20-hydroxyecdysone-induced bone morphogenetic protein-2-dependent osteogenic differentiation through the ERK pathway in human periodontal ligament stem cells

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 48-56

  Jian, Cong Xiang ^a   Liu, Xiao Fei ^b   Hu, Jun ^a   Li, Chen Jun ^c   Zhang, Gang ^a   Li, Yan ^a   Zhu, Ji Wen ^d   Tan, Ying Hui ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b JINAN MILITARY GENERAL HOSPITAL   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

^d Department of Emergency   (China)

Author keywords

20 Hydroxyecdysone; Bone morphogenetic protein 2; ERK; Osteogenic differentiation; Periodontal ligament stem cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; ECDYSTERONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NOGGIN; TRANSCRIPTION FACTOR RUNX2;

ADOLESCENT; ADULT; ALKALINE PHOSPHATASE GENE; ARTICLE; BONE MORPHOGENETIC PROTEIN 2 GENE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; GENE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; OSSIFICATION; OSTEOBLAST; OSTEOCALCIN GENE; PERIODONTAL LIGAMENT; PERIODONTAL LIGAMENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RUNT RELATED TRANSCRIPTION FACTOR 2 GENE; TYPE 1 COLLAGEN GENE;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL PROLIFERATION; ECDYSTERONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; OSTEOGENESIS; PERIODONTAL LIGAMENT; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84871928493     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.044     Document Type: Article

References (46)

