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Volumn 105, Issue 1, 2011, Pages 58-64

XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results

Author keywords

5 fluorouracil folinic acid; capecitabine; colorectal cancer; overall survival; oxaliplatin

Indexed keywords

BEVACIZUMAB; CAPECITABINE; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; PLACEBO;

EID: 79959740774     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.201     Document Type: Article
Times cited : (201)

References (18)
  • 3
    • 79959700257 scopus 로고    scopus 로고
    • XELOX vs FOLFOX4: Update of efficacy results from XELOX-1/NO16966, a randomized phase III trial of first-line treatment for patients (pts) with metastatic colorectal cancer (MCRC)
    • Florida, USA, 25-27 January
    • Cassidy J, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Sirzen F, Gilberg F, Saltz L (2008b) XELOX vs FOLFOX4: update of efficacy results from XELOX-1/NO16966, a randomized phase III trial of first-line treatment for patients (pts) with metastatic colorectal cancer (MCRC). Presented at the ASCO GI Cancers Symposium: Orlando, Florida, USA, 25-27 January (abstract 341)
    • (2008) ASCO GI Cancers Symposium: Orlando , pp. 341
    • Cassidy, J.1    Clarke, S.2    Diaz-Rubio, E.3    Scheithauer, W.4    Figer, A.5    Wong, R.6    Koski, S.7    Sirzen, F.8    Gilberg, F.9    Saltz, L.10
  • 4
    • 63449087000 scopus 로고    scopus 로고
    • Costs associated with complications are lower with capecitabine than with 5-fluorouracil in patients with colorectal cancer
    • Chu E, Schulman KL, Zelt S (2009) Costs associated with complications are lower with capecitabine than with 5-fluorouracil in patients with colorectal cancer. Cancer 115: 1412-1423
    • (2009) Cancer , vol.115 , pp. 1412-1423
    • Chu, E.1    Schulman, K.L.2    Zelt, S.3
  • 5
    • 65849108886 scopus 로고    scopus 로고
    • Randomised trial comparing biweekly oxalipla-tin plus oral capecitabine versus oxaliplatin plus i.v. bolus fluorouracil/ leucovorin in metastatic colorectal cancer patients: Results of the Southern Italy Cooperative Oncology study 0401
    • Southern Italy Cooperative Oncology Group
    • Comella P, Massidda B, Filippelli G, Farris A, Natale D, Barberis G, Maiorino L, Palmeri S, Condemi G, Southern Italy Cooperative Oncology Group (2009) Randomised trial comparing biweekly oxalipla-tin plus oral capecitabine versus oxaliplatin plus i.v. bolus fluorouracil/ leucovorin in metastatic colorectal cancer patients: results of the Southern Italy Cooperative Oncology study 0401. J Cancer Res Clin Oncol 135: 217-226
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 217-226
    • Comella, P.1    Massidda, B.2    Filippelli, G.3    Farris, A.4    Natale, D.5    Barberis, G.6    Maiorino, L.7    Palmeri, S.8    Condemi, G.9
  • 6
    • 79959726614 scopus 로고    scopus 로고
    • Capecitabine (CAP) versus 5-fluorouracil (FU) in combination with oxaliplatin (OX) as 1st-line chemotherapy (CT) for advanced colorectal cancer (ACRC): Meta-analysis of randomized clinical trials (RCT)
    • (Suppl; abstract 4056)
    • Cuppone F, Bria E, Sperduti I, Di Maio M, Carlini P, Milella M, Cognetti F, Terzoli E, Giannarelli D (2008) Capecitabine (CAP) versus 5-fluorouracil (FU) in combination with oxaliplatin (OX) as 1st-line chemotherapy (CT) for advanced colorectal cancer (ACRC): meta-analysis of randomized clinical trials (RCT). J Clin Oncol 26: 192s (Suppl; abstract 4056)
    • (2008) J Clin Oncol , vol.26
    • Cuppone, F.1    Bria, E.2    Sperduti, I.3    Di Maio, M.4    Carlini, P.5    Milella, M.6    Cognetti, F.7    Terzoli, E.8    Giannarelli, D.9
  • 8
    • 34948892881 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish Cooperative Group for the treatment of digestive tumors trial
    • DOI 10.1200/JCO.2006.09.8467
    • D́az-Rubio E, Tabernero J, Gómez-España A, Massut́ B, Sastre J, Chaves M, Abad A, Carrato A, Queralt B, Reina JJ, Maurel J, González-Flores E, Aparicio J, Rivera F, Losa F, Aranda E, Spanish Cooperative Group for the Treatment of Digestive Tumors Trial (2007) Phase III study of capecitabine plus oxaliplatin versus continuous infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors trial. J Clin Oncol 25: 4224-4230 (Pubitemid 47548562)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.27 , pp. 4224-4230
