Involvement of κ-opioid receptors in visceral nociception in mice

Neurogastroenterology and Motility

Volumn 20, Issue 10, 2008, Pages 1157-1164

  Larsson, M H ^a   Bayati, A ^a   Lindstrom E ^a   Larsson, H ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

opioid receptors; CRD; Mouse; Visceral sensitivity

Indexed keywords

ASIMADOLINE; FENTANYL; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; OPIATE ANTAGONIST;

ABDOMINAL WALL MUSCULATURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; ELECTROGASTROGRAPHY; ELECTROMYOGRAPHY; EVOKED MUSCLE RESPONSE; FEMALE; INTESTINE DISTENSION; MOUSE; NEUROMUSCULAR FUNCTION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; TRANSGENIC MOUSE; VISCERAL PAIN; VISCEROMOTOR RESPONSE;

ANALGESICS, OPIOID; ANIMALS; COLON; DILATATION, PATHOLOGIC; ELECTROMYOGRAPHY; FEMALE; FENTANYL; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NALOXONE; NARCOTIC ANTAGONISTS; NOCICEPTORS; PAIN; PAIN MEASUREMENT; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; RECTUM;

EID: 51849162746     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01161.x     Document Type: Article

References (26)

1. Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999 45 : 43ii 7.
2. Naliboff BD, Munakata J, Fullerton S et al. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut 1997 41 : 505 12.
3. Verne GN, Robinson ME, Price DD. Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome. Pain 2001 93 : 7 14.
4. Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973 14 : 125 32.
5. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995 109 : 40 52.
6. Lembo T, Naliboff BD, Matin K et al. Irritable bowel syndrome patients show altered sensitivity to exogenous opioids. Pain 2000 87 : 137 47.
7. Delvaux M, Louvel D, Lagier E, Scherrer B, Abitbol J-L, Frexinos J. The [kappa] agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome. Gastroenterology 1999 116 : 38 45.
8. Delvaux M, Beck A, Jacob J, Bouzamondo H, Weber FT, Frexinos J. Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2004 20 : 237 46.
9. Szarka LA, Camilleri M, Burton D et al. Efficacy of on-demand asimadoline, a peripheral [kappa]-opioid agonist, in females with irritable bowel syndrome. Clin Gastroenterol Hepatol 2007 5 : 1268 75.
10. Sengupta JN, Su X, Gebhart GF. Kappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colon. Gastroenterology 1996 111 : 968 80.
11. Su X, Julia V, Gebhart GF. Effects of Intracolonic opioid receptor agonists on polymodal pelvic nerve afferent fibers in the rat. J Neurophysiol 2000 83 : 963 70.
12. Danzebrink RM, Green SA, Gebhart GF. Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat. Pain 1995 63 : 39 47.
13. Burton MB, Gebhart GF. Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation. J Pharmacol Exp Ther 1998 285 : 707 15.
14. Tammpere A, Brusberg M, Axenborg J, Hirsch I, Larsson H, Lindström E. Evaluation of pseudo-affective responses to noxious colorectal distension in rats by manometric recordings. Pain 2005 116 : 220 6.
15. Larsson M, Arvidsson S, Ekman C, Bayati A. A model for chronic quantitative studies of colorectal sensitivity using balloon distension in conscious mice - effects of opioid receptor agonists. Neurogastroenterol Motil 2003 15 : 371 81.
16. Kamp EH, Jones RC 3rd., Tillman SR, Gebhart GF. Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice. Am J Physiol Gastrointest Liver Physiol 2003 284 : G434 44.
17. Gschossmann JM, Mayer EA, Miller JC, Raybould HE. Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to colorectal distension in rats. Neurogastroenterol Motil 2002 14 : 403 8.
18. Greenwood-Van Meerveld B, Gardner CJ, Little PJ, Hicks GA, Dehaven-Hudkins DL. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil 2004 16 : 46 53.
19. Ness TJ, Gebhart GF. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Res 1988 450 : 153 69.
20. Simonin F, Valverde O, Smadja C et al. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J 1998 17 : 886 97.
21. Abrahamson MH, Bayati A. Involvement of kappa-opioid receptors in visceral nociception in mice. Gastroenterology 2000 118 : A379.
22. Su X, Sengupta JN, Gebhart GF. Effects of kappa opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension. J Neurophysiol 1997 78 : 1003 12.
23. Barber A, Bartoszyk GD, Bender HM et al. A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753. Br J Pharmacol 1994 113 : 1317 27.
24. Soulard CD, Guerif S, Payne A, Dahl SG. Differential effects of fedotozine compared to other kappa agonists on diuresis in rats. J Pharmacol Exp Ther 1996 279 : 1379 85.
25. Verma-Gandhu M, Bercik P, Motomura Y et al. CD4 + T-cell modulation of visceral nociception in mice. Gastroenterology 2006 130 : 1721 8.
26. Martinez V, Thakur S, Mogil JS, Tache Y, Mayer EA. Differential effects of chemical and mechanical colonic irritation on behavioral pain response to intraperitoneal acetic acid in mice. Pain 1999 81 : 179 86.