Activation of oriLyt, the lytic origin of DNA replication of Epstein-Barr virus, by BZLF1

Virology

Volumn 220, Issue 2, 1996, Pages 367-376

  Schepers, Aloys ^a   Pich, Dagmar ^a   Hammerschmid, Wolfgang ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSCRIPTION REGULATION; VIRUS MUTANT;

HUMAN HERPESVIRUS 4;

EID: 0029944992     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0325     Document Type: Article

References (60)

1. Baer, R., Bankier, A. T., Biggin, M. D., Deininger, P. L., Farrell, P. J., Gibson, T. J., Hatfull, G., Hudson, G. S., Satchwell, S. C., Seguin, C., Tufnell, P. S., and Barell, B. G. (1984). DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature (London) 310, 207-211.
2. Baumann, R., Grogan, E., Ptashne, M., and Miller, G. (1993). Changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency. J. Virol. 90, 4436-4440.
3. Ben Bassat, H., Goldblum, N., Mitrani, S., Goldblum, T., Yoffey, J. M., Cohen, M. M., Bentwich, Z., Ramot, B., Klein, E., and Klein, G. (1977). Establishment in continuous culture of a new type of lymphocyte from a "Burkitt like" malignant lymphoma (line D.G.-75). Int. J. Cancer 19, 27-33.
4. Bennett-Cook, E. R., and Hassell, J. A. (1991). Activation of polyomavirus DNA replication by yeast GAL4 is dependent on its transcriptional activation domains. EMBO J. 10, 959-969.
5. Chang, Y. N., Dong, D. L., Hayward, G. S., and Hayward, S. D. (1990). The Epstein-Barr virus Zta transactivator: A member of the bZIP family with unique DNA-binding specificity and a dimerization domain that lacks the characteristic heptad leucine zipper motif. J. Virol. 64, 3358-3369.
6. Chavrier, P., Gruffat, H., Chevallier-Greco, A., Buisson, M., and Sergeant, A. (1989). The Epstein-Barr virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities. J. Virol. 63, 607-614.
7. Cheng, L., and Kelly, T. J. (1989). Transcriptional activator nuclear factor I stimulates the replication of SV40 minichromosomes in vivo and in vitro. Cell 59, 541-551.
8. Chevallier-Greco, A., Gruffat, H., Manet, E., Calender, A., and Sergeant, A. (1989). The Epstein-Barr virus (EBV) DR enhancer contains two functionally different domains: Domain A is constitutive and cell specific, domain B is transactivated by the EBV early protein R. J. Virol. 63, 615-623.
9. Chevallier-Greco, A., Manet, E., Chavrier, P., Mosnier, C., Daillie, J., and Sergeant, A. (1986). Both Epstein-Barr virus (EBV)-encoded transacting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J. 5, 3243-3249.
10. Chi, T., and Carey, M. (1993). The ZEBRA activation domain: Modular organization and mechanism of action. Mol. Cell. Biol. 13, 7045-7055.
11. Chi, T., Lieberman, P., Ellwood, K., and Carey, M. (1995). A general mechanism for transcriptional synergy by eukaryotic activators. Nature (London) 377, 254-257.
12. Conaway, R. C., and Conaway, J. W. (1993). General initiation factors for RNA polymerase II. Annu. Rev. Biochem. 62, 161-190.
13. Countryman, J., and Miller, G. (1985). Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA. Proc. Natl. Acad. Sci. USA 82, 4085-4089.
14. Cox, M. A., Leahy, J., and Hardwick, J. M. (1990). An enhancer within the divergent promoter of Epstein-Barr virus responds synergistically to the R and Z transactivators. J. Virol. 64, 313-321.
15. de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., and Subramani, S. (1987). Firefly luciferase gene: Structure and expression in mammalian cells. Mol. Cell. Biol. 7, 725-737.
16. DePamphilis, M. L. (1993). Eukaryotic DNA replication: Anatomy of an origin. Annu. Rev. Biochem. 62, 29-63.
17. Diffley, J. F., and Stillman, B. (1989). Similarity between the transcriptional silencer binding proteins ABF1 and RAP1. Science 246,1034-1038.
