Human lymphotropic viruses: HTLV-1 and HTLV-2

Clinical Virology: Third Edition

Volumn , Issue , 2022, Pages 709-736

  Blattner, William A ^a   Charurat, Manhattan E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Adult t cell leukemia (ATL); Cellular apoptosis; HTLV 1 associated myelopathy (HAM); Human t cell lymphotropic virus type 1; Human t cell lymphotropic virus type 2; PCR assay

Indexed keywords

EID: 84871916534     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1128/9781555815981.ch32     Document Type: Chapter

References (185)

1. Alberts, B., D. Bray, A. Johnson, J. Lewis, M. Raff, K. Roberst, P. Walter. 1998. Essential Cell Biology: an Introduction to the Molecular Biology of the Cell. Garland Science Publishing, New York, NY.
2. Araujo, A., W. W. Hall. 2004. Human T- lymphotropic virus type II and neurological disease. Ann. Neurol. 56:10-19.
3. Araujo, A. P., L. M. Fontenelle, P. A. Padua, H. S. Maia Filho, Q. Araujo Ade. 2002. Juvenile human T lymphotropic virus type 1-associated myelopathy. Clin. Infect. Dis. 35:201-204.
4. Azran, I., Y. Schavinsky-Khrapunsky, E. Priel, M. Hu- leihel, M. Aboud. 2004. Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence. Int. J. Mol. Med. 14:909-915.
5. Bangham, C. R. 2000. The immune response to HTLV- I. Curr. Opin. Immunol. 12:397-402.
6. Bangham, C. R. M. 2000. HTLV-I infections. J. Clin. Pathol. 53:581-586.
7. Bangham, C. R. M., A. G. Kermode, S. E. Hall. 1996. The cytotoxic T-lymphocyte response to HTLV-I: the main determinant of disease? Semin. Virol. 7:41-48.
8. Barouch, D. H., Z. Y. Yang, W. P. Kong, B. Korioth- Schmitz, S. M. Sumida, D. M. Truitt, M. G. Kishko, J. C. Arthur, A. Miura, J. R. Mascola, N. L. Letvin, G. J. Nabel. 2005. A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates. J. Virol. 79:8828-8834.
9. Barre-Sinoussi, F., J.-C. Chermann, F. Rey, M. T. Nu- geyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler- Blin, F. Vezinet-Brun, C. Rouzioux, W. Rozenbaum, L. Montagnier. 1983. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868-871.
10. Bartholomew, C., W. Charles, C. Saxinger, W. Blattner, M. Robert-Guroff, C. Raju, P. Ratan, W. Ince, D. Quamina, K. Basdeo-Maharaj. 1985. Racial and other characteristics of human T cell leukemia/lymphoma (HTLV-I) and AIDS (HTLV-III) in Trinidad. Br. Med. J. 290:1243-1246.
11. Bartholomew, C., W. C. Saxinger, J. W. Clark, M. Gail, A. Dudgeon, B. Mahabir, B. Hull-Drysdale, F. Cleg- horn, R. C. Gallo, W. A. Blattner. 1987. Transmission of HTLV-I and HIV among homosexual men in Trinidad. JAMA 257:2604-2608.
12. Bazarbachi, A., D. Ghez, Y. Lepelletier, R. Nasr, H. de The, M. E. El-Sabban, O. Hermine. 2004. New therapeutic approaches for adult T-cell leukaemia. Lancet Oncol. 5:664-672.
13. Bazarbachi, A., R. Nasr, M. E. El-Sabban, A. Mahe, R. Mahieux, A. Gessain, N. Darwiche, G. Dbaibo, J. Ker- sual, Y. Zermati, L. Dianoux, M. K. Chelbi-Alix, H. de The, O. Hermine. 2000. Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma. Leukemia 14:716-721.
14. Biggar, R. J., Z. Buskell-Bales, P. N. Yakshe, D. Caussy, G. Gridley, L. Seeff. 1991. Antibody to human retroviruses among drug users in three east coast American cities, 1972-1976. J. Infect. Dis. 163:57-63.
15. Biggar, R. J., J. Ng, N. Kim, M. Hisada, H. C. Li, B. Cranston, B. Hanchard, E. M. Maloney. 2006. Human leukocyte antigen concordance and the transmission risk via breast-feeding of human T cell lymphotropic virus type I.J. Infect. Dis. 193:277-282.
16. Blattner, W. A., V. S. Kalynaraman, M. Robert-Guroff, T. A. Lister, D. A. Galton, P. S. Sarin, M. H. Crawford, D. Catovsky, M. Greaves, R. C. Gallo. 1982. The human type-C retrovirus, HTLV, in Blacks from the Caribbean region, relationship to adult T-cell leukemia/lymphoma. Int. J. Cancer 30:257-264.
17. Blattner, W. A., A. Nomura, J. W. Clark, G. Y. Ho, Y. Nakao, R. Gallo, M. Robert-Guroff. 1986. Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii. Proc. Natl. Acad. Sci. USA 83:4895-4898.
18. Blattner, W. A., C. Saxinger, D. Riedel, B. Hull, G. Taylor, F. Cleghorn, R. Gallo, B. Blumberg, C. Bartholomew. 1990. A study of HTLV-I and its associated risk factors in Trinidad and Tobago. J. Acquir. Immune Defic. Syndr. 3:1102-1108.
19. Blot, V., L. Delamarre, F. Perugi, D. Pham, S. Beni- chou, R. Benarous, T. Hanada, A. H. Chishti, M. C. Dokhelar, C. Pique. 2004. Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. J. Cell Sci. 117:3983-3993.
20. Bovolenta, C., E. Pilotti, M. Mauri, M. Turci, P. Cian- cianaini, P. Fisicaro, U. Bertazzoni, G. Poli, C. Ca- soli. 2002. Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony- stimulating factor. Blood 99:224-231.
21. Brauweiler, A., J. E. Gerrus, J. C. Reed, J. K. Nyborg. 1997. Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology 231:135-140.
22. Brodine, S. K., K. C. Hyams, C. A. Molgaard, S. I. Ito, R. J. Thomas, C. R. Roberts, A. L. Golbeck, E. C. Oldfield III, W. A. Blattner. 1995. The risk of human T cell leukemia virus and viral hepatitis infection among US Marines stationed in Okinawa, Japan. J. Infect. Dis. 171:693-696.
