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Volumn 19, Issue 1, 2013, Pages 225-235

Progression-free survival as a surrogate endpoint for median overall survival in metastatic colorectal cancer: Literature-based analysis from 50 randomized first-line trials

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; VASCULOTROPIN;

EID: 84871954676     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-1515     Document Type: Article
Times cited : (66)

References (87)
  • 2
    • 77953243023 scopus 로고    scopus 로고
    • Surrogate endpoints for overall survival in digestive oncology trials: Which candidates? A questionnaires survey among clinicians and methodologists
    • Methy N, Bedenne L, Bonnetain F. Surrogate endpoints for overall survival in digestive oncology trials: which candidates? A questionnaires survey among clinicians and methodologists. BMC Cancer 2010;10:277.
    • (2010) BMC Cancer , vol.10 , pp. 277
    • Methy, N.1    Bedenne, L.2    Bonnetain, F.3
  • 3
    • 47249152394 scopus 로고    scopus 로고
    • Endpoints and surrogate endpoints in colorectal cancer: A review of recent developments
    • Piedbois P, Buyse M. Endpoints and surrogate endpoints in colorectal cancer: a review of recent developments. Curr Opin Oncol 2008;20:466-71.
    • (2008) Curr Opin Oncol , vol.20 , pp. 466-471
    • Piedbois, P.1    Buyse, M.2
  • 4
    • 52649094924 scopus 로고    scopus 로고
    • Surrogate endpoints for overall survival in advanced colorectal cancer: A clinician's perspective
    • Piedbois P, Miller Croswell J. Surrogate endpoints for overall survival in advanced colorectal cancer: a clinician's perspective. Stat Methods Med Res 2008;17:519-27.
    • (2008) Stat Methods Med Res , vol.17 , pp. 519-527
    • Piedbois, P.1    Miller Croswell, J.2
  • 5
    • 77949321968 scopus 로고    scopus 로고
    • Progression-free survival as surrogate and as true end point: Insights from the breast and colorectal cancer literature
    • Saad ED, Katz A, Hoff PM, Buyse M. Progression-free survival as surrogate and as true end point: insights from the breast and colorectal cancer literature. Ann Oncol 2010;21:7-12.
    • (2010) Ann Oncol , vol.21 , pp. 7-12
    • Saad, E.D.1    Katz, A.2    Hoff, P.M.3    Buyse, M.4
  • 6
    • 35649022759 scopus 로고    scopus 로고
    • Surrogate end points for median overall survival in metastatic colorectal cancer: Literature-based analysis from 39 randomized controlled trials of first-line chemotherapy
    • Tang PA, Bentzen SM, Chen EX, Siu LL. Surrogate end points for median overall survival in metastatic colorectal cancer: literature-based analysis from 39 randomized controlled trials of first-line chemotherapy. J Clin Oncol 2007;25:4562-8.
    • (2007) J Clin Oncol , vol.25 , pp. 4562-4568
    • Tang, P.A.1    Bentzen, S.M.2    Chen, E.X.3    Siu, L.L.4
  • 7
    • 80053467288 scopus 로고    scopus 로고
    • Progression-free survival as a primary endpoint in clinical trials of metastatic colorectal cancer
    • Gill S, Berry S, Biagi J, Butts C, Buyse M, Chen E, et al. Progression-free survival as a primary endpoint in clinical trials of metastatic colorectal cancer. Curr Oncol 2011;18(Suppl 2):S5-S10.
    • (2011) Curr Oncol , vol.18 , Issue.SUPPL. 2
    • Gill, S.1    Berry, S.2    Biagi, J.3    Butts, C.4    Buyse, M.5    Chen, E.6
  • 8
    • 84864004759 scopus 로고    scopus 로고
    • Overall survival: Patient outcome, therapeutic objective, clinical trial end point, or public health measure?
    • Saad ED, Buyse M. Overall survival: patient outcome, therapeutic objective, clinical trial end point, or public health measure? J Clin Oncol 2012;30:1750-4.
    • (2012) J Clin Oncol , vol.30 , pp. 1750-1754
    • Saad, E.D.1    Buyse, M.2
  • 9
    • 84860496547 scopus 로고    scopus 로고
    • Progression-free survival: Meaningful or simply measurable?
    • Booth CM, Eisenhauer EA. Progression-free survival: meaningful or simply measurable? J Clin Oncol 2012;30:1030-3.
    • (2012) J Clin Oncol , vol.30 , pp. 1030-1033
    • Booth, C.M.1    Eisenhauer, E.A.2
  • 10
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM, Schmoll H-J. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004;22:1209-14.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3    Schmoll, H.-J.4
  • 11
    • 0030268577 scopus 로고    scopus 로고
    • Surrogate end points in clinical trials: Are we being misled?
    • Fleming TR, DeMets DL. Surrogate end points in clinical trials: are we being misled? Ann Intern Med 1996;125:605-13.
