메뉴 건너뛰기




Volumn 48, Issue 9, 2012, Pages 570-576

Change in lipoperoxidation but not in scavenging enzymes activity during polyamine embryoprotection in rat embryo cultured in hyperglycemic media

Author keywords

Embryoprotection; Lipoperoxidation; Oxidative stress; Polyamines; Scavenging enzymes

Indexed keywords

ARGININE; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; POLYAMINE; PROTECTIVE AGENT; PUTRESCINE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SPERMIDINE; SUPEROXIDE DISMUTASE;

EID: 84872033494     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-012-9548-2     Document Type: Article
Times cited : (10)

References (55)
  • 1
    • 79960161408 scopus 로고    scopus 로고
    • Embryonic catalase protects against endogenous and phenytoin-enhanced dna oxidation and embryopathies in acatalasemic and human catalase-expressing mice
    • Abramov J. P.; Wells P. G. Embryonic catalase protects against endogenous and phenytoin-enhanced DNA oxidation and embryopathies in acatalasemic and human catalase-expressing mice. FASEB J 25: 2188-2200; 2011a.
    • (2011) FASEB J , vol.25 , pp. 2188-2200
    • Abramov, J.P.1    Wells, P.G.2
  • 2
    • 79953118534 scopus 로고    scopus 로고
    • Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoinenhanced oxidative stress
    • Abramov J. P.; Wells P. G. Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoinenhanced oxidative stress. Toxicol Sci 120: 428-438; 2011b.
    • (2011) Toxicol Sci , vol.120 , pp. 428-438
    • Abramov, J.P.1    Wells, P.G.2
  • 3
    • 0000024076 scopus 로고
    • Oxidoreductases acting on groups other than choh. 3.9 catalase: Hydrogen-peroxidase: Hydrogen-peroxidase oxidoreductase e.c. 1.11.1.6. In
    • Bergmeyer H. U. (ed). Weinheim, Verlag Chemie
    • Aebi H. E. Oxidoreductases acting on groups other than CHOH. 3.9 Catalase: hydrogen-peroxidase: hydrogen-peroxidase oxidoreductase E.C. 1.11.1.6. In: Bergmeyer H. U. (ed) Methods of enzymatic analysis, vol. 3. Weinheim, Verlag Chemie, pp 273-286; 1983.
    • (1983) Methods of Enzymatic Analysis , vol.3 , pp. 273-286
    • Aebi, H.E.1
  • 4
    • 0015153416 scopus 로고
    • Superoxide dismutase: Improved assays and assay aplicable to acrylamide gels
    • Beauchamp C.; Fridovich I. Superoxide dismutase: improved assays and assay aplicable to acrylamide gels. Analyt Biochem 44: 276-287; 1971.
    • (1971) Analyt Biochem , vol.44 , pp. 276-287
    • Beauchamp, C.1    Fridovich, I.2
  • 5
    • 84984538874 scopus 로고    scopus 로고
    • Polyamines reduces lipid peroxidation induced by different prooxidant agents
    • Bellé N. A. V.; Dalmolin G. D.; Fonini G.; Rubin M. A.; Rocha J. B. T. Polyamines reduces lipid peroxidation induced by different prooxidant agents. Brain Res 1008: 245-251; 2004.
    • (2004) Brain Res , vol.1008 , pp. 245-251
    • Bellé, N.A.V.1    Dalmolin, G.D.2    Fonini, G.3    Rubin, M.A.4    Rocha, J.B.T.5
  • 6
    • 0031425104 scopus 로고    scopus 로고
    • Decreased catalase activity in malformation-prone embryos of diabetic rats
    • Cederberg J.; Eriksson U. H. Decreased catalase activity in malformation-prone embryos of diabetic rats. Teratology 56: 350-357; 1997.
