Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK

Journal of Molecular Medicine

Volumn 90, Issue 6, 2012, Pages 707-718

  Song, Ling Jun ^a   Liu, Rui Jun ^a   Zeng, Zhi ^a   Alper, Seth L ^b   Cui, Heng Jing ^a   Lu, Yang ^a   Zheng, Lin ^a   Yan, Zhao Wen ^a   Fu, Guo Hui ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anion exchanger 2; ERK; Gastrin; Tumor suppressor P16

Indexed keywords

ANION EXCHANGER 2; ANTIPORTER; EARLY GROWTH RESPONSE FACTOR 1; GASTRIN; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P16; UNCLASSIFIED DRUG;

ADULT; ANION EXCHANGE; ARTICLE; CANCER PROGNOSIS; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANION TRANSPORT PROTEINS; ANTINEOPLASTIC AGENTS; ANTIPORTERS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EARLY GROWTH RESPONSE PROTEIN 1; GASTRINS; HUMANS; IMMUNOHISTOCHEMISTRY; MAP KINASE SIGNALING SYSTEM; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84862686152     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0851-2     Document Type: Article

References (35)

1. MW Saif E Chu 2010 Biology of colorectal cancer Cancer J 16 196 201 10.1097/PPO.0b013e3181e076af 20526096 10.1097/PPO.0b013e3181e076af 1:CAS:528:DC%2BC3cXovV2rt7w%3D
2. A Plotnikov D Chuderland Y Karamansha O Livnah R Seger 2011 Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation Mol Cell Biol 31 3515 3530 10.1128/MCB.05424-11 21730285 10.1128/MCB.05424-11 1:CAS:528: DC%2BC3MXhtV2gtb%2FL
3. Kang YH, Yang IJ, Shin HM (2011) Herbal formula HMC05 prevents human aortic smooth muscle cell migration and proliferation by inhibiting the ERK1/2 MAPK signaling cascade. J Nat Med. doi: 10.1007/s11418-011-0573-3
4. QB She E Halilovic Q Ye W Zhen S Shirasawa T Sasazuki DB Solit N Rosen 2010 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors Cancer Cell 18 39 51 10.1016/j.ccr.2010.05.023 20609351 10.1016/j.ccr.2010.05.023 1:CAS:528:DC%2BC3cXpslSjt7k%3D
5. SL Alper 2006 Molecular physiology of SLC4 anion exchangers Exp Physiol 91 153 161 10.1113/expphysiol.2005.031765 16239253 10.1113/expphysiol.2005. 031765 1:CAS:528:DC%2BD28XhtFWlu7s%3D
6. SL Alper 2009 Molecular physiology and genetics of Na+-independent SLC4 anion exchangers J Exp Biol 212 1672 1683 10.1242/jeb.029454 19448077 10.1242/jeb.029454 1:CAS:528:DC%2BD1MXptVeisrg%3D
7. H Rossmann SL Alper M Nader Z Wang M Gregor U Seidler 2000 Three 5â€-variant mRNAs of anion exchanger AE2 in stomach and intestine of mouse, rabbit, and rat Ann NY Acad Sci 915 81 91 11193604 10.1111/j.1749-6632. 2000.tb05226.x 1:CAS:528:DC%2BD3MXntVChug%3D%3D
8. Y Yang PP Wu J Wu WW Shen YL Wu AF Fu L Zheng XL Jin GH Fu 2008 Expression of anion exchanger 2 in human gastric cancer Exp Oncol 30 81 87 18438347 1:STN:280:DC%2BD1c3nslyltg%3D%3D
9. TT Wu YH Hsieh CC Wu JH Tsai YS Hsieh CY Huang JY Liu 2006 Overexpression of anion exchanger 2 in human hepatocellular carcinoma Chin J Physiol 49 192 198 17058451 1:CAS:528:DC%2BD28Xptlaqs7Y%3D
10. JM Hwang SH Kao YH Hsieh KL Li PH Wang LS Hsu JY Liu 2009 Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells Mol Cell Biochem 327 135 144 10.1007/s11010-009-0051-3 19224338 10.1007/s11010-009-0051-3 1:CAS:528:DC%2BD1MXmtlOrsrw%3D