    • (1996) Ann Intern Med , vol.125 , pp. 605-613
    • Fleming, T.R.1    DeMets, D.L.2
  • 12
    • 0037986306 scopus 로고    scopus 로고
    • End points and United States Food and Drug Administration approval of oncology drugs
    • Johnson JR, Williams G, Pazdur R. End points and United States Food and Drug Administration approval of oncology drugs. J Clin Oncol 2003;21:1404-11.
    • (2003) J Clin Oncol , vol.21 , pp. 1404-1411
    • Johnson, J.R.1    Williams, G.2    Pazdur, R.3
  • 13
    • 0024520844 scopus 로고
    • Surrogate endpoints in clinical trials: Definition and operational criteria
    • Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1989;8:431-40.
    • (1989) Stat Med , vol.8 , pp. 431-440
    • Prentice, R.L.1
  • 14
    • 60749096036 scopus 로고    scopus 로고
    • Surrogate and mediating endpoints: Current status and future directions
    • Prentice RL. Surrogate and mediating endpoints: current status and future directions. J Natl Cancer Inst 2009;101:216-7.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 216-217
    • Prentice, R.L.1
  • 15
    • 0022393322 scopus 로고
    • Food and Drug Administration requirements for approval of new anticancer drugs
    • Johnson JR, Temple R. Food and Drug Administration requirements for approval of new anticancer drugs. Cancer Treat Rep 1985;69:1155-9.
    • (1985) Cancer Treat Rep , vol.69 , pp. 1155-1159
    • Johnson, J.R.1    Temple, R.2
  • 16
    • 0031708453 scopus 로고    scopus 로고
    • Criteria for the validation of surrogate endpoints in randomized experiments
    • Buyse M, Molenberghs G. Criteria for the validation of surrogate endpoints in randomized experiments. Biometrics 1998;54:1014-29.
    • (1998) Biometrics , vol.54 , pp. 1014-1029
    • Buyse, M.1    Molenberghs, G.2
  • 17
    • 0001863948 scopus 로고    scopus 로고
    • The validation of surrogate endpoints in meta-analyses of randomized experiments
    • Buyse M, Molenberghs G, Burzykowski T, Renard D, Geys H. The validation of surrogate endpoints in meta-analyses of randomized experiments. Biostatistics 2000;1:49-67.
    • (2000) Biostatistics , vol.1 , pp. 49-67
    • Buyse, M.1    Molenberghs, G.2    Burzykowski, T.3    Renard, D.4    Geys, H.5
  • 18
    • 0026573094 scopus 로고
    • Statistical validation of intermediate endpoints for chronic diseases
    • Freedman LS, Graubard BI, Schatzkin A. Statistical validation of intermediate endpoints for chronic diseases. Stat Med 1992;11:167-78.
    • (1992) Stat Med , vol.11 , pp. 167-178
    • Freedman, L.S.1    Graubard, B.I.2    Schatzkin, A.3
  • 19
    • 61649098633 scopus 로고    scopus 로고
    • Progression-free survival and time to progression as primary end points in advanced breast cancer: Often used, sometimes loosely defined
    • Saad ED, Katz A. Progression-free survival and time to progression as primary end points in advanced breast cancer: often used, sometimes loosely defined. Ann Oncol 2009;20:460-4.
    • (2009) Ann Oncol , vol.20 , pp. 460-464
    • Saad, E.D.1    Katz, A.2
  • 20
    • 77951936254 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of metastatic colorectal cancer: A review
    • Tol J, Punt CJ. Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review. Clin Ther 2010;32:437-53.
    • (2010) Clin Ther , vol.32 , pp. 437-453
    • Tol, J.1    Punt, C.J.2
  • 21
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, Altman DG, The PG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6:e1000097.
    • (2009) PLoS Med , vol.6
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4    The, P.G.5
  • 22
    • 77951642723 scopus 로고    scopus 로고
    • Overall survival and post-progression survival in advanced breast cancer: A review of recent randomized clinical trials
    • Saad ED, Katz A, Buyse M. Overall survival and post-progression survival in advanced breast cancer: a review of recent randomized clinical trials. J Clin Oncol 2010;28:1958-62.
    • (2010) J Clin Oncol , vol.28 , pp. 1958-1962
    • Saad, E.D.1    Katz, A.2    Buyse, M.3
  • 23
    • 84862986717 scopus 로고    scopus 로고
    • Meta-analysis of the association between progression-free survival and overall survival in metastatic colorectal cancer
    • Chirila C, Odom D, Devercelli G, Khan S, Sherif BN, Kaye JA, et al. Meta-analysis of the association between progression-free survival and overall survival in metastatic colorectal cancer. Int J Colorectal Dis 2012;27:623-34.