    • (1997) Teratology , vol.56 , pp. 350-357
    • Cederberg, J.1    Eriksson, U.H.2
  • 7
    • 22944446399 scopus 로고    scopus 로고
    • Antioxidative treatment of pregnant diabetic rats diminishes embryonic dysmorphogenesis
    • Cederberg J.; Eriksson U. H. Antioxidative treatment of pregnant diabetic rats diminishes embryonic dysmorphogenesis. Birth Def Res (Part A) 73: 498-505; 2005.
    • (2005) Birth Def Res (Part A , vol.73 , pp. 498-505
    • Cederberg, J.1    Eriksson, U.H.2
  • 8
    • 0033961243 scopus 로고    scopus 로고
    • Increased mrna levels of mn-sod and catalase in embryos of diabetic rats from a malformation-resistant strain
    • Cederberg J.; Galli J.; Holger L.; Eriksson U. Increased mRNA levels of Mn-SOD and catalase in embryos of diabetic rats from a malformation-resistant strain. Diabetes 49: 101-107; 2000.
    • (2000) Diabetes , vol.49 , pp. 101-107
    • Cederberg, J.1    Galli, J.2    Holger, L.3    Eriksson, U.4
  • 9
    • 0034987977 scopus 로고    scopus 로고
    • Combined treatment with vitamin e and vitamin c decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy
    • Cederberg J.; Simán C. M.; Eriksson U. J. Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatr Res 49: 755-762; 2001.
    • (2001) Pediatr Res , vol.49 , pp. 755-762
    • Cederberg, J.1    Simán, C.M.2    Eriksson, U.J.3
  • 11
    • 4344564153 scopus 로고    scopus 로고
    • Hydroxyl radical scavenging and singlet oxygen quenching properties of polyamines
    • Das K. C.; Misra H. P. Hydroxyl radical scavenging and singlet oxygen quenching properties of polyamines. Mol Cell Biochem 262: 127-133; 2004.
    • (2004) Mol Cell Biochem , vol.262 , pp. 127-133
    • Das, K.C.1    Misra, H.P.2
  • 12
    • 21744442394 scopus 로고    scopus 로고
    • Rayah ana. Embryopathy in experimental diabetic gestation: Assessment of oxidative stress and antioxidant defense
    • El-Bassiouni E. A.; Helmy M. H.; Rawash N. A.; El-Zoghby S. M.; Kamel M. A. E. Rayah ANA. Embryopathy in experimental diabetic gestation: assessment of oxidative stress and antioxidant defense. Br J Biomed Sci 62: 71-76; 2005.
    • (2005) Br J Biomed Sci , vol.62 , pp. 71-76
    • El-Bassiouni, E.A.1    Helmy, M.H.2    Rawash, N.A.3    El-Zoghby, S.M.4    Kamel, M.A.E.5
  • 13
    • 0029896116 scopus 로고    scopus 로고
    • Altered levels of scavenging enzymes in embryos subjected to a diabetic environment
    • Forsberg H.; Borg L. A.; Cagliero E.; Eriksson U. J. Altered levels of scavenging enzymes in embryos subjected to a diabetic environment. Free Radic Res 24: 451-459; 1996.
    • (1996) Free Radic Res , vol.24 , pp. 451-459
    • Forsberg, H.1    Borg, L.A.2    Cagliero, E.3    Eriksson, U.J.4
  • 14
    • 0018941081 scopus 로고
    • Inhibition of murine embryonic development by α- difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase
    • Fozard J. R.; Prat M. L.; Nellikunja J. P.; Grove J. Inhibition of murine embryonic development by α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. Eur J Pharmacol 65: 379-391; 1980a.
    • (1980) Eur J Pharmacol , vol.65 , pp. 379-391
    • Fozard, J.R.1    Prat, M.L.2    Nellikunja, J.P.3    Grove, J.4
  • 16
    • 0026691361 scopus 로고
    • Variation in development of rat embryos at the presomite period
    • Fujinaga M.; Baden J. M. Variation in development of rat embryos at the presomite period. Teratology 45: 661-670; 1992.