23. Calattini, S., S. A. Chevalier, R. Duprez, P. Afonso, A. Froment, A. Gessain, R. Mahieux. 2006. Human T- cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human Tax3 protein. J. Virol. 80:9876-9888.
24. Calattini, S., S. A. Chevalier, R. Duprez, S. Bassot, A. Froment, R. Mahieux, A. Gessain. 2005. Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa. Retrovirology 2:30.
25. Carneiro-Proietti, A. B., B. C. Catalan-Soares, C. M. Castro-Costa, E. L. Murphy, E. C. Sabino, M. Hisada, B. Galvao-Castro, L. C. Alcantara, C. Remondegui, K. Verdonck, F. A. Proietti. 2006. HTLV in the Americas: challenges and perspectives. Rev. Panam. Salud Publico. 19:44-53.
26. Casoli, C., E. Pilotti, U. Bertazzoni. 2007. Molecular and cellular interactions of HIV-1/HTLV coinfection and impact on AIDS progression. AIDS Rev. 9:140-149.
27. Catovsky, D., M. F. Greaves, M. Rose, D. A. Galton, A. W. Goolden, D. R. McCluskey, J. M. White, I. Lampert, G. Bourikas, R. Ireland, A. I. Brownell, J. M. Bridges, W. A. Blattner, R. C. Gallo. 1982. Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet i:639-643.
28. Centers for Disease Control. 1992. Update: serologic testing for human T-lymphotrophic virus type 1-United States. Morb. Mortal. Wkly. Rep. 41:259.
29. Centers for Disease Control and Prevention and the U.S.P.H.S. Working Group. 1993. Guidelines for counseling persons infected with human T-lymphotropic virus type I (HTLV-I) and type II (HTLV-II). Ann. Intern. Med. 118:448-454.
30. Chen, Y. M., A. Okayama, T. H. Lee, N. Tachibana, N. Mueller, M. Essex. 1991. Sexual transmission of human T-cell leukemia virus type I associated with the presence of anti-Tax antibody. Proc. Natl. Acad. Sci. USA 88: 1182-1186.
31. Chiyoda, S., K. Kinoshita, S. Egawa, J. Inoue, K. Wa- tanabe, M. Ifuku. 2001. Decline in the positive rate of human T-lymphotropic virus type-1 (HTLV-1) antibodies among blood donors in Nagasaki. Intern. Med. 40: 14-17.
32. Chlichlia, K., M. Busslinger, M. E. Peter, H. Walczak, P. H. Krammer, V. Schirrmacher, K. Khazaie. 1997. ICE-proteases mediate HTLV-I Tax-induced apoptotic T- cell death. Oncogene 14:2265-2272.
33. Cho, I., M. Sugimoto, S. Mita, M. Tokunaga, F. Ima- mura, M. Ando. 1995. In vivo proviral burden and viral RNA expression in T cell subsets of patients with human T lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis. Am. J. Trop. Med. Hyg. 53:412-418.
34. Ciancianaini, P., G. Magnani, E. Barchi, D. Padrini, T. Zauli, S. Ghezzi, C. Grosso, C. Casoli, U. Bertaz-zoni. 2001. Serological and clinical follow-up of an Italian IVDU cohort of HTLV-II /HIV-1 co-infected patients. Evidence of direct relationship between CD4 count and HTLV-II proviral load. AIDS Res. Hum. Retrovir. 17: S70.
35. Cleghorn, F. R., A. Manns, R. Falk, P. Hartge, B. Han- chard, N. Jack, E. Williams, E. Jaffe, F. White, C. Bartholomew, et al. 1995. Effect of human T-lymphotropic virus type I infection on non-Hodgkin's lymphoma incidence. J. Natl. Cancer Inst. 87:1009-10l4.
36. Datta, A., L. Silverman, A. J. Phipps, H. Hiraragi, L. Ratner, M. D. Lairmore. 2007. Human T- lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival. Retrovirology 4:49.
37. De Castro-Costa, C. M., A. Q. Araujo, M. M. Barreto, O. M. Takayanagui, M. P. Sohler, E. L. da Silva, S. M. de Paula, R. Ishak, J. G. Ribas, L. C. Rovirosa, H. Carton, E. Gotuzzo, W. W. Hall, S. Montano, E. L. Murphy, J. Oger, C. Remondegui, G. P. Taylor. 2006. Proposal for diagnostic criteria of tropical spastic paraparesis /HTLV-I-associated myelopathy (TSP/HAM). AIDS Res. Hum. Retrovir. 22:931-935.
38. Delaporte, E., M. Peeters, J. P. Durand, A. Dupont, D. Schrijvers, L. Bedjabaga, C. Honore, S. Ossari, A. Tre- bucq, R. Josse, M. Merlin. 1989. Seroepidemio- logical survey of HTLV-I infection among randomized populations of western central African countries. J. Ac- quir. Immune Defic. Syndr. 2:410-413.
39. Derse, D., B. Crise, Y. Li, G. Princler, N. Lum, C. Stewart, C. F. McGrath, S. H. Hughes, D. J. Munroe, X. Wu. 2007. Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses. J. Virol. 81:6731-6741.
40. Donegan, E., M. P. Busch, J. A. Galleshaw, G. M. Shaw, J. W. Mosley for The Transfusion Safety Study Group. 1990. Transfusion of blood components from a donor with human T-lymphotropic virus type II (HTLV- II) infection. Ann. Intern. Med. 113:555-556.
41. Endo, K., A. Hirata, K. Iwai, M. Sakurai, M. Fukushi, M. Oie, M. Higuchi, W. W. Hall, F. Gejyo, M. Fujii. 2002. Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. J. Virol. 76:2648-2653.
42. Ezaki, K., M. Hirano, R. Ohno, K. Yamada, K. Naito, Y. Hirota, S. Shirakawa, K. Kimura. 1991. A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia- lymphoma. Cancer 68:695-698.
43. Farid, R., M. Etemadi, H. Baradaran, B. Nikkin. 1993. Seroepidemiology and virology of HTLV-I in the city of Mashhad, northeastern Iran. Serodiagn. Immuno- ther. Infect. Dis. 5:251.