    • (2012) Int J Colorectal Dis , vol.27 , pp. 623-634
    • Chirila, C.1    Odom, D.2    Devercelli, G.3    Khan, S.4    Sherif, B.N.5    Kaye, J.A.6
  • 24
    • 0035648331 scopus 로고    scopus 로고
    • Validation of surrogate end points in multiple randomized clinical trials with failure time end points
    • Burzykowski T, Molenberghs G, Buyse M, Geys H, Renard D. Validation of surrogate end points in multiple randomized clinical trials with failure time end points. J R Stat Soc: Ser C (Appl Stat) 2001;50:405-22.
    • (2001) J R Stat Soc: ser C (Appl Stat) , vol.50 , pp. 405-422
    • Burzykowski, T.1    Molenberghs, G.2    Buyse, M.3    Geys, H.4    Renard, D.5
  • 25
    • 84858860230 scopus 로고    scopus 로고
    • Meta-analysis for surrogacy: Accelerated failure time models and semicompeting risks modeling
    • Ghosh D, Taylor JM, Sargent DJ. Meta-analysis for surrogacy: accelerated failure time models and semicompeting risks modeling. Biometrics 2012;68:226-32.
    • (2012) Biometrics , vol.68 , pp. 226-232
    • Ghosh, D.1    Taylor, J.M.2    Sargent, D.J.3
  • 26
    • 0028927937 scopus 로고
    • Calculating correlation coefficients with repeated observations: Part 2 - Correlation between subjects
    • Bland JM, Altman DG. Calculating correlation coefficients with repeated observations: part 2 - correlation between subjects. BMJ 1995;310:633.
    • (1995) BMJ , vol.310 , pp. 633
    • Bland, J.M.1    Altman, D.G.2
  • 27
    • 0028926373 scopus 로고
    • Statistics notes: Calculating correlation coefficients with repeated observations: part 1 - Correlation within subjects
    • Bland JM, Altman DG. Statistics notes: calculating correlation coefficients with repeated observations: part 1 - correlation within subjects. BMJ 1995;310:446.
    • (1995) BMJ , vol.310 , pp. 446
    • Bland, J.M.1    Altman, D.G.2
  • 28
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff PM, Ansari R, Batist G, Cox J, Kocha W, Kuperminc M, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol 2001;19:2282-92.
    • (2001) J Clin Oncol , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3    Cox, J.4    Kocha, W.5    Kuperminc, M.6
  • 29
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
    • Van Cutsem E, Twelves C, Cassidy J, Allman D, Bajetta E, Boyer M, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol 2001;19:4097-106.
    • (2001) J Clin Oncol , vol.19 , pp. 4097-4106
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3    Allman, D.4    Bajetta, E.5    Boyer, M.6
  • 30
    • 17744418861 scopus 로고    scopus 로고
    • Randomized phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952
    • Kohne CH, Wils J, Lorenz M, Schoffski P, Voigtmann R, Bokemeyer C, et al. Randomized phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952. J Clin Oncol 2003;21:3721-8.
    • (2003) J Clin Oncol , vol.21 , pp. 3721-3728
    • Kohne, C.H.1    Wils, J.2    Lorenz, M.3    Schoffski, P.4    Voigtmann, R.5    Bokemeyer, C.6
  • 31
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, Navarro M, James RD, Karasek P, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000;355:1041-7.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3    Navarro, M.4    James, R.D.5    Karasek, P.6
  • 32
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group.NEngl JMed 2000;343:905-14.
    • (2000) NEngl JMed , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3    Rosen, L.S.4    Fehrenbacher, L.5    Moore, M.J.6
  • 33
    • 24644432555 scopus 로고    scopus 로고
    • Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986
    • Kohne CH, van Cutsem E, Wils J, Bokemeyer C, El-Serafi M, Lutz MP, et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol 2005;23:4856-65.
    • (2005) J Clin Oncol , vol.23 , pp. 4856-4865
    • Kohne, C.H.1    Van Cutsem, E.2    Wils, J.3    Bokemeyer, C.4    El-Serafi, M.5    Lutz, M.P.6
  • 34
    • 60549103258 scopus 로고    scopus 로고
    • Randomized study of weekly irinotecan plus high-dose 5-fluorouracil (FUIRI) versus biweekly irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) as first-line chemotherapy for patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors Study
    • Aranda E, Valladares M, Martinez-Villacampa M, Benavides M, Gomez A, Massutti B, et al. Randomized study of weekly irinotecan plus high-dose 5-fluorouracil (FUIRI) versus biweekly irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) as first-line chemotherapy for patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors Study. Ann Oncol 2009;20:251-7.
    • (2009) Ann Oncol , vol.20 , pp. 251-257
    • Aranda, E.1    Valladares, M.2    Martinez-Villacampa, M.3    Benavides, M.4    Gomez, A.5    Massutti, B.6
  • 35
    • 43049109526 scopus 로고    scopus 로고
    • A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer
    • Glimelius B, Sorbye H, Balteskard L, Bystrom P, Pfeiffer P, Tveit K, et al. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer. Ann Oncol 2008;19:909-14.