    • (1992) Teratology , vol.45 , pp. 661-670
    • Fujinaga, M.1    Baden, J.M.2
  • 18
    • 0035102208 scopus 로고    scopus 로고
    • Oxidative stress and protection against reactive species in the pre-implantation embro and its surroundings
    • Guérin P.; Mouatassim S. E.; Ménézo Y. Oxidative stress and protection against reactive species in the pre-implantation embro and its surroundings. Hum Reprod Upd 7: 175-189; 2001.
    • (2001) Hum Reprod Upd , vol.7 , pp. 175-189
    • Guérin, P.1    Mouatassim, S.E.2    Ménézo, Y.3
  • 20
    • 0022411174 scopus 로고
    • Modification and standardization of the culture of early postimplantation embryos for toxicological studies
    • Klug S.; Lewandowski C.; Neubert D. Modification and standardization of the culture of early postimplantation embryos for toxicological studies. Arch Toxicol 58: 84-88; 1985.
    • (1985) Arch Toxicol , vol.58 , pp. 84-88
    • Klug, S.1    Lewandowski, C.2    Neubert, D.3
  • 22
    • 0021020198 scopus 로고
    • Ornithine decarboxylase inhibitors and fetal growth retardation in mice
    • Mannen C. A.; Hood R. D.; Farina J. Ornithine decarboxylase inhibitors and fetal growth retardation in mice. Teratology 28: 237-242; 1983.
    • (1983) Teratology , vol.28 , pp. 237-242
    • Mannen, C.A.1    Hood, R.D.2    Farina, J.3
  • 23
    • 0028869409 scopus 로고
    • Agmatine and spermidine reduce collagen accumulation in kidneys of diabetic db/db mice
    • Marx M.; Trittenwein G.; Aufricht C.; Hoeger H.; Lubec B. Agmatine and spermidine reduce collagen accumulation in kidneys of diabetic db/db mice. Nephron 69: 155-158; 1995.
    • (1995) Nephron , vol.69 , pp. 155-158
    • Marx, M.1    Trittenwein, G.2    Aufricht, C.3    Hoeger, H.4    Lubec, B.5
  • 24
    • 4243460383 scopus 로고
    • Polyamines and human reproduction. In
    • Bachrach U.; Heimer Y. (eds). CRC Press, Florida
    • Méndez J. D. Polyamines and human reproduction. In: Bachrach U.; Heimer Y. (eds) The physiology of polyamines, vol. 1. CRC Press, Florida, pp 23-38; 1989.
    • (1989) The Physiology of Polyamines , vol.1 , pp. 23-38
    • Méndez, J.D.1
  • 25
    • 29244459119 scopus 로고    scopus 로고
    • Inhibition by l-Arginine and spermidine of hemoglobin glycation and lipid peroxidation in rats with induced diabetes
    • Mendez J. D.; Balderas F. Inhibition by L-Arginine and spermidine of hemoglobin glycation and lipid peroxidation in rats with induced diabetes. Biomed Pharmacother 60: 26-31; 2006.
    • (2006) Biomed Pharmacother , vol.60 , pp. 26-31
    • Mendez, J.D.1    Balderas, F.2
  • 26
    • 0020551661 scopus 로고
    • Inhibition of rat embryonic development by the intrauterine administration of α-difluoromethylornithine
    • Méndez J. D.; Díaz-Flores M.; Durán G.; Hicks J. J. Inhibition of rat embryonic development by the intrauterine administration of α-difluoromethylornithine. Contraception 28: 93-98; 1983.
    • (1983) Contraception , vol.28 , pp. 93-98
    • Méndez, J.D.1    Díaz-Flores, M.2    Durán, G.3    Hicks, J.J.4
  • 27
    • 0343938873 scopus 로고    scopus 로고
    • Embryotoxicity for diabetes induced in rat: Prevention for l-Arginine and polyamines
    • Méndez J. D.; Palomar-Morales M. Embryotoxicity for diabetes induced in rat: prevention for L-Arginine and polyamines. Reprod Toxicol 13: 501-509; 1999.