44. Feuer, G., P. L. Green. 2005. Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2. Oncogene 24:5996-6004.
45. Fox, R. I., M. Stern, P. Michelson. 2000. Update in Sjogren syndrome. Curr. Opin. Rheumatol. 12:391-398.
46. Franchini, G. 2001. HTLV and immortalization/transfor- mation: current concepts and clinical relevance. AIDS Res. Hum. Retrovir. 17:S5.
47. Frangione-Beebe, M., B. Albrecht, N. Dakappagari, R. T. Rose, C. L. Brooks, S. P. Schwendeman, M. D. Lairmore, P. T. Kaumaya. 2000. Enhanced immu- nogenicity of a conformational epitope of human T- lymphotropic virus type 1 using a novel chimeric peptide. Vaccine 19:1068-1081.
48. Fukushima, T., Y. Miyazaki, S. Honda, F. Kawano, Y. Moriuchi, M. Masuda, R. Tanosaki, A. Utsunomiya, N. Uike, S. Yoshida, J. Okamura, M. Tomonaga. 2005. Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia 19:829-834.
49. Gallo, R., S. Z. Salahuddin, M. Popovic, G. Shearer, M. Kaplan, B. F. Haynes, T. J. Palker, R. R. Redfield, J. Oleske, B. Safai, F. White, P. Foster, P. D. Markham. 1984. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500-503.
50. Gallo, R., F. Wong-Staal, L. Montagnier, W. A. Haseltine, M. Yoshida. 1988. HIV/HTLV gene nomenclature. Nature 333:504.
51. Gallo, R. C., P. S. Sarin, E. P. Gelmann, M. Robert- Guroff, E. Richardson, V. S. Kalynaraman, D. Mann, G. D. Sidhu, R. E. Stahl, S. Zolla-Pazner, J. Leibowitch, M. Popovic. 1983. Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220:865-867.
52. Garcia-Vallejo, F., M. C. Dominguez, O. Tamayo. 2005. Autoimmunity and molecular mimicry in tropical spastic paraparesis /human T-lymphotropic virus- associated myelopathy. Braz. J. Med. Biol. Res. 38:241250.
53. Gaudray, G., F. Gachon, J. Basbous, M. Biard- Piechaczyk, C. Devaux, J. M. Mesnard. 2002. The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J. Virol. 76: 12813-12822.
54. Gessain, A., F. Barin, J. C. Vernant, O. Gout, L. Maurs, A. Calender, G. De The. 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet ii:407-410.
55. Gessain, A., R. Mahieux. 2000. A virus called HTLV-1. Epidemiological aspects. Presse Med. 29:2233-2239.
56. Gessain, A., R. Yanagihara, G. Franchini, R. M. Gar- ruto, C. L. Jenkins, A. B. Ajdukiewicz, R. C. Gallo, D. C. Gajdusek. 1991. Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands. Proc. Natl. Acad. Sci. USA 88:7694-7698.
57. Ghez, D., Y. Lepelletier, S. Lambert, J.-M. Fourneau, V. Blot, S. Janvier, B. Arnulf, P. M. van Endert, N. Hev- eker, C. Pique, O. Hermine. 2006. Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry. J. Virol. 80:6844-6854.
58. Gill, P. S., W. Harrington, M. H. Kaplan, R. C. Ribeiro, J. M. Bennett, H. A. Liebman, M. Bernstein-Singer, B. M. Espina, L. Cabral, S. Allen, S. Kornblau, M. C. Pike, A. M. Levine. 1995. Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. N. Engl. J. Med. 332:1744-1748.
59. Grassmann, R., M. Aboud, K. T. Jeang. 2005. Molecular mechanisms of cellular transformation by HTLV- 1 Tax. Oncogene 24:5976-5985.
60. Guerreiro, J. B., S. B. Santos, D. J. Morgan, A. F. Porto, A. L. Muniz, J. Lotto, A. L. Teixeira, Jr., M. M. Teix- eira, E. M. Carvalho. 2006. Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state. Clin. Exp. Immunol. 145:296-301.
61. Hall, W. W., C. R. Liu, O. Schneewind, H. Takahashi, M. H. Kaplan, G. Roupe, A. Vahlne. 1991. Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides. Science 253:317-320.
62. Hanon, E., S. Hall, G. P. Taylor, M. Saito, R. Davis, Y. Tanaka, K. Usuku, M. Osame, J. N. Weber, C. R. Bangham. 2000. Abundant Tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood 95:1386-1392.
63. Hanon, E., J. C. Stinchcombe, M. Saito, B. E. Asquith, G. P. Taylor, Y. Tanaka, J. N. Weber, G. M. Griffiths, C. R. Bangham. 2000. Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lym- photropic virus type I. Immunity 13:657-664.
64. Harhaj, N. S., S. C. Sun, E. W. Harhaj. 2007. Activation of NF-KB by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin- dependent relocalization of IKB kinase. J. Biol. Chem. 282:4185-4192.
65. Heneine, W., R. F. Khabbaz, R. B. Lal, J. E. Kaplan. 1992. Sensitive and specific polymerase chain reaction assays for diagnosis of human T-cell lymphotropic virus type I (HTLV-I) and HTLV-II infections in HTLV-I/II- seropositive individuals. J. Clin. Microbiol. 30:1605-1607.
66. Hermine, O., H. Dombret, J. Poupon, B. Arnulf, F. Lef- rere, P. Rousselot, G. Damaj, R. Delarue, J. P. Fermand, J. C. Brouet, L. Degos, B. Varet, H. de The, A. Bazarbachi. 2004. Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma. Hematol. J. 5:130-134.
67. Higuchi, M., C. Tsubata, R. Kondo, S. Yoshida, M. Takahashi, M. Oie, Y. Tanaka, R. Mahieux, M. Matsuoka, M. Fujii. 2007. Cooperation of NF-KB2/P100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line. J. Virol. 81:1190011907.
68. Hino, S., S. Katamine, K. Kawase, T. Miyamoto, H. Doi, Y. Tsuji, T. Yamabe. 1994. Intervention of maternal transmission of HTLV-1 in Nagasaki, Japan. Leukemia 8(Suppl. 1):S68-S70.
69. Ho, G. Y., A. M. Nomura, K. Nelson, H. Lee, B. F. Polk, W. A. Blattner. 1991. Declining seropreva- lence and transmission of HTLV-I in Japanese families who immigrated to Hawaii. Am. J. Epidemiol. 134:981987.
