The inhibitory effects and mechanisms of rhamnogalacturonan i pectin from potato on HT-29 colon cancer cell proliferation and cell cycle progression

International Journal of Food Sciences and Nutrition

Volumn 64, Issue 1, 2013, Pages 36-43

  Cheng, Hairong ^a   Zhang, Zhongyu ^a   Leng, Jiayi ^a   Liu, Dan ^a   Hao, Miao ^a   Gao, Xiaoge ^a   Tai, Guihua ^a,b   Zhou, Yifa ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

CDK 1; Cell cycle arrest; Cyclin B1; Human colon cancer; Rhamnogalacturonan I

Indexed keywords

ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; MESSENGER RNA; PECTIN; PLANT MEDICINAL PRODUCT; RHAMNOGALACTURONAN I;

ARTICLE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL STRAIN HT29; CHEMISTRY; COLON; COLON TUMOR; DIET THERAPY; DOWN REGULATION; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYTOTHERAPY; POTATO;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL PROLIFERATION; COLON; COLONIC NEOPLASMS; DOWN-REGULATION; HT29 CELLS; HUMANS; PECTINS; PHYTOTHERAPY; PLANT PREPARATIONS; RNA, MESSENGER; SOLANUM TUBEROSUM;

SOLANUM TUBEROSUM;

EID: 84872042702     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.3109/09637486.2012.694853     Document Type: Article

References (26)

1. Cao Y, Gao X, Zhang W, Zhang G, Nguyen AK, Liu X, et al. 2011. Dietary fiber enhances TGF-beta signaling and growth inhibition in the gut. Am J Physiol Gastrointest Liver Physiol 301: G156-G164.
2. Chauhan D, Li G, Podar K, Hideshima T, Neri P, He D, et al. 2005. A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Cancer Res 65:8350-8358.
3. Cheng H, Li S, Fan Y, Gao X, Hao M, Wang J, et al. 2011. Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells. Med Oncol 28:175-181.
4. Comalada M, Bailon E, de Haro O, Lara-Villoslada F, Xaus J, Zarzuelo A, Galvez J. 2006. The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype. J Cancer Res Clin Oncol 132:487-497.
5. Coradini D, Pellizzaro C, Marimpietri D, Abolafio G, Daidone MG. 2000. Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells. Cell Prolif 33: 139-146.
6. Grana X, Reddy EP. 1995. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11:211-219.
7. Gunning AP, Bongaerts RJ, Morris VJ. 2009. Recognition of galactan components of pectin by galectin-3. FASEB J 23: 415-424.
8. Hsieh TC, Wu JM. 1995. Changes in cell growth, cyclin/kinase, endogenous phosphoproteins and nm23 gene expression in human prostatic JCA-1 cells treated with modified citrus pectin. Biochem Mol Biol Int 37:833-841.
9. Inohara H, Raz A. 1994. Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions. Glycoconj J 11:527-532.
10. Jackson CL, Dreaden TM, Theobald LK, Tran NM, Beal TL, Eid M, et al. 2007. Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 17:805-819.
11. Kelly GS. 1999. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev 4:96-103.
12. Liu LS, Fishman ML, Kost J, Hicks KB. 2003. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 24: 3333-3343.
13. Lock K, Pomerleau J, Causer L, Altmann DR, McKee M. 2005. The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bull World Health Organ 83:100-108.
14. Margolis SS, Perry JA, Weitzel DH, Freel CD, Yoshida M, Haystead TA, Kornbluth S. 2006. A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. Mol Biol Cell 17:1779-1789.
15. Martinez M, Gullon B, Yanez R, Alonso JL, Parajo JC. 2010. Kinetic assessment on the autohydrolysis of pectin-rich by-products. Chem Eng J 162:480-486.
16. Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, Raz A. 2002. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 94:1854-1862.
17. Newman DJ, Cragg GM. 2007. Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461-477.
18. Olano-Martin E, Rimbach GH, Gibson GR, Rastall RA. 2003. Pectin and pectic-oligosaccharides induce apoptosis in in vitro human colonic adenocarcinoma cells. Anticancer Res 23: 341-346.
19. Paterson I, Anderson EA. 2005. Chemistry. The renaissance of natural products as drug candidates. Science 310:451-453.
20. Perez S, Rodriguez-Carvajal MA, Doco T. 2003. A complex plant cell wall polysaccharide: rhamnogalacturonan II. A structure in quest of a function. Biochimie 85:109-121.
21. Pienta KJ, Naik H, Akhtar A, Yamazaki K, Replogle TS, Lehr J, et al. 1995. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst 87:348-353.
22. Riccardi C, Nicoletti I. 2006. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc 1:1458-1461.
23. Shike M, Winawer SJ, Greenwald PH, Bloch A, Hill M, Butler MS. 2008. Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 25:475-516.
24. Shike M, Winawer SJ, Greenwald PH, Bloch A, Hill MJ, Swaroop SV. 1990. Primary prevention of colorectal cancer. The WHO Collaborating Centre for the Prevention of Colorectal Cancer. Bull World Health Organ 68:377-385.
25. Taylor WR, Stark GR. 2001. Regulation of the G2/M transition by p53. Oncogene 20:1803-1815.
26. Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. 2006. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40:235-243.