Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 6, 2009, Pages

  Sweetser, Seth ^a   Camilleri, Michael ^a,d   Linker Nord, Sara J ^a   Burton, Duane D ^a   Castenada, Lorna ^c   Croop, Robert ^c   Tong, Gary ^c   Dockens, Randy ^c   Zinsmeister, Alan R ^b  

^a Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

^b Mayo Clinic   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Corticotropin releasing factor; Diarrhea predominant irritable bowel syndrome; Gastrointestinal transit; Pexacerfont; Randomized trial

Indexed keywords

BMS 562086; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; PEXACERFONT; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ABDOMINAL DISTENSION; ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLON MOTILITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG HALF LIFE; DRUG INDUCED HEADACHE; FEMALE; FLATULENCE; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TRACT SCINTISCANNING; GASTROINTESTINAL TRANSIT; HUMAN; INTESTINE FUNCTION; IRRITABLE COLON; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; AGED; ANXIETY; DEFECATION; DEPRESSION; DOUBLE-BLIND METHOD; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; HUMANS; IRRITABLE BOWEL SYNDROME; MIDDLE AGED; PYRAZOLES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; TRIAZINES; YOUNG ADULT;

EID: 67049095870     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00011.2009     Document Type: Article

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