    • (1999) Reprod Toxicol , vol.13 , pp. 501-509
    • Méndez, J.D.1    Palomar-Morales, M.2
  • 28
    • 79952619247 scopus 로고    scopus 로고
    • Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase
    • Miller L.; Wells P. G. Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase. Toxicol Appl Pharmacol 252: 55-61; 2011.
    • (2011) Toxicol Appl Pharmacol , vol.252 , pp. 55-61
    • Miller, L.1    Wells, P.G.2
  • 29
    • 0029045169 scopus 로고
    • Polyamines may increase the percentage of in-vitro fertilized murine oocytes that develop into blastocysts
    • Muzikova E.; Clark D. A. Polyamines may increase the percentage of in-vitro fertilized murine oocytes that develop into blastocysts. Human Reprod 10: 1172-1177; 1995.
    • (1995) Human Reprod , vol.10 , pp. 1172-1177
    • Muzikova, E.1    Clark, D.A.2
  • 30
    • 0017928819 scopus 로고
    • Whole-embryo culture and the study of mammalian embryos during organogenesis
    • New D. A. T. Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev 53: 81-122; 1978.
    • (1978) Biol Rev , vol.53 , pp. 81-122
    • New, D.A.T.1
  • 31
    • 0035870135 scopus 로고    scopus 로고
    • Involvement of polyamines in b cell receptor-mediated apoptosis: Spermine functions as a negative modulator
    • Nitta T.; Igarashi K.; Yamashita A.; Yamamoto M.; Yamamoto N. Involvement of polyamines in B cell receptor-mediated apoptosis: spermine functions as a negative modulator. Exp Cell Res 265: 174-183; 2001.
    • (2001) Exp Cell Res , vol.265 , pp. 174-183
    • Nitta, T.1    Igarashi, K.2    Yamashita, A.3    Yamamoto, M.4    Yamamoto, N.5
  • 32
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Okhawa H.; Ohishi W.; Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analyt Biochem 95: 351-358; 1979.
    • (1979) Analyt Biochem , vol.95 , pp. 351-358
    • Okhawa, H.1    Ohishi, W.2    Yagi, K.3
  • 33
    • 34447268977 scopus 로고    scopus 로고
    • Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy
    • Ornoy A. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod Toxicol 24: 31-41; 2007.
    • (2007) Reprod Toxicol , vol.24 , pp. 31-41
    • Ornoy, A.1
  • 34
    • 77951721709 scopus 로고    scopus 로고
    • Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: Studies on cultured rat embryos
    • Ornoy A.; Rand S. B.; Bischitz N. Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: Studies on cultured rat embryos. Birth Def Res (Part B) 89: 106-115; 2010.
    • (2010) Birth Def Res (Part B , vol.89 , pp. 106-115
    • Ornoy, A.1    Rand, S.B.2    Bischitz, N.3
  • 35
    • 0032787041 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ros) in the diabetes-induced anomalies in rat embryos in vitro: Reduction in antioxidant enzymes and low-molecular-weight antioxidants (lmwa) may be the causative factor for increased anomalies
    • Ornoy A.; Zaken V.; Kohen R. Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies. Teratology 60: 376-386; 1999.
    • (1999) Teratology , vol.60 , pp. 376-386
    • Ornoy, A.1    Zaken, V.2    Kohen, R.3
  • 36
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythocyte glutathione peroxidase
    • Paglia E. D.; Valentine N. W. Studies on the quantitative and qualitative characterization of erythocyte glutathione peroxidase. J Lab Clin Med 70: 158-168; 1967.
    • (1967) J Lab Clin Med , vol.70 , pp. 158-168
    • Paglia, E.D.1    Valentine, N.W.2
  • 38
    • 0032101936 scopus 로고    scopus 로고
    • Sensitization of tnfinduced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines
    • Penning L. C.; Schipper R. G.; Vercammen D.; Verhofstad A. A.; Denecker T.; Beyaert R.; Vandenabeele P. Sensitization of TNFinduced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine 10: 423-431; 1998.