70. Ijichi, S., T. Matsuda, I. Maruyama, T. Izumihara, K. Kojima, T. Niimura, Y. Maruyama, S. Sonoda, A. Yo- shida, M. Osame. 1990. Arthritis in a human T lymphotropic virus type I (HTLV-I) carrier. Ann. Rheum. Dis. 49:718-721.
71. Ishitsuka, K., K. Takamura. 2007. Treatment of adult T-cell leukemia/lymphoma: past, present, future. Eur. J. Haematol. 80:185-196.
72. Jacobson, S., A. Gupta, D. Mattson, E. Mingioli, D. E. McFarlin. 1990. Immunological studies in tropical spastic paraparesis. Ann. Neurol. 27:149-156.
73. Jacobson, S., J. S. Reuben, R. D. Streilein, T. J. Palker. 1991. Induction of CD4 +, human T lymphotropic virus type-1-specific cytotoxic T lymphocytes from patients with HAM/TSP. Recognition of an immunogenic region of the gp46 envelope glycoprotein of human T lymphotropic virus type-1. J. Immunol. 146:11551162.
74. Jacobson, S., H. Shida, D. E. McFarlin, A. S. Fauci, S. Koenig. 1990. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV- I associated neurological disease. Nature 348:245-248.
75. Jeang, K. T., S. G. Widen, O. J. Semmes IV, S. H. Wilson. 1990. HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. Science 247:1082-1084.
76. Jeffery, K. J., K. Usuku, S. E. Hall, W. Matsumoto, G. P. Taylor, J. Procter, M. Bunce, G. S. Ogg, K. I. Welsh, J. N. Weber, A. L. Lloyd, M. A. Nowak, M. Nagai, D. Kodama, S. Izumo, M. Osame, C. R. Bangham. 1999. HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I- associated myelopathy. Proc. Natl. Acad. Sci. USA 96: 3848-3853.
77. Jin, D. Y., F. Spencer, K. T. Jeang. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93:8191.
78. Jones, K. S., K. Fugo, C. Petrow-Sadowski, Y. Huang, D. C. Bertolette, I. Lisinski, S. W. Cushman, S. Jacobson, F. W. Ruscetti. 2006. Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells. J. Virol. 80:8291-8302.
79. Kajiyama, W., S. Kashiwagi, H. Nomura, H. Ikematsu, J. Hayashi, W. Ikematsu. 1986. Seroepidemiologic study of antibody to adult T-cell leukemia virus in Okinawa, Japan. Am. J. Epidemiol. 123:41-47.
80. Kalynaraman, V. S., M. G. Sarngadharan, M. Robert- Guroff, I. Miyoshi, D. Golde, R. C. Gallo. 1982. A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218:571-573.
81. Kao, S. Y., F. J. Lemoine, S. J. Marriott. 2000. HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA-damaging agents. Oncogene 19: 2240-2248.
82. Kao, S. Y., F. J. Lemoine, S. J. Marriott. 2000. Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway. J. Biol. Chem. 275:35926-35931.
83. Kaplan, J. E., R. F. Khabbaz, E. L. Murphy, S. Herman- sen, C. Roberts, R. Lal, W. Heneine, D. Wright, L. Ma- tijas, R. Thomson, D. Rudolph, W. M. Switzer, S. Kleinman, M. Busch, G. B. Schreiber for The Retrovirus Epidemiology Donor Study Group. 1996. Male- to-female transmission of human T-cell lymphotropic virus types I and II: association with viral load. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12:193-201.
84. Kasai, T., Y. Iwanaga, H. Iha, K. T. Jeang. 2002. Prevalent loss of mitotic spindle checkpoint in adult T- cell leukemia confers resistance to microtubule inhibitors. J. Biol. Chem. 277:5187-5193.
85. Kataoka, R., N. Takehara, Y. Iwahara, T. Sawada, Y. Ohtsuki, Y. Dawei, H. Hoshino, I. Miyoshi. 1990. Transmission of HTLV-I by blood transfusion and its prevention by passive immunization in rabbits. Blood 76: 1657-1661.
86. Kawakami, A., T. Nakashima, H. Sakai, S. Urayama, S. Yamasaki, A. Hida, M. Tsuboi, H. Nakamura, H. Ida, K. Migita, Y. Kawabe, K. Eguchi. 1999. Inhibition of caspase cascade by HTLV-I Tax through induction of NF-KB nuclear translocation. Blood 94:3847-3854.
87. Kazanji, M., J. Tartaglia, G. Franchini, B. de Thoisy, A. Talarmin, H. Contamin, A. Gessain, G. de The. 2001. Immunogenicity and protective efficacy of recombinant human T-cell leukemia/lymphoma virus type 1 NYVAC and naked DNA vaccine candidates in squirrel monkeys (Saimiri sciureus). J. Virol. 75:5939-5948.
88. Kitajima, M., Y. Korogi, Y. Shigematsu, L. Liang, M. Matsuoka, T. Yamamoto, M. Jhono, K. Eto, M. Takahashi. 2002. Central nervous system lesions in adult T- cell leukaemia: MRI and pathology. Neuroradiology 44: 559-567.
89. Kiyokawa, T., M. Seiki, S. Iwashita, K. Imagawa, F. Shimizu, M. Yoshida. 1985. p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 82: 8359-8363.
90. Klimas, N. G., J. B. Page, R. Patarca, D. Chitwood, R. Morgan, M. A. Fletcher. 1993. Effects of retroviral infections on immune function in African- American intravenous drug users. AIDS 7:331-335.
91. Korber, B., A. Okayama, R. Donnelly, N. Tachibana, M. Essex. 1991. Polymerase chain reaction analysis of defective human T-cell leukemia virus type I proviral genomes in leukemic cells of patients with adult T-cell leukemia. J. Virol. 65:5471-5476.
92. Kubo, T., S. W. Zhu, S. Ijichi, H. Takahashi, W. W. Hall. 1994. Molecular characterization of human T-cell leukemia virus, type II (HTLV-II). AIDS Res. Hum. Retrovir. 10:465.
93. LaGrenade, L., B. Hanchard, V. Fletcher, B. Cranston, W. Blattner. 1990. Infective dermatitis of Jamaican children: a marker for HTLV-I infection. Lancet 336: 1345-1347.