    • (2008) Ann Oncol , vol.19 , pp. 909-914
    • Glimelius, B.1    Sorbye, H.2    Balteskard, L.3    Bystrom, P.4    Pfeiffer, P.5    Tveit, K.6
  • 36
    • 79955506636 scopus 로고    scopus 로고
    • Intermittent versus continuous chemotherapy in advanced colorectal cancer: A randomised 'GISCAD' trial
    • Labianca R, Sobrero A, Isa L, Cortesi E, Barni S, Nicolella D, et al. Intermittent versus continuous chemotherapy in advanced colorectal cancer: a randomised 'GISCAD' trial. Ann Oncol 2011;22:1236-42.
    • (2011) Ann Oncol , vol.22 , pp. 1236-1242
    • Labianca, R.1    Sobrero, A.2    Isa, L.3    Cortesi, E.4    Barni, S.5    Nicolella, D.6
  • 37
    • 0033989203 scopus 로고    scopus 로고
    • Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    • Giacchetti S, Perpoint B, Zidani R, Le Bail N, Faggiuolo R, Focan C, et al. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2000;18:136-47.
    • (2000) J Clin Oncol , vol.18 , pp. 136-147
    • Giacchetti, S.1    Perpoint, B.2    Zidani, R.3    Le Bail, N.4    Faggiuolo, R.5    Focan, C.6
  • 38
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000;18:2938-47.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • De Gramont, A.1    Figer, A.2    Seymour, M.3    Homerin, M.4    Hmissi, A.5    Cassidy, J.6
  • 39
    • 0001120708 scopus 로고    scopus 로고
    • Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC)
    • abstr 512
    • Grothey A, Deschler B, Kroening H, Ridwelski K, Reichardt P, Kretzschmar A, et al. Phase III study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC). Proc Am Soc Clin Oncol 21: 2002 (abstr 512).
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Grothey, A.1    Deschler, B.2    Kroening, H.3    Ridwelski, K.4    Reichardt, P.5    Kretzschmar, A.6
  • 40
    • 77949324847 scopus 로고    scopus 로고
    • A randomized study comparing short-time infusion of oxaliplatin in combination with capecitabine XELOX(30) and chronomodulated XELOX(30) as first-line therapy in patients with advanced colorectal cancer
    • Qvortrup C, Jensen BV, Fokstuen T, Nielsen SE, Keldsen N, Glimelius B, et al. A randomized study comparing short-time infusion of oxaliplatin in combination with capecitabine XELOX(30) and chronomodulated XELOX(30) as first-line therapy in patients with advanced colorectal cancer. Ann Oncol 2010;21:87-91.
    • (2010) Ann Oncol , vol.21 , pp. 87-91
    • Qvortrup, C.1    Jensen, B.V.2    Fokstuen, T.3    Nielsen, S.E.4    Keldsen, N.5    Glimelius, B.6
  • 41
    • 34948892881 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial
    • Diaz-Rubio E, Tabernero J, Gomez-Espana A, Massuti B, Sastre J, Chaves M, et al. Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial. J Clin Oncol 2007;25:4224-30.
    • (2007) J Clin Oncol , vol.25 , pp. 4224-4230
    • Diaz-Rubio, E.1    Tabernero, J.2    Gomez-Espana, A.3    Massuti, B.4    Sastre, J.5    Chaves, M.6
  • 42
    • 60649088752 scopus 로고    scopus 로고
    • Two different first-line 5-fluorouracil regimens with or without oxaliplatin in patients with metastatic colorectal cancer
    • Cunningham D, Sirohi B, Pluzanska A, Utracka-Hutka B, Zaluski J, Glynne-Jones R, et al. Two different first-line 5-fluorouracil regimens with or without oxaliplatin in patients with metastatic colorectal cancer. Ann Oncol 2009;20:244-50.
    • (2009) Ann Oncol , vol.20 , pp. 244-250
    • Cunningham, D.1    Sirohi, B.2    Pluzanska, A.3    Utracka-Hutka, B.4    Zaluski, J.5    Glynne-Jones, R.6
  • 43
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer - A GERCOR study
    • Tournigand C, Cervantes A, Figer A, Lledo G, Flesch M, Buyse M, et al. OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer - a GERCOR study. J Clin Oncol 2006;24:394-400.
    • (2006) J Clin Oncol , vol.24 , pp. 394-400
    • Tournigand, C.1    Cervantes, A.2    Figer, A.3    Lledo, G.4    Flesch, M.5    Buyse, M.6
  • 44
    • 33747060772 scopus 로고    scopus 로고
    • Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: The European Organisation for Research and Treatment of Cancer Chronotherapy Group
    • Giacchetti S, Bjarnason G, Garufi C, Genet D, Iacobelli S, Tampellini M, et al. Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Cancer Chronotherapy Group. J Clin Oncol 2006;24:3562-9.
