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Volumn 10, Issue 1, 2013, Pages 13-23

New treatments for IBS

Author keywords

[No Author keywords available]

Indexed keywords

ALOSETRON; ASIMADOLINE; AST 120; AV 608; CHENODEOXYCHOLIC ACID; COLESEVELAM; CROMOGLYCATE DISODIUM; DEXLOXIGLUMIDE; DIGESTIVE TRACT AGENT; DISACCHARIDE; JNJ 38488502; LINACLOTIDE; LUBIPROSTONE; LX 1031; MEBEVERINE; MESALAZINE; MONOSACCHARIDE; NARONAPRIDE; OLIGOSACCHARIDE; OPIATE ANTAGONIST; PEXACERFONT; PLACEBO; POLYOL; PROBIOTIC AGENT; PRUCALOPRIDE; RAMOSETRON; RIFAXIMIN; TEGASEROD; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELUSETRAG;

EID: 84871964134     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2012.207     Document Type: Review
Times cited : (30)

References (130)
  • 1
    • 0036678922 scopus 로고    scopus 로고
    • The epidemiology of irritable bowel syndrome in North America: A systematic review
    • Saito, Y., Schoenfeld, P. & Locke, G. R. III. The epidemiology of irritable bowel syndrome in North America: a systematic review. Am. J. Gastroenterol. 97, 1910-1915 (2002).
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 1910-1915
    • Saito, Y.1    Schoenfeld, P.2    Locke Iii, G.R.3
  • 2
    • 20444464327 scopus 로고    scopus 로고
    • Irritable bowel syndrome in the United States: Prevalence, symptom patterns and impact
    • Hungin, A. P., Chang, L., Locke, G. R. III, Dennis, E. H. & Barghout, V. Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Aliment. Pharmacol. Ther. 21, 1365-1375 (2005).
    • (2005) Aliment. Pharmacol. Ther. , vol.21 , pp. 1365-1375
    • Hungin, A.P.1    Chang, L.2    Locke Iii, G.R.3    Dennis, E.H.4    Barghout, V.5
  • 3
    • 20044364384 scopus 로고    scopus 로고
    • Irritable bowel syndrome in developing countries - A disorder of civilization or colonization?
    • Gwee, K. A. Irritable bowel syndrome in developing countries - a disorder of civilization or colonization? Neurogastroenterol. Motil. 17, 317-324 (2005).
    • (2005) Neurogastroenterol. Motil. , vol.17 , pp. 317-324
    • Gwee, K.A.1
  • 4
    • 33644834606 scopus 로고    scopus 로고
    • A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation
    • Malagelada, J. R. A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation. Int. J. Clin. Pract. 60, 57-63 (2006).
    • (2006) Int. J. Clin. Pract. , vol.60 , pp. 57-63
    • Malagelada, J.R.1
  • 5
    • 84866755417 scopus 로고    scopus 로고
    • Psychological variables add incremental value to miological makers in differentiating IBS from health volunteer [abstract Tu1392]
    • Jones, M. P. et al. Psychological variables add incremental value to miological makers in differentiating IBS from health volunteer [abstract Tu1392]. Gastroenterology 142 (Suppl. 1), S-820 (2012).
    • (2012) Gastroenterology , vol.142 , Issue.SUPPL. 1 , pp. 820
    • Jones, M.P.1
  • 6
    • 0033986139 scopus 로고    scopus 로고
    • The impact of functional gastrointestinal disorders on quality of life
    • Koloski, N. A., Talley, N. J. & Boyce, P. M. The impact of functional gastrointestinal disorders on quality of life. Am. J. Gastroenterol. 95, 67-71 (2000).
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 67-71
    • Koloski, N.A.1    Talley, N.J.2    Boyce, P.M.3
  • 7
    • 1142298618 scopus 로고    scopus 로고
    • Quality of life in managed care patients with irritable bowel syndrome
    • Wilson, A. et al. Quality of life in managed care patients with irritable bowel syndrome. Manag. Care Interface 17, 24-28 (2004).
    • (2004) Manag. Care Interface , vol.17 , pp. 24-28
    • Wilson, A.1
  • 8
    • 11144306503 scopus 로고    scopus 로고
    • Suicidal ideation in patients with irritable bowel syndrome
    • Miller, V., Hopkins, L. & Whorwell, P. J. Suicidal ideation in patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 2, 1064-1068 (2004).
    • (2004) Clin. Gastroenterol. Hepatol. , vol.2 , pp. 1064-1068
    • Miller, V.1    Hopkins, L.2    Whorwell, P.J.3
  • 9
    • 0242584898 scopus 로고    scopus 로고
    • The economic consequences of irritable bowel syndrome: A US employer perspective
    • Leong, S. et al. The economic consequences of irritable bowel syndrome: a US employer perspective. Arch. Intern. Med. 163, 929-935 (2003).
    • (2003) Arch. Intern. Med. , vol.163 , pp. 929-935
    • Leong, S.1
  • 10
    • 0034914194 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Towards a cost-effective approach
    • Martin, R. et al. Irritable bowel syndrome: towards a cost-effective approach. Am. J. Manag. Care 7, S268-S275 (2001).
    • (2001) Am. J. Manag. Care , vol.7
    • Martin, R.1
  • 11
    • 19844368345 scopus 로고    scopus 로고
    • Impairment in work productivity and health-related quality of life in patients with IBS
    • Dean, B. B. et al. Impairment in work productivity and health-related quality of life in patients with IBS. Am. J. Manag. Care 11, S17-S26 (2005).
    • (2005) Am. J. Manag. Care , vol.11
    • Dean, B.B.1
  • 12
    • 0030900827 scopus 로고    scopus 로고
    • Irritable bowel syndrome: A technical review of practice guideline development
    • Drossman, D. A., Whitehead, W. E. & Camilleri, M. Irritable bowel syndrome: a technical review of practice guideline development. Gastroenterology 112, 2120-2137 (1997).
    • (1997) Gastroenterology , vol.112 , pp. 2120-2137
    • Drossman, D.A.1    Whitehead, W.E.2    Camilleri, M.3
  • 13
    • 0020663287 scopus 로고
    • Organic and functional disorders in 2000 gastroenterology outpatients
    • Harvey, R. F., Salih, S. Y. & Read, A. E. Organic and functional disorders in 2000 gastroenterology outpatients. Lancet 1, 632-634 (1983).
    • (1983) Lancet , vol.1 , pp. 632-634
    • Harvey, R.F.1    Salih, S.Y.2    Read, A.E.3
  • 14
    • 0031408954 scopus 로고    scopus 로고
    • Differences between individuals with self-reported irritable bowel syndrome (IBS) and IBS-like symptoms
    • Hahn, B. A., Saunders, W. B. & Maier, W. C. Differences between individuals with self-reported irritable bowel syndrome (IBS) and IBS-like symptoms. Dig. Dis. Sci. 42, 2585-2590 (1997).