94. Lairmore, M. D., B. Albrecht, C. D'Souza, J. W. Nis- bet, W. Ding, J. T. Bartoe, P. L. Green, W. Zhang. 2000. In vitro and in vivo functional analysis of human T cell lymphotropic virus type 1 pX open reading frames I and II. AIDS Res. Hum. Retrovir. 16: 1757-1764.
95. Lal, R. B., S. M. Owen, D. L. Rudolph, C. Dawson, H. Prince. 1995. In vivo cellular tropism of human T-lymphotropic virus type II is not restricted to CD8 + cells. Virology 210:441-447.
96. Larsen, O., S. Andersson, Z. da Silva, K. Hedegaard, A. Sandstrom, A. Naucler, F. Dias, M. Melbye, P. Aaby. 2000. Prevalences of HTLV-1 infection and associated risk determinants in an urban population in Guinea-Bissau, West Africa. J. Acquir. Immune Defic. Syndr. 25:157-163.
97. Lee, H. H., P. Swanson, J. D. Rosenblatt, I. S. Chen, W. C. Sherwood, D. E. Smith, G. E. Tegtmeier, L. P. Fernando, C. T. Fang, M. Osame, S. H. Kleinman. 1991. Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors. Lancet 337: 1435-1439.
98. Leon-Ponte, M., O. Noya, N. Bianco, G. Echev- erria de Perez. 1996. Highly endemic human T- lymphotropic virus type II (HTLV-II) infection in a Venezuelan Guahibo Amerindian group. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13:281-286.
99. Levin, M. C., S. M. Lee, Y. Morcos, J. Brady, J. Stuart. 2002. Cross-reactivity between immunodominant human T lymphotropic virus type I Tax and neurons: implications for molecular mimicry. J. Infect. Dis. 186:1514-1517.
100. Lewis, M. J., V. W. Gautier, X. P. Wang, M. H. Kaplan, W. W. Hall. 2000. Spontaneous production of C-C chemokines by individuals infected with human T lymphotropic virus type II (HTLV-II) alone and HTLV- II/HIV-1 coinfected individuals. J. Immunol. 165:41274132.
101. Li, H. C., R. J. Biggar, W. J. Miley, E. M. Maloney, B. Cranston, B. Hanchard, M. Hisada. 2004. Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I.J. Infect. Dis. 190:1275-1278.
102. Li, H. C., T. Fujiyoshi, H. Lou, S. Yashiki, S. Sonoda, L. Cartier, L. Nunez, I. Munoz, S. Horai, K. Ta-jima. 1999. The presence of ancient human T-cell lym- photropic virus type I provirus DNA in an Andean mummy. Nat. Med. 5:1428-1432.
103. Liang, M. H., T. Geisbert, Y. Yao, S. H. Hinrichs, C. Z. Giam. 2002. Human T-lymphotropic virus type 1 oncoprotein Tax promotes S-phase entry but blocks mitosis. J. Virol. 76:4022-4033.
104. Lima, M. A., R. C. Harab, D. Schor, M. J. Andrada-Serpa, A. Q. Araujo. 2007. Subacute progression of human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J. Neurovirol. 13:468-473.
105. Lynch, M. P., P. T. Kaumaya. 2006. Advances in HTLV-1 peptide vaccines and therapeutics. Curr. Protein Pept. Sci. 7:137-145.
106. Madeleine, M. M., S. Z. Wiktor, J. J. Goedert, A. Manns, P. H. Levine, R. J. Biggar, W. A. Blattner. 1993. HTLV-I and HTLV-II world-wide distribution: reanalysis of 4, 832 immunoblot results. Int. J. Cancer 54: 255-260.
107. Mahieux, R., A. Gessain. 2005. New human retroviruses: HTLV-3 and HTLV-4. Med. Trop. 65:525-528.
108. Maloney, E. M., R. J. Biggar, J. V. Neel, M. E. Taylor, B. H. Hahn, G. M. Shaw, W. A. Blattner. 1992. Endemic human T cell lymphotropic virus type II infection among isolated Brazilian Amerindians. J. Infect. Dis. 166:100-107.
109. Maloney, E. M., E. L. Murphy, J. P. Figueroa, W. N. Gibbs, B. Cranston, B. Hanchard, M. Holding- Cobham, K. Malley, W. A. Blattner. 1991. Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica. II. Geographic and ecologic determinants. Am. J. Epidemiol. 133:1125-1134.
110. Manel, N., N. Taylor, S. Kinet, F. J. Kim, L. Swainson, M. Lavanya, J. L. Battini, M. Sitbon. 2004. HTLV envelopes and their receptor GLUT1, the ubiquitous glucose transporter: a new vision on HTLV infection? Front. Biosci. 9:3218-3241.
111. Manns, A., R. J. Wilks, E. L. Murphy, G. Haynes, J. P. Figueroa, M. Barnett, B. Hanchard, W. A. Blattner. 1992. A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion. Int. J. Cancer 51:886-891.
112. Marinho, J., B. Galvao-Castro, L. C. Rodrigues, M. L. Barreto. 2005. Increased risk of tuberculosis with human T-lymphotropic virus-1 infection: a case-control study. J. Acquir. Immune Defic. Syndr. 40:625-628.
113. Marsh, B. J. 1996. Infectious complications of human T cell leukemia /lymphoma virus type I infection. Clin. Infect. Dis. 23:138-145.
114. Matsuzaki, H., H. Hata, N. Asou, M. Yoshida, F. Matsuno, M. Takeya, K. Yamaguchi, I. Sanada, K. Ta- katsuki. 1992. Human T-cell leukemia virus-1-positive cell line established from a patient with small cell lung cancer. Jpn. J. Cancer Res. 83:450-457.
115. Matutes, E. 2007. Adult T-cell leukaemia/lymphoma. J. Clin. Pathol. 60:1373-1377.
116. Menna-Barreto, M. 2006. HTLV-II transmission to a health care worker. Am. J. Infect. Control 34:158-160.
117. Moarbess, G., H. El-Hajj, Y. Kfoury, M. E. El-Sabban, Y. Lepelletier, O. Hermine, C. Deleuze-Masquefa, P. A. Bonnet, A. Bazarbachi. 2008. EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase dependent apoptosis in T cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma. Blood 111:3770-3777.