    • (1998) Cytokine , vol.10 , pp. 423-431
    • Penning, L.C.1    Schipper, R.G.2    Vercammen, D.3    Verhofstad, A.A.4    Denecker, T.5    Beyaert, R.6    Vandenabeele, P.7
  • 39
    • 0346457636 scopus 로고    scopus 로고
    • Maternal fuels, diabetic embryopathy: Pathomechanisms and prevention
    • Reece E. A. Maternal fuels, diabetic embryopathy: pathomechanisms and prevention. Semin Reprod Endocrinol 17: 183-194; 1999.
    • (1999) Semin Reprod Endocrinol , vol.17 , pp. 183-194
    • Reece, E.A.1
  • 40
    • 0027195611 scopus 로고
    • Effects of altered maternal metabolism during gastrulation and neurulation stages of embryogenesis
    • Sadler T.W.; Denno K. M.; Hunter 3rd E. S. Effects of altered maternal metabolism during gastrulation and neurulation stages of embryogenesis. Ann N Y Acad Sci 678: 48-61; 1993.
    • (1993) Ann N Y Acad Sci , vol.678 , pp. 48-61
    • Sadler, T.W.1    Denno, K.M.2    Hunter III, E.S.3
  • 41
    • 27744529221 scopus 로고    scopus 로고
    • Polyamines and apoptosis
    • Seiler N.; Raul F. Polyamines and apoptosis. J Cell Mol Med 9: 623-642; 2005.
    • (2005) J Cell Mol Med , vol.9 , pp. 623-642
    • Seiler, N.1    Raul, F.2
  • 42
    • 79961060269 scopus 로고    scopus 로고
    • Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam
    • Singh C. K.; Kumar A.; Hitchcock D. B.; Fan D.; Goodwin R.; LaVoie H. A.; Nagarkatti A.; DiPette D. J.; Singh U. S. Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam. Mol Nutr Food Res 55: 1-11; 2011.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1-11
    • Singh, C.K.1    Kumar, A.2    Hitchcock, D.B.3    Fan, D.4    Goodwin, R.5    LaVoie, H.A.6    Nagarkatti, A.7    DiPette, D.J.8    Singh, U.S.9
  • 43
    • 0031424896 scopus 로고    scopus 로고
    • Free radical scavenging enzymes in fetal dismorphogenesis among offspring of diabetic rats
    • Sivan E.; Lee Y. C.; Wu Y. K.; Reece E. A. Free radical scavenging enzymes in fetal dismorphogenesis among offspring of diabetic rats. Teratology 56: 343-349; 1997.
    • (1997) Teratology , vol.56 , pp. 343-349
    • Sivan, E.1    Lee, Y.C.2    Wu, Y.K.3    Reece, E.A.4
  • 44
    • 0030005968 scopus 로고    scopus 로고
    • Pregnancy outcomes in the diabetes control and complications trial
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. Pregnancy outcomes in the diabetes control and complications trial. Am J Obstet Gynecol 174: 1343-1353; 1996.
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1343-1353
  • 45
    • 0242300698 scopus 로고    scopus 로고
    • Follow-up report on the diagnosis of diabetes mellitus
    • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26: 3160-3167; 2003.
    • (2003) Diabetes Care , vol.26 , pp. 3160-3167
  • 46
    • 0032927809 scopus 로고    scopus 로고
    • Effects of epidermal growth factor on mdamb-468 breast cancer cells: Alterations in polyamine biosynthesis and the expression of p21/cip1/waf1
    • Thomas T.; Balabhadrapathruni S.; Gardner C. R.; Hong J.; Faaland C. A.; Thomas T. J. Effects of epidermal growth factor on MDAMB-468 breast cancer cells: alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF1. J Cell Physiol 179: 257-266; 1999.
    • (1999) J Cell Physiol , vol.179 , pp. 257-266
    • Thomas, T.1    Balabhadrapathruni, S.2    Gardner, C.R.3    Hong, J.4    Faaland, C.A.5    Thomas, T.J.6
  • 47
    • 0015298529 scopus 로고
    • Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase
    • Thurman R. G.; Ley H. G.; Scholz R. Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem 25: 420-430; 1972.
