Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population

Journal of Medical Genetics

Volumn 49, Issue 12, 2012, Pages 747-752

  Park, Hansoo ^a,b   Lee, Seungbok ^a   Kim, Hyun Jin ^a   Ju, Young Seok ^a,c   Shin, Jong Yeon ^a,d   Hong, Dongwan ^a,e   von Grotthuss, Marcin ^b   Lee, Dong Sung ^a   Park, Changho ^f   Kim, Jennifer Hayeon ^a   Kim, Boram ^a   Yoo, Yun Joo ^a   Cho, Sung Il ^a   Sung, Joohon ^a   Lee, Charles ^b   Kim, Jong Il ^a,d,f   Seo, Jeong Sun ^a,c,d,f  

^a Seoul National University   (South Korea)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Macrogen Inc   (South Korea)

^d Psoma Therapeutics Inc   (South Korea)

^e National Cancer Center   (South Korea)

^f Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 8;

ARTICLE; AUDITORY STIMULATION; COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER VARIATION; EXOME; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUSIC; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; COMPARATIVE GENOMIC HYBRIDIZATION; EXOME; FAMILY; FEMALE; GANGLIOSIDE GALACTOSYLTRANSFERASE; GENETIC ASSOCIATION STUDIES; GENETIC LINKAGE; HUMANS; MALE; MIDDLE AGED; MONGOLIA; MUSIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOMOTOR PERFORMANCE; YOUNG ADULT;

EID: 84872045396     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmedgenet-2012-101209     Document Type: Article

References (50)