    • (1997) Dig. Dis. Sci. , vol.42 , pp. 2585-2590
    • Hahn, B.A.1    Saunders, W.B.2    Maier, W.C.3
  • 15
    • 33846989359 scopus 로고    scopus 로고
    • Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    • Guilarte, M. et al. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 56, 203-209 (2007).
    • (2007) Gut , vol.56 , pp. 203-209
    • Guilarte, M.1
  • 16
    • 65449165950 scopus 로고    scopus 로고
    • Postinfectious irritable bowel syndrome
    • Spiller, R. & Garsed, K. Postinfectious irritable bowel syndrome. Gastroenterology 136, 1979-1988 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1979-1988
    • Spiller, R.1    Garsed, K.2
  • 17
    • 0031812434 scopus 로고    scopus 로고
    • Gastrointestinal illness and the biopsychosocial model
    • Drossman, D. A. Gastrointestinal illness and the biopsychosocial model. Psychosom. Med. 60, 258-267 (1998).
    • (1998) Psychosom. Med. , vol.60 , pp. 258-267
    • Drossman, D.A.1
  • 18
    • 34547665614 scopus 로고    scopus 로고
    • Psychological factors at work and in everyday life are associated with irritable bowel syndrome
    • Faresjö, A. et al. Psychological factors at work and in everyday life are associated with irritable bowel syndrome. Eur. J. Epidemiol. 22, 473-480 (2007).
    • (2007) Eur. J. Epidemiol. , vol.22 , pp. 473-480
    • Faresjö, A.1
  • 19
    • 84860649408 scopus 로고    scopus 로고
    • The brain-gut pathway in functional gastrointestinal disorders is bidirectional: A 12-year prospective population-based study
    • Koloski, N. A. et al. The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut 61, 1284-1290 (2012).
    • (2012) Gut , vol.61 , pp. 1284-1290
    • Koloski, N.A.1
  • 20
    • 33646547623 scopus 로고    scopus 로고
    • Reports of 'satisfactory relief' by IBS patients receiving usual medical care are confounded by baseline symptom severity and do not accurately reflect symptom improvement
    • Whitehead, W. E. et al. Reports of 'satisfactory relief' by IBS patients receiving usual medical care are confounded by baseline symptom severity and do not accurately reflect symptom improvement. Am. J. Gastroenterol. 101, 1057-1065 (2006).
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 1057-1065
    • Whitehead, W.E.1
  • 21
    • 0026636839 scopus 로고
    • The irritable bowel syndrome: Review and a graduated multicomponent treatment approach
    • Drossman, D. & Thompson, W. G. The irritable bowel syndrome: review and a graduated multicomponent treatment approach. Ann. Intern. Med. 116, 1009-1116 (1992).
    • (1992) Ann. Intern. Med. , vol.116 , pp. 1009-1116
    • Drossman, D.1    Thompson, W.G.2
  • 22
    • 0028816304 scopus 로고
    • The irritable bowel syndrome: Long-term prognosis and the physician-patient interaction
    • Owens, D. M., Nelson, D. K. & Talley, N. J. The irritable bowel syndrome: long-term prognosis and the physician-patient interaction. Ann. Intern. Med. 122, 107-112 (1995).
    • (1995) Ann. Intern. Med. , vol.122 , pp. 107-112
    • Owens, D.M.1    Nelson, D.K.2    Talley, N.J.3
  • 24
    • 43249121870 scopus 로고    scopus 로고
    • Components of placebo effect: Randomised controlled trial in patients with irritable bowel syndrome
    • Kaptchuk, T. J. et al. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ 336, 999-1003 (2008).
    • (2008) BMJ , vol.336 , pp. 999-1003
    • Kaptchuk, T.J.1
  • 25
    • 78650988467 scopus 로고    scopus 로고
    • Placebos without deception: A randomized controlled trial in irritable bowel syndrome
    • Kaptchuk, T. J. et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS ONE 5, e15591 (2010).
    • (2010) PLoS ONE , vol.5
    • Kaptchuk, T.J.1
  • 26
    • 33645349849 scopus 로고    scopus 로고
    • Investigating placebo effects in irritable bowel syndrome: A novel research design
    • Conboy, L. A. et al. Investigating placebo effects in irritable bowel syndrome: a novel research design. Contemp. Clin. Trials 27, 123-134 (2006).
    • (2006) Contemp. Clin. Trials , vol.27 , pp. 123-134
    • Conboy, L.A.1
  • 27
    • 3042530665 scopus 로고    scopus 로고
    • Self-management for women with irritable bowel syndrome
    • Heitkemper, M. M. et al. Self-management for women with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 2, 585-596 (2004).
    • (2004) Clin. Gastroenterol. Hepatol. , vol.2 , pp. 585-596
    • Heitkemper, M.M.1
  • 28
    • 0043172622 scopus 로고    scopus 로고
    • A group-based patient education programme for high-anxiety patients with Crohn or ulcerative colitis
    • Larsson, K. et al. A group-based patient education programme for high-anxiety patients with Crohn or ulcerative colitis. Scand. J. Gastroenterol. 38, 763-769 (2003).
    • (2003) Scand. J. Gastroenterol. , vol.38 , pp. 763-769
    • Larsson, K.1
  • 29
    • 77949460069 scopus 로고    scopus 로고
    • Structured patient education is superior to written information in the management of patients with irritable bowel syndrome: A randomized controlled study
    • Ringström, G. et al. Structured patient education is superior to written information in the management of patients with irritable bowel syndrome: a randomized controlled study. Eur. J. Gastroenterol. Hepatol. 22, 420-428 (2010).
    • (2010) Eur. J. Gastroenterol. Hepatol. , vol.22 , pp. 420-428
    • Ringström, G.1
  • 30
    • 0021679841 scopus 로고
    • Controlled trial of hypnotherapy in the treatment of severe refractory irritable bowel syndrome
    • Whorwell, P. J., Prior, A. & Faragher, E. B. Controlled trial of hypnotherapy in the treatment of severe refractory irritable bowel syndrome. Lancet 2, 1232-1234 (1984).
    • (1984) Lancet , vol.2 , pp. 1232-1234
    • Whorwell, P.J.1    Prior, A.2    Faragher, E.B.3
  • 31
    • 0024563831 scopus 로고
    • Individual and group hypnotherapy in the treatment of refractory irritable bowel syndrome
    • Harvey, R. F., Hinton, R. A., Gunary, R. M. & Barry, R. E. Individual and group hypnotherapy in the treatment of refractory irritable bowel syndrome. Lancet 1, 424-425 (1989).