11. LR Gawenis C Ledoussal LM Judd V Prasad SL Alper A Stuart-Tilley AL Woo C Grisham LP Sanford T Doetschman ML Miller GE Shull 2004 Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric J Biol Chem 279 30531 30539 10.1074/jbc.M403779200 15123620 10.1074/jbc.M403779200 1:CAS:528:DC%2BD2cXlsFKhsrk%3D
12. S Frische AS Zolotarev YH Kim J Praetorius S Alper S Nielsen SM Wall 2004 AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading Am J Physiol Renal Physiol 286 F1163 F1170 10.1152/ajprenal.00409.2003 14749257 10.1152/ajprenal.00409.2003 1:CAS:528:DC%2BD2cXkvFCqsbY%3D
13. H Tian N Zhang WH Suo T Wang LJ Song J Wu Q Liu WW Shen GH Fu 2010 Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells Int J Cancer 127 1462 1474 10.1002/ijc.25124 20020491 10.1002/ijc.25124 1:CAS:528:DC%2BC3cXpt1OhsLk%3D
14. WW Shen J Wu L Cai BY Liu Y Gao GQ Chen GH Fu 2007 Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma Neoplasia 9 812 819 17971901 10.1593/neo.07403 1:CAS:528:DC%2BD2sXhtl2rtrzE
15. GH Fu Y Wang YH Xi WW Shen XY Pan WZ Shen XS Jiang GQ Chen 2005 Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1) FEBS Lett 579 2105 2110 10.1016/j.febslet.2005.02.063 15811326 10.1016/j.febslet. 2005.02.063 1:CAS:528:DC%2BD2MXjtlWisLo%3D
16. S Naik RS Dothager J Marasa CL Lewis D Piwnica-Worms 2009 Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant {beta}-catenin activation in colon cancer Clin Cancer Res 15 7529 7537 10.1158/1078-0432.CCR-09-0336 20008853 10.1158/1078-0432.CCR-09-0336 1:CAS:528:DC%2BD1MXhsFGgurrI
17. A Munne M Fabre ML Marinoso M Gallen FX Real 1999 Nuclear beta-catenin in colorectal tumors: to freeze or not to freeze? Colon cancer team at IMAS J Histochem Cytochem 47 1089 1094 10424893 10.1177/002215549904700813 1:CAS:528:DyaK1MXltFWqsb0%3D
18. C Zhou M Tiberi B Liang SL Alper JM Baltz 2009 HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization PLoS One 4 e7417 10.1371/journal.pone.0007417 19823673 10.1371/journal.pone.0007417
19. G Vares Y Uehara T Ono T Nakajima B Wang K Taki T Matsumoto Y Oghiso K Tanaka K Ichinohe S Nakamura S Tanaka M Nenoi 2011 Transcription factor-recognition sequences potentially involved in modulation of gene expression after exposure to low-dose-rate gamma-rays in the mouse liver J Radiat Res (Tokyo) 52 249 256 10.1269/jrr.10110 1:CAS:528:DC%2BC3MXlsVykurk%3D
20. C Vindis MH Seguelas S Lanier A Parini C Cambon 2001 Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase Kidney Int 59 76 86 10.1046/j.1523-1755.2001.00468.x 11135060 10.1046/j.1523-1755.2001.00468.x 1:CAS:528:DC%2BD3MXot1yntA%3D%3D
21. V Baron ED Adamson A Calogero G Ragona D Mercola 2006 The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin Cancer Gene Ther 13 115 124 10.1038/sj.cgt.7700896 16138117 10.1038/sj.cgt.7700896 1:CAS:528: DC%2BD28XkvFOgtw%3D%3D
22. M Zagurovskaya MM Shareef A Das A Reeves S Gupta M Sudol MT Bedford J Prichard M Mohiuddin MM Ahmed 2009 EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells Oncogene 28 1121 1131 10.1038/onc.2008.461 19137013 10.1038/onc.2008.461 1:CAS:528:DC%2BD1MXitlGlu7o%3D
