Applicability of confocal laser scanning microscopy for evaluation and monitoring of cutaneous wound healing

Journal of Biomedical Optics

Volumn 17, Issue 7, 2012, Pages

  Lange Asschenfeldt, Susanne ^a   Bob, Adrienne ^a   Terhorst, Dorothea ^a   Ulrich, Martina ^a   Fluhr, Joachim ^a   Mendez, Gil ^a   Roewert Huber, Hans Joachim ^a   Stockfleth, Eggert ^a   Lange Asschenfeldt, Bernhard ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

In vivo reflectance confocal microscopy; Noninvasive skin imaging; Wound healing

Indexed keywords

ADULT; AGED; ARTICLE; CONFOCAL MICROSCOPY; EVALUATION; FEASIBILITY STUDY; FEMALE; HUMAN; INJURY; MALE; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PENETRATING TRAUMA; SKIN; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; SKIN; WOUND HEALING; WOUNDS, PENETRATING;

EID: 84872020717     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.7.076016     Document Type: Article

References (38)

1. R. G. Sibbald et al., "Preparing the wound bed-debridement, bacterial balance, and moisture balance," Ostomy Wound Manage 46(11), 14-22, 24-18, 30-15 (2000).
2. S. Enoch, J. E. Grey, and K. G. Harding, "ABC of wound healing. Non-surgical and drug treatments," BMJ 332(7546), 900-903 (2006). (Pubitemid 44365590)
3. C. T. Hess and R. S. Kirsner, "Orchestrating wound healing: assessing and preparing the wound bed," Adv. Skin Wound Care 16(5), 246-257 (2003).
4. J. Panuncialman et al., "Wound edge biopsy sites in chronic wounds heal rapidly and do not result in delayed overall healing of the wounds," Wound Repair Regen. 18(1), 21-25 (2010).
5. J. M. Davidson, "Animal models for wound repair," Arch. Dermatol. Res. 290(14), S1-S11 (1998).
6. A. Scheid et al., "Genetically modified mouse models in studies on cutaneous wound healing," Exp. Physiol. 85(6), 687-704 (2000).
7. R. C. Fang and T. A. Mustoe, "Animal models of wound healing: utility in transgenic mice," J. Biomater. Sci. Polym. Ed. 19(8), 989-1005 (2008). (Pubitemid 351957386)
8. Y. K. Hong et al., "VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins," FASEB J. 18(10), 1111-1113 (2004).
9. R. Mani, "Science of measurements in wound healing," Wound Repair Regen. 7(5), 330-334 (1999). (Pubitemid 29523008)
10. S. Astner et al., "Non-invasive evaluation of the kinetics of allergic and irritant contact dermatitis," J. Invest. Dermatol. 124(2), 351-359 (2005). (Pubitemid 40175882)
11. M. A. Altintas et al., "Differentiation of superficial-partial vs. deep-partial thickness burn injuries in vivo by confocal-laser-scanning microscopy," Burns 35(1), 80-86 (2009).
12. A. A. Altintas et al., "To heal or not to heal: predictive value of in vivo reflectance-mode confocal microscopy in assessing healing course of human burn wounds," J. Burn Care Res. 30(6), 1007-1012 (2009).
13. D. Ratner, "Skin grafting," Semin. Cutan. Med. Surg. 22(4), 295-305 (2003). (Pubitemid 38067661)
14. R. G. Sibbald et al., "Special considerations in wound bed preparation 2011: an update(c)," Adv. Skin Wound Care 24(9), 415-436; quiz 437-418 (2011).
15. M. Ulrich et al., "Reflectance confocal microscopy for noninvasive monitoring of therapy and detection of subclinical actinic keratoses," Dermatology 220(1), 15-24 (2010).
16. M. Rajadhyaksha, R. R. Anderson, and R. H. Webb, "Video-rate confocal scanning laser microscope for imaging human tissues in vivo," Appl. Opt. 38(10), 2105-2115 (1999). (Pubitemid 129306953)
17. M. Rajadhyaksha et al., "In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology," J. Invest. Dermatol. 113(3), 293-303 (1999). (Pubitemid 29449064)