    • (1989) Lancet , vol.1 , pp. 424-425
    • Harvey, R.F.1    Hinton, R.A.2    Gunary, R.M.3    Barry, R.E.4
  • 32
    • 0032313549 scopus 로고    scopus 로고
    • The treatment of irritable bowel syndrome with hypnotherapy
    • Galovski, T. E. & Blanchard, E. B. The treatment of irritable bowel syndrome with hypnotherapy. Appl. Psychophysiol. Biofeedback 23, 219-232 (1998).
    • (1998) Appl. Psychophysiol. Biofeedback , vol.23 , pp. 219-232
    • Galovski, T.E.1    Blanchard, E.B.2
  • 33
    • 0036845698 scopus 로고    scopus 로고
    • Hypnosis treatment for severe irritable bowel syndrome: Investigation of mechanisms and effects on symptoms
    • Palsson, O. S., Turner, M. J., Johnson, D. A., Burnett, C. K. & Whitehead, W. E. Hypnosis treatment for severe irritable bowel syndrome: investigation of mechanisms and effects on symptoms. Dig. Dis. Sci. 47, 2605-2614 (2002).
    • (2002) Dig. Dis. Sci. , vol.47 , pp. 2605-2614
    • Palsson, O.S.1    Turner, M.J.2    Johnson, D.A.3    Burnett, C.K.4    Whitehead, W.E.5
  • 34
    • 84866771300 scopus 로고    scopus 로고
    • Hypnotherapy for irritable bowel syndrome: An audit of 1000 patients [abstract Sa1407]
    • Miller, V. et al. Hypnotherapy for irritable bowel syndrome: an audit of 1000 patients [abstract Sa1407]. Gastroenterology 142 (Suppl. 1), S-296 (2012).
    • (2012) Gastroenterology , vol.142 , Issue.SUPPL. 1
    • Miller, V.1
  • 35
    • 84856749534 scopus 로고    scopus 로고
    • Effects of gut-directed hypnotherapy on IBS in different clinical settings - Results from two randomized, controlled trials
    • Lindfors, P. et al. Effects of gut-directed hypnotherapy on IBS in different clinical settings - results from two randomized, controlled trials. Am. J. Gastroenterol. 107, 276-285 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 276-285
    • Lindfors, P.1
  • 36
    • 0030049375 scopus 로고    scopus 로고
    • Symptomatology, quality of life and economic features of irritable bowel syndrome - The effect of hypnotherapy
    • Houghton, L. A., Heyman, D. J. & Whorwell, P. J. Symptomatology, quality of life and economic features of irritable bowel syndrome - the effect of hypnotherapy. Aliment. Pharmacol. Ther. 10, 91-95 (1996).
    • (1996) Aliment. Pharmacol. Ther. , vol.10 , pp. 91-95
    • Houghton, L.A.1    Heyman, D.J.2    Whorwell, P.J.3
  • 37
    • 78649723737 scopus 로고    scopus 로고
    • Mood color choice helps predict response to hypnotherapy in patients with irritable bowel syndrome
    • Carruthers, H. R., Morris, J., Tarrier, N. & Whorwell, P. J. Mood color choice helps predict response to hypnotherapy in patients with irritable bowel syndrome. BMC Complement. Altern. Med. 10, 75 (2010).
    • (2010) BMC Complement. Altern. Med. , vol.10 , pp. 75
    • Carruthers, H.R.1    Morris, J.2    Tarrier, N.3    Whorwell, P.J.4
  • 38
    • 10644239892 scopus 로고    scopus 로고
    • Psychological treatments for irritable bowel syndrome: A systematic review and meta-analysis
    • Lackner, J. M., Mesmer, C., Morley, S., Dowzer, C. & Hamilton, S. Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J. Consult. Clin. Psychol. 72, 1100-1113 (2004).
    • (2004) J. Consult. Clin. Psychol. , vol.72 , pp. 1100-1113
    • Lackner, J.M.1    Mesmer, C.2    Morley, S.3    Dowzer, C.4    Hamilton, S.5
  • 39
    • 61649089108 scopus 로고    scopus 로고
    • Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis
    • Ford, A. C., Talley, N. J., Schoenfeld, P. S., Quigley, E. M. & Moayyedi, P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 58, 367-378 (2009).
    • (2009) Gut , vol.58 , pp. 367-378
    • Ford, A.C.1    Talley, N.J.2    Schoenfeld, P.S.3    Quigley, E.M.4    Moayyedi, P.5
  • 40
    • 79961026588 scopus 로고    scopus 로고
    • Internet-delivered exposure-based treatment vs. stress management for irritable bowel syndrome: A randomized trial
    • Ljótsson, B. et al. Internet-delivered exposure-based treatment vs. stress management for irritable bowel syndrome: a randomized trial. Am. J. Gastroenterol. 106, 1481-1491 (2010).
    • (2010) Am. J. Gastroenterol. , vol.106 , pp. 1481-1491
    • Ljótsson, B.1
  • 41
    • 80052510988 scopus 로고    scopus 로고
    • Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial
    • Gaylord, S. A. et al. Mindfulness training reduces the severity of irritable bowel syndrome in women: results of a randomized controlled trial. Am. J. Gastroenterol. 106, 1678-1688 (2011).
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 1678-1688
    • Gaylord, S.A.1
  • 42
    • 0037444986 scopus 로고    scopus 로고
    • Fsti Predictors of conventional and alternative health care seeking for irritable bowel syndrome and functional dyspepsia
    • Koloski, N. A., Talley, N. J., Huskic, S. S. & Boyce, P. M. Predictors of conventional and alternative health care seeking for irritable bowel syndrome and functional dyspepsia. Aliment. Pharmacol. Ther. 17, 841-851 (2003).
    • (2003) Aliment. Pharmacol. Ther. , vol.17 , pp. 841-851
    • Koloski, N.A.1    Talley, N.J.2    Huskic, S.S.3    Boyce, P.M.4
  • 43
    • 84861874440 scopus 로고    scopus 로고
    • Acupuncture for irritable bowel syndrome: Systematic review and meta-analysis
    • Manheimer, E. et al. Acupuncture for irritable bowel syndrome: systematic review and meta-analysis. Am. J. Gastroenterol. 107, 835-847 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 835-847
    • Manheimer, E.1
  • 44
    • 33645518857 scopus 로고    scopus 로고
    • Herbal medicines for treatment of irritable bowel syndrome
    • Art. No.: CD004116
    • Liu, J. P., Yang, M., Liu, Y. X., Wei, M. L. & Grimsgaard, S. Herbal medicines for treatment of irritable bowel syndrome. Cochrane Database Syst. Rev., Issue 1. Art. No.: CD004116. http://dx.doi.org/10.1002/14651858.CD004116. pub2.