    • (2006) J Clin Oncol , vol.24 , pp. 3562-3569
    • Giacchetti, S.1    Bjarnason, G.2    Garufi, C.3    Genet, D.4    Iacobelli, S.5    Tampellini, M.6
  • 45
    • 33644681094 scopus 로고    scopus 로고
    • Randomised Phase III study of biweekly 24-h infusion of high-dose 5FU with folinic acid and oxaliplatin versus monthly plus 5-FU/folinic acid in first-line treatment of advanced colorectal cancer
    • Hospers GA, Schaapveld M, Nortier JW, Wils J, van Bochove A, de Jong RS, et al. Randomised Phase III study of biweekly 24-h infusion of high-dose 5FU with folinic acid and oxaliplatin versus monthly plus 5-FU/folinic acid in first-line treatment of advanced colorectal cancer. Ann Oncol 2006;17:443-9.
    • (2006) Ann Oncol , vol.17 , pp. 443-449
    • Hospers, G.A.1    Schaapveld, M.2    Nortier, J.W.3    Wils, J.4    Van Bochove, A.5    De Jong, R.S.6
  • 46
    • 34948857445 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO Colorectal Study Group
    • Porschen R, Arkenau HT, Kubicka S, Greil R, Seufferlein T, Freier W, et al. Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group. J Clin Oncol 2007;25:4217-23.
    • (2007) J Clin Oncol , vol.25 , pp. 4217-4223
    • Porschen, R.1    Arkenau, H.T.2    Kubicka, S.3    Greil, R.4    Seufferlein, T.5    Freier, W.6
  • 47
    • 78649873169 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX-6) as first-line treatment for metastatic colorectal cancer
    • Ducreux M, Bennouna J, Hebbar M, Ychou M, Lledo G, Conroy T, et al. Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX-6) as first-line treatment for metastatic colorectal cancer. Int J Cancer 2011;128:682-90.
    • (2011) Int J Cancer , vol.128 , pp. 682-690
    • Ducreux, M.1    Bennouna, J.2    Hebbar, M.3    Ychou, M.4    Lledo, G.5    Conroy, T.6
  • 48
    • 80053384385 scopus 로고    scopus 로고
    • Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): An open-label, randomised, phase 3 trial
    • Ducreux M, Malka D, Mendiboure J, Etienne PL, Texereau P, Auby D, et al. Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial. Lancet Oncol 2011;12:1032-44.
    • (2011) Lancet Oncol , vol.12 , pp. 1032-1044
    • Ducreux, M.1    Malka, D.2    Mendiboure, J.3    Etienne, P.L.4    Texereau, P.5    Auby, D.6
  • 49
    • 79959740774 scopus 로고    scopus 로고
    • XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results
    • Cassidy J, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results. Br J Cancer 2011;105:58-64.
    • (2011) Br J Cancer , vol.105 , pp. 58-64
    • Cassidy, J.1    Clarke, S.2    Diaz-Rubio, E.3    Scheithauer, W.4    Figer, A.5    Wong, R.6
  • 50
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, Andre T, Achille E, Lledo G, Flesh M, Mery-Mignard D, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004;22:229-37.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3    Lledo, G.4    Flesh, M.5    Mery-Mignard, D.6
  • 51
    • 24644457747 scopus 로고    scopus 로고
    • Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A multicenter study of the Gruppo Oncologico Dell'Italia Meridionale
    • Colucci G, Gebbia V, Paoletti G, Giuliani F, Caruso M, Gebbia N, et al. Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol 2005;23:4866-75.
    • (2005) J Clin Oncol , vol.23 , pp. 4866-4875
    • Colucci, G.1    Gebbia, V.2    Paoletti, G.3    Giuliani, F.4    Caruso, M.5    Gebbia, N.6
  • 52
    • 21344459245 scopus 로고    scopus 로고
    • Oxaliplatin plus high-dose folinic acid and 5-fluorouracil i.v. bolus (OXAFAFU) versus irinotecan plus high-dose folinic acid and 5-fluorouracil i.v. bolus (IRIFAFU) in patients with metastatic colorectal carcinoma: A Southern Italy Cooperative Oncology Group phase III trial
    • Comella P, Massidda B, Filippelli G, Palmeri S, Natale D, Farris A, et al. Oxaliplatin plus high-dose folinic acid and 5-fluorouracil i.v. bolus (OXAFAFU) versus irinotecan plus high-dose folinic acid and 5-fluorouracil i.v. bolus (IRIFAFU) in patients with metastatic colorectal carcinoma: a Southern Italy Cooperative Oncology Group phase III trial. Ann Oncol 2005;16:878-86.