118. Modahl, L. E., K. C. Young, K. F. Varney, H. Khayam- Bashi, E. L. Murphy. 1995. Injection drug users seropositive for human T-lymphotropic virus type II (HTLV-II) are at increased risk for pneumonia. J. Acquir. Immune Defic. Synd. Hum. Retrovirol. 10:260.
119. Mori, N., M. Morishita, T. Tsukazaki, C. Z. Giam, A. Kumatori, Y. Tanaka, N. Yamamoto. 2001. Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/ p300. Blood 97:2137-2144.
120. Morofuji-Hirata, M., W. Kajiyama, K. Nakashima, A. Noguchi, J. Hayashi, S. Kashiwagi. 1993. Prevalence of antibody to human T-cell lymphotropic virus type I in Okinawa, Japan, after an interval of 9 years. Am. J. Epidemiol. 137:43-48.
121. Mueller, N., N. Tachibana, S. O. Stuver, A. Okayama, J. Ishizaki, E. Shishime, K. Murai, S. Shioiri, K. Tsuda. 1990. Epidemiologic perspectives of HTLV-I, p. 281-294. In W.A. Blattner (ed.), Human Retrovirology: HTLV. Lippincott-Raven, Philadelphia, PA.
122. Mulloy, J. C., T. Kislyakova, A. Cereseto, L. Casareto, A. LoMonico, J. Fullen, M. V. Lorenzi, A. Cara, C. Nicot, C.-Z. Giam, G. Franchini. 1998. Human T- cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain. J. Virol. 72:8852-8860.
123. Murata, K., Y. Yamada. 2007. The state of the art in the pathogenesis of ATL and new potential targets associated with HTLV-1 and ATL. Int. Rev. Immunol. 26:249-268.
124. Murphy, E. L., J. P. Figueroa, W. N. Gibbs, A. Brath- waite, M. Holding-Cobham, D. Waters, B. Cranston, B. Hanchard, W. A. Blattner. 1989. Sexual transmission of human T-lymphotropic virus type I (HTLV- I). Ann. Intern. Med. 111:555-560.
125. Murphy, E. L., J. P. Figueroa, W. N. Gibbs, M. Holding-Cobham, B. Cranston, K. Malley, A. J. Bodner, S. S. Alexander, W. A. Blattner. 1991. Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica. I. Demographic determinants. Am. J. Epidemiol. 133:1114-1124.
126. Murphy, E. L., B. Wang, R. A. Sacher, J. Fridey, J. W. Smith, C. C. Nass, B. Newman, H. E. Ownby, G. Gar- ratty, S. T. Hutching, G. B. Schreiber. 2004. Respiratory and urinary tract infections, arthritis, asthma associated with HTLV-I and HTLV-II infection. Emerg. Infect. Dis. 10:109-116.
127. Murphy, E. L., Y. Wu, H. E. Ownby, J. W. Smith, R. K. Ruedy, R. A. Thomson, D. I. Ameti, D. J. Wright, G. J. Nemo. 2001. Delayed hypersensitivity skin testing to mumps and Candida albicans antigens is normal in middle-aged HTLV-I- and-II-infected U.S. cohorts. AIDS Res. Hum. Retrovir. 17:1273-1277.
128. Nagai, M., M. B. Brennan, J. A. Sakai, C. A. Mora, S. Jacobson. 2001. CD8+ T cells are an in vivo reservoir for HTLV-I. Blood 98:1858-1861.
129. Nagai, M., K. Usuku, W. Matsumoto, D. Kodama, N. Takenouchi, T. Moritoyo, S. Hashiguchi, M. Ichinose, C. R. Bangham, S. Izumo, M. Osame. 1998. Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J. Neurovirol. 4: 586-593.
130. Nakao, K., N. Ohba, M. Nakagawa, M. Osame. 1999. Clinical course of HTLV-I-associated uveitis. Jpn. J. Ophthalmol. 43:404-409.
131. Narikawa, K., K. Fujihara, T. Misu, J. Feng, J. Fujimori, I. Nakashima, I. Miyazawa, H. Sato, S. Sato, Y. Itoyama. 2005. CSF-chemokines in HTLV-I- associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-alpha. J. Neuroimmunol. 159: 177-182.
132. Nicot, C., R. Opavsky, R. Mahieux, J. M. Johnson, J. N. Brady, L. Wolff, G. Franchini. 2000. Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells. AIDS Res. Hum. Retrovir. 16: 1629-1632.
133. Oger, J. 2007. HTLV-1 infection and the viral etiology of multiple sclerosis. J. Neurol. Sci. 262:100-104.
134. Oh, U., Y. Yamano, C. A. Mora, J. Ohayon, F. Bag- nato, J. A. Butman, J. Dambrosia, T. P. Leist, H. McFarland, S. Jacobson. 2005. Interferon-beta1a therapy in human T-lymphotropic virus type I-associated neurologic disease. Ann. Neurol. 57:526-534.
135. Oliveira Mde, F., C. Brites, N. Ferraz, P. Magalhaes, F. Almeida, A. Bittencourt. 2005. Infective dermatitis associated with the human T cell lymphotropic virus type I in Salvador, Bahia, Brazil. Clin. Infect. Dis. 40: e90-e96.
136. Orland, J. R., J. Engstrom, J. Fridey, R. A. Sacher, J. W. Smith, C. Nass, G. Garratty, B. Newman, D. Smith, B. Wang, K. Loughlin, E. L. Murphy for the HTLV Outcomes Study. 2003. Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes Study. Neurology 61:1588-1594.
137. Parker, C. E., S. Daenke, S. Nightingale, C. R. Bangham. 1992. Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. Virology 188:628-636.
138. Parkin, D. M. 2006. The global health burden of infection-associated cancers in the year 2002. Int. J. Cancer 118:3030-3044.
139. Poiesz, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, R. C. Gallo. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77:7415-7419.
140. Price, J., B. A. Cant, J. A. Barbara, R. S. Tedder. 2001. Human T-cell leukaemia/lymphoma virus risk may be enhanced in some selected donor populations. Vox. Sang. 80:148-150.
