Block of Death-Receptor Apoptosis Protects Mouse Cytomegalovirus from Macrophages and Is a Determinant of Virulence in Immunodeficient Hosts

PLoS Pathogens

Volumn 8, Issue 12, 2012, Pages

  Ebermann, Linda ^a   Ruzsics, Zsolt ^b   Guzmán, Carlos A ^a   van Rooijen, Nico ^c   Casalegno Garduño, Rosaely ^a   Koszinowski, Ulrich ^b   Čičin Šain, Luka ^a,d  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DEATH RECEPTOR; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS GENE; DEPLETION; FIBROBLAST; FLOW CYTOMETRY; GENE; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; SURVIVAL; T LYMPHOCYTE; VIROGENESIS; VIRULENCE;

ADAPTIVE IMMUNITY; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; CELL LINE; COMMON VARIABLE IMMUNODEFICIENCY; CYSTEINE PROTEINASE INHIBITORS; FIBROBLASTS; HERPESVIRIDAE INFECTIONS; HUMANS; INTERFERON-GAMMA; MACROPHAGES; MICE; MICE, KNOCKOUT; MUROMEGALOVIRUS; VIRAL PROTEINS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MAIZE CHLOROTIC MOTTLE VIRUS; MURID HERPESVIRUS 1; MUS;

EID: 84872008769     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003062     Document Type: Article

References (32)

1. Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, et al. (1997) Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A 94: 1172-1176.
2. Brune W, (2011) Inhibition of programmed cell death by cytomegaloviruses. Virus Res 157: 144-150.
3. Nguyen ML, Blaho JA, (2007) Apoptosis during herpes simplex virus infection. Adv Virus Res 69: 67-97.
4. Burgert HG, Ruzsics Z, Obermeier S, Hilgendorf A, Windheim M, et al. (2002) Subversion of host defense mechanisms by adenoviruses. Curr Top Microbiol Immunol 269: 273-318.
5. Chaumorcel M, Lussignol M, Mouna L, Cavignac Y, Fahie K, et al. (2012) The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1. J Virol 86: 2571-2584.
6. Orvedahl A, Alexander D, Talloczy Z, Sun Q, Wei Y, et al. (2007) HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe 1: 23-35.
7. Jurak I, Schumacher U, Simic H, Voigt S, Brune W, (2008) Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell death. J Virol 82: 4812-4822.
8. Goldmacher VS, Bartle LM, Skaletskaya A, Dionne CA, Kedersha NL, et al. (1999) A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc Natl Acad Sci U S A 96: 12536-12541.
9. Arnoult D, Bartle LM, Skaletskaya A, Poncet D, Zamzami N, et al. (2004) Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci U S A 101: 7988-7993.
10. Menard C, Wagner M, Ruzsics Z, Holak K, Brune W, et al. (2003) Role of murine cytomegalovirus US22 gene family members in replication in macrophages. Journal of virology 77: 5557-5570.
11. Skaletskaya A, Bartle LM, Chittenden T, McCormick AL, Mocarski ES, et al. (2001) A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc Natl Acad Sci U S A 98: 7829-7834.
12. McCormick AL, Roback L, Livingston-Rosanoff D, St Clair C, (2010) The human cytomegalovirus UL36 gene controls caspase-dependent and-independent cell death programs activated by infection of monocytes differentiating to macrophages. J Virol 84: 5108-5123.
13. Patterson CE, Shenk T, (1999) Human cytomegalovirus UL36 protein is dispensable for viral replication in cultured cells. J Virol 73: 7126-7131.
14. Cicin-Sain L, Ruzsics Z, Podlech J, Bubic I, Menard C, et al. (2008) Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene. J Virol 82: 2056-2064.
15. Reboredo M, Greaves RF, Hahn G, (2004) Human cytomegalovirus proteins encoded by UL37 exon 1 protect infected fibroblasts against virus-induced apoptosis and are required for efficient virus replication. J Gen Virol 85: 3555-3567.
16. Cicin-Sain L, Podlech J, Messerle M, Reddehase MJ, Koszinowski UH, (2005) Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host. J Virol 79: 9492-9502.
17. van Rooijen N, van Nieuwmegen R, (1984) Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study. Cell and tissue research 238: 355-358.
18. van Rooijen N, Kors N, Kraal G, (1989) Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. Journal of leukocyte biology 45: 97-104.
19. Schaap-Nutt A, Sommer M, Che X, Zerboni L, Arvin AM, (2006) ORF66 protein kinase function is required for T-cell tropism of varicella-zoster virus in vivo. J Virol 80: 11806-11816.
20. Brune W, Menard C, Heesemann J, Koszinowski UH, (2001) A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism. Science 291: 303-305.
21. Lembo D, Donalisio M, Hofer A, Cornaglia M, Brune W, et al. (2004) The ribonucleotide reductase R1 homolog of murine cytomegalovirus is not a functional enzyme subunit but is required for pathogenesis. J Virol 78: 4278-4288.
22. Fliss PM, Jowers TP, Brinkmann MM, Holstermann B, Mack C, et al. (2012) Viral mediated redirection of NEMO/IKKgamma to autophagosomes curtails the inflammatory cascade. PLoS Pathog 8: e1002517.
23. Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, et al. (2011) RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471: 368-372.
24. Upton JW, Kaiser WJ, Mocarski ES, (2010) Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 7: 302-313.
25. Mack C, Sickmann A, Lembo D, Brune W, (2008) Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein. Proc Natl Acad Sci U S A 105: 3094-3099.
26. Hamano S, Yoshida H, Takimoto H, Sonoda K, Osada K, et al. (1998) Role of macrophages in acute murine cytomegalovirus infection. Microbiol Immunol 42: 607-616.
27. Hanson LK, Slater JS, Karabekian Z, Virgin HWt, Biron CA, et al. (1999) Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis. J Virol 73: 5970-5980.
28. van Rooijen N, Hendrikx E, (2010) Liposomes for specific depletion of macrophages from organs and tissues. Methods in molecular biology 605: 189-203.
29. Davignon JL, Castanie P, Yorke JA, Gautier N, Clement D, et al. (1996) Anti-human cytomegalovirus activity of cytokines produced by CD4+ T-cell clones specifically activated by IE1 peptides in vitro. J Virol 70: 2162-2169.
30. Lucin P, Jonjic S, Messerle M, Polic B, Hengel H, et al. (1994) Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. J Gen Virol 75 (Pt 1): 101-110.
31. Podlech J, Holtappels R, Grzimek NKA, Reddehase MJ (2002) Animal models: murine cytomegalovirus. In: Kaufmann SHE, Kabelitz D, editors. Methods in Microbiology. San Diego, CA: Academic Press. pp. 493-525.
32. Reddehase MJ, Weiland F, Munch K, Jonjic S, Luske A, et al. (1985) Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. Journal of virology 55: 264-273.