    • (2005) Ann Oncol , vol.16 , pp. 878-886
    • Comella, P.1    Massidda, B.2    Filippelli, G.3    Palmeri, S.4    Natale, D.5    Farris, A.6
  • 53
    • 34447255724 scopus 로고    scopus 로고
    • Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): A randomised controlled trial
    • Seymour MT, Maughan TS, Ledermann JA, Topham C, James R, Gwyther SJ, et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial. Lancet 2007;370:143-52.
    • (2007) Lancet , vol.370 , pp. 143-152
    • Seymour, M.T.1    Maughan, T.S.2    Ledermann, J.A.3    Topham, C.4    James, R.5    Gwyther, S.J.6
  • 54
    • 34447277453 scopus 로고    scopus 로고
    • Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): A phase III randomised controlled trial
    • Koopman M, Antonini NF, Douma J, Wals J, Honkoop AH, Erdkamp FL, et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet 2007;370:135-42.
    • (2007) Lancet , vol.370 , pp. 135-142
    • Koopman, M.1    Antonini, N.F.2    Douma, J.3    Wals, J.4    Honkoop, A.H.5    Erdkamp, F.L.6
  • 55
    • 78650683300 scopus 로고    scopus 로고
    • Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer
    • Fischer von Weikersthal L, Schalhorn A, Stauch M, Quietzsch D, Maubach PA, Lambertz H, et al. Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer. Eur J Cancer 2011;47:206-14.
    • (2011) Eur J Cancer , vol.47 , pp. 206-214
    • Fischer Von Weikersthal, L.1    Schalhorn, A.2    Stauch, M.3    Quietzsch, D.4    Maubach, P.A.5    Lambertz, H.6
  • 56
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004;22:23-30.
    • (2004) J Clin Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6
  • 57
    • 34547097252 scopus 로고    scopus 로고
    • Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX): Intergroup trial N9741 in first-line treatment of metastatic colorectal cancer
    • Ashley AC, Sargent DJ, Alberts SR, Grothey A, Campbell ME, Morton RF, et al. Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX): intergroup trial N9741 in first-line treatment of metastatic colorectal cancer. Cancer 2007;110:670-7.
    • (2007) Cancer , vol.110 , pp. 670-677
    • Ashley, A.C.1    Sargent, D.J.2    Alberts, S.R.3    Grothey, A.4    Campbell, M.E.5    Morton, R.F.6
  • 58
    • 33645309877 scopus 로고    scopus 로고
    • FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): A multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG)
    • Souglakos J, Androulakis N, Syrigos K, Polyzos A, Ziras N, Athanasiadis A, et al. FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG). Br J Cancer 2006;94:798-805.
    • (2006) Br J Cancer , vol.94 , pp. 798-805
    • Souglakos, J.1    Androulakis, N.2    Syrigos, K.3    Polyzos, A.4    Ziras, N.5    Athanasiadis, A.6
  • 59
    • 34249000361 scopus 로고    scopus 로고
    • Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest
    • Falcone A, Ricci S, Brunetti I, Pfanner E, Allegrini G, Barbara C, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 2007;25:1670-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1670-1676
    • Falcone, A.1    Ricci, S.2    Brunetti, I.3    Pfanner, E.4    Allegrini, G.5    Barbara, C.6
  • 60
    • 78651297593 scopus 로고    scopus 로고
    • Randomized trial of two induction chemotherapy regimens in metastatic colorectal cancer: An updated analysis
    • Masi G, Vasile E, Loupakis F, Cupini S, Fornaro L, Baldi G, et al. Randomized trial of two induction chemotherapy regimens in metastatic colorectal cancer: an updated analysis. J Natl Cancer Inst 2011;103:21-30.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 21-30
    • Masi, G.1    Vasile, E.2    Loupakis, F.3    Cupini, S.4    Fornaro, L.5    Baldi, G.6
  • 61
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, Patel T, Hamm JT, Hecht JR, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005;23:3697-705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3    Patel, T.4    Hamm, J.T.5    Hecht, J.R.6
  • 62
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 63
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008;26:2013-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3    Scheithauer, W.4    Figer, A.5    Wong, R.6
  • 64
    • 77955232505 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab (BEV)-based combination regimens in patients with metastatic colorectal cancer (mCRC): Randomized phase II study of BEV + FOLFIRI versus BEV + XELIRI (FNCLCC ACCORD 13/0503 study)
    • abstr 4086
    • Ducreux M, Adenis A, Mendiboure J, Francois E, Boucher E, Chauffert B, et al. Efficacy and safety of bevacizumab (BEV)-based combination regimens in patients with metastatic colorectal cancer (mCRC): randomized phase II study of BEV + FOLFIRI versus BEV + XELIRI (FNCLCC ACCORD 13/0503 study). J Clin Oncol 27:15s, 2009 (suppl; abstr 4086).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Ducreux, M.1    Adenis, A.2    Mendiboure, J.3    Francois, E.4    Boucher, E.5    Chauffert, B.6
  • 65
    • 77955497309 scopus 로고    scopus 로고
    • Capecitabine, bevacizumab and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group Randomized, Phase III MAX Study
    • Tebbutt NC, Wilson K, Gebski VJ, Cummins MM, Zannino D, van Hazel GA, et al. Capecitabine, bevacizumab and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized, Phase III MAX Study. J Clin Oncol 2010;28:3191-8.