    • Cochrane Database Syst. Rev. , vol.1
    • Liu, J.P.1    Yang, M.2    Liu, Y.X.3    Wei, M.L.4    Grimsgaard, S.5
  • 45
    • 1342310220 scopus 로고    scopus 로고
    • Treatment of irritable bowel syndrome with herbal preparations: Results of a double-blind, randomized, placebo-controlled, multi-centre trial
    • Madisch, A., Holtmann, G., Plein, K. & Hotz, J. Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial. Aliment. Pharmacol. Ther. 19, 271-279 (2004).
    • (2004) Aliment. Pharmacol. Ther. , vol.19 , pp. 271-279
    • Madisch, A.1    Holtmann, G.2    Plein, K.3    Hotz, J.4
  • 46
    • 70349682327 scopus 로고    scopus 로고
    • The multi-herbal drug STW 5 (Iberogast) has prosecretory action in the human intestine
    • Krueger, D. et al. The multi-herbal drug STW 5 (Iberogast) has prosecretory action in the human intestine. Neurogastroenterol. Motil. 21, 1203-e110 (2009).
    • (2009) Neurogastroenterol. Motil. , vol.21
    • Krueger, D.1
  • 48
    • 57749192461 scopus 로고    scopus 로고
    • Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: Systematic review and meta-analysis
    • Ford, A. C. et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ 337, a2313 (2008).
    • (2008) BMJ , vol.337
    • Ford, A.C.1
  • 49
    • 84881264436 scopus 로고    scopus 로고
    • Soluble or insoluble fibre in primary care? Randomised placebo controlled trial
    • Bijkerk, C. J. et al. Soluble or insoluble fibre in primary care? Randomised placebo controlled trial. BMJ 339, b3154 (2009).
    • (2009) BMJ , vol.339
    • Bijkerk, C.J.1
  • 50
    • 0035103853 scopus 로고    scopus 로고
    • Food-related gastrointestinal symptoms in the irritable bowel syndrome
    • Simrén, M. et al. Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 63, 108-115 (2001).
    • (2001) Digestion , vol.63 , pp. 108-115
    • Simrén, M.1
  • 51
    • 33746098966 scopus 로고    scopus 로고
    • Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia?
    • Park, M. I. & Camilleri, M. Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? Neurogastroenterol. Motil. 18, 595-607 (2006).
    • (2006) Neurogastroenterol. Motil. , vol.18 , pp. 595-607
    • Park, M.I.1    Camilleri, M.2
  • 52
    • 34447099633 scopus 로고    scopus 로고
    • Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome
    • Wahnschaffe, U., Schulzke, J. D., Zeitz, M. & Ullrich, R. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 5, 844-850 (2007).
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , pp. 844-850
    • Wahnschaffe, U.1    Schulzke, J.D.2    Zeitz, M.3    Ullrich, R.4
  • 53
    • 79955601393 scopus 로고    scopus 로고
    • HLA-DQ genotype is associated with accelerated small bowel transit in patients with diarrhea-predominant irritable bowel syndrome
    • Vazquez-Roque, M. I. et al. HLA-DQ genotype is associated with accelerated small bowel transit in patients with diarrhea-predominant irritable bowel syndrome. Eur. J. Gastroenterol. Hepatol. 23, 481-487 (2011).
    • (2011) Eur. J. Gastroenterol. Hepatol. , vol.23 , pp. 481-487
    • Vazquez-Roque, M.I.1
  • 54
    • 79952362194 scopus 로고    scopus 로고
    • Gluten causes gastrointestinal symptoms in subjects without celiac disease: A double-blind randomized placebo-controlled trial
    • Biesiekierski, J. R. et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am. J. Gastroenterol. 106, 508-514 (2011).
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 508-514
    • Biesiekierski, J.R.1
  • 55
    • 45849125772 scopus 로고    scopus 로고
    • Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: Randomized placebo-controlled evidence
    • Shepherd, S., Parker, F. C., Muir, J. G. & Gibson, P. R. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin. Gastroenterol. Hepatol. 7, 765-771 (2008).
    • (2008) Clin. Gastroenterol. Hepatol. , vol.7 , pp. 765-771
    • Shepherd, S.1    Parker, F.C.2    Muir, J.G.3    Gibson, P.R.4
  • 56
    • 80054983182 scopus 로고    scopus 로고
    • Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome
    • Staudacher, H. M., Whelan, K., Irving, P. M. & Lorner, M. C. Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome. J. Hum. Nutr. Diet. 24, 487-495 (2011).
    • (2011) J. Hum. Nutr. Diet. , vol.24 , pp. 487-495
    • Staudacher, H.M.1    Whelan, K.2    Irving, P.M.3    Lorner, M.C.4
  • 57
    • 0032105431 scopus 로고    scopus 로고
    • Effects of an irritable bowel syndrome educational class on health-promoting behaviours and symptoms
    • Colwell, L. J., Prather, C. M., Phillips, S. F. & Zinsmeister, A. R. Effects of an irritable bowel syndrome educational class on health-promoting behaviours and symptoms. Am. J. Gastroenterol. 93, 901-905 (1998).
    • (1998) Am. J. Gastroenterol. , vol.93 , pp. 901-905
    • Colwell, L.J.1    Prather, C.M.2    Phillips, S.F.3    Zinsmeister, A.R.4
  • 58
  • 59
    • 79955595435 scopus 로고    scopus 로고
    • Physical activity improves symptoms in irritable bowel syndrome: A randomized controlled trial
    • Johannesson, E., Simrén, M., Strid, H., Bajor, A. & Sadik, R. Physical activity improves symptoms in irritable bowel syndrome: a randomized controlled trial. Am. J. Gastroenterol. 106, 915-922 (2010).
    • (2010) Am. J. Gastroenterol. , vol.106 , pp. 915-922
    • Johannesson, E.1    Simrén, M.2    Strid, H.3    Bajor, A.4    Sadik, R.5
  • 61
    • 79960575909 scopus 로고    scopus 로고
    • Outcome of biofeedback therapy in dyssynergic defecation patients with and without irritable bowel syndrome
    • Patcharatrakul, T. & Gonlachanvit, S. Outcome of biofeedback therapy in dyssynergic defecation patients with and without irritable bowel syndrome. J. Clin. Gastroenterol. 45, 593-598 (2011).
    • (2011) J. Clin. Gastroenterol. , vol.45 , pp. 593-598
    • Patcharatrakul, T.1    Gonlachanvit, S.2
  • 62
    • 33745569311 scopus 로고    scopus 로고
    • Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome
    • Whorwell, P. J. et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am. J. Gastroenterol. 101, 326-333 (2006).