141. Primo, J. R., C. Brites, F. Oliveira Mde, O. MorenoCarvalho, M. Machado, A. L. Bittencourt. 2005. Infective dermatitis and human T cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in childhood and adolescence. Clin. Infect. Dis. 41:535-541.
142. Prince, H. E., E. R. Jensen, J. York. 1992. Lymphocyte subsets in HTLV-II-infected former blood donors: relationship to spontaneous lymphocyte proliferation. Clin. Immunol. Immunopathol. 65:201-206.
143. Proietti, F. A., A. B. Carneiro-Proiletti, B. C. Catalan- Soares, E. L. Murphy. 2005. Global epidemiology of HTLV-I infection and associated diseases. Oncogene 24:6058-6068.
144. Reeves, W. C., J. R. Cutler, F. Gracia, J. E. Kaplan, L. Castillo, T. M. Hartley, M. M. Brenes, M. Larreategui, S. de Loo de Lao, C. Archbold, et al. 1990. Human T cell lymphotropic virus infection in Guaymi Indians from Panama. Am. J. Trop. Med. Hyg. 43:410-418.
145. Roberts, C. R., D. R. Fipps, J. F. Brundage, S. E. Wright, M. Goldenbaum, S. S. Alexander, D. S. Burke. 1992. Prevalence of human T-lymphotropic virus in civilian applicants for the United States Armed Forces. Am. J. Public Health 82:70-73.
146. Rosenblatt, J. D., J. V. Giorgi, D. W. Golde, J. B. Ezra, A. Wu, C. D. Winberg, J. Glaspy, W. Wachsman, I. S. Chen. 1988. Integrated human T-cell leukemia virus II genome in CD8 + T cells from a patient with ''atypical'' hairy cell leukemia: evidence for distinct T and B cell lymphoproliferative disorders. Blood 71:363369.
147. Rosenblatt, J. D., D. W. Golde, W. Wachsman, J. V. Giorgi, A. Jacobs, G. M. Schmidt, S. Quan, J. C. Gas- son, I. S. Chen. 1986. A second isolate of HTLV- II associated with atypical hairy-cell leukemia. N. Engl. J. Med. 315:372-377.
148. Rosenblatt, J. D., S. Plaeger-Marshall, J. V. Giorgi, P. Swanson, I. S. Chen, E. Chin, H. J. Wang, M. Canavaggio, M. A. Hausner, A. C. Black. 1990. A clinical, hematologic, immunologic analysis of 21 HTLV-II-infected intravenous drug users. Blood 76:409417.
149. Ross, T. M., S. M. Pettiford, P. L. Green. 1996. The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes. J. Virol. 70:5194-5202.
150. Roucoux, D. F., B. Wang, D. Smith, C. C. Nass, J. Smith, S. T. Hutching, B. Newman, T. H. Lee, D. M. Chafets, E. L. Murphy. 2005. A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II. J. Infect. Dis. 191:1490-1497.
151. Saito, M., M. Nakagawa, S. Kaseda, T. Matsuzaki, M. Jonosono, N. Eiraku, R. Kubota, N. Takenouchi, M. Nagai, Y. Furukawa, K. Usuku, S. Izumo, M. Osame. 2004. Decreased human T lymphotropic virus type I (HTLV-I) provirus load and alteration in T cell phenotype after interferon-alpha therapy for HTLV-I- associated myelopathy/tropical spastic paraparesis. J. Infect. Dis. 189:29-40.
152. Sarngadharan, M. G., A. L. DeVico, L. Bruch, J. Schupbach, R. C. Gallo. 1984. HTLV-III: the eti- ologic agent of AIDS. Princess Takamatsu Symp. 15:301308.
153. Satoh, M., A. Kokaze. 2004. Treatment strategies in controlling strongyloidiasis. Expert Opin. Pharma- cother. 5:2293-2301.
154. Shames, B. D., A. M. D'Alessandro, H. W. Sol- linger. 2002. Human T-cell lymphotrophic virus infection in organ donors: a need to reassess policy? Am. J. Transplant. 2:658-663.
155. Sinha-Datta, U., A. Datta, S. Ghorbel, M. D. Dodon, C. Nicot. 2007. Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication. J. Biol. Chem. 282: 14608-14615.
156. Sonoda, S. 1990. Genetic and immunologic determinants of HTLV-I associated diseases, p. 315. In W.A. Blattner (ed.), Human Retrovirology: HTLV. Lippincott- Raven, Philadelphia, PA.
157. Switzer, W. M., I. Hewlett, L. Aaron, N. D. Wolfe, D. S. Burke, W. Heneine. 2006. Serologic testing for human T-lymphotropic virus-3 and -4. Transfusion 46:1647-1648.
158. Switzer, W. M., S. H. Qari, N. D. Wolfe, D. S. Burke, T. M. Folks, W. Heneine. 2006. Ancient origin and molecular features of the novel human T-lymphotropic virus type 3 revealed by complete genome analysis. J. Virol. 80:7424-7438.
159. Tachibana, N., A. Okayama, S. Ishihara, S. Shioiri, K. Murai, K. Tsuda, N. Goya, Y. Matsuo, M. Essex, S. Stuver, N. Mueller. 1992. High HTLV-I proviral DNA level associated with abnormal lymphocytes in peripheral blood from asymptomatic carriers. Int. J. Cancer 51:593-595.
160. Taguchi, H., I. Miyoshi. 1989. Immune suppression in HTLV-I carriers: a predictive sign of adult T-cell leukemia. Acta Med. Okayama 43:317-321.
161. Tajima, K., R. Amakawa, K. Uehira, N. Matsumoto, T. Shimizu, Y. Miyazaki, M. Fujimoto, Y. Kishimoto, S. Fukuhara. 2000. Adult T-cell leukemia successfully treated with allogeneic bone marrow transplantation. Int. J. Hematol. 71:290-293.
162. Takatsuki, K. 2005. Discovery of adult T-cell leukemia. Retrovirology 2:16.
163. Takemoto, S., R. Trovato, A. Cereseto, C. Nicot, T. Kislyakova, L. Casareto, T. Waldmann, G. Torelli, G. Franchini. 2000. p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells. Blood 95:3939-3944.
164. Tanaka, G., A. Okayama, T. Watanabe, S. Aizawa, S. Stuver, N. Mueller, C. C. Hsieh, H. Tsubouchi. 2005. The clonal expansion of human T lymphotropic virus type 1-infected T cells: a comparison between seroconverters and long-term carriers. J. Infect. Dis. 191: 1140-1147.
