Effects of echinacoside on MPP+ -induced mitochondrial fragmentation, mitophagy and cell apoptosis in SH-SY5Y cells

Journal of Chinese Integrative Medicine

Volumn 10, Issue 12, 2012, Pages 1427-1432

  Zhu, Min ^a   Zhou, Mi ^a   Shi, Ying ^a   Li, Wen Wei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Cistanche; DNA; DNA fragmentation; L methyl 4 phenylpyridinium; Mitochondrial; Neuroblastoma

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ECHINACOSIDE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG MEGADOSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMAGING SYSTEM; LOW DRUG DOSE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOPHAGY; NEUROBLASTOMA CELL;

1-METHYL-4-PHENYLPYRIDINIUM; APOPTOSIS; CELL LINE, TUMOR; GLYCOSIDES; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION;

EID: 84872034112     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20121215     Document Type: Article

References (18)

1. Zhao Q, Gao J, Li W, Cai D. Neurotrophic and neuro-rescue effects of echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain Res. 2010; 1346: 224-236.
2. Zhao X, Pu XP, Geng XC. Effects of echinacoside on protein expression from substantia nigra and striatal tissue in mouse MPTP model of Parkinson's disease by using 2-dimensional electrophoresis analysis. Zhongguo Yao Li Xue Tong Bao. 2008; 24(1): 28-32. Chinese with abstract in English. Chinese Source.2008; 24(1): 28-32.
3. Feng XY, Zhu M, Zhang QQ, Chen YP, Li WW. Selective protective effects of echinacoside on nigral dopaminergic neurons in rats exposed to rotenone. J Chin Integr Med. 2012; 10(7): 777-783. English with abstract in Chinese. Chinese Source. 2012; 10(7):777-783.
4. Li WW, Zhu M, Lu CZ. The role of mitochondrial dynamics in neurodegeneration. Sheng Li Ke Xue Jin Zhan. 2011; 42(5): 347-352. Chinese with abstract in English. Chinese Source. 2011; 42(5): 347-352.
5. Griinewald A, Gegg ME, Taanman JW, King RH, Kock N, Klein C, Schapira AH. Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp Neurol. 2009; 219(1): 266-273.
6. Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Kriiger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C. Loss-of-function of human PINK1 results in mito- chondrial pathology and can be rescued by Parkin. J Neurosci. 2007; 27(45): 12413-12418.
7. Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. JBiolChem. 2009; 284(20): 13843-13855.
8. Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C. Inhibition of • 1431 • mitochondrial fusion by a-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J. 2010; 29(20): 3571-3589.
9. Zhu M, Li W, Lu C. Role of a-synuclein protein levels in mitochondrial morphology and cell survival in cell lines. PLoS One. 2012; 7(4): e36377.
10. Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell. 2011; 10(5): 807-823.
11. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins GA, Bossy-Wetzel E. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006; 25(16): 3900-3911.
12. Sheridan C, Martin SJ. Mtochondrial fission/fusion dynamics and apoptosis. Mitochondrion. 2010; 10(6): 640-648.
13. Twig G, Shirihai OS. The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011; 14(10): 1939-1951.
14. Chen H, Chan DC. Mitochondrial dynamics - fusion, fission, movement, and mitophagy - in neurodegenerative diseases. Hum Mol Genet. 2009; 18(R2): R169-R176.
15. Biieler H. Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease. Apoptosis. 2010; 15(11): 1336-1353.
16. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X. Amyloid-Β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/ fusion proteins. Proc Natl Acad Sci USA. 2008; 105(49): 19318-19323.
17. Wang H, Lim PJ, Karbowski M, Monteiro MJ. Effects of overexpression of huntingtin proteins on mitochondrial integrity. Hum Mol Genet. 2009; 18(4): 737-752.
18. Song W, Song Y, Kincaid B, Bossy B, Bossy-Wetzel E. Mutant SODl(G93A) triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-la. Neurobiol Dis. 2012 Jul 20. [Epub ahead of print]