Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3′5′-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromogranin A promoter

Molecular Endocrinology

Volumn 16, Issue 12, 2002, Pages 2802-2818

  Raychowdhury, Raktima ^b   Schäfer, Georgia ^a   Fleming, John ^b   Rosewicz, Stefan ^a   Wiedenmann, Bertram ^a   Wang, Timothy C ^b   Höcker, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGRANIN A; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; GASTRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DNA RESPONSIVE ELEMENT; EPITHELIUM CELL; GENE CONTROL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; STOMACH EPITHELIUM;

BINDING SITES; CELL NUCLEUS; CHROMOGRANIN A; CHROMOGRANINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ENZYME INHIBITORS; EPITHELIAL CELLS; FLAVONOIDS; GASTRINS; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOBLOTTING; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037521077     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2001-0292     Document Type: Article

References (46)

1. O'Connor DT, Wu H, Gill BM, Rozansky DJ, Tang K, Mahata SK, Mahata M, Eskeland NL, Videen JS, Zhang X, Takiyuddin MA, Parmer RJ 1993 Hormone storage vesicle proteins. Transcriptional basis of the widespread neuroendocrine expression of chromogranin A, and evidence of its diverse biological actions, intracellular and extracellular. Ann NY Acad Sci 729:36-45
2. Bauerfeind R, Ohashi M, Huttner WB 1994 Biogenesis of secretory granules and synaptic vesicles. Facts and hypotheses. Ann NY Acad Sci 733:385-390
3. Iacangelo A, Eiden L 1995 Chromogranin A: Current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway. Regul Pept 58:65-88
4. Tatemoto K, Efendic S, Mutt V, Makk G, Feistner GJ, Barchas JD 1986 Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature 324:476-478
5. Angeletti RH, Aardal S, Serck-Hanssen G, Gee P, Helle KB 1994 Vasoinhibitory activity of synthetic peptides from the amino terminus of chromogranin A. Acta Physiol Scand 152:11-19
6. Gasparri A, Sidoli A, Sanchez LP, Longhi R, Siccardi AG, Marchisto PC, Corti A 1997 Chromogranin A fragments modulate cell adhesion. Identification and characterization of a pro-adhesive domain. J Biol Chem 272:20835-20843
7. Cetin Y, Grube D 1991 Immunoreactivities for chromogranin A and B, and secretogranin II in the guinea pig entero-endocrine system: Cellular distributions and intercellular heterogeneities. Cell Tissue Res 264:231-241
8. Stabile BE, Howard TJ, Passaro E, O'Connor DT 1990 Source of plasma chromogranin A elevation in gastrinoma patients. Arch Surg 125:451-453
9. Dimaline R, Evans D, Forster ER, Sandvik AK, Dockray GJ 1993 Control of gastric corpus chromogranin A messenger RNA abundance in the rat. Am J Physiol 264:G583-G588
10. Watkinson A, Dockray GJ 1992 Functional control of chromogranin A and B concentrations in the body of the rat stomach. Regul Pept 40:51-61
11. Chen D, Monstein HJ, Nylander AG, Zhao CM, Sundler F, Hakanson R 1994 Acute responses of rat stomach enterochromaffinlike cells to gastrin: Secretory activation and adaptation. Gastroenterology 107:18-27
12. Nagata A, Ito M, Iwata N, Kuno J, Takano H, Minowa O, Chihara K, atsui T, Noda T 1997 G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci USA 93:11825-11830
13. Koh TJ, Goldenring JR, Ito S, Mashimo H, Kopin AS, Varro A, Dockray GJ, Wang TC 1997 Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology 113:1015-1025
14. Höcker M, Raychouwdhury R, Plath T, O'Connor DT, Wu H, Wiedenmann B, Rosewicz S, Wang TC 1998 Sp1 and CREB mediate gastrin-dependent regulation of chromogranin A promoter activity in gastric carcinoma cells. J Biol Chem 273:30000-30007
15. Höcker M, Cramer T, O'Connor DT, Rosewicz S, Wiedenmann B, Wang TC 2001 Neuroendocrine-specific and gastrin-dependent expression of a chromogranin A-luciferase fusion gene in transgenic mice. Gastroenterology 121:43-55
16. Tang K, Wu H, Mahata SK, Gill BM, Parmer RJ, O'Connor DT 1997 Stimulus coupling to transcription vs. secretion in pheochromocytoma cells. Convergent and divergent signal transduction pathways and the crucial roles for route of cytosolic calcium entry and protein kinase C. J Clin Invest 100:1180-1192
17. Wu H, Mahata SK, Mahata M, Webster NJ, Parmer RJ, O'Connor DT 1995 A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. J Clin Invest 96:568-578
18. Mouland AJ, Bevan S, White JH, Hendy GN 1994 Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression. J Biol Chem 269:6918-6926