18. K. Swindells et al., "Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo," J. Am. Acad. Dermatol. 50(2), 220-228 (2004). (Pubitemid 38174279)
19. A. J. Singer and R. A. Clark, "Cutaneous wound healing," N. Engl. J. Med. 341(10), 738-746 (1999). (Pubitemid 29407375)
20. S. Gonzalez et al., "Characterization of psoriasis in vivo by reflectance confocal microscopy," J. Med. 30(5-6), 337-356 (1999). (Pubitemid 30366338)
21. S. Gonzalez et al., "Allergic contact dermatitis: correlation of in vivo confocal imaging to routine histology," J. Am. Acad. Dermatol. 40(5, Pt. 1), 708-713 (1999). (Pubitemid 29230357)
22. P. Guitera et al., "Morphologic features of melanophages under in vivo reflectance confocal microscopy," Arch. Dermatol. 146(5), 492-498 (2010).
23. K. J. Busam et al., "Morphologic features of melanocytes, pigmented keratinocytes, and melanophages by in vivo confocal scanning laser microscopy," Mod. Pathol. 14(9), 862-868 (2001). (Pubitemid 32889243)
24. S. Gonzalez et al., "Real-time evidence of in vivo leukocyte trafficking in human skin by reflectance confocal microscopy," J. Invest. Dermatol. 117(2), 384-386 (2001). (Pubitemid 34205729)
25. M. Demarchez, D. Asselineau, and J. Czernielewski, "Migration of Langerhans cells into human epidermis of "reconstructed" skin, normal skin, or healing skin, after grafting onto the nude mouse," J. Invest. Dermatol. 100(5), 648-652 (1993). (Pubitemid 23128360)
26. B. Lange-Asschenfeldt et al., "Effects of a topically applied wound ointment on epidermal wound healing studied by in vivo fluorescence laser scanning microscopy analysis," J. Biomed. Opt. 14(5), 054001 (2009).
27. D. Terhorst et al., "Reflectance confocal microscopy for the evaluation of acute epidermal wound healing," Wound Repair Regen. 19(6), 671-679 (2011).
28. J. V. Dovi, A. M. Szpaderska, and L. A. DiPietro, "Neutrophil function in the healing wound: adding insult to injury?," Thromb Haemost. 92(2), 275-280 (2004). (Pubitemid 39172307)
29. C. Nathan, "Neutrophils and immunity: challenges and opportunities," Nat. Rev. Immunol. 6(3), 173-182 (2006). (Pubitemid 43290987)
30. A. N. Gurjala et al., "Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing," Wound Repair Regen. 19(3), 400-410 (2011).
31. B. Guggenheim et al., "Application of the Zurich biofilm model to problems of cariology," Caries Res. 38(3), 212-222 (2004). (Pubitemid 38716212)
32. T. R. Neu et al, "Advanced imaging techniques for assessment of structure, composition and function in biofilm systems," FEMS Microbiol. Ecol. 72(1), 1-21 (2010).
33. J. R. Lawrence et al., "Optical sectioning of microbial biofilms," J. Bac-teriol. 173(20), 6558-6567 (1991).
34. S. M. McCarty et al., "The role of endogenous and exogenous enzymes in chronic wounds: a focus on the implications of aberrant levels of both host and bacterial proteases in wound healing," Wound Repair Regen. 20(2), 125-136 (2012).
35. M. De Mattei et al., "Time-and dose-dependent effects of chronic wound fluid on human adult dermal fibroblasts," Dermatol. Surg. 34(3), 347-356 (2008). (Pubitemid 351316826)
36. A. Lorber et al., "Correlation of image analysis features and visual morphology in melanocytic skin tumours using in vivo confocal laser scanning microscopy," Skin Res. Technol. 15(2), 237-241 (2009).
37. A. Gerger et al., "Diagnostic image analysis of malignant melanoma in in vivo confocal laser-scanning microscopy: a preliminary study," Skin Res. Technol. 14(3), 359-363 (2008).
38. M. Wiltgen et al., "Automatic identification of diagnostic significant regions in confocal laser scanning microscopy of melanocytic skin tumors," Methods Inf. Med. 47(1), 14-25 (2008). (Pubitemid 351160343)