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 326-333
    • Whorwell, P.J.1
  • 63
    • 15744374565 scopus 로고    scopus 로고
    • Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
    • O'Mahony, L. et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 128, 541-551 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 541-551
    • O'Mahony, L.1
  • 64
    • 77749318556 scopus 로고    scopus 로고
    • The efficacy of probiotics in the therapy of irritable bowel syndrome: A systematic review
    • Moayyedi, P. et al. The efficacy of probiotics in the therapy of irritable bowel syndrome: a systematic review. Gut 59, 325-332 (2010).
    • (2010) Gut , vol.59 , pp. 325-332
    • Moayyedi, P.1
  • 65
    • 65449172901 scopus 로고    scopus 로고
    • The utility of probiotics in the treatment of irritable bowel syndrome: A systematic review
    • Brenner, D. M., Moeller, M. J., Chey, W. D. & Schoenfeld, P. S. The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review. Am. J. Gastroenterol. 104, 1033-1049 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1033-1049
    • Brenner, D.M.1    Moeller, M.J.2    Chey, W.D.3    Schoenfeld, P.S.4
  • 66
    • 49649088887 scopus 로고    scopus 로고
    • Meta-analysis of probiotics for the treatment of irritable bowel syndrome
    • McFarland, L. V. & Dublin, S. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J. Gastroenterol. 14, 2650-2661 (2008).
    • (2008) World J. Gastroenterol. , vol.14 , pp. 2650-2661
    • McFarland, L.V.1    Dublin, S.2
  • 68
    • 63049127784 scopus 로고    scopus 로고
    • A systematic review and meta-analysis: Probiotics in the treatment of irritable bowel syndrome
    • Hoveyda, N. et al. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol. 9, 15 (2009).
    • (2009) BMC Gastroenterol. , vol.9 , pp. 15
    • Hoveyda, N.1
  • 69
    • 70249101728 scopus 로고    scopus 로고
    • Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS)
    • Art NoCD003019
    • Huertas-Ceballos, A., Logan, S., Bennett, C. & MacArthur, C. Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst. Rev., Issue 1. Art. No.:CD003019 http:dx.doi.org/10.1002/14651858.CD003019.pub2.
    • Childhood. Cochrane Database Syst. Rev. , vol.1
    • Huertas-Ceballos, A.1    Logan, S.2    Bennett, C.3    MacArthur, C.4
  • 70
    • 80054982160 scopus 로고    scopus 로고
    • Probiotics and prebiotics in the management of irritable bowel syndrome: A review of recent clinical trials and systematic reviews
    • Whelan, K. Probiotics and prebiotics in the management of irritable bowel syndrome: a review of recent clinical trials and systematic reviews. Curr. Opin. Clin. Nutr. Metab. Care 14, 581-587 (2011).
    • (2011) Curr. Opin. Clin. Nutr. Metab. Care , vol.14 , pp. 581-587
    • Whelan, K.1
  • 71
    • 58149103805 scopus 로고    scopus 로고
    • Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome - Results of two randomized, placebo-controlled studies
    • Drossman, D. A. et al. Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment. Pharmacol. Ther. 29, 329-341 (2009).
    • (2009) Aliment. Pharmacol. Ther. , vol.29 , pp. 329-341
    • Drossman, D.A.1
  • 72
    • 84856707088 scopus 로고    scopus 로고
    • Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation
    • Chey, W. D. et al. Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation. Aliment. Pharmacol. Ther. 35, 587-599 (2012).
    • (2012) Aliment. Pharmacol. Ther. , vol.35 , pp. 587-599
    • Chey, W.D.1
  • 73
    • 84871983182 scopus 로고    scopus 로고
    • Patient response to lubiprostone for the treatment of moderate to severe irritable bowel syndrome with constipation (IBS-C) [abstract Su1198]
    • Joswick, T. R., Woldegeorgis, F. & Ueno, R. Patient response to lubiprostone for the treatment of moderate to severe irritable bowel syndrome with constipation (IBS-C) [abstract Su1198]. Gastroenterology 142 (Suppl. 1), S-449 (2012).
    • (2012) Gastroenterology , vol.142 , Issue.SUPPL. 1
    • Joswick, T.R.1    Woldegeorgis, F.2    Ueno, R.3
  • 74
    • 43549127335 scopus 로고    scopus 로고
    • Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: A randomized controlled trial
    • Chey, W., Paré, P., Viegas, A., Ligozio, G. & Shetzline, M. A. Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial. Am. J. Gastroenterol. 103, 1217-1225 (2008).
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 1217-1225
    • Chey, W.1    Paré, P.2    Viegas, A.3    Ligozio, G.4    Shetzline, M.A.5
  • 75
    • 34249104574 scopus 로고    scopus 로고
    • Novartis suspends tegaserod sales at FDA's request
    • Thompson, C. A. Novartis suspends tegaserod sales at FDA's request. Am. J. Health Syst. Pharm. 64, 1020 (2007).
    • (2007) Am. J. Health Syst. Pharm. , vol.64 , pp. 1020
    • Thompson, C.A.1
  • 76
    • 84858287886 scopus 로고    scopus 로고
    • Systematic review: Cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders
    • Tack, J. et al. Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders. Aliment. Pharmacol. Ther. 35, 745-767 (2012).
    • (2012) Aliment. Pharmacol. Ther. , vol.35 , pp. 745-767
    • Tack, J.1
  • 77
    • 44349130441 scopus 로고    scopus 로고
    • A placebo-controlled trial of prucalopride for severe chronic constipation
    • Camilleri, M., Kerstens, R., Rykx, A. & Vandeplassche, L. A placebo-controlled trial of prucalopride for severe chronic constipation. N. Engl. J. Med. 358, 2344-2354 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2344-2354
    • Camilleri, M.1    Kerstens, R.2    Rykx, A.3    Vandeplassche, L.4
  • 78
    • 58149084950 scopus 로고    scopus 로고
    • Clinical trial: The efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - A 12 week, randomized, double blind, placebo-controlled study
    • Quigley, E. M., Vandeplassche, L., Kerstens, R. & Ausma, J. Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12 week, randomized, double blind, placebo-controlled study. Aliment. Pharmacol. Ther. 29, 315-328 (2009).
    • (2009) Aliment. Pharmacol. Ther. , vol.29 , pp. 315-328
    • Quigley, E.M.1    Vandeplassche, L.2    Kerstens, R.3    Ausma, J.4
  • 79
    • 61649119045 scopus 로고    scopus 로고
    • Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    • Tack, J., van Outryve, M., Beyens, G., Kerstens, R. & Vandeplassche, L. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut 58, 357-365 (2009).
