The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit

Bone

Volumn 52, Issue 2, 2013, Pages 718-724

  Fahlgren, Anna ^a,b   Yang, Xu ^a   Ciani, Cesare ^a   Ryan, James A ^a   Kelly, Natalie ^a,c   Ko, Frank C ^c   van der Meulen, Marjolein C H ^a,c   Bostrom, Mathias P G ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b LINKÖPING UNIVERSITY   (Sweden)

^c Cornell University ^*  (United States)

Author keywords

Bone adaptation; Cancellous bone; Implant; Loading; PTH; Surgery

Indexed keywords

PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1; PROCOLLAGEN C PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE IMPLANT; BONE INJURY; BONE MASS; BONE REMODELING; CELL PROLIFERATION; CONTROLLED STUDY; EXPERIMENTAL RABBIT; NONHUMAN; OSSIFICATION; OSTEOBLAST; TRABECULAR BONE; WEIGHT BEARING;

ANALYSIS OF VARIANCE; ANIMALS; BIOMECHANICS; FEMUR; IMPLANTS, EXPERIMENTAL; PARATHYROID HORMONE; RABBITS; WEIGHT-BEARING;

EID: 84871810785     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.05.005     Document Type: Article

References (32)

1. Skripitz R., Aspenberg P. Early effect of parathyroid hormone (1-34) on implant fixation. Clin Orthop Relat Res 2001, 427-432.
2. Skripitz R., Aspenberg P. Implant fixation enhanced by intermittent treatment with parathyroid hormone. J Bone Joint Surg Br 2001, 83:437-440.
3. Chambers T.J., Evans M., Gardner T.N., Turner-Smith A., Chow J.W. Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner 1993, 20:167-178.
4. DeSouza R. Transforming possibilities of care: goan migrant motherhood in New Zealand. Contemp Nurse 2005, 20:87-101.
5. Fritton J.C., Myers E.R., Wright T.M., van der Meulen M.C. Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia. Bone 2005, 36:1030-1038.
6. Goldstein S.A., Matthews L.S., Kuhn J.L., Hollister S.J. Trabecular bone remodeling: an experimental model. J Biomech 1991, 24(Suppl. 1):135-150.
7. van der Meulen M.C., Morgan T.G., Yang X., Baldini T.H., Myers E.R., Wright T.M., et al. Cancellous bone adaptation to in vivo loading in a rabbit model. Bone 2006, 38:871-877.
8. van der Meulen M.C., Yang X., Morgan T.G., Bostrom M.P. The effects of loading on cancellous bone in the rabbit. Clin Orthop Relat Res 2009, 467:2000-2006.
9. Willie B.M., Yang X., Kelly N.H., Han J., Nair T., Wright T.M., et al. Cancellous bone osseointegration is enhanced by in vivo loading. Tissue Eng Part C Methods 2010, 16:1399-1406.
10. Daugaard H., Elmengaard B., Andreassen T., Bechtold J., Lamberg A., Soballe K. Parathyroid hormone treatment increases fixation of orthopedic implants with gap healing: a biomechanical and histomorphometric canine study of porous coated titanium alloy implants in cancellous bone. Calcif Tissue Int 2011, 88:294-303.
11. Daugaard H., Elmengaard B., Andreassen T.T., Baas J., Bechtold J.E., Soballe K. The combined effect of parathyroid hormone and bone graft on implant fixation. J Bone Joint Surg Br 2011, 93:131-139.
12. Kamo K., Miyakoshi N., Kasukawa Y., Nozaka K., Sasaki H., Shimada Y. Intermittent weekly administration of human parathyroid hormone (1-34) improves bone-hydroxyapatite block bonding in ovariectomized rats. J Bone Miner Metab 2010, 28:634-640.
13. Hollister S.J., Guldberg R.E., Kuelske C.L., Caldwell N.J., Richards M., Goldstein S.A. Relative effects of wound healing and mechanical stimulus on early bone response to porous-coated implants. J Orthop Res 1996, 14:654-662.
14. McKee M.D., Pedraza C.E., Kaartinen M.T. Osteopontin and wound healing in bone. Cells Tissues Organs 2011, 194(2-4):313-319.
15. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
16. Chow J.W., Fox S., Jagger C.J., Chambers T.J. Role for parathyroid hormone in mechanical responsiveness of rat bone. Am J Physiol 1998, 274:E146-E154.
17. Kim C.H., Takai E., Zhou H., von Stechow D., Muller R., Dempster D.W., et al. Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment. J Bone Miner Res 2003, 18:2116-2125.
18. Sugiyama T., Saxon L.K., Zaman G., Moustafa A., Sunters A., Price J.S., et al. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice. Bone 2008, 43:238-248.
19. Gardner M.J., van der Meulen M.C., Carson J., Zelken J., Ricciardi B.F., Wright T.M., et al. Role of parathyroid hormone in the mechanosensitivity of fracture healing. J Orthop Res 2007, 25:1474-1480.
20. O'Brien C.A., Plotkin L.I., Galli C., Goellner J.J., Gortazar A.R., Allen M.R., et al. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One 2008, 3:e2942.
21. Lindsay R., Zhou H., Cosman F., Nieves J., Dempster D.W., Hodsman A.B. Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium. J Bone Miner Res 2007, 22:495-502.
22. Iida-Klein A., Zhou H., Lu S.S., Levine L.R., Ducayen-Knowles M., Dempster D.W., et al. Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. J Bone Miner Res 2002, 17:808-816.
23. Jilka R.L., O'Brien C.A., Bartell S.M., Weinstein R.S., Manolagas S.C. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J Bone Miner Res 2010, 25:2427-2437.
24. Ma Y.L., Zeng Q., Donley D.W., Ste-Marie L.G., Gallagher J.C., Dalsky G.P., et al. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. J Bone Miner Res 2006, 21:855-864.
25. Jilka R.L., O'Brien C.A., Ali A.A., Roberson P.K., Weinstein R.S., Manolagas S.C. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone 2009, 44:275-286.
26. Li M., Liang H., Shen Y., Wronski T.J. Parathyroid hormone stimulates cancellous bone formation at skeletal sites regardless of marrow composition in ovariectomized rats. Bone 1999, 24:95-100.
27. Watson P., Lazowski D., Han V., Fraher L., Steer B., Hodsman A. Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor I gene expression in ovariectomized rats. Bone 1995, 16:357-365.
28. Rubin M.R., Cosman F., Lindsay R., Bilezikian J.P. The anabolic effects of parathyroid hormone. Osteoporos Int 2002, 13:267-277.
29. Sample S.J., Behan M., Smith L., Oldenhoff W.E., Markel M.D., Kalscheur V.L., et al. Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. J Bone Miner Res 2008, 23:1372-1381.
30. Pierroz D.D., Bonnet N., Baldock P.A., Ominsky M.S., Stolina M., Kostenuik P.J., et al. Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL. J Biol Chem 2010, 285:28164-28173.
31. Aspenberg P., Wermelin K., Tengwall P., Fahlgren A. Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats. Acta Orthop 2008, 79:111-115.
32. Lynch M.E., Main R.P., Xu Q., Walsh D.J., Schaffler M.B., Wright T.M., van der Meulen M.C.H. Cancellous bone adaptation to dynamic tibial compression is not sex-dependent in growing mice. J Appl Physiol 2010, 109:685-691.