Blocking a2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation

Journal of Immunology

Volumn 190, Issue 1, 2013, Pages 138-146

  Wei, Wei ^a,b   Du, Changsheng ^a   Lv, Jie ^a,b   Zhao, Guixian ^c,d   Li, Zhenxin ^c,d   Wu, Zhiying ^c,d   Hasḱo, György ^e   Xie, Xin ^a,b  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c FUDAN UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e University of Medicine and Dentistry of New Jersey   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; CVT 6883; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; PHOSPHOLIPASE C BETA; PROTEIN KINASE C; UNCLASSIFIED DRUG; GROWTH INHIBITOR; IL6 PROTEIN, HUMAN; INTERLEUKIN 6, MOUSE; INTERLEUKIN-6, MOUSE;

ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LYMPHATIC SYSTEM DISEASE; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; TH17 CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; COCULTURE; DRUG ANTAGONISM; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; UPREGULATION;

ADULT; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GROWTH INHIBITORS; HUMANS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; RECEPTOR, ADENOSINE A2B; TH17 CELLS; UP-REGULATION;

EID: 84871830994     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103721     Document Type: Article

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