    • Diaz-Rubio, E.1    Tabernero, J.2    Gomez-Espana, A.3    Massuti, B.4    Sastre, J.5    Chaves, M.6    Abad, A.7    Carrato, A.8    Queralt, B.9    Reina, J.J.10    Maurel, J.11    Gonzalez-Flores, E.12    Aparicio, J.13    Rivera, F.14    Losa, F.15    Aranda, E.16
  • 9
    • 2342443299 scopus 로고    scopus 로고
    • Is overall survival a realistic primary end point in advanced colorectal cancer studies? A critical assessment based on four clinical trials comparing fluorouracil plus leucovorin with the same treatment combined either with oxaliplatin or with CPT-11
    • DOI 10.1093/annonc/mdh127
    • Di Leo A, Buyse M, Bleiberg H (2004) Is overall survival a realistic primary end point in advanced colorectal cancer studies? A critical assessment based on four clinical trials comparing fluorouracil plus leucovorin with the same treatment combined either with oxaliplatin or with CPT-11. Ann Oncol 15: 545-549 (Pubitemid 38559586)
    • (2004) Annals of Oncology , vol.15 , Issue.4 , pp. 545-549
    • Di Leo, A.1    Buyse, M.2    Bleiberg, H.3
  • 10
    • 78649873169 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX-6) as first-line treatment for metastatic colorectal cancer
    • GI Group of the French Anti-Cancer Centers
    • Ducreux M, Bennouna J, Hebbar M, Ychou M, Lledo G, Conroy T, Adenis A, Faroux R, Rebischung C, Bergougnoux L, Kockler L, Douillard JY, GI Group of the French Anti-Cancer Centers (2011) Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX-6) as first-line treatment for metastatic colorectal cancer. Int J Cancer 128: 682-690
    • (2011) Int J Cancer , vol.128 , pp. 682-690
    • Ducreux, M.1    Bennouna, J.2    Hebbar, M.3    Ychou, M.4    Lledo, G.5    Conroy, T.6    Adenis, A.7    Faroux, R.8    Rebischung, C.9    Bergougnoux, L.10    Kockler, L.11    Douillard, J.Y.12
  • 11
    • 40749096576 scopus 로고    scopus 로고
    • Cost comparison of XELOX compared to FOLFOX4 with or without bevacizumab (bev) in metastatic colorectal cancer
    • (Suppl, abstract 4074)
    • Garrison L, Cassidy J, Saleh M, Lee F, Mena R, Fuloria J, Chang V, Ervin T, Stella P, Saltz L (2007) Cost comparison of XELOX compared to FOLFOX4 with or without bevacizumab (bev) in metastatic colorectal cancer. J Clin Oncol 25: 18S (Suppl, abstract 4074)
    • (2007) J Clin Oncol , vol.25
    • Garrison, L.1    Cassidy, J.2    Saleh, M.3    Lee, F.4    Mena, R.5    Fuloria, J.6    Chang, V.7    Ervin, T.8    Stella, P.9    Saltz, L.10
  • 13
    • 34948857445 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO colorectal study group
    • DOI 10.1200/JCO.2006.09.2684
    • Porschen R, Arkenau H-T, Kubicka S, Greil R, Seufferlein T, Freier W, Kretzschmar A, Graeven U, Grothey A, Hinke A, Schmiegel W, Schmoll HJ, AIO Colorectal Study Group (2007) Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group. J Clin Oncol 25: 4217-4223 (Pubitemid 47548561)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.27 , pp. 4217-4223
    • Porschen, R.1    Arkenau, H.-T.2    Kubicka, S.3    Greil, R.4    Seufferlein, T.5    Freier, W.6    Kretzschmar, A.7    Graeven, U.8    Grothey, A.9    Hinke, A.10    Schmiegel, W.11    Schmoll, H.-J.12
  • 14
    • 53049092394 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: A randomized phase III noninferiority study
    • Rothenberg ML, Cox JV, Butts C, Navarro M, Bang YJ, Goel R, Gollins S, Siu LL, Laguerre S, Cunningham D (2008) Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study. Ann Oncol 19: 1720-1726
    • (2008) Ann Oncol , vol.19 , pp. 1720-1726
    • Rothenberg, M.L.1    Cox, J.V.2    Butts, C.3    Navarro, M.4    Bang, Y.J.5    Goel, R.6    Gollins, S.7    Siu, L.L.8    Laguerre, S.9    Cunningham, D.10
  • 16
    • 51849110732 scopus 로고    scopus 로고
    • A comparison of medical resource use for 4 chemotherapy regimens as first-line treatment for metastatic colorectal cancer (MCRC): XELOX vs. FOLFOX4 ± bevacizumab (A)
    • (Suppl, abstract 4098)
    • Scheithauer W, Cassidy J, Figer A, Wong R, Koski S, Lichinitser M, Yang T, Clarke S, Diaz-Rubio E, Garrison L (2007) A comparison of medical resource use for 4 chemotherapy regimens as first-line treatment for metastatic colorectal cancer (MCRC): XELOX vs. FOLFOX4 ± bevacizumab (A). J Clin Oncol 25: 18S (Suppl, abstract 4098)
    • (2007) J Clin Oncol , vol.25
    • Scheithauer, W.1    Cassidy, J.2    Figer, A.3    Wong, R.4    Koski, S.5    Lichinitser, M.6    Yang, T.7    Clarke, S.8    Diaz-Rubio, E.9    Garrison, L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.