Association of BST-2 gene variants with HIV disease progression underscores the role of BST-2 in HIV type 1 infection

Journal of Infectious Diseases

Volumn 207, Issue 3, 2013, Pages 411-419

  Laplana, Marina ^a   Caruz, Antonio ^c   Pineda, Juan Antonio ^d   Puig, Teresa ^b   Fibla, Joan ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

^c UNIVERSITY OF JAÉN   (Spain)

^d HOSPITAL UNIVERSITARIO DE VALME   (Spain)

Author keywords

BST 2; CD317; HIV 1 disease progression; HIV 1 infection; rs10415893; rs3217318; tetherin

Indexed keywords

ARTICLE; BONE MARROW STROMAL CELL ANTIGEN 2 GENE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DISEASE COURSE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HETEROZYGOTE DETECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INDEL MUTATION; INFECTION RISK; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL PREDICTION; SURVIVAL TIME; VIRUS PARTICLE; 3' UNTRANSLATED REGION; ADULT; ALLELE; BST 2 GENE; GENE DELETION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENOTYPE; INFECTION SENSITIVITY; MALE; MOLECULAR CLONING; OUTCOME ASSESSMENT; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; AMINO ACID SEQUENCE; ANTIGENS, CD; BASE SEQUENCE; DISEASE PROGRESSION; FEMALE; GENE ORDER; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GPI-LINKED PROTEINS; HIV INFECTIONS; HIV-1; HUMANS; MALE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

ANTIRETROVIRUS AGENT;

EID: 84872043968     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis685     Document Type: Article

References (29)

1. Ohtomo T, Sugamata Y, Ozaki Y, et al. Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Biophys Res Commun 1999; 258:583-91.
2. Neil SJD, Zang T, Bieniasz PD. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 2008; 451:425-30.
3. Van Damme N, Goff D, Katsura C, et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 2008; 3:245-52.
4. Zhang J, Liang C. BST-2 diminishes HIV-1 infectivity. J Virol 2010; 84:12336-43.
5. Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Früh K, Moses AV. Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a ßTrCP-dependent mechanism. J Virol 2009; 83:7931-47.
6. Hauser H, Lopez LA, Yang SJ, et al. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirol 2010; 7:51.
7. Neil S, Eastman S, Jouvenet N, Bieniasz P. HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane. PLoS Pathog 2006; 2:e39.
8. Ishikawa J, Kaisho T, Tomizawa H, et al. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics 1995; 26: 527-34.
9. Erikson E, Adam T, Schmidt S, et al. In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1. 24/tetherin in humans. Proc Natl Acad Sci USA 2011; 108: 13688-93.
10. Homann S, Smith D, Little S, Richman D, Guatelli J. Upregulation of BST-2/Tetherin by HIV infection in vivo. J Virol 2011; 85:10659-68.
11. Yondola MA, Fernandes F, Belicha-Villanueva A, et al. Budding capability of the influenza virus neuraminidase can be modulated by tetherin. J Virol 2011; 85:2480-91.
12. Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol 2010; 18:388-96.
13. Douglas JL, Gustin JK, Viswanathan K, Mansouri M, Moses AV, Früh K. The Great Escape: Viral Strategies to Counter BST-2/Tetherin. PLoS Pathog 2010; 6:e1000913.
14. Hrecka K, Hao C, Gierszewska M, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 2011; 474:658-61.
15. Laguette N, Sobhian B, Casartelli N, et al. SAMHD1 is the dendriticand myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 2011; 474:654-57.
16. Wolf D, Goff SP. Host restriction factors blocking retroviral replication. Annu Rev Genet 2008; 42:143-63.
17. Javanbakht H, An P, Gold B, et al. Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 2006; 354:15-27.
18. Valcke HS, Bernard NF, Bruneau J, Alary M, Tsoukas CM, Roger M. APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians. AIDS 2006; 20:1984-6.
19. Nieto G, Barber Y, Rubio MC, Rubio M, Fibla J. Association between AIDS disease progression rates and the Fok-I polymorphism of the VDR gene in a cohort of HIV-1 seropositive patients. J Steroid Biochem 2004; 89-90:199-207.
20. Barber Y, Rubio MC, Fernández E, Rubio M, Fibla J. Host genetic background at CCR5 chemokine receptor and vitamin D receptor loci and human immunodeficiency virus (HIV) type 1 disease progression among HIV-seropositive injection drug users. J Infect Dis 2001; 184:1279-88.
21. de la Torre MS, Torres C, Nieto G, et al. Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users. J Infect Dis 2008; 197:405-10.
22. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-5.
23. García-Moruja C, Alonso-Lobo J, Rueda P, et al. Functional characterization of SDF-1 proximal promoter. J Mol Biol 2005; 348:43-62.
24. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559-75.
25. Lehtonen A, Matikainen S, Julkunen I. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J Immunol 1997; 159:794-803.
26. Kaslow RA, Dorak T, Tang JJ. Influence of host genetic variation on susceptibility to HIV type 1 infection. J Infect Dis 2005; 191 (Suppl 1):S68-77.
27. Rockman MV, Wray GA. Abundant raw material for cis-regulatory evolution in humans. Mol Biol Evol 2002; 19:1991-2004.
28. Beaty JS, Sukiennicki TL, Nepom GT. Allelic variation in transcription modulates MHC class II expression and function. Microbes Infect 1999; 1:919-27.
29. Sauter D, Schindler M, Specht A, et al. Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host Microbe 2009; 6:409-21.