23. Y Hong KS Ho KW Eu PY Cheah 2007 A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis Clin Cancer Res 13 1107 1114 10.1158/1078-0432.CCR-06-1633 17317818 10.1158/1078-0432.CCR-06-1633 1:CAS:528:DC%2BD2sXhvF2hsLw%3D
24. AJ Wilson AC Chueh L Togel GA Corner N Ahmed S Goel DS Byun S Nasser MA Houston M Jhawer HJ Smartt LB Murray C Nicholas BG Heerdt D Arango LH Augenlicht JM Mariadason 2010 Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction Cancer Res 70 609 620 10.1158/0008-5472.CAN-09-2327 20068171 10.1158/0008-5472.CAN-09-2327 1:CAS:528:DC%2BC3cXltlWqsg%3D%3D
25. D Mahalingam A Natoni M Keane A Samali E Szegezdi 2010 Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells Br J Cancer 102 754 764 10.1038/sj.bjc.6605545 20087343 10.1038/sj.bjc.6605545 1:CAS:528:DC%2BC3cXitVWgtrY%3D
26. LR Gawenis EM Bradford SL Alper V Prasad GE Shull 2010 AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon Am J Physiol Gastrointest Liver Physiol 298 G493 G503 10.1152/ajpgi.00178.2009 20110461 10.1152/ajpgi.00178.2009 1:CAS:528: DC%2BC3cXksl2qu70%3D
27. A Currid B Ortega MA Valverde 2004 Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel J Physiol 555 241 250 10.1113/jphysiol.2003.059295 14673180 10.1113/jphysiol.2003.059295 1:CAS:528:DC%2BD2cXhvFOrt7g%3D
28. VM Rajendran HJ Binder 2000 Characterization and molecular localization of anion transporters in colonic epithelial cells Ann NY Acad Sci 915 15 29 11193571 10.1111/j.1749-6632.2000.tb05220.x 1:CAS:528:DC%2BD3MXntVChsA%3D%3D
29. C Pientong T Ekalaksananan U Swadpanich B Kongyingyoes O Kritpetcharat P Yuenyao N Ruckait 2003 Immunocytochemical detection of p16INK4a protein in scraped cervical cells Acta Cytol 47 616 623 12920756 10.1159/000326578
30. Q Liu LJ Song WQ Xu L Zhao L Zheng ZW Yan GH Fu 2009 Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma Mol Med Report 2 169 174 10.3892/mmr-00000079 21475808 1:CAS:528:DC%2BD1MXis1agt7o%3D
31. R Emig A Magener V Ehemann A Meyer F Stilgenbauer M Volkmann D Wallwiener HP Sinn 1998 Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation Br J Cancer 78 1661 1668 9862580 10.1038/bjc.1998.739 1:CAS:528:DyaK1MXhslKltQ%3D%3D
32. XL Feng L Li YN Gao JJ Zhang T Xiao JM Ying JD Gao YT Sun SJ Cheng 2011 Overexpression of c-erbB-2 and loss of p16 have molecular diagnostic relevance but no prognostic value in lung cancer Med Oncol 28 336 341 10.1007/s12032-010- 9452-0 20237870 10.1007/s12032-010-9452-0 1:CAS:528:DC%2BC3MXisV2gsL0%3D
33. SC Kudahetti G Fisher L Ambroisine D Prowse MW Kattan CS Foster H Moller T Oliver A Fletcher C Cooper V Reuter P Scardino J Cuzick DM Berney 2010 Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer Pathology 42 519 523 10.3109/00313025.2010.508788 20854069 10.3109/00313025. 2010.508788
34. G Pintus B Tadolini AM Posadino B Sanna M Debidda C Carru L Deiana C Ventura 2003 PKC/Raf/MEK/ERK signaling pathway modulates native-LDL-induced E2F-1 gene expression and endothelial cell proliferation Cardiovasc Res 59 934 944 14553833 10.1016/S0008-6363(03)00526-1 1:CAS:528:DC%2BD3sXnvVertrk%3D
35. JI Fenton SD Hursting SN Perkins NG Hord 2006 Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line Carcinogenesis 27 1507 1515 10.1093/carcin/bgl018 16597643 10.1093/carcin/bgl018 1:CAS:528:DC%2BD28XmsVensr8%3D