    • (2009) Gut , vol.58 , pp. 357-365
    • Tack, J.1    Van Outryve, M.2    Beyens, G.3    Kerstens, R.4    Vandeplassche, L.5
  • 80
    • 78649690668 scopus 로고    scopus 로고
    • Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    • Johnston, J. M. et al. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 139, 1877-1886 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 1877-1886
    • Johnston, J.M.1
  • 81
    • 77249122338 scopus 로고    scopus 로고
    • Efficacy of linaclotide for patients with chronic constipation
    • Lembo, A. et al. Efficacy of linaclotide for patients with chronic constipation. Gastroenterology 138, 886-895 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 886-895
    • Lembo, A.1
  • 82
    • 84871967869 scopus 로고    scopus 로고
    • Effects of Linaclotide Treatment on Patient-reported Ratings of Change for Symptoms of Irritable Bowel Syndrome with Constipation (IBS-C): Pooled 12-week Findings from Two Phase 3 Trials
    • Locke, G. R. et al. Effects of linaclotide treatment on patient-reported ratings of change for symptoms of irritable bowel syndrome with constipation (IBS-C): Pooled 12-week findings from two phase 3 trials. Gastroenterology 142 (Suppl. 1), S-737 (2012).
    • (2012) Gastroenterology , vol.142 , Issue.SUPPL. 1
    • Locke, G.R.1
  • 83
    • 84869491248 scopus 로고    scopus 로고
    • Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety
    • Chey, W. D. et al. Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am. J. Gastroenterol. http://dx.doi.org/10.1038/ ajg.2012.254.
    • Am. J. Gastroenterol
    • Chey, W.D.1
  • 84
    • 84869493876 scopus 로고    scopus 로고
    • A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation
    • Rao, M. et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am. J. Gastroenterol. http://dx.doi.org/10/1038/ajg.2012.255.
    • Am. J. Gastroenterol.
    • Rao, M.1
  • 85
    • 80053193146 scopus 로고    scopus 로고
    • Randomised clinical trial: The safety and efficacy of AST-120 in non-constipating irritable bowel syndrome - A double blind, placebo controlled study
    • Tack, J. F., Miner, P. B., Fishcer, L. & Harris M. S. Randomised clinical trial: the safety and efficacy of AST-120 in non-constipating irritable bowel syndrome - a double blind, placebo controlled study. Aliment. Pharmacol. Ther. 34, 868-877 (2011).
    • (2011) Aliment. Pharmacol. Ther. , vol.34 , pp. 868-877
    • Tack, J.F.1    Miner, P.B.2    Fishcer, L.3    Harris, M.S.4
  • 86
    • 78650864077 scopus 로고    scopus 로고
    • Rifaximin therapy for patients with irritable bowel syndrome without constipation
    • Pimental, M. et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N. Engl. J. Med. 364, 22-32 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 22-32
    • Pimental, M.1
  • 87
    • 84855462831 scopus 로고    scopus 로고
    • The efficacy and safety of rifaximin for the irritable bowel syndrome: A systematic review and meta-analysis
    • Menees, S., Maneerattannaporn, M., Kim, H. M. & Chey, W. D. The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta-analysis. Am. J. Gastroenterol. 107, 28-35 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 28-35
    • Menees, S.1    Maneerattannaporn, M.2    Kim, H.M.3    Chey, W.D.4
  • 88
    • 79959699085 scopus 로고    scopus 로고
    • Effects of rifaximin treatment and retreatment in nonconstipated IBS subjects
    • Pimentel, M. et al. Effects of rifaximin treatment and retreatment in nonconstipated IBS subjects. Dig. Dis. Sci. 56, 2067-2072 (2011).
    • (2011) Dig. Dis. Sci. , vol.56 , pp. 2067-2072
    • Pimentel, M.1
  • 89
    • 84858958766 scopus 로고    scopus 로고
    • Evaluation of harm in the pharmacotherapy of irritable bowel syndrome
    • Shah, E., Kim, S., Chong, K., Lembo, A. & Pimentel, M. Evaluation of harm in the pharmacotherapy of irritable bowel syndrome. Am. J. Gastroenterol. 125, 381-393 (2012).
    • (2012) Am. J. Gastroenterol. , vol.125 , pp. 381-393
    • Shah, E.1    Kim, S.2    Chong, K.3    Lembo, A.4    Pimentel, M.5
  • 90
    • 13744263696 scopus 로고    scopus 로고
    • A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS
    • Chang, L. et al. A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS. Am. J. Gastroenterol. 100, 115-123 (2005).
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 115-123
    • Chang, L.1
  • 91
    • 0037295146 scopus 로고    scopus 로고
    • Efficacy of alosetron in irritable bowel syndrome: A meta-analysis of randomised, placebo-controlled trials
    • Cremonini, F., Delgado-Aros, S. & Camilleri, M. Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomised, placebo-controlled trials. Neurogastroenterol. Motil. 15, 79-86 (2003).
    • (2003) Neurogastroenterol. Motil. , vol.15 , pp. 79-86
    • Cremonini, F.1    Delgado-Aros, S.2    Camilleri, M.3
  • 92
    • 33646441324 scopus 로고    scopus 로고
    • Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: Systematic review of clinical trials and post-marketing surveillance data
    • Chang, L. et al. Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance data. Am. J. Gastroenterol. 101, 1069-1079 (2006).
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 1069-1079
    • Chang, L.1
  • 93
    • 67650455908 scopus 로고    scopus 로고
    • Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: Systematic review and meta-analysis
    • Ford, A. et al. Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am. J. Gastroenterol. 104, 1831-1843 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1831-1843
    • Ford, A.1
  • 94
    • 77950520996 scopus 로고    scopus 로고
    • Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: Clinical characteristics, outcomes and incidences
    • Chang, L., Tong, K. & Ameen, V. Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes and incidences. Am. J. Gastroenterol. 105, 866-875 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 866-875
    • Chang, L.1    Tong, K.2    Ameen, V.3
  • 95
    • 44949243897 scopus 로고    scopus 로고
    • And tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: A meta-analysis of eight randomized, placebo-controlled, 12-week trials
    • Rahimi, R., Nikfar, S. & Abdollahi, M. Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin. Ther. 30, 884-901 (2008).
    • (2008) Clin. Ther. , vol.30 , pp. 884-901
    • Rahimi, R.1    Nikfar, S.2    Efficacy, A.M.3
  • 96
    • 48049093262 scopus 로고    scopus 로고
    • A phase II trial of the novel serotonin type 3 receptor antagonist in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome
    • Matsueda, K., Harasawa, S., Hongo, M., Hiwatashi, N. & Sasaki, D. A phase II trial of the novel serotonin type 3 receptor antagonist in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome. Digestion 77, 225-235 (2008).
