Nucleotide-binding Oligomerization Domain-1 Ligand Induces Inflammation and Attenuates Glucose Uptake in Human Adipocytes

Chinese Medical Sciences Journal

Volumn 27, Issue 3, 2012, Pages 147-152

  Zhou, Yi jun ^a   Li, Ai ^a   Song, Yu ling ^a   Li, Yan ^a   Zhou, Hui ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

human adipocyte; inflammation; insulin resistance; nucleotide binding oligomerization domain 1

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 4; CYTOKINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; NOD1 PROTEIN, HUMAN;

ADIPOCYTE; ADULT; ARTICLE; BIOSYNTHESIS; CELL CULTURE; FEMALE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADIPOCYTES; ADULT; CELLS, CULTURED; CYTOKINES; FEMALE; GLUCOSE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; LIGANDS; MIDDLE AGED; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN;

MLCS; MLOWN;

EID: 84871913399     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1001-9294(14)60047-X     Document Type: Article

References (18)

1. Hotamisligil, GS, Erbay, E, Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8 (2008), 923–934.
2. Steinberg, GR, Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance. Cell Cycle 6 (2007), 888–894.
3. Cseh, K, Baranyi, E, Winkler, G, The role of cytokines of the innate and adaptive immune system in the regulation of insulin resistance. Diabetologia 42 (1999), 497–498.
4. Schertzer, JD, Klip, A, Give a NOD to insulin resistance. Am J Physiol Endocrinol Metab 301 (2011), E585–E586.
5. Davis, JE, Gabler, NK, Walker-Daniels, J, et al. The c-Jun N-terminal kinase mediates the induction of oxidative stress and insulin resistance by palmitate and toll-like receptor 2 and 4 ligands in 3T3-L1 adipocytes. Horm Metab Res 41 (2009), 523–530.
6. Himes, RW, Smith, CW, Tlr2 is critical for diet-induced metabolic syndrome in a murine model. FASEB J 24 (2010), 731–739.
7. Poggi, M, Bastelica, D, Gual, P, et al. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50 (2007), 1267–1276.
8. Shi, H, Kokoeva, MV, Inouye, K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116 (2006), 3015–3025.
9. Magalhaes, JG, Lee, J, Geddes, K, et al. Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol 41 (2011), 1445–1455.
10. Zhao, L, Hu, P, Zhou, Y, et al. NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 301 (2011), E587–E598.
11. Stroh, T, Batra, A, Glauben, R, et al. Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes. J Immunol 181 (2008), 3620–3627.
12. Ceddia, RB, Somwar, R, Maida, A, et al. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 48 (2005), 132–139.
13. Pickup, JC, Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27 (2004), 813–823.
14. Bes-Houtmann, S, Roche, R, Hoareau, L, et al. Presence of functional TLR2 and TLR4 on human adipocytes. Histochem Cell Biol 127 (2007), 131–137.
15. Kopp, A, Buechler, C, Neumeier, M, et al. Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity (Silver Spring) 17 (2009), 648–656.
16. Barnes, PJ, Karin, M, Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336 (1997), 1066–1071.
17. Rotter, V, Nagaev, I, Smith, U, Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin resistant subjects. J Biol Chem 278 (2003), 45777–45784.
18. Stienstra, R, van Diepen, JA, Tack, CJ, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci USA 108 (2011), 15324–15329.