1. Darwin C. The descent of man, and selection in relation to sex. New York: D. Appleton and company, 1871.
2. Miller GF. The mating mind: how sexual choice shaped the evolution of human nature. 1st edn. New York: Doubleday, 2000.
3. Fitch WT. The biology and evolution of music: a comparative perspective. Cognition 2006;100:173-215.
4. Peretz I, Coltheart M. Modularity of music processing. Nat Neurosci 2003;6:688-91.
5. Coltheart M. Modularity and cognition. Trends Cogn Sci 1999;3:115-20.
6. Halpern AR, O'Connor MG. Implicit memory for music in Alzheimer's disease. Neuropsychology 2000;14:391-7.
7. Peretz I, Cummings S, Dube MP. The genetics of congenital amusia (tone deafness): a family-aggregation study. Am J Hum Genet 2007;81:582-8.
8. Peretz I, Ayotte J, Zatorre RJ, Mehler J, Ahad P, Penhune VB, Jutras B. Congenital amusia: a disorder of fine-grained pitch discrimination. Neuron 2002;33:185-91.
9. Profita J, Bidder TG. Perfect pitch. Am J Med Genet 1988;29:763-71.
10. Drayna D, Manichaikul A, de Lange M, Snieder H, Spector T. Genetic correlates of musical pitch recognition in humans. Science 2001;291:1969-72.
11. Pulli K, Karma K, Norio R, Sistonen P, Goring HH, Jarvela I. Genome-wide linkage scan for loci of musical aptitude in Finnish families: evidence for a major locus at 4q22. J Med Genet 2008;45:451-6.
12. Theusch E, Basu A, Gitschier J. Genome-wide study of families with absolute pitch reveals linkage to 8q24.21 and locus heterogeneity. Am J Hum Genet 2009;85:112-19.
13. Ukkola LT, Onkamo P, Raijas P, Karma K, Jarvela I. Musical aptitude is associated with AVPR1A-haplotypes. PLoS One 2009;4:e5534.
14. Morley AP, Narayanan M, Mines R, Molokhia A, Baxter S, Craig G, Lewis CM, Craig I. AVPR1A and SLC6A4 polymorphisms in choral singers and non-musicians: a gene association study. PLoS One 2012;7:e31763.
15. Ott J, Kamatani Y, Lathrop M. Family-based designs for genome-wide association studies. Nat Rev Genet 2011;12:465-74.
16. Katoh T, Mano S, Ikuta T, Munkhbat B, Tounai K, Ando H, Munkhtuvshin N, Imanishi T, Inoko H, Tamiya G. Genetic isolates in East Asia: a study of linkage disequilibrium in the X chromosome. Am J Hum Genet 2002;71:395-400.
17. Nakajima T, Wooding S, Sakagami T, Emi M, Tokunaga K, Tamiya G, Ishigami T, Umemura S, Munkhbat B, Jin F, Guan-Jun J, Hayasaka I, Ishida T, Saitou N, Pavelka K, Lalouel JM, Jorde LB, Inoue I. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world. Am J Hum Genet 2004;74:898-916.
18. Katoh T, Munkhbat B, Tounai K, Mano S, Ando H, Oyungerel G, Chae GT, Han H, Jia GJ, Tokunaga K, Munkhtuvshin N, Tamiya G, Inoko H. Genetic features of Mongolian ethnic groups revealed by Y-chromosomal analysis. Gene 2005;346:63-70.
19. Kimura T, Kobayashi T, Munkhbat B, Oyungerel G, Bilegtsaikhan T, Anar D, Jambaldorj J, Munkhsaikhan S, Munkhtuvshin N, Hayashi H, Oka A, Inoue I, Inoko H. Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians. Hum Genet 2008;123:655-60.
20. Kalmus H, Fry DB. On tune deafness (dysmelodia): frequency, development, genetics and musical background. Ann Hum Genet 1980;43:369-82.
21. Peretz I, Gaudreau D, Bonnel AM. Exposure effects on music preference and recognition. Mem Cognit 1998;26:884-902.
22. Ayotte J, Peretz I, Hyde K. Congenital amusia: a group study of adults afflicted with a music-specific disorder. Brain 2002;125(Pt 2):238-51.
23. Leal MC, Shin YJ, Laborde ML, Calmels MN, Verges S, Lugardon S, Andrieu S, Deguine O, Fraysse B. Music perception in adult cochlear implant recipients. Acta Otolaryngol 2003;123:826-35.
24. Haumann S, Mühler R, Ziese M, Specht H. Diskrimination musikalischer Tonhöhen bei Patienten mit Kochleaimplantat. HNO 2007;55:613-19.
25. Ju YS, Park H, Lee MK, Kim JI, Sung J, Cho SI, Seo JS. A genome-wide Asian genetic map and ethnic comparison: the GENDISCAN study. BMC Genomics 2008;9:554.
26. Im SW, Kim HJ, Lee MK, Yi JH, Jargal G, Sung J, Cho SI, Kim JI. Genome-wide linkage analysis for ocular and nasal anthropometric traits in a Mongolian population. Exp Mol Med 2010;42:799-804.
27. Paik SH, Kim HJ, Son HY, Lee S, Im SW, Ju YS, Yeon JH, Jo SJ, Eun HC, Seo JS, Kwon OS, Kim JI. Gene mapping study for constitutive skin color in an isolated Mongolian population. Exp Mol Med 2012;44:241-9.
28. Lee MK, Cho SI, Kim H, Song YM, Lee K, Kim JI, Kim DM, Chung TY, Kim YS, Seo JS, Ham DI, Sung J. Epidemiologic characteristics of intraocular pressure in the Korean and Mongolian populations: the Healthy Twin and the GENDISCAN study. Ophthalmology 2012;119:450-7.
29. Kristiansson K, Naukkarinen J, Peltonen L. Isolated populations and complex disease gene identification. Genome Biol 2008;9:109.
30. Arcos-Burgos M, Muenke M. Genetics of population isolates. Clin Genet 2002;61:233-47.
31. Haumann S, Muhler R, Ziese M, von Specht H. (Discrimination of musical pitch with cochlear implants). HNO 2007;55:613-19.
32. Nikjeh DA, Lister JJ, Frisch SA. The relationship between pitch discrimination and vocal production: comparison of vocal and instrumental musicians. J Acoust Soc Am 2009;125:328-38.
33. McPeek MS, Sun L. Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 2000;66:1076-94.
34. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998;63:259-66.
35. Weeks DE, Sobel E, O'Connell JR, Lange K. Computer programs for multilocus haplotyping of general pedigrees. Am J Hum Genet 1995;56:1506-7.
36. Heath SC. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet 1997;61:748-60.
37. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-211.
38. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97-101.
39. Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM. PBAT: tools for family-based association studies. Am J Hum Genet 2004;74:367-9.
40. Laird NM, Lange C. Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet 2006;7:385-94.
41. Henikoff S, Henikoff JG. Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci U S A 1992;89:10915-19.
42. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. A method and server for predicting damaging missense mutations. Nat Methods 2010;7:248-9.
43. Dugas JC, Tai YC, Speed TP, Ngai J, Barres BA. Functional genomic analysis of oligodendrocyte differentiation. J Neurosci 2006;26:10967-83.
44. Han X, D MH, McKeel DW Jr, Kelley J, Morris JC. Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J Neurochem 2002;82:809-18.
45. Marks N, Berg MJ, Saito M. Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons. Brain Res 2008;1191:136-47.
46. Chen M, Xu R. Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon. BMC Neurosci 2011;12:1.
47. Mick E, Todorov A, Smalley S, Hu X, Loo S, Todd RD, Biederman J, Byrne D, Dechairo B, Guiney A, McCracken J, McGough J, Nelson SF, Reiersen AM, Wilens TE, Wozniak J, Neale BM, Faraone SV. Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010;49:898-905 e3.
48. Barlett JC, Halpern AR, Dowling WJ. Recognition of familiar and unfamiliar melodies in normal aging and Alzheimer's disease. Mem Cognit 1995;23:531-46.
49. Takeuchi AH, Hulse SH. Absolute pitch. Psychol Bull 1993;113:345-61.
50. Gregersen PK, Kowalsky E, Kohn N, Marvin EW. Early childhood music education and predisposition to absolute pitch: teasing apart genes and environment. Am J Med Genet 2001;98:280-2.