Reproductive Status Is Associated with the Severity of Fibrosis in Women with Hepatitis C

PLoS ONE

Volumn 7, Issue 9, 2013, Pages

  Villa, Erica ^a   Vukotic, Ranka ^a   Cammà, Calogero ^b   Petta, Salvatore ^b   Di Leo, Alfredo ^c   Gitto, Stefano ^a   Turola, Elena ^a   Karampatou, Aimilia ^a   Losi, Luisa ^d   Bernabucci, Veronica ^a   Cenci, Annamaria ^e   Tagliavini, Simonetta ^e   Baraldi, Enrica ^e   De Maria, Nicola ^a   Gelmini, Roberta ^d   Bertolini, Elena ^a   Rendina, Maria ^c   Francavilla, Antonio ^f  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITY HOSPITAL OF TRIESTE   (Italy)

^e Neuroradiology Unit   (Italy)

^f NATIONAL INSTITUTE FOR DIGESTIVE DISEASES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; TESTOSTERONE;

ADULT; ARTICLE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HEPATITIS C; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; REPRODUCTIVE HEALTH; SEX DIFFERENCE; SEX HORMONE DETERMINATION;

CASE-CONTROL STUDIES; FEMALE; HEPATITIS C; HUMANS; INFERTILITY, FEMALE; LIVER CIRRHOSIS; MALE; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

HEPATITIS C VIRUS;

EID: 84872041311     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044624     Document Type: Article

References (29)

1. Yen T, Keeffe EB, Ahmed A, (2003) The epidemiology of hepatitis C virus infection. J Clin Gastroenterol 36: 47-53.
2. George SL, Bacon BR, Brunt EM, Mihindukulasuriya KL, Hoffmann J, et al. (2009) Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patients. Hepatology 49: 729-738.
3. Petta S, Amato M, Cabibi D, Cammà C, Di Marco V, et al. (2010) Visceral Adiposity Index is Associated with Histological Findings and with High Viral Load in Patients with Chronic Hepatitis C Due to Genotype 1. Hepatology 52: 1543-1552.
4. Conte D, Fraquelli M, Prati D, Colucci A, Minola E, (2000) Prevalence and Clinical Course of Chronic Hepatitis C Virus (HCV) Infection and Rate of HCV Vertical Transmission in a Cohort of 15,250 Pregnant Women. Hepatology 31: 751-5.
5. Poynard T, Bedossa P, Opolon P, (1997) Natural history of liver fibrosis progression in chronic hepatitis C. Lancet. 349: 825-832.
6. Deuffic-Burban S, Poynard T, Valleron AJ, (2002) Quantification of fibrosis progression in patients with chronic hepatitis C using a Markov model. J Viral Hepat 9: 114-122.
7. Yasuda M, Shimizu I, Shiba M, Ito S, (1999) Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats. Hepatology 29: 719-727.
8. Shimizu I, Mizobuchi Y, Yasuda M, Shiba M, Ma YR, et al. (1999) Inhibitory effect of estradiol on activation of rat hepatic stellate cells in vivo and in vitro. Gut 44: 127-136.
9. Di Martino V, Lebray P, Myers RP, Pannier E, Paradis V, et al. (2004) Progression of liver fibrosis in women infected with hepatitis C: long-term benefit of estrogen exposure. Hepatology 40: 1426-1433.
10. Codes L, Asselah T, Cazals-Hatem D, Tubach F, Vidaud D, et al. (2007) Liver fibrosis in women with chronic hepatitis C: evidence for the negative role of the menopause and steatosis and the potential benefit of hormone replacement therapy. Gut 56: 390-395.
11. Villa E, Karampatou A, Cammà C, Di Leo A, Luongo M, et al. (2011) Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C. Gastroenterology. 140: 818-829.
12. Pfeilschifter J, Köditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause 2002 Endocr Rev. 23: 90-119.
13. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, et al. (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22: 696-699.
14. SAS Technical Report, SAS/STAS software (1992): changes & enhancement, release 6. 07. Vol. 7. Cary, NC: SAS Institute Inc.
15. Van Disseldorp J, Faddy MJ, Themmen AP, De Jong FH, Peeters PH, et al. (2008) Relationship of serum antimullerian hormone concentration to age at menopause. J Clin Endocrinol Metab 93: 2129-2134.
16. Riggs RM, Duran EH, Baker MW, Kimble TD, Hobeika E, et al. (2008) Assessment of ovarian reserve with anti-Mullerian hormone: a comparison of the predictive value of anti-Mullerian hormone, follicle-stimulating hormone, inhibin B, and age. Am J Obstet Gynecol 199 202: e1-8.
17. La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon NS, et al. (2009) Anti-Mullerian hormone (AMH): what do we still need to know? Hum Reprod 24: 2264-2275.
18. Seifer DB, Baker VL, Leader B, (2011) Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertil Steril 95: 747-750.
19. Sweeting MJ, De Angelis D, Neal KR, Ramsay ME, Irving WL, et al. (2006) Estimated progression rates in three United Kingdom hepatitis C cohorts differed according to method of recruitment. J Clin Epidemiol 59: 144-152.
20. White DL, Tavakoli-Tabasi S, Kuzniarek J, Pascua R, Ramsey DJ, et al. (2012) Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males. Hepatology 55: 759-768.
21. Miyaaki H, Ichikawa T, Taura N, Miuma S, Shibata H, et al. (2011) Predictive value of the fibrosis scores in patients with chronic hepatitis C associated with liver fibrosis and metabolic syndrome. Intern Med 50: 1137-1141.
22. Hoefs JC, Shiffman ML, Goodman ZD, Kleiner DE, Dienstag JL, et al. (2011) Rate of progression of hepatic fibrosis in patients with chronic hepatitis c: results from the HALT-C trial. Gastroenterology 141: 900-908.
23. Xu JW, Gong J, Chang XM, Luo JY, Dong L, et al. (2002) Estrogen reduces CCl4-induced liver fibrosis in rats. World J Gastroenterol 8: 883-887.
24. Itagaki T, Shimizu I, Cheng X, Yuan Y, Oshio A, et al. (2005) Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress-induced activation of cultured rat hepatic stellate cells. Gut 54: 1782-1789.
25. Friedman SL, (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88: 125-172.
26. Kireev RA, Tresguerres AC, Garcia C, Borras C, Ariznavarreta C, et al. (2010) Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats. Biogerontology 11: 229-243.
27. Rogers A, Eastell R, (2001) The effect of 17 β-estradiol on production of cytokines in cultures of peripheral blood. Bone 29: 30-34.
28. Shimizu I, Omoya T, Kondo Y, Kusaka Y, Tsutsui A, et al. (2001) Estrogen therapy in a male patient with chronic hepatitis C and irradiation-induced testicular dysfunction. Intern Med 40: 100-104.
29. Maffei L, Murata Y, Rochira V, Tubert G, Aranda C, et al. (2004) Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment. J Clin Endocrinol Metab 89: 61-70.