecule at OriLyt. J Virol 85: 2837-2850.
60. Rennekamp AJ, Wang P, Lieberman PM. 2010. Evidence for DNA hairpin recognition by Zta at the Epstein-Barr virus origin of lytic replication. J Virol 84: 7073-7082.
61. Ritzi M, Tillack K, Gerhardt J, Ott E, Humme S, Kremmer E, HammerschmidtW, Schepers A. 2003. Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. J Cell Sci 116: 3971-3984.
62. Sarkari F, Sanchez-Alcaraz T, Wang S, Holowaty MN, Sheng Y, Frappier L. 2009. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog 5: e1000624.
63. Sato Y, Shirata N, Murata T, Nakasu S, Kudoh A, Iwahori S, Nakayama S, Chiba S, Isomura H, Kanda T, et al. 2010. Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication. Cell Cycle 9: 807-814.
64. Schepers A, PichD, HammerschmidtW. 1993a. Atranscription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus. EMBO J 12: 3921-3929.
65. Schepers A, Pich D, Mankertz J, HammerschmidtW. 1993b. cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. J Virol 67: 4237-4245.
66. Schepers A, PichD, HammerschmidtW. 1996. Activation of oriLyt, the lytic origin of DNA replication of Epstein-Barr virus, by BZLF1. Virology 220: 367-376.
67. Schepers A, Ritzi M, Bousset K, Kremmer E, Yates JL, Harwood J, Diffley JF, HammerschmidtW. 2001. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. EMBO J 20: 4588-4602.
68. Schildgen O, Graper S, Blumel J, Matz B. 2005. Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein. J Virol 79: 7273-7278.
69. Sears J, Kolman J, Wahl GM, Aiyar A. 2003. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Virol 77: 11767-11780.
70. Sears J, Ujihara M, Wong S, Ott C, Middeldorp J, Aiyar A. 2004. The amino terminus of Epstein-Barr virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomes. J Virol 78: 11487-11505.
71. Shaw JE, Levinger LF, Carter CW Jr. 1979. Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines. J Virol 29: 657-665.
72. Shirakata M, Imadome KI, Hirai K. 1999. Requirement of replication licensing for the dyad symmetry element-dependent replication of the Epstein-Barr virus oriP minichromosome. Virology 263: 42-54.
73. Sugimoto A, Kanda T, Yamashita Y, Murata T, Saito S, Kawashima D, Isomura H, Nishiyama Y, Tsurumi T. 2011. Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation. J Virol 85: 6127-6135.
74. Takagi S, Takada K, Sairenji T. 1991. Formation of intranuclear replication compartments of Epstein-Barr virus with redistribution of BZLF1 and BMRF1 gene products. Virology 185: 309-315.
75. Tempera I, Lieberman PM. 2010. Chromatin organization of gammaherpesvirus latent genomes. Biochim Biophys Acta 1799: 236-245.
76. Tsurumi T. 2001. EBVreplication enzymes. Curr Top Microbiol Immunol 258: 65-87.
77. Tsurumi T, Kobayashi A, Tamai K, Daikoku T, Kurachi R, Nishiyama Y. 1993. Functional expression and characterization of the Epstein-Barr virus DNA polymerase catalytic subunit. J Virol 67: 4651-4658.
78. Vereide DT, Sugden B. 2011. Lymphomas differ in their dependence on Epstein-Barr virus. Blood 117: 1977-1985.
79. Wang CY, Sugden B. 2008. Identifying a property of origins of DNA synthesis required to support plasmids stably in human cells. Proc Natl Acad Sci 105: 9639-9644.
80. Wang J, Lindner SE, Leight ER, Sugden B. 2006. Essential elements of a licensed, mammalian plasmid origin of DNA synthesis. Mol Cell Biol 26: 1124-1134.
81. Wensing B, Stuhler A, Jenkins P, Hollyoake M, Karstegl CE, Farrell PJ. 2001. Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP. J Virol 75: 6235-6241.
82. Wilkinson DE, Weller SK. 2004. Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response. J Virol 78: 4783-4796.
83. Wu H, Kapoor P, Frappier L. 2002. Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1. J Virol 76: 2480-2490.
84. Yates JL. 1996. Epstein-Barr virusDNA replication. InDNA replication in eukaryotic cells (ed. DePamphilis ML), pp. 751-774. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
85. Yates JL, Camiolo SM, Bashaw JM. 2000. The minimal replicator of Epstein-Barr virus oriP. J Virol 74: 4512-4522.
86. Yin Y, Manoury B, Fahraeus R. 2003. Self-inhibition of synthesis and antigen presentation by Epstein-Barr virusencoded EBNA1. Science 301: 1371-1374.
87. Zhang Q, Holley-Guthrie E, Ge JQ, Dorsky D, Kenney S. 1997. The Epstein-Barr virus (EBV) DNA polymerase accessory protein, BMRF1, activates the essential downstream component of the EBV oriLyt. Virology 230: 22-34.
88. Zhou J, Chau CM, Deng Z, Shiekhattar R, Spindler MP, Schepers A, Lieberman PM. 2005. Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J 24: 1406-1417.