Long chain omega-3 fatty acids: Micronutrients in disguise

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 88, Issue 1, 2013, Pages 91-95

  Innis, S M ^a   Novak, E M ^a   Keller, B O ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

DHA; Dietary intake; EPA; Liver; Metabolic development

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A OXIDASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CARBOHYDRATE; CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE IA; DOCOSAHEXAENOIC ACID; GLUCOSE; GLYCINE HYDROXYMETHYLTRANSFERASE; ICOSAPENTAENOIC ACID; LONG CHAIN FATTY ACID; NITROGEN; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PYRUVATE KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRACE ELEMENT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID METABOLISM; ARTICLE; CALORIC INTAKE; CARBOHYDRATE ANALYSIS; ENERGY METABOLISM; FATTY ACID OMEGA OXIDATION; GENETIC VARIABILITY; GLUCONEOGENESIS; GLYCOLYSIS; HUMAN; LIPOLYSIS; METABOLIC REGULATION; NONHUMAN; NUTRITIONAL ASSESSMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DIET; PROTEIN EXPRESSION; PROTEIN INTAKE; PROTEOMICS;

ANIMALS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS, ESSENTIAL; FATTY ACIDS, OMEGA-3; HUMANS; LIVER; MICRONUTRIENTS; NUTRITIONAL STATUS;

ANIMALIA;

EID: 84872016707     PISSN: 09523278     EISSN: 15322823     Source Type: Journal    
DOI: 10.1016/j.plefa.2012.05.007     Document Type: Article

References (56)