    • (2010) J Clin Oncol , vol.28 , pp. 3191-3198
    • Tebbutt, N.C.1    Wilson, K.2    Gebski, V.J.3    Cummins, M.M.4    Zannino, D.5    Van Hazel, G.A.6
  • 66
    • 84856304557 scopus 로고    scopus 로고
    • First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: The phase III MACRO TTD study
    • Diaz-Rubio E, Gomez-Espana A, Massuti B, Sastre J, Abad A, Valladares M, et al. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the phase III MACRO TTD study. Oncologist 2012;17:15-25.
    • (2012) Oncologist , vol.17 , pp. 15-25
    • Diaz-Rubio, E.1    Gomez-Espana, A.2    Massuti, B.3    Sastre, J.4    Abad, A.5    Valladares, M.6
  • 67
    • 84862991983 scopus 로고    scopus 로고
    • XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: A Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis
    • Pectasides D, Papaxoinis G, Kalogeras K, Eleftheraki A, Xanthakis I, Makatsoris T, et al. XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: a Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis. BMC Cancer 2012;12:271.
    • (2012) BMC Cancer , vol.12 , pp. 271
    • Pectasides, D.1    Papaxoinis, G.2    Kalogeras, K.3    Eleftheraki, A.4    Xanthakis, I.5    Makatsoris, T.6
  • 68
    • 80054779014 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: A randomized phase III ARTIST trial
    • Guan ZZ, Xu JM, Luo RC, Feng FY, Wang LW, Shen L, et al. Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: a randomized phase III ARTIST trial. Chin J Cancer 2011;30:682-9.
    • (2011) Chin J Cancer , vol.30 , pp. 682-689
    • Guan, Z.Z.1    Xu, J.M.2    Luo, R.C.3    Feng, F.Y.4    Wang, L.W.5    Shen, L.6
  • 69
    • 84856435741 scopus 로고    scopus 로고
    • Randomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/metastatic colorectal cancer (mCRC)
    • Souglakos J, Ziras N, Kakolyris S, Boukovinas I, Kentepozidis N, Makrantonakis P, et al. Randomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/metastatic colorectal cancer (mCRC). Br J Cancer 2012;106:453-9.
    • (2012) Br J Cancer , vol.106 , pp. 453-459
    • Souglakos, J.1    Ziras, N.2    Kakolyris, S.3    Boukovinas, I.4    Kentepozidis, N.5    Makrantonakis, P.6
  • 70
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I, Folprecht G, Nowacki MP, Cascinu S, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011;29:2011-9.
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3    Folprecht, G.4    Nowacki, M.P.5    Cascinu, S.6
  • 71
    • 78649745934 scopus 로고    scopus 로고
    • Identification of potentially responsive subsets when cetuximab is added to oxaliplatin-fluoropyrimidine chemotherapy (CT) in first-line advanced colorectal cancer (aCRC): Mature results of the MRC COIN trial
    • abstr 3502
    • Maughan TS, Adams R, Smith CG, Seymour MT, Wilson RH, Meade AM, et al. Identification of potentially responsive subsets when cetuximab is added to oxaliplatin-fluoropyrimidine chemotherapy (CT) in first-line advanced colorectal cancer (aCRC): mature results of the MRC COIN trial. J Clin Oncol 28:15s, 2010 (suppl; abstr 3502).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Maughan, T.S.1    Adams, R.2    Smith, C.G.3    Seymour, M.T.4    Wilson, R.H.5    Meade, A.M.6
  • 72
    • 79959571031 scopus 로고    scopus 로고
    • Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Adams RA, Meade AM, Seymour MT, Wilson RH, Madi A, Fisher D, et al. Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet Oncol 2011;12:642-53.
    • (2011) Lancet Oncol , vol.12 , pp. 642-653
    • Adams, R.A.1    Meade, A.M.2    Seymour, M.T.3    Wilson, R.H.4    Madi, A.5    Fisher, D.6
  • 73
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009;27:663-71.
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    De Braud, F.6
  • 74
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009;27:672-80.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6
  • 75
    • 84860785653 scopus 로고    scopus 로고
    • Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer
    • Saltz L, Badarinath S, Dakhil S, Bienvenu B, Harker WG, Birchfield G, et al. Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer. Clin Colorectal Cancer 2012;11:101-11.
    • (2012) Clin Colorectal Cancer , vol.11 , pp. 101-111
    • Saltz, L.1    Badarinath, S.2    Dakhil, S.3    Bienvenu, B.4    Harker, W.G.5    Birchfield, G.6
  • 77
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
    • Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 2011;22:1535-46.