    • (2008) Digestion , vol.77 , pp. 225-235
    • Matsueda, K.1    Harasawa, S.2    Hongo, M.3    Hiwatashi, N.4    Sasaki, D.5
  • 97
    • 52149088774 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea predominant irritable bowel syndrome
    • Matsueda, K., Harasawa, S., Hongo, M., Hiwatashi, N. & Sasaki, D. A randomized, double-blind, placebo-controlled trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea predominant irritable bowel syndrome. Scand. J. Gastroenterol. 43, 1202-1211 (2008).
    • (2008) Scand. J. Gastroenterol. , vol.43 , pp. 1202-1211
    • Matsueda, K.1    Harasawa, S.2    Hongo, M.3    Hiwatashi, N.4    Sasaki, D.5
  • 98
    • 42249111897 scopus 로고    scopus 로고
    • Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: A comparative study with opioid receptors agonists, a muscarinic receptors antagonist and a synthetic polymer
    • Hirata, T. et al. Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptors agonists, a muscarinic receptors antagonist and a synthetic polymer. Neurogastroenterol. Motil. 20, 557-565 (2008).
    • (2008) Neurogastroenterol. Motil. , vol.20 , pp. 557-565
    • Hirata, T.1
  • 99
    • 33847365318 scopus 로고    scopus 로고
    • Pharmacological profile of ramosetron, a novel therapeutic agent for IBS
    • Hirata, T., Funatsu, T., Keto, Y., Nakata, M. & Sasamata, M. Pharmacological profile of ramosetron, a novel therapeutic agent for IBS. Inflammopharmacology 15, 5-9 (2007).
    • (2007) Inflammopharmacology , vol.15 , pp. 5-9
    • Hirata, T.1    Funatsu, T.2    Keto, Y.3    Nakata, M.4    Sasamata, M.5
  • 100
    • 81855185606 scopus 로고    scopus 로고
    • Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: A multicenter, randomized clinical trial, compared with mebeverine
    • Lee, K. J. et al. Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine. Neurogastroenterol. Motil. 23, 1098-1104 (2011).
    • (2011) Neurogastroenterol. Motil. , vol.23 , pp. 1098-1104
    • Lee, K.J.1
  • 101
    • 79551714477 scopus 로고    scopus 로고
    • LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhoea associated with increased serotonin
    • Camilleri, M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhoea associated with increased serotonin. Neurogastroenterol. Motil. 23, 193-200 (2011).
    • (2011) Neurogastroenterol. Motil. , vol.23 , pp. 193-200
    • Camilleri, M.1
  • 102
    • 84862832724 scopus 로고    scopus 로고
    • Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome related colonic hypersensitivity
    • Asano, T. et al. Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome related colonic hypersensitivity. Biochem. Biophys. Res. Commun. 420, 444-449 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.420 , pp. 444-449
    • Asano, T.1
  • 103
    • 79960370359 scopus 로고    scopus 로고
    • Effect of β-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
    • Ciacci, C. et al. Effect of β-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS. Eur. Rev. Med. Pharmacol. Sci. 15, 637-643 (2011).
    • (2011) Eur. Rev. Med. Pharmacol. Sci. , vol.15 , pp. 637-643
    • Ciacci, C.1
  • 104
    • 84855354656 scopus 로고    scopus 로고
    • Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: A pilot study
    • Tillisch, K. et al. Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study. Aliment. Pharmacol. Ther. 35, 360-367 (2012).
    • (2012) Aliment. Pharmacol. Ther. , vol.35 , pp. 360-367
    • Tillisch, K.1
  • 105
    • 0000975818 scopus 로고    scopus 로고
    • Influence of dexloxiglumide on visceromotor and pain response induced by rectal distension in rats
    • Bonnafous, C. et al. Influence of dexloxiglumide on visceromotor and pain response induced by rectal distension in rats. Gastroenterology 122 (Suppl.), A527 (2002).
    • (2002) Gastroenterology , vol.122 , Issue.SUPPL.
    • Bonnafous, C.1
  • 106
    • 46749119725 scopus 로고    scopus 로고
    • A phase III, 6-month, double-blind, placebo-controlled trial of the selective CCK-1 antagonist dexloxiglumide in constipation-predominant IBS: The DARWIN study [abstract 1050]
    • Whorwell, P. et al. A phase III, 6-month, double-blind, placebo-controlled trial of the selective CCK-1 antagonist dexloxiglumide in constipation-predominant IBS: the DARWIN study [abstract 1050]. Gastroenterology 134 (Suppl. 1), A157 (2008).
    • (2008) Gastroenterology , vol.134 , Issue.SUPPL. 1
    • Whorwell, P.1
  • 108
    • 35548931920 scopus 로고    scopus 로고
    • Efficacy of on-demand asimadoline, a peripheral κ-opioid agonist, in females with irritable bowel syndrome
    • Szarka, L. A. et al. Efficacy of on-demand asimadoline, a peripheral κ-opioid agonist, in females with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 5, 1268-1275 (2007).
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , pp. 1268-1275
    • Szarka, L.A.1
  • 109
    • 84871976917 scopus 로고    scopus 로고
    • Effect of a κ-opioid agonists, i.v. JNJ-38488502, on sensation of colonic distensions in healthy male volunteers
    • Floyd, B. N. et al. Effect of a κ-opioid agonists, i.v. JNJ-38488502, on sensation of colonic distensions in healthy male volunteers. Neurogastroenterol. Motil. 28, 239-249 (2009).
    • (2009) Neurogastroenterol. Motil. , vol.28 , pp. 239-249
    • Floyd, B.N.1
  • 110
  • 111
    • 77952140176 scopus 로고    scopus 로고
    • Effects of chenodeoxycholic acid on gastrointestinal and colonic transit and bowel function in healthy volunteers [abstract T1247]
    • Odunsi, S. T. et al. Effects of chenodeoxycholic acid on gastrointestinal and colonic transit and bowel function in healthy volunteers [abstract T1247]. Gastroenterology 136 (Suppl. 1), A-531 (2009).
    • (2009) Gastroenterology , vol.136 , Issue.SUPPL. 1
    • Odunsi, S.T.1
  • 112
    • 84861524726 scopus 로고    scopus 로고
    • Pilot study: A randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea
    • Money, M. E., Walkowiak, J., Virgilio, C. & Talley, N. J. Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea. Frontline Gastroenterol. 2, 48-56 (2011).
    • (2011) Frontline Gastroenterol. , vol.2 , pp. 48-56
    • Money, M.E.1    Walkowiak, J.2    Virgilio, C.3    Talley, N.J.4
  • 113
    • 65349128160 scopus 로고    scopus 로고
    • Treatment of irritable bowel syndrome-diarrhea with pancrealipase or coleseveelam and association with steatorrhea
    • Money, M. E., Hofmann, A. F., Hagey, L. R., Walkowiak, J. & Talley, N. J. Treatment of irritable bowel syndrome-diarrhea with pancrealipase or coleseveelam and association with steatorrhea. Pancreas 38, 232-233 (2009).