18. Farrell, P. J., Rowe, D. T., Rooney, C. M., and Kouzarides, T. (1989). Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos. EMBO J. 8, 127-132.
19. Felsenfeld, G. (1992). Chromatin as an essential part of the transcriptional mechanism. Nature (London) 355, 219-224.
20. Fixman, E. D., and Hayward, S. D. (1995). Replication of Epstein-Barr virus oriLyt: Lack of a dedicated virally encoded origin-binding protein and dependence on Zta in cotransfection assays. J. Virol. 69, 2998-3006.
21. Flemington, E., and Speck, S. H. (1990). Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues. Proc. Natl. Acad. Sci. USA 87, 9459-9463.
22. Flemington, E. K., Borras, A. M., Lytle, J. P., and Speck, S. H. (1992). Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain. J. Virol. 66, 922-929.
23. Frappier, L., and O'Donnell, M. (1991). Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus. Proc. Natl. Acad. Sci. USA 88, 10875-10879.
24. Giot, J. F., Mikaelian, I., Buisson, M., Manet, E., Joab, I., and Nicolas, J. C. (1991). Transcriptional interference between the EBV transcription factors EB1 and R: Both DNA-binding and activation domains of EB1 are required. Nucleic Acids Res. 19, 1251-1258.
25. Glaser, R., and Nonoyama, M. (1974). Host cell regulation of induction of Epstein-Barr virus. J. Virol. 14, 174-176.
26. Gruffat, H., Moreno, N., and Sergeant, A. (1990). The Epstein-Barr virus (EBV) ORIIyt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z. J. Virol. 64, 2810-2818.
27. Gruffat, H., Renner, O., Pich, D., and Hammerschmidt, W. (1995). Cellular proteins bind to the downstream component of the lytic origin of DNA replication of Epstein-Barr virus. J. Virol. 69, 1878-1886.
28. Guo, Z. S., and DePamphilis, M. L. (1992). Specific transcription factors stimulate simian virus 40 and polyomavirus origins of DNA replication. Mol. Cell. Biol. 12, 2514-2524.
29. Haigh, A., Greaves, R., and O'Hare, P. (1990). Interference with the assembly of a virus-host transcription complex by peptide competition. Nature (London) 344, 257-259.
30. Hammerschmidt, W., and Mankertz, J. (1991). Herpesviral DNA replication: Between the known and the unknown. Semin. Virol. 2, 257-269.
31. Hammerschmidt, W., and Sugden, B. (1988). Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55, 427-433.
32. Hardwick, J. M., Lieberman, P. M., and Hayward, S. D. (1988). A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen. J. Virol. 62, 2274-2284.
33. He, Z., Brinton, B. T., Greenblatt, J., Hassell, J. A., and Ingles, C. J. (1993). The transactivator proteins VP16 and GAL4 bind replication factor A. Cell 73, 1223-1232.
34. Heintz, N. H. (1992). Transcription factors and the control of DNA replication. Curr. Opinion Cell Biol. 4, 459-467.
35. Keegan, L., Gill, G., and Ptashne, M. (1986). Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science 231, 699-704.
36. Kornberg, A., and Baker, T. A. (1992). "DNA Replication," 2nd ed. Freeman, New York.
37. Kouzarides, T., Packham, G., Cook, A., and Farrell, P. J. (1991). The BZLF1 protein has a coiled coil structure dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper. Oncogene 6, 195-204.
38. Kuo, S. R., Liu, J. S., Broker, T. R., and Chow, L. T. (1994). Cell-free replication of the human papillomavirus DNA with homologous viral E1 and E2 proteins and human cell extracts. J. Biol. Chem. 269, 24058-24065.
39. Laux, G., Freese, U. K., and Bornkamm, G. W. (1985). Structure and evolution of two related transcription units of Epstein-Barr virus carrying small tandem repeats. J. Virol. 56, 987-995.
40. Li, R., and Botchan, M. R. (1993). The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell 73, 1207-1221.
41. Lieberman, P. M., and Berk, A. J. (1990). In vitro transcriptional activation, dimerization, and DNA-binding specificity of the Epstein-Barr virus Zta protein. J. Virol. 64, 2560-2568.
