Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis

Kidney International

Volumn 83, Issue 1, 2013, Pages 41-49

  Hatano, Ryo ^a   Fujii, Eiko ^a   Segawa, Hiroko ^b   Mukaisho, Kenichi ^c   Matsubara, Mitsunobu ^d   Miyamoto, Ken Ichi ^b   Hattori, Takanori ^c   Sugihara, Hiroyuki ^c   Asano, Shinji ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

calcium; phosphate uptake; vitamin D

Indexed keywords

CALCITRIOL; CALCIUM; EZRIN; MESSENGER RNA; PHOSPHATE; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGER REGULATORY FACTOR 1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BONE DENSITY; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DUODENUM; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HYPOCALCEMIA; HYPOPHOSPHATEMIA; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSTEOMALACIA; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VITAMIN BLOOD LEVEL;

EID: 84871811002     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.308     Document Type: Article

References (26)

1. Biber J, Hernando N, Forster I et al. Regulation of phosphate transport in proximal tubules. Pflugers Arch 2009; 458: 39-52.
2. Murer H, Hernando N, Forster I et al. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol Rev 2000; 80: 1373-1409.
3. Forster IC, Hernando N, Biber J et al. Proximal tubular handling of phosphate: a molecular perspective. Kidney Int 2006; 70: 1548-1559.
4. Bacic D, Wagner CA, Hernando N et al. Novel aspects in regulated expression of the renal type IIa Na/Pi-cotransporter. Kidney Int Suppl 2004; 91: S5-S12.
5. Weinman EJ, Steplock D, Shenolikar S et al. Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. Am J Physiol Renal Physiol 2011; 300: F231-F235.
6. + exchanger regulatory factor-1 complexes. Am J Physiol Cell Physiol 2005; 289: C159-C167.
7. Shenolikar S, Voltz JW, Minkoff CM et al. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci USA 2002; 99: 11470-11475.
8. Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002; 3: 586-599.
9. Morales FC, Takahashi Y, Kreimann EL et al. Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia. Proc Natl Acad Sci USA 2004; 101: 17705-17710.
10. Nashiki K, Taketani Y, Takeichi T et al. Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells. Kidney Int 2005; 68: 1137-1147.
11. Mahon MJ. Ezrin promotes functional expression and parathyroid hormone-mediated regulation of the sodium-phosphate cotransporter 2a in LLC-PK1 cells. Am J Physiol Renal Physiol 2008; 294: F667-F675.
12. Saotome I, Curto M, McClatchey AI. Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell 2004; 6: 855-864.
13. Tamura A, Kikuchi S, Hata M et al. Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol 2005; 169: 21-28.
14. Hoenderop JG, Nilius R, Bindels RJ. Calcium absorption across epithelia. Physiol Rev 2005; 85: 373-422.
15. Beck L, Karaplis AC, Amizuka N et al. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 1998; 95: 5372-5377.
16. Segawa H, Onitsuka A, Furutani J et al. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol 2009; 297: F671-F678.
17. i cotransporters. Proc Natl Acad Sci USA 2002; 99: 11957-11962.
18. i cotransporter with PDZ protein. J Biol Chem 2001; 276: 9206-9213.
19. Villa-Bellosta R, Barac-Nieto M, Breusegem SY et al. Interactions of the growth-related, type IIc renal sodium/phosphate cotransporter with PDZ proteins. Kidney Int 2008; 73: 456-464.
20. i cotransporter (Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channels 1 and 2. Pflugers Arch 2002; 444: 670-676.
21. Van Cromphaut SJ, Dewerchin M, Hoenderop JG et al. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci USA 2001; 98: 13324-13329.
22. 2+ channels TRPV5 and TRPV6 with the intestine-and kidney-enriched PDZ protein NHERF4. Pflugers Arch 2006; 452: 407-417.
23. Alizadeh Naderi AS, Reilly RF. Hereditary disorders of renal phosphate wasting. Nat Rev Nephrol 2010; 6: 657-665.
24. Li YC, Pirro AE, Amling M et al. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 1997; 94: 9831-9835.
25. Kondo T, Takeuchi K, Doi Y et al. ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis. J Cell Biol 1997; 139: 749-758.
26. Biber J, Stieger B, Stange G et al. Isolation of renal proximal tubular brush-border membranes. Nat Protoc 2007; 2: 1356-1359.