EGR1 is critical for gastrin-dependent upregulation of anion exchanger 2 in gastric cancer cells

FEBS Journal

Volumn 280, Issue 1, 2013, Pages 174-183

  Wang, Ting ^a   Zhao, Lei ^a   Yang, Ye ^b   Tian, Hua ^a   Suo, Wen Hao ^a   Yan, Min ^a   Fu, Guo Hui ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Digestive Medicine   (China)

Author keywords

anion exchanger 2; EGR1; gastric cancer; gastrin; intracellular pH

Indexed keywords

ANION EXCHANGER PROTEIN 2; ANION EXCHANGER PROTEIN 2A; ANION EXCHANGER PROTEIN 2A1; ANTIPORTER; CHOLECYSTOKININ B RECEPTOR; EARLY GROWTH RESPONSE FACTOR 1; GASTRIN; MEMBRANE PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ACIDITY; ANION EXCHANGER PROTEIN 2 GENE; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL CULTURE; CARCINOGENESIS; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE LOCATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; ONCOGENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STOMACH CANCER; TRANSCRIPTION REGULATION; UPREGULATION;

ANION TRANSPORT PROTEINS; ANTIPORTERS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; EARLY GROWTH RESPONSE PROTEIN 1; GASTRINS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN-ION CONCENTRATION; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; RECEPTOR, CHOLECYSTOKININ B; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; STOMACH NEOPLASMS; UP-REGULATION;

EID: 84872027165     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12058     Document Type: Article

References (30)

1. Medina JF, Acin A, &, Prieto J, (1997) Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene. Genomics 39, 74-85.
2. Alper SL, (2006) Molecular physiology of SLC4 anion exchangers. Exp Physiol 91, 153-161.
3. +-independent SLC4 anion exchangers. J Exp Biol 212, 1672-1683.
4. Banales JM, Masyuk TV, Bogert PS, Huang BQ, Gradilone SA, Lee SO, Stroope AJ, Masyuk AI, Medina JF, &, LaRusso NF, (2008) Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Am J Pathol 173, 1637-1646.
5. Medina JF, (2011) Role of the anion exchanger 2 in the pathogenesis and treatment of primary biliary cirrhosis. Dig Dis 29, 103-112.
6. Banales JM, Saez E, Uriz M, Sarvide S, Urribarri AD, Splinter P, Tietz Bogert PS, Bujanda L, Prieto J, Medina JF, et al,. (2012) Upregulation of microRNA 506 leads to decreased Cl(-)/HCO(3)(-) anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology 56, 687-697.
7. Beuers U, Maroni L, &, Elferink RO, (2012) The biliary HCO(3)(-) umbrella: experimental evidence revisited. Curr Opin Gastroenterol 28, 253-257.
8. Svastova E, Witarski W, Csaderova L, Kosik I, Skvarkova L, Hulikova A, Zatovicova M, Barathova M, Kopacek J, Pastorek J, et al,. (2012) Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain. J Biol Chem 287, 3392-3402.
9. Jansen ID, Mardones P, Lecanda F, de Vries TJ, Recalde S, Hoeben KA, Schoenmaker T, Ravesloot JH, van Borren MM, van Eijden TM, et al,. (2009) Ae2(a, b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. FASEB J 23, 3470-3481.
10. - exchanger Ae2 results in osteopetrosis in mice. Proc Natl Acad Sci USA 106, 1638-1641.
11. Recalde S, Muruzabal F, Looije N, Kunne C, Burrell MA, Saez E, Martinez-Anso E, Salas JT, Mardones P, Prieto J, et al,. (2006) Inefficient chronic activation of parietal cells in Ae2a, b(-/-) mice. Am J Pathol 169, 165-176.
12. Salas JT, Banales JM, Sarvide S, Recalde S, Ferrer A, Uriarte I, Oude Elferink RP, Prieto J, &, Medina JF, (2008) Ae2a, b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology 134, 1482-1493.
13. Hwang JM, Kao SH, Hsieh YH, Li KL, Wang PH, Hsu LS, &, Liu JY, (2009) Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells. Mol Cell Biochem 327, 135-144.
14. Liu CJ, Hwang JM, Wu TT, Hsieh YH, Wu CC, Hsieh YS, Tsai CH, Wu HC, Huang CY, &, Liu JY, (2008) Anion exchanger inhibitor DIDS induces human poorly-differentiated malignant hepatocellular carcinoma HA22T cell apoptosis. Mol Cell Biochem 308, 117-125.
15. Wu TT, Hsieh YH, Wu CC, Tsai JH, Hsieh YS, Huang CY, &, Liu JY, (2006) Overexpression of anion exchanger 2 in human hepatocellular carcinoma. Chin J Physiol 49, 192-198.
16. Song LJ, Liu RJ, Zeng Z, Alper SL, Cui HJ, Lu Y, Zheng L, Yan ZW, &, Fu GH, (2012) Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK. J Mol Med (Berl) 90, 707-718.
17. Yang Y, Wu PP, Wu J, Shen WW, Wu YL, Fu AF, Zheng L, Jin XL, &, Fu GH, (2008) Expression of anion exchanger 2 in human gastric cancer. Exp Oncol 30, 81-87.
18. Shen WW, Wu J, Cai L, Liu BY, Gao Y, Chen GQ, &, Fu GH, (2007) Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. Neoplasia 9, 812-819.
19. Medina JF, Lecanda J, Acin A, Ciesielczyk P, &, Prieto J, (2000) Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene. Biochem Biophys Res Commun 267, 228-235.
20. Zhao WF, Wang HB, Xie B, Hu LJ, Xu LH, Kuang BH, Li MZ, &, Zhang X, (2012) Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells. FEBS J 279, 2714-2726.
21. Zwang Y, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, Shema E, Lidor-Nili E, Jacob-Hirsch J, Amariglio N, et al,. (2011) Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals. Mol Cell 42, 524-535.
22. Kumbrink J, &, Kirsch KH, (2012) Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2. Neoplasia 14, 108-120.
23. van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, &, Becker AJ, (2012) Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J Biol Chem 287, 15489-15501.
24. Berna MJ, Seiz O, Nast JF, Benten D, Blaker M, Koch J, Lohse AW, &, Pace A, (2010) CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production. J Biol Chem 285, 38905-38914.
25. Chao C, Ives KL, Goluszko E, Kolokoltsov AA, Davey RA, Townsend CM Jr, &, Hellmich MR, (2005) SRC regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant. J Biol Chem 280, 33368-33373.
26. Raychowdhury R, Schafer G, Fleming J, Rosewicz S, Wiedenmann B, Wang TC, &, Hocker M, (2002) Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3′5′-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromogranin A promoter. Mol Endocrinol 16, 2802-2818.
27. Koehler JA, Baggio LL, Lamont BJ, Ali S, &, Drucker DJ, (2009) Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice. Diabetes 58, 2148-2161.
28. Tian H, Zhang N, Suo WH, Wang T, Song LJ, Wu J, Liu Q, Shen WW, &, Fu GH, (2010) Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells. Int J Cancer 127, 1462-1474.
29. Hille C, Berg M, Bressel L, Munzke D, Primus P, Lohmannsroben HG, &, Dosche C, (2008) Time-domain fluorescence lifetime imaging for intracellular pH sensing in living tissues. Anal Bioanal Chem 391, 1871-1879.
30. Townsend PD, Holliday PM, Fenyk S, Hess KC, Gray MA, Hodgson DR, &, Cann MJ, (2009) Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide. J Biol Chem 284, 784-791.