    • (1972) Eur J Biochem , vol.25 , pp. 420-430
    • Thurman, R.G.1    Ley, H.G.2    Scholz, R.3
  • 49
    • 22944432156 scopus 로고    scopus 로고
    • A diabetes-like environment increases malformation rate and diminishes prostaglandin e2 in rat embryos: Reversal by administration of vitamin e and folic acid
    • Wentzel P.; Eriksson U. J. A diabetes-like environment increases malformation rate and diminishes prostaglandin E2 in rat embryos: reversal by administration of vitamin E and folic acid. Birth Def Res (Part A) 73: 506-511; 2005.
    • (2005) Birth Def Res (Part A , vol.73 , pp. 506-511
    • Wentzel, P.1    Eriksson, U.J.2
  • 50
    • 58149339708 scopus 로고    scopus 로고
    • Decreased cardiac glutathione peroxidase levels and enhanced mandibular apoptosis in malformed embryos of diabetic rats
    • Wentzel P.; Gäreskog M.; Eriksson U. J. Decreased cardiac glutathione peroxidase levels and enhanced mandibular apoptosis in malformed embryos of diabetic rats. Diabetes 57: 3344-3352; 2008.
    • (2008) Diabetes , vol.57 , pp. 3344-3352
    • Wentzel, P.1    Gäreskog, M.2    Eriksson, U.J.3
  • 51
    • 0035001764 scopus 로고    scopus 로고
    • Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase c activity
    • Wentzel P.; Wentzel C. R.; Gäreskog M. F.; Eriksson U. J. Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity. Teratology 63: 193-201; 2001.
    • (2001) Teratology , vol.63 , pp. 193-201
    • Wentzel, P.1    Wentzel, C.R.2    Gäreskog, M.F.3    Eriksson, U.J.4
  • 52
    • 0031030575 scopus 로고    scopus 로고
    • Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose
    • Yang X.; Borg L. A.; Eriksson U. J. Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose. Am J Physiol 272(1 pt 1): E173-E180; 1997.
    • (1997) Am J Physiol , vol.272 , Issue.1 PART 1
    • Yang, X.1    Borg, L.A.2    Eriksson, U.J.3
  • 53
    • 34248572722 scopus 로고    scopus 로고
    • Folic acid supplementation affects ros scavenging enzymes, enhances vegf-A, and diminishes apoptotic state in yolk sacs of embryos of diabetic rats
    • Zabihi S.; Eriksson U. J.; Wentzel P. Folic acid supplementation affects ROS scavenging enzymes, enhances Vegf-A, and diminishes apoptotic state in yolk sacs of embryos of diabetic rats. Reprod Toxicol 23: 486-498; 2007.
    • (2007) Reprod Toxicol , vol.23 , pp. 486-498
    • Zabihi, S.1    Eriksson, U.J.2    Wentzel, P.3
  • 54
    • 0034952067 scopus 로고    scopus 로고
    • Vitamins c and e improve rat embryonic antioxidant defense mechanism in diabetic culture medium
    • Zaken V.; Kohen R.; Ornoy A. Vitamins C and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium. Teratology 64: 33-44; 2001.
    • (2001) Teratology , vol.64 , pp. 33-44
    • Zaken, V.1    Kohen, R.2    Ornoy, A.3
  • 55
    • 33644872133 scopus 로고    scopus 로고
    • Alterations in the expression of antioxidant genes and the levels of transcription factor nfkappa b in relation to diabetic embryopathy in the cohen diabetic rat model
    • Zangen S. W.; Ryu S.; Ornoy A. Alterations in the expression of antioxidant genes and the levels of transcription factor NFKappa B in relation to diabetic embryopathy in the Cohen diabetic rat model. Birth Def Res (Part A) 76: 107-114; 2006.
    • (2006) Birth Def Res (Part A , vol.76 , pp. 107-114
    • Zangen, S.W.1    Ryu, S.2    Ornoy, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.