42. Lieberman, P. M., and Berk, A. J. (1991). The Zta trans-activator protein stabilizes TFIID association with promoter DNA by direct protein-protein interaction. Genes Dev. 5, 2441-2454.
43. Lieberman, P. M., Berk, A. J., Baumann, R., Grogan, E., Ptashne, M., and Miller, G. (1994). A mechanism for TAFs in transcriptional activation: Activation domain enhancement of TFIID-TFIIA-promoter DNA complex formation changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency. Genes Dev. 8, 995-1006.
44. Lieberman, P. M., Hardwick, J. M., and Hayward, S. D. (1989). Responsiveness of the Epstein-Barr virus Notl repeat promoter to the Z transactivator is mediated in a cell-type-specific manner by two independent signal regions. J. Virol. 63, 3040-3050.
45. Lieberman, P. M., Hardwick, J. M., Sample, J., Hayward, G. S., and Hayward, S. D. (1990). The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions. J. Virol. 64, 1143-1155.
46. Mackey, D., Middleton, T., and Sugden, B. (1995). Multiple regions within EBNA1 can link DNAs. J. Virol. 69, 6199-6208.
47. Melendy, T., Sedman, J., and Stenlund, A. (1995). Cellular factors required for papillomavirus DNA replication. J. Virol. 69, 7857-7867.
48. Mikaelian, I., Drouet, E., Marechal, V., Denoyel, G., Nicolas, J. C., and Sergeant, A. (1993). The DNA-binding domain of two bZIP transcription factors, the Epstein-Barr virus switch gene product EB1 and Jun, is a bipartite nuclear targeting sequence. J. Virol. 67, 734-742.
49. Miller, G., Himmelfarb, H., Heston, L., Countryman, J., Gradoville, L., Baumann, R., Chi, T., and Carey, M. (1993). Comparing regions of the Epstein-Barr virus ZEBRA protein which function as transcriptional activating sequences in Saccharomyces cerevisiae and in B cells. J. Virol. 67, 7472-7481.
50. O'Neill, E. A., Fletcher, C., Burrow, C. R., Heintz, N., Roeder, R. G., and Kelly, T. J. (1988). Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III. Science 241, 1210-1213.
51. Ryon, J. J, Fixman, E. D., Houchens, C., Zong, J., Lieberman, P. M., Chang, Y. N., Hayward, G. S., and Hayward, S. D. (1993). The lytic origin of herpesvirus papio is highly homologous to Epstein-Barr virus ori-Lyt: Evolutionary conservation of transcriptional activation and replication signals. J. Virol. 67, 4006-4016.
52. Schepers, A., Pich, D., and Hammerschmidt, W. (1993a). A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus. EMBO J. 12, 3921-3929.
53. Schepers, A., Pich, D., Mankertz, J., and Hammerschmidt, W. (1993b). cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. J. Virol. 67, 4237-4245.
54. Silver, P. A., Keegan, L. P., and Ptashne, M. (1984). Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc. Natl. Acad. Sci. USA 81, 5951-5955.
55. Stillman, B. (1989). Initiation of eukaryotic DNA replication in vitro. Annu. Rev. Cell. Biol. 5, 197-245.
56. Takada, K., Shimizu, N., Sakuma, S., and Ono, Y. (1986).Trans-activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment. J. Virol. 57, 1016-1022.
57. Taylor, N., Flemington, E., Kolman, J. L., Baumann, R. P., Speck, S. H., and Miller, G. (1991). ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter. J. Virol. 65, 4033-4041.
58. Ustav, E., Ustav, M., Szymanski, P., and Stenlund, A. (1993). The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator. Proc. Natl. Acad. Sci. USA 90, 898-902.
59. van der Vliet, P. C. (1991). The role of cellular transcription factors in the enhancement of adenoviral DNA replication. Semin. Virol. 2, 271-280.
60. Yang, L., Li, R., Mohr, I. J., Clark, R., and Botchan, M. R. (1991). Activation of BPV-1 replication in vitro by the transcription factor E2. Nature (London) 353, 628-632.