Radiolabelling and PET brain imaging of the α1-adrenoceptor antagonist Lu AE43936

Nuclear Medicine and Biology

Volumn 40, Issue 1, 2013, Pages 135-140

  Risgaard, Rune ^a   Ettrup, Anders ^b   Balle, Thomas ^a,c   Dyssegaard, Agnete ^b   Hansen, Hanne Demant ^b   Lehel, Szabolcs ^b   Madsen, Jacob ^b   Pedersen, Henrik ^d   Püschl, Ask ^d   Badolo, Lassina ^d   Bang Andersen, Benny ^d   Knudsen, Gitte Moos ^b   Kristensen, Jesper Langgaard ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF SYDNEY   (Australia)

^d H LUNDBECK A S   (Denmark)

Author keywords

1 adrenoceptor; Antagonist; Octoclothepin; Permeability; PET; Radiolabelling

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CARBON 11; CLOROTEPINE; CYCLOSPORIN A; DIGOXIN; GLYCOPROTEIN; LU AE 43936; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOACCUMULATION; BLOOD LEVEL; BRAIN CORTEX; CONTROLLED STUDY; ENANTIOMER; FEMALE; ISOTOPE LABELING; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; RADIOACTIVITY; RADIOCHROMATOGRAPHY; RADIOISOTOPE DISTRIBUTION; RECEPTOR BINDING; STRUCTURE ANALYSIS; UPREGULATION;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; DIBENZOTHIEPINS; DOGS; FEMALE; ISOTOPE LABELING; LIGANDS; MADIN DARBY CANINE KIDNEY CELLS; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RECEPTORS, ADRENERGIC, ALPHA-1; STEREOISOMERISM;

EID: 84871920146     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.09.010     Document Type: Article

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