Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation

Cytokine

Volumn 59, Issue 2, 2012, Pages 252-257

  Yago, Toru ^a   Nanke, Yuki ^a   Kawamoto, Manabu ^a   Yamanaka, Hisashi ^a   Kotake, Shigeru ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Interkeukin 17; Osteoclasts; Tacrolimus; Th17

Indexed keywords

CD14 ANTIGEN; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN RECEPTOR;

ARTICLE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOLOGY; LYMPHOCYTE DIFFERENTIATION; MONOCYTE; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH17 CELL;

CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MONOCYTES; OSTEOCLASTS; OSTEOGENESIS; TACROLIMUS; TH17 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862316213     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.04.012     Document Type: Article

References (24)

1. Kotake S., Sato K., Kim K.J., Takahashi N., Udagawa N., Nakamura I., et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 1996, 11:88-95.
2. Kotake S., Udagawa N., Takahashi N., Matsuzaki K., Itoh K., Ishiyama S., et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999, 103:1345-1352.
3. Kotake S., Nanke Y., Yago T., Kawamoto M., Yamanaka H. Human osteoclastogenic T cells and human osteoclastology. Arthritis Rheum 2009, 60:3158-3163.
4. Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006, 203:2673-2682.
5. Ghoreschi K., Laurence A., Yang X.P., Tato C.M., McGeachy M.J., Konkel J.E., et al. Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature 2010, 467:967-971.
6. Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., et al. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 2007, 9:R96.
7. Sakuma S., Kato Y., Nishigaki F., Sasakawa T., Magari K., Miyata S., et al. FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. Br J Pharmacol 2000, 130:1655-1663.
8. Sakuma S., Kato Y., Nishigaki F., Magari K., Miyata S., Ohkubo Y., et al. Effects of FK506 and other immunosuppressive anti-rheumatic agents on T cell activation mediated IL-6 and IgM production in vitro. Int Immunopharmacol 2001, 1:749-757.
9. Neylan J.F. Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine. FK506 Kidney Transplant Study Group. Transplantation 1998, 65:515-523.
10. Ruzicka T., Bieber T., Schöpf E., Rubins A., Dobozy A., Bos J.D., et al. A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. N Engl J Med 1997, 337:816-821.
11. Kondo H., Abe T., Hashimoto H., Uchida S., Irimajiri S., Hara M., et al. Efficacy and safety of tacrolimus (FK506) in treatment of rheumatoid arthritis: a randomized, double blind, placebo controlled dose-finding study. J Rhuemtol 2004, 31:243-251.
12. Kotake S., Nanke Y., Mogi M., Kawamoto M., Furuya T., Yago T., et al. IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur J Immunol 2005, 35:3353-3363.
13. Liu H., Rohowsky-Kochan C. Regulation of IL-17 in human CCR6+ effector memory T cells. J Immunol 2008, 180:7948-7957.
14. Yago T., Nanke Y., Ichikawa N., Kobashigawa T., Mogi M., Kamatani N., et al. IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17. J Cell Biochem 2009, 108:947-955.
15. Tocci M.J., Matkovich D.A., Collier K.A., Kwok P., Dumont F., Lin S., et al. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol 1989, 143:718-726.
16. Andersson J., Nagy S., Groth C.G., Andersson U. Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. Immunology 1992, 75:136-142.
17. Miyazaki M., Fujikawa Y., Takita C., Tsumura H. Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis. Clin Rheumatol 2007, 26:231-239.
18. Igarashi K., Hirotani H., Woo J.T., Stern P.H. Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone 2004, 35:47-56.
19. Kawai S., Yamamoto K. Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients. Rheumatology (Oxford) 2006, 45:441-444.
20. Acosta-Rodriguez E.V., Rivino L., Geginat J., Jarrossay D., Gattorno M., Lanzavecchia A., et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007, 8:639-646.
21. Wilson N.J., Boniface K., Chan J.R., McKenzie B.S., Blumenschein W.M., Mattson J.D., et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007, 8:950-957.
22. Chen Z., Tato C.M., Muul L., Laurence A., O'Shea J.J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rhuem 2007, 56:2936-2946.
23. Leipe J., Grunke M., Dechant C., Reindl C., Kerzendorf U., Schulze-Koops H., et al. Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum 2010, 62:2876-2885.
24. Van Bezooijen R.L., Van Der Wee-Pals L., Papapoulos S.E., Löwik C.W. Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Ann Rheum Dis 2002, 61:870-876.