165. Taylor, G. P., P. Goon, Y. Furukawa, H. Green, A. Barfield, A. Mosley, H. Nose, A. Babiker, P. Rudge, K. Usuku, M. Osame, C. R. Bangham, J. N. Weber. 2006. Zidovudine plus lamivudine in human T-lymphotropic virus type-I-associated myelopathy: a randomised trial. Retrovirology 3:63.
166. Tsukahara, T., M. Kannagi, T. Ohashi, H. Kato, M. Arai, G. Nunez, Y. Iwanaga, N. Yamamoto, K. Ohtani, M. Nakamura, M. Fujii. 1999. Induction of Bcl-xL expression by human T-cell leukemia virus type 1 Tax through NF-KB in apoptosis-resistant T-cell tranfectants with Tax. J. Virol. 73:7981-7987.
167. Tsukasaki, K., S. Ikeda, K. Murata, T. Maeda, S. Ato- gami, H. Sohda, S. Momita, T. Jubashi, Y. Yamada, M. Mine, et al. 1993. Characteristics of chemotherapy- induced clinical remission in long survivors with aggressive adult T-cell leukemia/lymphoma. Leukocyte Res. 17:157-166.
168. Tsukasaki, K., K. Tobinai, M. Shimoyama, M. Kozuru, N. Uike, Y. Yamada, M. Tomonaga, K. Araki, M. Kasai, K. Takatsuki, M. Tara, C. Mikuni, T. Hotta. 2003. Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). Int. J. Hematol. 77:164-170.
169. Vandamme, A. M., M. Salemi, J. Desmyter. 1998. The simian origins of the pathogenic human T-cell lym- photropic virus type I. Trends Microbiol. 6:477-483.
170. Van Dooren, S., M. Salemi, A. M. Vandamme. 2001. Dating the origin of the African human T-cell lymphotropic virus type-i (HTLV-I) subtypes. Mol. Biol. Evol. 18:661-671.
171. Vidal, A. U., A. Gessain, M. Yoshida, F. Tekaia, B. Garin, B. Guillemain, T. Schulz, R. Farid, G. De The. 1994. Phylogenetic classification of human T cell leukaemia/lymphoma virus type I genotypes in five major molecular and geographical subtypes. J. Gen. Virol. 75:3655-3666.
172. Vitek, C. R., F. I. Gracia, R. Giusti, K. Fukuda, D. B. Green, L. C. Castillo, B. Armien, R. F. Khabbaz, P. H. Levine, J. E. Kaplan, W. A. Blattner. 1995. Evidence for sexual and mother-to-child transmission of human T lymphotropic virus type II among Guaymi Indians, Panama. J. Infect. Dis. 171:1022-1026.
173. Wattel, E., M. Cavrois, A. Gessain, S. Wain- Hobson. 1996. Clonal expansion of infected cells: a way of life for HTLV-I. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13(Suppl. 1):S92-S99.
174. Welles, S. L., N. Tachibana, A. Okayama, S. Shioiri, S. Ishihara, K. Murai, N. E. Mueller. 1994. Decreased reactivity to PPD among HTLV-I carriers in relation to virus and hematologic status. Int. J. Cancer 56: 337-340.
175. Wiktor, S. Z., E. J. Pate, E. L. Murphy, T. J. Palker, E. Champegnie, A. Ramlal, B. Cranston, B. Hanchard, W. A. Blattner. 1993. Mother-to-child transmission of human T-cell lymphotropic virus type I (HTLV-I) in Jamaica: association with antibodies to envelope glycoprotein (gp46) epitopes. J. Acquir. Immune Defic. Syndr. 6:1162-1167.
176. Wiktor, S. Z., E. J. Pate, P. S. Rosenberg, M. Barnett, P. Palmer, D. Medeiros, E. M. Maloney, W. A. Blattner. 1997. Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding. J. Hum. Virol. 1:37-44.
177. Wolfe, N. D., W. Heneine, J. K. Carr, A. D. Garcia, V. Shanmugam, U. Tamoufe, J. N. Torimiro, A. T. Prosser, M. Lebreton, E. Mpoudi-Ngole, F. E. Mc- Cutchan, D. L. Birx, T. M. Folks, D. S. Burke, W. M. Switzer. 2005. Emergence of unique primate T- lymphotropic viruses among central African bushmeat hunters. Proc. Natl. Acad. Sci. USA 102:7994-7999.
178. Xie, L., P. L. Green. 2005. Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2. J. Virol. 79:14536-14545.
179. Yamaguchi, K., T. Kiyokawa, G. Futami, T. Ishii, K. Takatsui. 1990. Pathogenesis of adult T-cell leukemia from clinical pathologic features, p. 163. In W.A. Blattner (ed.), Human Retrovirology: HTLV. Lippincott- Raven, Philadelphia, PA.
180. Yamaguchi, K., M. Shimoyama, K. Takatsuki. 1990. Adult T-Cell Leukemia and HTLV-1 Related Diseases. Eisai, Tokyo, Japan.
181. Yamano, Y., C. J. Cohen, N. Takenouchi, K. Yao. U. Tomaru, H. C. Li, Y. Reiter, S. Jacobson. 2004. Increased expression of human T lymphocyte virus type I (HTLV-1) Tax 11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease. J. Exp. Med. 199:1367-1377.
182. Yamano, Y., M. Nagai, M. Brennan, C. A. Mora, S. S. Soldan, U. Tomaru, N. Takenouchi, S. Izumo, M. Osame, S. Jacobson. 2002. Correlation of human T- cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood 99:88-94.
183. Yamano, Y., N. Takenouchi, H. C. Li, U. Tomaru, K. Yao, C. W. Grant, D. A. Maric, S. Jacobson. 2005. Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. J. Clin. Investig. 115:1361-1368.
184. Yoshida, M. 2001. Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu. Rev. Immunol. 19:475-496.
185. Zehender, G., L. Meroni, S. Varchetta, C. De Madda- lena, B. Cavalli, M. Gianotto, A. B. Bosisio, C. Colasante, G. Rizzardini, M. Moroni, M. Galli. 1998. Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy. J. Virol. 72:7664-7668.