    • (2009) Pancreas , vol.38 , pp. 232-233
    • Money, M.E.1    Hofmann, A.F.2    Hagey, L.R.3    Walkowiak, J.4    Talley, N.J.5
  • 114
    • 71549121350 scopus 로고    scopus 로고
    • Review article: New receptor targets for medical therapy in irritable bowel syndrome
    • Camilleri, M. Review article: new receptor targets for medical therapy in irritable bowel syndrome. Aliment. Pharmacol. Ther. 31, 35-46 (2010).
    • (2010) Aliment. Pharmacol. Ther. , vol.31 , pp. 35-46
    • Camilleri, M.1
  • 115
    • 71549163969 scopus 로고    scopus 로고
    • Clinical benefit in IBS after disodium cromoglycate involves mast cell-mediated recovery of health-like innate immunity genes expression profile in the jejunal mucosa [abstract 156]
    • Lobo, B. et al. Clinical benefit in IBS after disodium cromoglycate involves mast cell-mediated recovery of health-like innate immunity genes expression profile in the jejunal mucosa [abstract 156]. Gastroenterology 123 (Suppl. 1), A-30 (2009).
    • (2009) Gastroenterology , vol.123 , Issue.SUPPL. 1
    • Lobo, B.1
  • 116
    • 84871962585 scopus 로고    scopus 로고
    • Treatment with the mast cell stabilizer ketoifen decreases visceral hypersensitivity and improves symptoms in IBS patients [abstract OP397]
    • (UEGF) Meeting Vienna Austria
    • Klooker, T. et al. Treatment with the mast cell stabilizer ketoifen decreases visceral hypersensitivity and improves symptoms in IBS patients [abstract OP397]. Proceedings of the United European Gastroenterology Federation (UEGF) Meeting, Vienna, Austria (2008).
    • (2008) Proceedings of the United European Gastroenterology Federation
    • Klooker, T.1
  • 117
    • 67650523807 scopus 로고    scopus 로고
    • Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: A randomized controlled proof of concept study
    • Corinaldesi, R. et al. Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof of concept study. Aliment. Pharmacol. Ther. 30, 245-252 (2009).
    • (2009) Aliment. Pharmacol. Ther. , vol.30 , pp. 245-252
    • Corinaldesi, R.1
  • 118
    • 37149041916 scopus 로고    scopus 로고
    • Clinical trial: Dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome
    • Leventer, S. M. et al. Clinical trial: dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome. Aliment. Pharmacol. Ther. 27, 197-206 (2008).
    • (2008) Aliment. Pharmacol. Ther. , vol.27 , pp. 197-206
    • Leventer, S.M.1
  • 119
    • 67349132474 scopus 로고    scopus 로고
    • Atypical antipsychotic quetiapine in the management of severe refractory functional gastrointestinal disorders
    • Grover, M. et al. Atypical antipsychotic quetiapine in the management of severe refractory functional gastrointestinal disorders. Dig. Dis. Sci. 54, 1284-1291 (2009).
    • (2009) Dig. Dis. Sci. , vol.54 , pp. 1284-1291
    • Grover, M.1
  • 120
    • 34548127061 scopus 로고    scopus 로고
    • Effects of a second-generation α2δ Ligand (pregabalin) on Visceral Sensation in Hypersensitive Patients with irritable bowel syndrome
    • Houghton, L. A. et al. Effects of a second-generation α2δ ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome. Gut 56, 1218-1225 (2007).
    • (2007) Gut , vol.56 , pp. 1218-1225
    • Houghton, L.A.1
  • 121
    • 27744603267 scopus 로고    scopus 로고
    • Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome
    • Lee, K. J., Kim, J. H. & Cho, S. W. Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome. Aliment. Pharmacol. Ther. 22, 981-988 (2005).
    • (2005) Aliment. Pharmacol. Ther. , vol.22 , pp. 981-988
    • Lee, K.J.1    Kim, J.H.2    Cho, S.W.3
  • 122
    • 67049095870 scopus 로고    scopus 로고
    • Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?
    • Sweetser, S. et al. Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome? Am. J. Physiol. 296, G1299-G1306 (2009).
    • (2009) Am. J. Physiol. , vol.296
    • Sweetser, S.1
  • 123
    • 0024970366 scopus 로고
    • Bowel-flora alteration: A potential cure for inflammatory bowel disease and irritable bowel syndrome?
    • Borody, T. J. et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome? Med. J. Aust. 150, 604 (1989).
    • (1989) Med. J. Aust. , vol.150 , pp. 604
    • Borody, T.J.1
  • 124
    • 84856959355 scopus 로고
    • Bacteriotherapy for chronic constipation - A long term follow-up [abstract]
    • Andrews, P., Borody, T. J., Shortis, N. P. & Thompson, S. Bacteriotherapy for chronic constipation - a long term follow-up [abstract]. Gastroenterology 108 (Suppl. 2), A563 (1995).
    • (1995) Gastroenterology , vol.108 , Issue.SUPPL. 2
    • Andrews, P.1    Borody, T.J.2    Shortis, N.P.3    Thompson, S.4
  • 125
    • 84856969539 scopus 로고    scopus 로고
    • Fecal microbiota transplantation and emerging applications
    • Borody, T. J. & Khoruts, A. Fecal microbiota transplantation and emerging applications. Nat. Rev. Gastroenterol. Hepatol. 9, 88-96 (2012).
    • (2012) Nat. Rev. Gastroenterol. Hepatol. , vol.9 , pp. 88-96
    • Borody, T.J.1    Khoruts, A.2
  • 127
    • 70349306410 scopus 로고    scopus 로고
    • Hypnotherapy for functional gastrointestinal disorders: A review
    • Miller, V. & Whorwell, P. J. Hypnotherapy for functional gastrointestinal disorders: a review. Intl. J. Clin. Exp. Hypn. 57, 279-292 (2009).
    • (2009) Intl. J. Clin. Exp. Hypn. , vol.57 , pp. 279-292
    • Miller, V.1    Whorwell, P.J.2
  • 130
    • 77957747609 scopus 로고    scopus 로고
    • The IBAT inhibitor A3309 - A promising treatment option for patients with chronic idiopathic constipation [abstract S1299]
    • Simren, M. et al. The IBAT inhibitor A3309 - a promising treatment option for patients with chronic idiopathic constipation [abstract S1299]. Gastroenterology 138 (Suppl. 1), S-223 (2010).
    • (2010) Gastroenterology , vol.138 , Issue.SUPPL. 1
    • Simren, M.1


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