1. J.M. Albandar, and A. Kingman Gingival recession, gingival bleeding, and dental calculus in adults 30 years of age and older in the United States, 1988-1994 J. Periodontol. 70 1999 30 43
2. S. Auzoux-Bordenave, P.J. Hatt, and P. Porcheron Anti-proliferative effect of 20-hydroxyecdysone in a lepidopteran cell line Insect Biochem. Mol. Biol. 32 2002 217 223 (Pubitemid 34076086)
3. N. Beyer Nardi, and L. da Silva Meirelles Mesenchymal stem cells: isolation, in vitro expansion and characterization Handb. Exp. Pharmacol. 2006 249 282
4. R.E. Catalan, A.M. Martinez, M.D. Aragones, B.G. Miguel, A. Robles, and J.E. Godoy Alterations in rat lipid metabolism following ecdysterone treatment Comp. Biochem. Physiol. B 81 1985 771 775
5. A. Daluiski, T. Engstrand, M.E. Bahamonde, L.W. Gamer, E. Agius, S.L. Stevenson, K. Cox, V. Rosen, and K.M. Lyons Bone morphogenetic protein-3 is a negative regulator of bone density Nat. Genet. 27 2001 84 88 (Pubitemid 32044524)
6. P. Eickholz, T. Horr, F. Klein, S. Hassfeld, and T.S. Kim Radiographic parameters for prognosis of periodontal healing of infrabony defects: two different definitions of defect depth J. Periodontol. 75 2004 399 407 (Pubitemid 38461123)
7. T.F. Flemmig Periodontitis Ann. Periodontol. 4 1999 32 38
8. H. Fujiwara, and S. Ogai Ecdysteroid-induced programmed cell death and cell proliferation during pupal wing development of the silkworm Bombyx mori Dev. Genes Evol. 211 2001 118 123 (Pubitemid 32821492)
9. S. Gallea, F. Lallemand, A. Atfi, G. Rawadi, V. Ramez, S. Spinella-Jaegle, S. Kawai, C. Faucheu, L. Huet, R. Baron, and S. Roman-Roman Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells Bone 28 2001 491 498 (Pubitemid 32410000)
10. L. Gao, G. Cai, and X. Shi Beta-ecdysterone induces osteogenic differentiation in mouse mesenchymal stem cells and relieves osteoporosis Biol. Pharm. Bull. 31 2008 2245 2249
11. I.C. Gay, S. Chen, and M. MacDougall Isolation and characterization of multipotent human periodontal ligament stem cells Orthod. Craniofac. Res. 10 2007 149 160
12. N. Ghosh-Choudhury, C.C. Mandal, and G.G. Choudhury Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation J. Biol. Chem. 282 2007 4983 4993 (Pubitemid 47100994)
13. S. Ivanovski, S. Gronthos, S. Shi, and P.M. Bartold Stem cells in the periodontal ligament Oral Dis. 12 2006 358 363 (Pubitemid 43926812)
14. Y.Y. Jo, H.J. Lee, S.Y. Kook, H.W. Choung, J.Y. Park, J.H. Chung, Y.H. Choung, E.S. Kim, H.C. Yang, and P.H. Choung Isolation and characterization of postnatal stem cells from human dental tissues Tissue Eng. 13 2007 767 773
15. E. Karner, C.M. Backesjo, J. Cedervall, R.V. Sugars, L. Ahrlund-Richter, and M. Wendel Dynamics of gene expression during bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro Biochim. Biophys. Acta 1790 2009 110 118
16. I.S. Kim, B.C. Jeong, O.S. Kim, Y.J. Kim, S.E. Lee, K.N. Lee, J.T. Koh, and H.J. Chung Lactone form 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) stimulate the osteoblastic differentiation of mouse periodontal ligament cells via the ERK pathway J. Periodontal Res. 46 2011 204 213
17. R. Lafont, and L. Dinan Practical uses for ecdysteroids in mammals including humans: an update J. Insect Sci. 3 2003 7
18. C.F. Lai, L. Chaudhary, A. Fausto, L.R. Halstead, D.S. Ory, L.V. Avioli, and S.L. Cheng Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells J. Biol. Chem. 276 2001 14443 14450
19. B. Lindroos, K. Maenpaa, T. Ylikomi, H. Oja, R. Suuronen, and S. Miettinen Characterisation of human dental stem cells and buccal mucosa fibroblasts J. Biochem. Biophys. Res. Commun. 368 2008 329 335
20. R. Luedeman, and R.B. Levine Neurons and ecdysteroids promote the proliferation of myogenic cells cultured from the developing adult legs of Manduca sexta Dev. Biol. 173 1996 51 68 (Pubitemid 26063418)
21. H. Matsuda, T. Kawaba, and Y. Yamamoto Pharmacological studies of insect metamorphotic steroids Nihon Yakurigaku Zasshi 66 1970 551 563
22. K. Mimori, M. Komaki, K. Iwasaki, and I. Ishikawa Extracellular signal-regulated kinase 1/2 is involved in ascorbic acid-induced osteoblastic differentiation in periodontal ligament cells J. Periodontol. 78 2007 328 334
23. K. Nagatomo, M. Komaki, I. Sekiya, Y. Sakaguchi, K. Noguchi, S. Oda, T. Muneta, and I. Ishikawa Stem cell properties of human periodontal ligament cells J. Periodontal Res. 41 2006 303 310 (Pubitemid 44392300)