    • (2011) Ann Oncol , vol.22 , pp. 1535-1546
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3    De Braud, F.4    Schuch, G.5    Zubel, A.6
  • 78
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010;28:4697-705.
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3    Tabernero, J.4    Burkes, R.5    Barugel, M.6
  • 81
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT, Wilson RH, et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011;377:2103-14.
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3    Meade, A.M.4    Seymour, M.T.5    Wilson, R.H.6
  • 82
    • 79952768031 scopus 로고    scopus 로고
    • Cetuximab plus capecitabine and irinotecan compared with cetuximab plus capecitabine and oxaliplatin as first-line treatment for patients with metastatic colorectal cancer: AIO KRK-0104 - A randomized trial of the German AIO CRC study group
    • Moosmann N, von Weikersthal LF, Vehling-Kaiser U, Stauch M, Hass HG, Dietzfelbinger H, et al. Cetuximab plus capecitabine and irinotecan compared with cetuximab plus capecitabine and oxaliplatin as first-line treatment for patients with metastatic colorectal cancer: AIO KRK-0104 - a randomized trial of the German AIO CRC study group. J Clin Oncol 2011;29:1050-8.
    • (2011) J Clin Oncol , vol.29 , pp. 1050-1058
    • Moosmann, N.1    Von Weikersthal, L.F.2    Vehling-Kaiser, U.3    Stauch, M.4    Hass, H.G.5    Dietzfelbinger, H.6
  • 83
    • 79952153189 scopus 로고    scopus 로고
    • LBA20 - Randomized phase III study of 5-fluorouracil/folinate/oxaliplatin given continuously or intermittently with or without cetuximab, as first-line treatment of metastatic colorectal cancer: The nordic VII study (NCT00145314), by the Nordic Colorectal Cancer Biomodulation Group
    • Tveit K, Guren T, Glimelius B, Pfeiffer P, Sorbye H, Pyrhonen S, et al. LBA20 - randomized phase III study of 5-fluorouracil/folinate/oxaliplatin given continuously or intermittently with or without cetuximab, as first-line treatment of metastatic colorectal cancer: the nordic VII study (NCT00145314), by the Nordic Colorectal Cancer Biomodulation Group. Ann Oncol ESMO 2010 late-breaking abstracts LBA 20. 2010;21(Suppl 8):LBA20.
    • (2010) Ann Oncol ESMO 2010 Late-breaking Abstracts LBA 20 , vol.21 , Issue.SUPPL. 8
    • Tveit, K.1    Guren, T.2    Glimelius, B.3    Pfeiffer, P.4    Sorbye, H.5    Pyrhonen, S.6
  • 84
    • 84861198824 scopus 로고    scopus 로고
    • Biologic therapies in the metastatic colorectal cancer treatment continuum-applying current evidence to clinical practice
    • Peeters M, Price T. Biologic therapies in the metastatic colorectal cancer treatment continuum-applying current evidence to clinical practice. Cancer Treat Rev 2012;38:397-406.
    • (2012) Cancer Treat Rev , vol.38 , pp. 397-406
    • Peeters, M.1    Price, T.2
  • 85
    • 5444269445 scopus 로고    scopus 로고
    • Meta-analyses based on abstracted data: A step in the right direction, but only a first step
    • Piedbois P, Buyse M. Meta-analyses based on abstracted data: a step in the right direction, but only a first step. J Clin Oncol 2004;22:3839-41.
    • (2004) J Clin Oncol , vol.22 , pp. 3839-3841
    • Piedbois, P.1    Buyse, M.2
  • 86
    • 80755155711 scopus 로고    scopus 로고
    • Alternative end points to evaluate a therapeutic strategy in advanced colorectal cancer: Evaluation of progression-free survival, duration of disease control, and time to failure of strategy - An Aide et Recherche en Cancérologie Digestive Group Study
    • Chibaudel B, Bonnetain F, Shi Q, Buyse M, Tournigand C, Sargent DJ, et al. Alternative end points to evaluate a therapeutic strategy in advanced colorectal cancer: evaluation of progression-free survival, duration of disease control, and time to failure of strategy - an Aide et Recherche en Cancérologie Digestive Group Study. J Clin Oncol 2011;29:4199-204.
    • (2011) J Clin Oncol , vol.29 , pp. 4199-4204
    • Chibaudel, B.1    Bonnetain, F.2    Shi, Q.3    Buyse, M.4    Tournigand, C.5    Sargent, D.J.6
  • 87
    • 68949094312 scopus 로고    scopus 로고
    • Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy
    • Kopetz S, Chang GJ, Overman MJ, Eng C, Sargent DJ, Larson DW, et al. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 2009;27:3677-83.
    • (2009) J Clin Oncol , vol.27 , pp. 3677-3683
    • Kopetz, S.1    Chang, G.J.2    Overman, M.J.3    Eng, C.4    Sargent, D.J.5    Larson, D.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.