19. Nolan EM, Cheung TC, Burton DW, Deftos LJ 1996 Transcriptional regulation of the human chromogranin A gene by its 5′ distal regulatory element: Novel effects of orientation, structure, flanking sequences, and position on expression. Mol Cell Endocrinol 124:51-62
20. Canaff L, Bevan S, Wheeler DG, Mouland AJ, Rehfuss RP, White JH, Hendy GN 1998 Analysis of molecular mechanisms controlling neuroendocrine cell specific transcription of the chromogranin A gene. Endocrinology 139:1184-1196
21. Philipsen S, Suske G 1999 A tale of three fingers: The family of mammalian Sp/XKLF transcription factors. Nucleic Acid Res 27:2991-3000
22. Suske G 1999 The Sp-family of transcription factors. Gene 238:291-300
23. Gashler A, Sukhatme VP 1995 Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors. Prog Nucleic Acids Res Mol Biol 50:191-224
24. Yan YX, Nakagawa H, Lee MH, Rustgi AK 1997 Transforming growth factor-α enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter. J Biol Chem 272:33181-33190
25. Barroso I, Santisteban P 1999 Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription. J Biol Chem 274:17997-18004
26. Khachigian LM, Williams AJ, Collins T 1995 Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J Biol Chem 270:27679-27686
27. Khachigian LM, Lindner V, Williams AJ, Collins T 1996 Egr-1-induced endothelial gene expression: A common theme in vascular injury. Science 271:1427-1431
28. Wang ZY, Madden SL, Deuel TF, Rauscher 3rd FJ 1992 The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene. J Biol Chem 267:21999-22002
29. Thottassery JV, Sun D, Zambetti GP, Troutman A, Sukhatme VP, Schuetz EG, Schuetz JD 1999 Sp1 and Egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene. J Biol Chem 271:3199-3206
30. Thiel G, Kaufmann K, Magin A, Lietz M, Bach K, Cramer M 2000 The human transcriptional repressor NAB1: Expression and biological activity. Biochim Biophys Acta 1493:289-301
31. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C 1998 A dominant-negative inhibitor of CREB reveals tht it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol 18:967-977
32. Petersohn D, Thiel G 1996 Role of zinc-finger proteins Sp1 and zif268/Egr1 in transcriptional regulation of the human synaptobrevin II gene. Eur J Biochem 239:827-834
33. Gashler AL, Swaminathan S, Sukhatme VP 1993 A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol 13:4556-4571
34. Hagen G, Müller S, Beato M, Suske G 1994 Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J 13:3843-3851
35. Lee CQ, Yun Y, Hoeffler JP, Habener JP 1990 Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J 9:4455-4465
36. Wessler S, Rapp UR, Wiedenmann B, Meyer TF, Schöneberg T, Höcker M, Naumann M 2002 B-Raf/Rap1 signaling, but not c-Raf-1/Ras, induces the histidine decarboxylase promoter in Helicobacter pylori infection. FASEB J 16:417-419
37. Minc E, de Coppet P, Masson P, Thiery L, Dutertre S, Amor-Gueret M, Jaulin C 1999 The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. J Biol Chem 274:503-509
38. Cui MZ, Parry GC, Oeth P, Larson H, Smith M, Huang RP, Adamson ED, Mackman N 1996 Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and Egr-1. J Biol Chem 271:2731-2739
39. Zimmermann AG, Spychala J, Mitchell BS 1995 Characterization of the human inosine-5′-monophosphate dehydrogenase type II gene. J Biol Chem 270:6808-6814
40. Tsai EY, Falvo JV, Tsytsykova AV, Barczak AK, Reimold AM, Glimcher LH, Fenton MJ, Gordon DC, Dunn IF, Goldfeld AE 2000 A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor α promoter in vivo. Mol Cell Biol 16:6084-6094
41. Watson F, Kiernan RS, Deavall DG, Varro A, Dimaline R 2001 Transcriptional activation of the rat vesicular monoamine transporter 2 promoter in gastric epithelial cells: Regulation by gastrin. J Biol Chem 276:7661-7667
42. Gerhard M, Neumayer N, Presecan-Siedel E, Zanner R, Cramer T, Höcker M, Prinz C 2001 Gastrin induces expression and promoter activity of the vesicular monoamine transporter subtype 2. Endocrinology 142:3663-3672
43. Raychowdhury R, Zhang Z, Höcker M, Wang TC 1999 Activation of human histidine decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors. J Biol Chem 274:20961-969
44. Höcker M, Zhang Z, Fenstermacher DA, Tagerud S, Chulak M, Joseph D, Wang TC 1996 Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway. Am J Physiol 270:G619-G633
45. Höcker M, Zhang Z, Henihan R, Rosewicz S, Riecken EO, Koh TJ, Wang TC 1998 Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells. J Biol Chem 272:27015-27024
46. Wessler S, Höcker M, Fischer W, Wang TC, Rosewicz S, Haas R, Wiedenmann B, Meyer TF, Naumann M 2000 Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. J Biol Chem 275:3629-3636