24. S. Namura, H. Maeno, S. Takami, X.F. Jiang, S. Kamichi, K. Wada, and I. Nagata Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice Neurosci. Lett. 324 2002 117 120 (Pubitemid 34457818)
25. I. Oehme, S. Bosser, and M. Zornig Agonists of an ecdysone-inducible mammalian expression system inhibit Fas ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO Cell Death Differ. 13 2006 189 201 (Pubitemid 43102203)
26. N. Ozeki, P. Jethanandani, H. Nakamura, B.L. Ziober, and R.H. Kramer Modulation of satellite cell adhesion and motility following BMP2-induced differentiation to osteoblast lineage Biochem. Biophys. Res. Commun. 353 2007 54 59 (Pubitemid 44958340)
27. F. Pan, R. Zhang, G. Wang, and Y. Ding Oestrogen receptors are involved in the osteogenic differentiation of periodontal ligament stem cells Biosci. Rep. 31 2011 117 124
28. J.Y. Park, S.H. Jeon, and P.H. Choung Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis Cell Transplant. 20 2011 271 285
29. Y. Peng, Q. Kang, H. Cheng, X. Li, M.H. Sun, W. Jiang, H.H. Luu, J.Y. Park, R.C. Haydon, and T.C. He Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling J. Cell. Biochem. 90 2003 1149 1165 (Pubitemid 37485051)
30. R.M. Pluta, J.K.B. Afshar, R.J. Boock, and E.H. Oldfield Temporal changes in perivascular concentrations of oxyhemoglobin, deoxyhemoglobin, and methemoglobin after subarachnoid hemorrhage J. Neurosurg. 88 1998 557 561 (Pubitemid 28114731)
31. M.N. Rahaman, and J.J. Mao Stem cell-based composite tissue constructs for regenerative medicine J. Biotechnol. Bioeng. 91 2005 261 284 (Pubitemid 41076840)
32. V. Rosen BMP2 signaling in bone development and repair Cytokine Growth Factor Rev. 20 2009 475 480
33. B.M. Seo, M. Miura, S. Gronthos, P.M. Bartold, S. Batouli, J. Brahim, M. Young, P.G. Robey, C.Y. Wang, and S. Shi Investigation of multipotent postnatal stem cells from human periodontal ligament Lancet 364 2004 149 155 (Pubitemid 38891686)
34. K. Sláma Ecdysteroids: insect hormones, plant defensive factors, or human medicine? Phytoparasitica 21 1993 3 8
35. G. Smagghe, W. Vanhassel, C. Moeremans, D. De Wilde, S. Goto, M.J. Loeb, M.B. Blackburn, and R.S. Hakim Stimulation of midgut stem cell proliferation and differentiation by insect hormones and peptides Ann. N.Y. Acad. Sci. 1040 2005 472 475 (Pubitemid 40979845)
36. M.J. Somerman, M.F. Young, R.A. Foster, J.M. Moehring, G. Imm, and J.J. Sauk Characteristics of human periodontal ligament cells in vitro Arch. Oral Biol. 35 1990 241 247
37. W.H. Tang, Z. Chen, Z. Liu, J.H. Zhang, G. Xi, and H. Feng The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo Neurol. Res. 30 2008 571 580 (Pubitemid 352032553)
38. N. Toth, A. Szabo, P. Kacsala, J. Heger, and E. Zador 20-hydroxyecdysone increases fiber size in a muscle-specific fashion in rat Phytomedicine 15 2008 691 698
39. L. Trombelli Which reconstructive procedures are effective for treating the periodontal intraosseous defect? Periodontol. 2000 37 2005 88 105 (Pubitemid 43034333)
40. J.A. Vrotsos, A.O. Parashis, G.D. Theofanatos, and J.B. Smulow Prevalence and distribution of bone defects in moderate and advanced adult periodontitis J. Clin. Periodontol. 26 1999 44 48
41. S.K. Wu, H.C. Yeh, and C.P. Chan The prevalence and distribution of bone defects in patients with moderate to advanced periodontitis Chang Gung Med. J. 24 2001 423 430
42. J. Xu, W. Wang, Y. Kapila, J. Lotz, and S. Kapila Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells Stem Cells Dev. 18 2009 487 496
43. A. Yamashita, T. Takada, J. Narita, G. Yamamoto, and R. Torii Osteoblastic differentiation of monkey embryonic stem cells in vitro Cloning Stem Cells 7 2005 232 237 (Pubitemid 43121857)
44. Z. Yang, F. Jin, X. Zhang, D. Ma, C. Han, N. Huo, Y. Wang, Y. Zhang, Z. Lin, and Y. Jin Tissue engineering of cementum/periodontal-ligament complex using a novel three-dimensional pellet cultivation system for human periodontal ligament stem cells Tissue Eng. Part C Methods 15 2009 571 581
45. M. Zhao, S.E. Harris, D. Horn, Z. Geng, R. Nishimura, G.R. Mundy, and D. Chen Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation J. Cell Biol. 157 2002 1049 1060 (Pubitemid 34839779)
46. N.I. zur Nieden, G. Kempka, D.E. Rancourt, and H.J. Ahr Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages BMC Dev. Biol. 5 2005 1