1. Mozaffarian D., Rimm E.B. Fish intake, contaminants, and human health: evaluating the risks and the benefits. J. Am. Med. Assoc. 2006, 296:1885-1892.
2. Mozaffarian D. Fish and n-3 fatty acids for the prevention of fatal coronary heart disease and sudden cardiac death. Am. J. Clin. Nutr. 2008, 87:1991S-1996S.
3. Roth E.M., Harris W.S. Fish oil for primary and secondary prevention of coronary heart disease. Curr. Atheroscler. Rep. 2010, 12:66-72.
4. Skeaff C.M., Miller J. Dietary fat and coronary heart disease: summary of evidence from prospective cohort and randomised controlled trials. Ann. Nutr. Metab. 2009, 55:173-201.
5. Galli C., Calder P.C. Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. Ann. Nutr. Metab. 2009, 55:123-139.
6. Hibbeln J.R., Nieminen L.R., Blasbalg T.L, Riggs J.A., Lands.W.E. Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am. J. Clin. Nutr. 2006, 83:1483S-1493S.
7. Cole C.M., Frautschy S.A. DHA may prevent age-related dementia. J. Nutr. 2010, 140:869-874.
8. Makrides M., Smithers L.G., Gibson R.A. Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. in: Proceedings of the Nestle Nutrition Workshop Series Pediatric Program 2012, 65:13-123.
9. Madsen L., Frøyland L., Dyrøy E., Helland K., Berge.R.K. Docosahexaenoic and eicosapentaenoic acids are differently metabolized in rat liver during mitochondria and peroxisome proliferation. J. Lipid Res. 1998, 39:583-593.
10. DeLany J.P, Windhauser M.M., Champagne C.M., Bray G.A. Differential oxidation of individual dietary fatty acids in humans. Am. J. Clin. Nutr. 2000, 72:905-911.
11. Sastry P.S. Lipids of nervous tissue: composition and metabolism. Prog. Lipid Res. 1985, 24:69-176.
12. Fliesler S.J., Anderson R.E. Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res. 1983, 22:79-131.
13. Innis S.M. Dietary omega 3 fatty acids and the developing brain. Brain Res. 2008, 1237:35-43.
14. Feller S.E., Gawrisch K. Properties of docosahexaenoic-acid-containing lipids and their influence on the function of rhodopsin. Curr. Opin. Struct. Biol. 2005, 15:416-422.
15. Bazan N.G., Musto A.G., Knott E.J. Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. Mol. Neurobiol. 2011, 44:216-222.
16. Bazan N.G., Molina M.F., Gordon W.C. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu. Rev. Nutr. 2011, 31:321-351.
17. Connor W.E., Neuringer M., Barstad L., Lin D.S. Dietary deprivation of linolenic acid in rhesus monkeys: effects on plasma and tissue fatty acid composition and on visual function. Trans. Assoc. Am. Phys. 1984, 97:1-9.
18. Bourre J.M., Dumont O., Pascal G., Durand G. Dietary alpha-linolenic acid at 1.3g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. J. Nutr. 1993, 123:1313-1319.
19. Hrboticky N., Mackinnon M.J., Innis S.M. Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets. Am. J. Clin. Nutr. 1990, 51:173-182.
20. Martinez M. Tissue levels of polyunsaturated fatty acids during early human development. J. Pediatr 1992, 120:S129-138.
21. Jump D.B. Fatty acid regulation of hepatic lipid metabolism. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14:115-120.
22. Jump D.B. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr. Opin. Lipidol. 2008, 19:242-247.
23. Sampath H., Ntambi J.M. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu. Rev. Nutr. 2005, 25:317-340.
24. Novak E.M., Innis S.M. Dietary long chain n-3 fatty acids are more closely associated with protein than energy intakes from fat. Prostaglandins Leukotrines Essential Fatty Acids 2012, 86:107-112.
25. Novak E.M., Lee E.K., Innis S.M., Keller B.O. Identification of novel protein targets regulated by maternal dietary fatty acid composition in neonatal rat liver. J. Proteomics 2009, 73:41-49.
26. Novak E.M., Keller B.O., Innis S.M. Metabolic development in the liver and the implications of the n-3 fatty acid supply. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 302:G250-G259.
27. Institute of Medicine of the National Academies Dietary Reference Intakes: Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids 2002, National Academies Press, Washington, DC.
28. American Heart Association Nutrition Committee, Lichtenstein A.H., Appel L.J., Brands M., et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association nutrition committee. Circulation 2006, 114:82-96.
29. Kris-Etherton P.M., Innis S.M. American Dietetic Association and Dietitians of Canada: dietary fatty acids. J. Am. Diet. Assoc. 2007, 107:1599-1611.
30. Smit L.A., Mozaffarian D., Willet W. Review of fat and fatty acid requirements and criteria for developing dietary guidelines. Ann. Nutr. Metab. 2009, 55:44-55.
31. Brenna J.T., Varamini B., Jensen R.G., Diersen-Schade D.A., Boettcher J.A., Arterburn.L.M. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am. J. Clin. Nutr. 2007, 85:1457-1464.
32. Innis S.M. Human milk and formula fatty acids. J. Pediatr. 1992, 120:S56-S61.
33. Jensen R.G. Handbook of Milk Composition 1995, Academic Press, San Diego, USA.
34. Chan D.C., Watts G.F., Mori T.A., Barrett P.H., Redgrave T.G., Beilin L.J. Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Am. J. Clin. Nutr. 2003, 77:300-307.
35. Davidson M.H. Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am. J. Cardiol 2006, 98:27i-33i.
36. Lin Y., Smit M.J., Havinga R., Verkade H.J., Vonk R.J., Kuipers F. Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes. Biochim. Biophys. Acta 1995, 1256:88-96.
37. López-Soldado I., Avella M., Botham K.M. Differential influence of different dietary fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants. Metabolism 2009, 58:186-195.
38. Roche H.M., Gibney M.J. Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism. Am. J. Clin. Nutr. 2000, 71:232S-237S.
39. Innis S.M., Hansen J.W. Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. Am. J. Clin. Nutr. 1996, 64:159-167.
40. Innis S.M., Auestad N., Siegman J.S. Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. Lipids 1996, 31:617-625.
41. Keller H., Mahfoudi A., Dreyer C., Hihi A.K., Medin J., Ozato K., Wahli W. Peroxisome proliferator-activated receptors and lipid metabolism. Ann. NY Acad. Sci. 1993, 684:157-173.
42. Howell G., Deng X., Yellaturu C., Park E.A., Willcox H.G., Raghow R., Elam M.B. N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXR alpha. Biochem. Biophys. Acta 2009, 1791:1190-1196.
43. Arbuckle L.M., Innis S.M. Docosahexaenoic acid is transferred through maternal diet to milk and to tissues of natural milk-fed piglets. J. Nutr. 1993, 123:1668-1675.
44. Battaglia F.C., Meschia G. Principal substrates of fetal metabolism. Physiol. Rev. 1978, 58:499-527.
45. Girard J., Ferre P., Pegorier J.P., Duee P.H. Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol. Rev. 1992, 72:507-562.
46. Krahling J.B., Gee R., Gauger J.A., Tolbert N.E. Postnatal development of peroxisomal and mitochondrial enzymes in rat liver. J. Cell Physiol. 1979, 101:375-390.
47. Rasmussen B.B, Wolfe R.R. Regulation of fatty acid oxidation in skeletal muscle. Annu. Rev. Nutr. 1999, 19:463-484.
48. Lilja H.E., Finkel Y, Paulsson M, Lucas S. Prevention and reversal of intestinal failure-associated liver disease in premature infants with short bowel syndrome using intravenous fish oil in combination with omega-6/9 lipid emulsions. J. Pediatr. Surg. 2011, 46:1361-1367.
49. Park K.T., Nespor C., Kerner C., Park K.T., Nespor C., Kerner J. The use of omegaven in treating parenteral nutrition-associated liver disease. J. Perinatol 2011, 31:S57-S60.
50. Choi S.E., Lee Y.J., Hwang G.S., Lee S.J., Han S.J., Kim H.J., Lee L.W., Kim Y., Jun H.S., Kang Y Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death. Arch. Biochem. Biophys. 2011, 505:231-241.
51. Davis T.A., Nguyen H.V., Garcia-Bravo R., Fiorotto M.L., Jackson E.M., Lee D.R., Reeds.P.J. The amino acid composition of human milk is not unique. J. Nutr. 1994, 124:1126-1132.
52. Owen O.E., Kalhan S.C., Hanson.R.W. The key role of anaplerosis and cataplerosis for citric acid cycle function. J. Biol. Chem. 2002, 277:30409-30412.
53. Yang D., Brunengraber H. Glutamate: a window on liver intermediary metabolism. J. Nutr. 2000, 130:991S-994S.
54. Smith G.I, Atherton P., Reeds D.N., Mohammed B.S., Rankin D., Rennie M.J., Mittendorfer B. Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women. Clin. Sci. (London) 2011, 121:78-267.
55. J.M. Tishinsky, R.A. Gulli, K.L. Mullen, D.J. Dyck, L.E. Robinson, Fish oil prevents high saturated fat diet-induced impairments in adiponectin and insulin response in rodent soleus muscle, Am. J. Physiol. Regul. Integr. Comp. Physiol. (2011) Epub Dec 28.
56. Smith G.I., Atherton P., Reeds D.N., Mohammed B.S., Rankin D., Rennie M.J., Mittendorfer B. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am. J. Clin. Nutr. 2011, 93:41-402.