Unexpected role for properdin in complement C3 glomerulopathies

Journal of the American Society of Nephrology

Volumn 24, Issue 1, 2013, Pages 5-7

  Daha, Mohamed R ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C5; COMPLEMENT FACTOR H; PROPERDIN;

COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT LECTIN PATHWAY; DISEASE ACTIVITY; EDITORIAL; GENE MUTATION; GLOMERULONEPHRITIS; GLOMERULOPATHY; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; HEMOLYTIC UREMIC SYNDROME; HUMAN; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL;

EID: 84871868272     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012111110     Document Type: Editorial

References (15)

1. Walport MJ: Complement. First of two parts. N Engl J Med 344: 1058-1066, 2001
2. Fearon DT, Austen KF: Properdin: Binding to C3b and stabilization of the C3b-dependent C3 convertase. J Exp Med 142: 856-863, 1975
3. Ferreira VP, Herbert AP, Hocking HG, Barlow PN, Pangburn MK: Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. J Immunol 177: 6308-6316, 2006 (Pubitemid 44628849)
4. Józsi M, Oppermann M, Lambris JD, Zipfel PF: The C-terminus of complement factor H is essential for host cell protection. Mol Immunol 44: 2697-2706, 2007 (Pubitemid 46240314)
5. Pickering MC, Cook HT: Translational mini-review series on complement factor H: Renal diseases associated with complement factor H: Novel insights from humans and animals. Clin Exp Immunol 151: 210-230, 2008
6. Pickering MC, Cook HT, Warren J, Bygrave AE, Moss J, Walport MJ, Botto M: Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet 31: 424-428, 2002 (Pubitemid 35154455)
7. Høgåsen K, Jansen JH, Mollnes TE, Hovdenes J, Harboe M: Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency. J Clin Invest 95: 1054-1061, 1995
8. Rose KL, Paixao-Cavalcante D, Fish J, Manderson AP, Malik TH, Bygrave AE, Lin T, Sacks SH, Walport MJ, Cook HT, Botto M, Pickering MC: Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. J Clin Invest 118: 608-618, 2008 (Pubitemid 351206550)
9. Kemper C, Atkinson JP, Hourcade DE: Properdin: Emerging roles of a pattern-recognition molecule. Annu Rev Immunol 28: 131-155, 2010
10. Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, Ali YM, Botto M, Cook HT, Song W-C, Stover CM, Pickering MC: Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol 24: 43-52, 2013
11. Lesher AM, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert AP, Barlow PN, Eberhardt HU, Skerka C, Zipfel PF, Hamano T, Miwa T, Tung KS, Song WC: Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol 24: 53-65, 2013
12. Kimura Y, Zhou L, Miwa T, Song WC: Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J Clin Invest 120: 3545-3554, 2010
13. Zhou HF, Yan H, Stover CM, Fernandez TM, Rodriguez de Cordoba S, Song WC, Wu X, Thompson RW, Schwaeble WJ, Atkinson JP, Hourcade DE, Pham CT: Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A 109: E415-E422, 2012
14. Paixão-Cavalcante D, López-Trascasa M, Skattum L, Giclas PC, Goodship TH, de Córdoba SR, Truedsson L, Morgan BP, Harris CL: Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation. Kidney Int 82: 1084-1092, 2012
15. Ricklin D: Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy. Immunobiology 217: 1057-1066, 2012